相关标志物及肠道微生物对结直肠癌肝转移的研究进展

doi:10.16138/j.1673-6087.2025.02.14

摘要/Abstract

摘要：

结直肠癌（colorectal cancer,CRC）是消化道常见的恶性肿瘤之一，其肝转移是导致患者死亡的主要原因。肝转移患者早期缺乏典型临床症状，现有影像学方法检出率有限，生物标志物的研究对于预测治疗反应、监测疾病进展及制定个性化治疗方案至关重要。近年，CRC肝转移标志物的研究取得显著进展，为达到早发现、早诊断、早治疗的目的，本文总结既往研究中与CRC肝转移相关的各类生物标志物，旨在探讨其在CRC肝转移早期诊断中的应用价值，以期为临床实践提供参考

关键词: 结直肠癌, 肝转移, 生物标志物

Abstract:

Colorectal cancer (CRC) is one of the common malignant tumors in the digestive tract, and its liver metastasis is the main cause of death for patients. Due to the lack of typical clinical symptoms in patients with liver metastasis in the early stage, the study of biomarkers is crucial for predicting treatment response, monitoring disease progression, and formulating personalized treatment plans. In recent years, significant progress has been made in the research of CRC liver metastasis biomarkers to achieve the goals of early detection, early diagnosis and early treatment. This article summarizes various biomarkers related to CRC liver metastasis in previous studies, aiming to explore their application value in the early diagnosis of CRC liver metastasis, in order to provide a reference for clinical practice.

Key words: Colorectal cancer, Hepatic metastases, Biomarker

中图分类号:

R735

弓殷, 王学玲. 相关标志物及肠道微生物对结直肠癌肝转移的研究进展[J]. 内科理论与实践, 2025, 20(02): 178-182.

GONG Yin, WANG Xueling. Research progress on related markers and intestinal microorganisms in colorectal cancer liver metastasis[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(02): 178-182.

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