CAR-T细胞免疫治疗结肠直肠癌的研究现状与展望

doi:10.16139/j.1007-9610.2023.05.15

摘要/Abstract

摘要：

嵌合抗原受体T细胞（chimeric antigen receptor T cell, CAR-T细胞）免疫治疗是肿瘤治疗的全新方法，在血液肿瘤的治疗中获得显著成效。结肠直肠癌（colorectal cancer, CRC）作为实体肿瘤，具有与血液肿瘤不同的特性，这对CART细胞免疫治疗靶点的选取及治疗效果都存在着一定制约。因此，需根据CRC的特征选择特异性高和有效性强的治疗靶点，同时还需突破治疗产生的不良反应及实体肿瘤微环境等限制因素，使该疗法在CRC治疗中得以应用。本文旨在归纳CAR-T细胞免疫治疗CRC选择治疗靶点的策略，分析该治疗方式治疗CRC的制约因素，并展望CAR-T细胞免疫治疗CRC的前景。

关键词: 嵌合抗原受体T细胞, 结肠直肠癌, 免疫治疗

Abstract:

Chimeric antigen receptor T (CAR-T) cell therapy is a new method of immunotherapy for cancer that has achieved remarkable results in treating blood tumors. However, colorectal cancer(CRC), as a solid tumor, has different characteristics from hematological tumors, which impose certain constraints on the selection of its therapeutic targets and the effectiveness of treatment of CAR-T therapy. Therefore, it is necessary to select therapeutic targets with high specificity and effectiveness according to the characteristics of CRC, as well as to break through the constraints such as adverse effects caused by the treatment and the solid tumor microenvironment, to make CAR-T therapy applicable in the treatment of CRC. This article aimed to summarize the strategy of selecting therapeutic targets for CAR-T cell immunotherapy for CRC, analyze the restrictive factors of this therapy in the treatment of CRC, and forecast the prospect of CAR-T cell immunotherapy for CRC.

Key words: Chimeric antigen receptor T cell, Colorectal cancer, Immunotherapy

中图分类号:

张天帅, 周乐其综述, 于冠宇, 张卫审校. CAR-T细胞免疫治疗结肠直肠癌的研究现状与展望[J]. 外科理论与实践, 2023, 28(05): 483-487.

ZHANG Tianshuai, ZHOU Leqi, YU Guanyu, ZHANG Wei. Current status and prospect of CAR-T cell immunotherapy for colorectal cancer[J]. Journal of Surgery Concepts & Practice, 2023, 28(05): 483-487.

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