Abstract:

Objective: To investigate the correlation of glycosylated hemoglobin and fasting blood glucose level with severity of lesion in elderly patients with carotid artery atherosclerosis. Methods: A total of 144 patients with carotid artery atherosclerosis admitted to the Geriatrics Department of Shanghai Ruijin Hospital Luwan Branch from May 1, 2017 to May 31, 2018 were enrolled. According to the results of vascular ultrasonography, patients were categorized into mode-rate atherosclerosis group and severe atherosclerosis group. The general condition and related medical history were recor-ded, and the Crouse score of carotid artery plaque was calculated. On the second day of admission, fasting blood sample was taken to detect glycosylated hemoglobin and fasting blood glucose level. The correlation of glycosylated hemoglobin and fasting blood glucoselevel with severity of atherosclerotic lesion was analyzed. Results: Compared with moderate atherosclerosis group, the fasting blood glucose level [(6.86±1.98) mmol/L vs （5.72±1.33） mmol/L, P<0.05] and glycated hemoglobin [(6.47±2.53)% vs （5.43±1.24）%, P<0.05) of severe atherosclerosis group were significantly increased. Logistic regression analysis showed that glycated hemoglobin (r=0.578, P<0.05) and fasting blood glucose level (r=0.479, P<0.05) were positively correlated with the severity of carotid artery atherosclerosis. Conclusions: Glycated hemoglobin and fasting blood glucose level in elderly patients with carotid artery atherosclerosis are correlated significantly with the severity of carotid artery atherosclerosis.

Key woeds: Atherosclerosis; Glycated hemoglobin; Blood glucose; Crouse integral