肠道菌群介导阻塞性睡眠呼吸暂停患者代谢及心血管异常的作用及相关机制进展

doi:10.16138/j.1673-6087.2024.02.08

摘要/Abstract

摘要：

阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）是一种常见的以间歇性缺氧和睡眠片段化为主要病理特征的睡眠障碍性疾病，与高血压、动脉粥样硬化、胰岛素抵抗等多种代谢疾病的发生、发展关系密切。大量研究已发现OSA会引起肠道菌群紊乱从而对人体健康产生影响。本文就临床与动物模型中OSA引起肠道菌群紊乱以及相关代谢和心血管变化的可能机制以及由此衍生的辅助治疗新方法进行综述，旨在以肠道菌群为切入点，重新认识OSA和代谢及心血管异常之间的关系，为OSA及相关并发症的早期干预提供新思路。

关键词: 阻塞性睡眠呼吸暂停, 肠道菌群, 高血压, 动脉粥样硬化, 糖尿病

Abstract:

Obstructive sleep apnea (OSA) is a common sleep disorder characterized by intermittent hypoxia and sleep fragmentation, which is closely associated with the development of hypertension, atherosclerosis, insulin resistance and other metabolic diseases. A lot of studies have found that OSA can cause the disturbance of gut microbiota and affect human health. This paper reviews the possible mechanisms of gut microbiota disturbance and related metabolic and cardiovascular changes caused by OSA in clinical trials and animal models, and the new complementary therapies derived from them. The aim of the paper is to use gut microbiota as an entry point to re-understand the relationship between OSA and metabolic and cardiovascular abnormalities, and provides new ideas for early intervention of OSA and related complications.

Key words: Obstructive sleep apnea, Gut microbiota, Hypertension, Atherosclerosis, Diabetes mellitus

中图分类号:

R563.5

朱晓雯, 王鸿超, 吴文君. 肠道菌群介导阻塞性睡眠呼吸暂停患者代谢及心血管异常的作用及相关机制进展[J]. 内科理论与实践, 2024, 19(02): 130-135.

ZHU Xiaowen, WANG Hongchao, WU Wenjun. Role of gut microbiota in mediating metabolic and cardiovascular abnormalities in patients with obstructive sleep apnea and related mechanisms[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(02): 130-135.

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