内科理论与实践 ›› 2024, Vol. 19 ›› Issue (01): 77-81.doi: 10.16138/j.1673-6087.2024.01.14
收稿日期:
2023-10-30
出版日期:
2024-02-29
发布日期:
2024-04-28
通讯作者:
倪磊
E-mail:nilei625@139.com
HUANG Xianna1, CHEN Yunce1, ZHOU Min2, NI Lei1,2()
Received:
2023-10-30
Online:
2024-02-29
Published:
2024-04-28
Contact:
NI Lei
E-mail:nilei625@139.com
摘要:
糖尿病患者不仅是新型冠状病毒(新冠)的易感人群,并且在感染新冠后容易出现免疫失衡、过度炎症反应、多脏器功能损伤等并发症,导致病情更为复杂,危重症的概率显著升高,应引起临床医师重视。本文通过回顾国内外相关文献,总结了新冠导致糖代谢异常的机制,以及糖尿病患者感染新冠的临床特点和血糖管理的原则,以提高对此类患者的临床认知和治疗成功率。
中图分类号:
黄仙娜, 陈云册, 周敏, 倪磊. 糖尿病患者合并新型冠状病毒感染的研究进展[J]. 内科理论与实践, 2024, 19(01): 77-81.
HUANG Xianna, CHEN Yunce, ZHOU Min, NI Lei. Research progress on diabetes patients combined with COVID-19 infection[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(01): 77-81.
[1] |
Wang L, Gao P, Zhang M, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J]. JAMA, 2017, 317(24):2515-2523.
doi: 10.1001/jama.2017.7596 pmid: 28655017 |
[2] |
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395(10223):497-506.
doi: 10.1016/S0140-6736(20)30183-5 URL |
[3] |
Liu F, Long X, Zhang B, et al. ACE2 expression in pancreas may cause pancreatic damage after SARS-CoV-2 infection[J]. Clin Gastroenterol Hepatol, 2020, 18(9):2128-2130.
doi: 10.1016/j.cgh.2020.04.040 URL |
[4] |
Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression[J]. Lancet, 2020, 395(10229):1033-1034.
doi: S0140-6736(20)30628-0 pmid: 32192578 |
[5] |
Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome[J]. Lancet Respir Med, 2020, 8(4):420-422.
doi: 10.1016/S2213-2600(20)30076-X pmid: 32085846 |
[6] |
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China[J]. Lancet, 2020, 395(10223):507-513.
doi: 10.1016/S0140-6736(20)30211-7 URL |
[7] | Guo W, Li M, Dong Y, et al. Diabetes is a risk factor for the progression and prognosis of COVID-19[J]. Diabetes Metab Res Rev, 2020, 36(7):e3319. |
[8] | Chai X, Hu L, Zhang Y, et al. Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection[EB/J]. bioRxiv, 2020. https://europepmc.org/article/PPR/PPR111788. |
[9] | 彭玲玲. 新型冠状病毒肺炎合并糖尿病患者的高血糖影响因素分析[J]. 中国临床药理学杂志, 2020, 36(7):1-4. |
[10] | Leung C. Clinical features of deaths in the novel coronavirus epidemic in China[J]. Rev Med Virol, 2020, 30(3): e2103. |
[11] | 李莎, 白育庭. 糖尿病肺损伤的研究进展[J]. 湖北科技学院学报(医学版), 2014, 28(3):275-276. |
[12] |
Xu X, Chen P, Wang J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission[J]. Sci China Life Sci, 2020, 63(3):457-460.
doi: 10.1007/s11427-020-1637-5 pmid: 32009228 |
[13] |
Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin[J]. Nature, 2020, 579(7798):270-273.
doi: 10.1038/s41586-020-2012-7 |
[14] |
Fernandez C, Rysä J, Almgren P, et al. Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality[J]. J Intern Med, 2018, 284(4):377-387.
doi: 10.1111/joim.12783 pmid: 29888466 |
[15] |
Berbudi A, Rahmadika N, Tjahjadi AI, et al. Type 2 diabetes and its impact on the immune system[J]. Curr Diabetes Rev, 2020, 16(5):442-449.
doi: 10.2174/1573399815666191024085838 pmid: 31657690 |
[16] |
Hodgson K, Morris J, Bridson T, et al. Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections[J]. Immunology, 2015, 144(2):171-185.
doi: 10.1111/imm.12394 pmid: 25262977 |
[17] |
Lam VC, Lanier LL. NK cells in host responses to viral infections[J]. Curr Opin Immunol, 2017, 44:43-51.
doi: S0952-7915(16)30151-0 pmid: 27984782 |
[18] |
Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China[J]. Lancet Respir Med, 2020, 8(5):475-481.
doi: 10.1016/S2213-2600(20)30079-5 URL |
[19] | 张敏, 邸丽改, 马卫国, 等. 重症新型冠状病毒肺炎与2型糖尿病的相关性研究[J]. 热带医学杂志, 2022, 22(6):827-831. |
[20] |
Touch S, Clément K, André S. T cell populations and functions are altered in human obesity and type 2 diabetes[J]. Curr Diab Rep, 2017, 17(9):81.
doi: 10.1007/s11892-017-0900-5 URL |
[21] |
Wagner NM, Brandhorst G, Czepluch F, et al. Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk[J]. Obesity (Silver Spring), 2013, 21(3):461-468.
doi: 10.1002/oby.v21.3 URL |
[22] | 关欣, 关海霞, 谷野, 等. 新型冠状病毒肺炎患者核酸阳性持续时间延长可能与合并糖尿病相关[J]. 中华内分泌代谢杂志, 2020, 36(8):661-666. |
[23] | 杨芳, 朱新新, 王敏, 等. 糖尿病与非糖尿病患者感染新型冠状病毒肺炎临床结局比较[J]. 中国糖尿病杂志, 2021, 29(1):44-49. |
[24] | 王德平, 孙毓晗, 王信, 等. 重型及危重型新型冠状病毒肺炎合并糖尿病患者的临床特征及疾病转归[J]. 实用医学杂志, 2021, 37(24):3097-3100. |
[25] |
Seiglie J, Platt J, Cromer SJ, et al. Diabetes as a risk factor for poor early outcomes in patients hospitalized with COVID-19[J]. Diabetes Care, 2020, 43(12):2938-2944.
doi: 10.2337/dc20-1506 pmid: 32847827 |
[26] |
Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome[J]. Lancet Respir Med, 2020, 8(4):420-422.
doi: 10.1016/S2213-2600(20)30076-X pmid: 32085846 |
[27] |
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China[J]. Lancet, 2020, 395(10229):1054-1062.
doi: S0140-6736(20)30566-3 pmid: 32171076 |
[28] | Wu J, Huang J, Zhu G, et al. Elevation of blood glucose level predicts worse outcomes in hospitalized patients with COVID-19[J]. BMJ Open Diabetes Res Care, 2020, 8(1):e001476. |
[29] |
Zhu L, She ZG, Cheng X, et al. Association of blood glucose control and outcomes in patients with COVID-19 and pre-existing type 2 diabetes[J]. Cell Metab, 2020, 31(6):1068-1077.
doi: S1550-4131(20)30238-2 pmid: 32369736 |
[30] |
Toniolo A, Cassani G, Puggioni A, et al. The diabetes pandemic and associated infections: suggestions for clinical microbiology[J]. Rev Med Microbiol, 2019, 30(1):1-17.
doi: 10.1097/MRM.0000000000000155 pmid: 30662163 |
[31] | 中华医学会糖尿病学分会. 糖尿病患者合新型冠状病毒肺炎的管理建议[J]. 中华糖尿病杂志, 2020, 12(2):73-75. |
[32] | 中国医师协会内分泌代谢科医师分会, 中国住院患者血糖管理专家组. 中国住院患者血糖管理专家共识[J]. 中华内分泌代谢杂志, 2017, 33(1):1-10. |
[33] |
Torres A, Motos A, Cillóniz C, et al. Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19[J]. Intensive Care Med, 2022, 48(7):850-864.
doi: 10.1007/s00134-022-06726-w |
[1] | 刘远航, 常保国, 牟勇, 等. 股前外侧游离皮瓣修复重度糖尿病足溃疡创面的应用观察 #br# [J]. 组织工程与重建外科杂志, 2025, 21(4): 337-. |
[2] | 茆致远 王琛.
四氧化三锰纳米酶促进糖尿病创面愈合的机制研究
[J]. 组织工程与重建外科杂志, 2025, 21(4): 353-. |
[3] | 郭根宇, 张楚乔, 许尹梅, 等. 通过整合生物信息学分析与机器学习揭示糖尿病足溃疡缺氧相关生物标志物[J]. 组织工程与重建外科杂志, 2025, 21(3): 238-. |
[4] | 郭娟, 杨志芳, 吉日. 超声在糖尿病肾病诊断中的应用进展[J]. 诊断学理论与实践, 2025, 24(03): 342-348. |
[5] | 陈蕊华, 丁晓颖, 刘芳, 王庆国, 王育璠. 1例线粒体DNA A3243G点突变病例家系临床表型和基因型分析[J]. 内科理论与实践, 2025, 20(03): 204-209. |
[6] | 史曼曼, 马毓华, 郑金鑫, 柯燕容, 王语欣, 刘剑, 王伟铭. 1990年至2021年全球及中国2型糖尿病导致的慢性肾脏病疾病负担及危险因素分析[J]. 诊断学理论与实践, 2025, 24(03): 268-278. |
[7] | 张计委, 吴小琼, 崔金煌, 俞春明, 黎衍云. 中老年人群糖代谢状态与全因死亡及心脑血管疾病死亡风险的关联研究[J]. 内科理论与实践, 2025, 20(02): 120-125. |
[8] | 张杰, 徐顺, 刘琰, 施燕. 基于网络药理学及转录组学揭示虎黄洗剂促进糖尿病创面愈合机制[J]. 内科理论与实践, 2025, 20(01): 18-23. |
[9] | 严佳怡, 马骏, 钟逸斐, 张先闻. 中医药改善糖尿病肾脏疾病间质纤维化的作用机制研究现状[J]. 内科理论与实践, 2025, 20(01): 38-45. |
[10] | 刘嘉琳, 张莉. 中西医结合呼吸康复治疗在新型冠状病毒肺炎中的研究进展[J]. 内科理论与实践, 2025, 20(01): 63-66. |
[11] | 宁光. 中国糖尿病的防控现状与挑战[J]. 诊断学理论与实践, 2025, 24(01): 1-6. |
[12] | 张珂, 张唯一, 孙海天, 曹铭峰, 张新焕. 细胞失巢相关基因PDK4与2型糖尿病发病相关——基于生物信息的研究[J]. 诊断学理论与实践, 2025, 24(01): 27-34. |
[13] | 雷朝闻尉, 饶佳玲, 周梦雪, 杨虹. 胰腺脂肪沉积的危险因素及相关疾病的研究进展[J]. 诊断学理论与实践, 2025, 24(01): 72-79. |
[14] | 何翠环, 石德荣, 孙丹丹, 李育蕊, 夏广昊. 胰高血糖素样肽1受体激动剂在糖尿病视网膜病变中的作用机制研究进展[J]. 诊断学理论与实践, 2025, 24(01): 80-88. |
[15] | 邹慧敏, 王遂军. 中国糖尿病诊断标准演变及特殊人群血糖管理[J]. 诊断学理论与实践, 2025, 24(01): 14-20. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||