Research advances in adipose tissue aging related cytological changes and molecular

doi:10.16150/j.1671-2870.2022.05.019

Abstract

Abstract:

Adipose tissue coordinates energy storage and expenditure is one of the important organisms for maintaining energy metabolic homeostasis. Aging or intracellular or external stimuli may induce senescence of adipose progenitor and stem cells as well as mature adipocytes, which are accompanied by immune cell infiltration, diminished lipid storage and lipolysis capacity in white adipose tissue and impaired thermogenesis in brown and beige adipose tissue. These ultimately trigger metabolic diseases such as obesity and type 2 diabetes. Interventions for aging of adipose tissue mainly include drug therapy, caloric restriction, and gene editing, but there is still a lack of mature therapeutic options. Therefore, cytological alterations of adipose tissue aging and its molecular mechanisms can help to comprehensively understand the dynamic changes of adipose tissue during the aging process, which may provide theoretical clues to explore the pathogenesis of aging-related metabolic diseases and develop clinical therapeutic targets.

Key words: Adipose tissue, Aging, Obesity, Metabolic disease

CLC Number:

R329.2⁺5

YE Yafen, YANG Ying, HAN Junfeng. Research advances in adipose tissue aging related cytological changes and molecular[J]. Journal of Diagnostics Concepts & Practice, 2022, 21(05): 650-654.

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