中药通过干预铁死亡治疗帕金森病的机制研究进展

doi:10.16138/j.1673-6087.2024.05.13

摘要/Abstract

摘要：

铁死亡作为近年来新兴识别的一种程序性细胞死亡（programmed cell death, PCD）形式，其核心机制主要涉及细胞内依赖铁的脂质过氧化物的积累。越来越多的研究表明，铁死亡在帕金森病（Parkinson disease，PD）的起病及进展中扮演着至关重要的角色。本文旨在详细评述铁死亡的分子调控机制，并汇总关于PD治疗中最新研究进展及传统中医治疗方法。通过对这一新兴研究领域的深入探讨，总结中药活性成分及复方等通过铁死亡途径对PD进程进行干预的现状与进展，期待为靶向铁死亡在PD治疗中的应用提供坚实的理论基础和创新思路。

关键词: 铁死亡, 帕金森病, 脂质过氧化, 铁代谢, α-突触核蛋白

Abstract:

Ferroptosis is a newly recognized form of programmed cell death in recent years, and its core mechanism mainly involves the accumulation of iron-dependent lipid peroxides in cells. More and more studies suggest that ferroptosis plays a critical role in the onset and progression of Parkinson disease (PD). This article aims to review the molecular regulatory mechanism of ferroptosis in detail and the latest research progress on ferroptosis in treatment of PD and the therapeutic methods of traditional Chinese medicine for it. Through in-depth discussion of this emerging research field, the current status and progress of active ingredients and compounds of traditional Chinese medicine intervening process of PD through ferroptosis pathway were summarized, which was expected to provide a solid theoretical basis and innovative ideas for the application of targeting ferroptosis in the PD treatment.

Key words: Ferroptosis, Parkinson disease, Lipid peroxidation, Iron metabolism, Alpha-synuclein

中图分类号:

R742

李媛媛, 姚小玲, 曲彦洁, 陈敬贤. 中药通过干预铁死亡治疗帕金森病的机制研究进展[J]. 内科理论与实践, 2024, 19(05): 351-356.

LI Yuanyuan, YAO Xiaoling, QU Yanjie, CHEN Jingxian. Research progress on mechanism of traditional Chinese medicine in treating Parkinson disease by interfering with ferroptosis[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(05): 351-356.

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