Journal of Diagnostics Concepts & Practice ›› 2020, Vol. 19 ›› Issue (1): 74-79.doi: 10.16150/j.1671-2870.2020.01.015
• Original articles • Previous Articles Next Articles
HU Yinga, BAO Yujiea, BAI Yupana, LU Guanzhua, CHENG Yajiaoa, GUO Zhuyingb, XU Jiea()
Received:
2019-10-05
Online:
2020-02-25
Published:
2020-02-25
Contact:
XU Jie
E-mail:dr.xu@aliyun.com
CLC Number:
HU Ying, BAO Yujie, BAI Yupan, LU Guanzhu, CHENG Yajiao, GUO Zhuying, XU Jie. Analysis of clinical and laboratory characteristics of EB virus infection in 67 adult patients[J]. Journal of Diagnostics Concepts & Practice, 2020, 19(1): 74-79.
观察指标 | 青中年组(n=19) | 老年组(n=48) | 统计值 | P值 |
---|---|---|---|---|
白细胞计数(×109/L) | 7.2±3.2 | 7.0±4.3 | t=0.027 | 0.979 |
中性粒细胞计数(×109/L) | 4.5±2.5 | 5.3±4.0 | t=-0.894 | 0.979 |
单核细胞计数(×109/L) | 0.6±0.3 | 0.5±0.3 | t=0.861 | 0.374 |
血小板计数(×109/L) | 218.2±105.6 | 158.3±94.5 | t=2.170 | 0.034 |
ALT (U/L) | 53.0(250.0,1 380.5) | 26.0(15.3,90.8) | Z=-1.280 | 0.200 |
AST (U/L) | 57.0(22.0,110.0) | 36.5(21.5,90.8) | Z=-0.912 | 0.362 |
GGT (U/L) | 84.0(23.0,151.0) | 53.0(22.0,134.0) | Z=-0.710 | 0.478 |
ALP (U/L) | 100(76.0,120.0) | 103(70.0,150.0) | Z=-0.042 | 0.967 |
TBIL (μmol/L) | 14.0(10.0,57.9) | 12.6(10.2,27.4) | Z=-0.250 | 0.802 |
DBIL (μmol/L) | 3.1(2.2,17.7) | 2.2(2.3,7.7) | Z=-0.278 | 0.781 |
IBIL (μmol/L) | 10.3(7.4,24.4) | 99.0(7.2,20.1) | Z=-0.529 | 0.597 |
[1] |
Sarwari NM, Khoury JD, Hernandez CM. Chronic Epstein Barr virus infection leading to classical Hodgkin lymphoma[J]. BMC Hematol, 2016, 16:19.
doi: 10.1186/s12878-016-0059-3 pmid: 27437106 |
[2] |
Landais E, Saulquin X, Houssaint E. The human T cell immune response to Epstein-Barr virus[J]. Int J Dev Biol, 2005, 49(2-3):285-292.
pmid: 15906243 |
[3] |
de Paschale M, Clerici P. Serological diagnosis of Epstein-Barr virus infection: Problems and solutions[J]. World J Virol, 2012, 1(1):31-43.
doi: 10.5501/wjv.v1.i1.31 pmid: 24175209 |
[4] |
Vedham V, Verma M, Mahabir S. Early-life exposures to infectious agents and later cancer development[J]. Cancer Med, 2015, 4(12):1908-1922.
doi: 10.1002/cam4.538 URL |
[5] |
Cohen JI. Epstein-barr virus vaccines[J]. Clin Transl Immunology, 2015, 4(1):e32.
doi: 10.1038/cti.2014.27 URL |
[6] |
Vine LJ, Shepherd K, Hunter JG, et al. Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis[J]. Aliment Pharmacol Ther, 2012, 36(1):16-21.
doi: 10.1111/j.1365-2036.2012.05122.x URL |
[7] | 孙佳, 赵龙凤. 47例成人EB病毒感染临床分析[J]. 中华传染病杂志, 2018, 36(6):358-360. |
[8] | 强春倩, 荆国红, 徐学彩, 等. 104例EB病毒感染肝功能损害患者的临床特点及预后分析[J]. 中华实验和临床感染病杂志:电子版, 2014. 8(3):410-413. |
[9] | 宋培新, 孙静, 唐勤. 53例成人EB病毒感染相关疾病临床分析[J]. 中国血液流变学杂志, 2008, 18(4):551-554. |
[10] | 人类年龄划分又有新标准[J]. 民俗研究, 2001, 17(3):26. |
[11] |
Hislop AD, Taylor GS, Sauce D, et al. Cellular responses to viral infection in humans: lessons from Epstein-Barr virus[J]. Annu Rev Immunol, 2007, 25:587-617.
doi: 10.1146/annurev.immunol.25.022106.141553 URL |
[12] |
Tsurumi T, Fujita M, Kudoh A. Latent and lytic Epstein-Barr virus replication strategies[J]. Rev Med Virol, 2005, 15(1):3-15.
doi: 10.1002/rmv.441 URL |
[13] | 汪洋. EB病毒的流行病学研究进展[J]. 国际检验医学杂志, 2010, 31(12):1405-1407. |
[14] |
Fugl A, Andersen CL. Epstein-Barr virus and its associa-tion with disease-a review of relevance to general practice[J]. BMC Fam Pract, 2019, 20(1):62.
doi: 10.1186/s12875-019-0954-3 pmid: 31088382 |
[15] |
Kimura H, Fujiwara S. Overview of EBV-associated T/NK-cell lymphoproliferative diseases[J]. Front Pediatr, 2019, 6:417.
doi: 10.3389/fped.2018.00417 URL |
[16] |
Vranic S, Cyprian FS, Akhtar S, et al. The role of Epstein-Barr virus in cervical cancer: A brief update[J]. Front Oncol, 2018, 8:113.
doi: 10.3389/fonc.2018.00113 pmid: 29719817 |
[17] |
Bedri S, Sultan AA, Alkhalaf M, et al. Epstein-Barr virus (EBV) status in colorectal cancer: a mini review[J]. Hum Vaccin Immunother, 2019: 15(3):603-610.
doi: 10.1080/21645515.2018.1543525 URL |
[18] | 苗彦, 林棱, 姚瑾, 等. 60例成人 EB 病毒感染临床特点分析[J]. 中国临床医生杂志, 2015, 43(10):37-40. |
[19] |
Chatterjee B, Deng Y, Holler A, et al. CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo[J]. PLoS Pathog, 2019, 15(5):e1007748.
doi: 10.1371/journal.ppat.1007748 URL |
[20] |
Vallejo AN. CD 28 extinction in human T cells: altered functions and the program of T-cell senescence[J]. Immunol Rev, 2005, 205:158-169.
pmid: 15882352 |
[21] |
Weinberger B, Welzl K, Herndler-Brandstetter D, et al. CD28(-)CD8(+) T cells do not contain unique clonotypes and are therefore dispensable[J]. Immunol Lett, 2009, 127(1):27-32.
doi: 10.1016/j.imlet.2009.08.008 pmid: 19715728 |
[22] |
Yin H, Qu J, Peng Q, et al. Molecular mechanisms of EBV-driven cell cycle progression and oncogenesis[J]. Med Microbiol Immunol, 2019, 208(5):573-583.
doi: 10.1007/s00430-018-0570-1 URL |
[23] | 徐婷娟, 沈国栋, 程民, 等. T淋巴细胞亚群检测在老年肿瘤患者中的临床意义[J]. 中国临床保健杂志, 2018, 21(5):623-625. |
[24] | Qin L, Jing X, Qiu Z, et al. Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults[J]. Aging (Albany NY), 2016, 8(5):848-859. |
[25] |
Ebell MH. Epstein-Barr virus infectious mononucleosis[J]. Am Fam Physician, 2004, 70(7):1279-1287.
pmid: 15508538 |
[26] | 汪国蓉, 王强, 凡翟明, 等. 化学发光免疫分析法在检测儿童EB病毒感染中的应用[J]. 中华医院感染学杂志, 2012, 22(15):3430-3432. |
[27] |
Gulley ML, Tang W. Laboratory assays for Epstein-Barr virus-related disease[J]. J Mol Diagn, 2008, 10(4):279-292.
doi: 10.2353/jmoldx.2008.080023 URL |
[28] |
Wang Z, Lv Z, Ding H, et al. Role of serum EBV-VCA IgG detection in assessing gastric cancer risk and prognosis in Northern Chinese population[J]. Cancer Med, 2018, 7(11):5760-5774.
doi: 10.1002/cam4.1792 URL |
[29] |
Analysis of plasma Epstein-Barr virus DNA to screen for nasopharyngeal cancer[J]. N Engl J Med, 2018, 378(10):973.
doi: 10.1056/NEJMx180004 URL |
[30] |
Kim KY, Le QT, Yom SS, et al. Clinical utility of Epstein-Barr virus DNA testing in the treatment of nasopharyngeal carcinoma patients[J]. Int J Radiat Oncol Biol Phys, 2017, 98(5):996-1001.
doi: 10.1016/j.ijrobp.2017.03.018 URL |
[31] |
Brussel A, Brack K, Muth E, et al. Use of a new RNA next generation sequencing approach for the specific detection of virus infection in cells[J]. Biologicals, 2019, 59:29-36.
doi: S1045-1056(19)30026-0 pmid: 30992161 |
[1] | LIN Xia, GAO Chao, HUANG Pei, WANG Gang, LIN Guozhen, REN Rujing. Analysis of clinical and imaging manifestations in 8 patients with MOGAG and literature review [J]. Journal of Diagnostics Concepts & Practice, 2022, 21(05): 606-612. |
[2] | SHI Dongmei, WANG Xiaolin, CHEN Lu, XIE Qing. Clinical characteristics and misdiagnosis analysis of sparganosis:A retrospective study of 52 cases [J]. Journal of Diagnostics Concepts & Practice, 2020, 19(1): 37-43. |
[3] | WANG Juan, WANG Kaiwen, ZHAO Jiangfeng. Value of anti-melanoma differentiation-related gene 5 antibody for assessing disease activity and prognosis in patients with dermatomyositis-associated interstitial lung disease [J]. Journal of Diagnostics Concepts & Practice, 2019, 18(2): 155-159. |
[4] | LU Xiaoxue, DA Qian. Clinical characteristics and pathological features of Kimura disease: report of 13 case and review of literature [J]. Journal of Diagnostics Concepts & Practice, 2017, 16(06): 639-644. |
[5] | . [J]. Journal of Diagnostics Concepts & Practice, 2014, 13(01): 49-53. |
[6] | . [J]. Journal of Diagnostics Concepts & Practice, 2008, 7(03): 326-329. |
[7] | . [J]. Journal of Diagnostics Concepts & Practice, 2005, 4(01): 62-64. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||