利妥昔单抗序贯贝利木单抗治疗神经精神狼疮1例

doi:10.16138/j.1673-6087.2025.04.10

内科理论与实践 ›› 2025, Vol. 20 ›› Issue (04): 316-318.doi: 10.16138/j.1673-6087.2025.04.10

利妥昔单抗序贯贝利木单抗治疗神经精神狼疮1例

陈雪, 孙明芳, 戴欢子()

陆军军医大学大坪医院风湿免疫科，重庆 400042

收稿日期:2024-09-13 出版日期:2025-07-31 发布日期:2025-10-27
通讯作者: 戴欢子 E-mail: daihuanzi@tmmu.edu.cn
基金资助:
重庆市自然科学基金面上项目（重点项目）(CSTB2024NSCQ-KJFZZDX0049)

A case of neuropsychiatric lupus successfully treated with sequential therapy of rituximab and belimumab therapy

CHEN Xue, SUN Mingfang, DAI Huanzi()

Department of Rheumatology and Immunology, Daping Hospital, Army Military Medical University, Chongqing 400042, China

Received:2024-09-13 Online:2025-07-31 Published:2025-10-27

摘要/Abstract

摘要：

神经精神狼疮是系统性红斑狼疮严重并发症，尤其是累及中枢神经系统时，死亡率明显增加，且目前尚无标准治疗方案。本文报道1例以精神行为异常、谵语为主要表现的神经精神狼疮患者，予以利妥昔单抗序贯贝利木单抗治疗后患者症状缓解，实验室及影像学指标明显改善，为神经精神狼疮的治疗提供了新策略。

关键词: 系统性红斑狼疮, 神经精神狼疮, 利妥昔单抗, 贝利木单抗

Abstract:

Neuropsychiatric lupus erythematosus (NPSLE) is a severe complication of systemic lupus erythematosus, it leads to a significantly increased mortality rate when it affects the central nervous system. Currently, there is no established standard treatment regimen for this condition. This article reports a case study of a patient with NPSLE, who primarily presented abnormal mental and behavioral and incoherent speech. Following sequential treatment with rituximab and belimumab, the patient’s symptoms were relieved and laboratory imaging indicators were significantly improved, which provided a new potential therapeutic strategy for NPSLE.

Key words: Systemic lupus erythematosus, Neuropsychiatric lupus erythematosus, Rituximab, Belimumab

中图分类号:

R593.2

陈雪, 孙明芳, 戴欢子. 利妥昔单抗序贯贝利木单抗治疗神经精神狼疮1例[J]. 内科理论与实践, 2025, 20(04): 316-318.

CHEN Xue, SUN Mingfang, DAI Huanzi. A case of neuropsychiatric lupus successfully treated with sequential therapy of rituximab and belimumab therapy[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(04): 316-318.

图/表 2

参考文献 18

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利妥昔单抗序贯贝利木单抗治疗神经精神狼疮1例

A case of neuropsychiatric lupus successfully treated with sequential therapy of rituximab and belimumab therapy

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