Progress in the pathogenesis and treatment of focal segmental glomerulosclerosis

doi:10.16138/j.1673-6087.2023.05.012

Abstract

CLC Number:

R692

XU Lichen, LI Guisen. Progress in the pathogenesis and treatment of focal segmental glomerulosclerosis[J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(05): 363-367.

References 49

[1]	Rosenberg AZ, Kopp JB. Focal segmental glomerulosclerosis[J]. Clin J Am Soc Nephrol, 2017, 12(3): 502-517. doi: 10.2215/CJN.05960616 URL
[2]	Xu X, Wang G, Chen N, et al. Long-term exposure to air pollution and increased risk of membranous nephropathy in China[J]. J Am Soc Nephrol, 2016, 27(12): 3739-3746. pmid: 27365535
[3]	O’Shaughnessy MM, Hogan SL, Thompson BD, et al. Glomerular disease frequencies by race, sex and region: results from the International Kidney Biopsy Survey[J]. Nephrol Dial Transplant, 2018, 33(4): 661-669. doi: 10.1093/ndt/gfx189 URL
[4]	Bukosza EN, Kratochwill K, Kornauth C, et al. Podocyte RNA sequencing reveals Wnt- and ECM-associated genes as central in FSGS[J]. PloS one, 2020, 15(4): e0231898. doi: 10.1371/journal.pone.0231898 URL
[5]	D’Agati VD, Kaskel FJ, Falk RJ. Focal segmental glomerulosclerosis[J]. N Engl J Med, 2011, 365(25): 2398-2411. doi: 10.1056/NEJMra1106556 URL
[6]	Zink CM, Ernst S, Riehl J, et al. Trends of renal diseases in Germany: review of a regional renal biopsy database from 1990 to 2013[J]. Clin Kidney J, 2019, 12(6): 795-800. doi: 10.1093/ckj/sfz023 pmid: 31808446
[7]	Simon P, Ramee MP, Boulahrouz R, et al. Epidemiologic data of primary glomerular diseases in Western France[J]. Kidney Int, 2004, 66(3): 905-908. doi: 10.1111/j.1523-1755.2004.00834.x pmid: 15327379
[8]	Stokes MB, D’Agati VD. Morphologic variants of focal segmental glomerulosclerosis and their significance[J]. Adv Chronic Kidney Dis, 2014, 21(5): 400-407. doi: 10.1053/j.ackd.2014.02.010 URL
[9]	Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s[J]. Nature, 1993, 362(6423): 801-809. doi: 10.1038/362801a0
[10]	Swarnalatha G, Ram R, Ismal KM, et al. Focal and segmental glomerulosclerosis: does prognosis vary with the variants?[J]. Saudi J Kidney Dis Transpl, 2015, 26(1):173-181. pmid: 25579744
[11]	Sun L, Zhao R, Zhang L, et al. Salvianolic acid A inhibits PDGF-BB induced vascular smooth muscle cell migration and proliferation while does not constrain endothelial cell proliferation and nitric oxide biosynthesis[J]. Molecules, 2012 Mar 14, 17(3): 3333-3347. doi: 10.3390/molecules17033333 pmid: 22418933
[12]	Gao W, Ferguson G, Connell P, et al. Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1α expression[J]. Diab Vasc Dis Res, 2014, 11(4): 270-280. doi: 10.1177/1479164114533356 URL
[13]	Canaud G, Dion D, Zuber J, et al. Recurrence of nephrotic syndrome after transplantation in a mixed population of children and adults: course of glomerular lesions and value of the Columbia classification of histological variants of focal and segmental glomerulosclerosis (FSGS)[J]. Nephrol Dial Transplant, 2010, 25(4): 1321-1328. doi: 10.1093/ndt/gfp500 URL
[14]	Avila-Casado Mdel C, Perez-Torres I, Auron A, et al. Proteinuria in rats induced by serum from patients with collapsing glomerulopathy[J]. Kidney Int, 2004, 66(1):133-143. pmid: 15200420
[15]	Gallon L, Leventhal J, Skaro A, et al. Resolution of recurrent focal segmental glomerulosclerosis after retransplantation[J]. N Engl J Med, 2012, 366(17): 1648-1649. doi: 10.1056/NEJMc1202500 URL
[16]	Downie ML, Gallibois C, Parekh RS, et al. Nephrotic syndrome in infants and children: pathophysiology and management[J]. Paediatr Int Child Health, 2017, 37(4):248-258. doi: 10.1080/20469047.2017.1374003 URL
[17]	Delville M, Sigdel TK, Wei C, et al. A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation[J]. Sci Transl Med, 2014, 6(256): 256ra136.
[18]	Wei C, El Hindi S, Li J, et al. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis[J]. Nat Med, 2011, 17(8): 952-960. doi: 10.1038/nm.2411 pmid: 21804539
[19]	Hayek SS, Leaf DE, Samman Tahhan A, et al. Soluble urokinase receptor and acute kidney injury[J]. N Engl J Med, 2016, 374(9): 891. doi: 10.1056/NEJMc1600136 URL
[20]	Kudose S, Batal I, Santoriello D, et al. Kidney biopsy findings in patients with COVID-19[J]. J Am Soc Nephrol, 2020, 31(9): 1959-1968. doi: 10.1681/ASN.2020060802 pmid: 32680910
[21]	Klomjit N, Alexander MP, Fervenza FC, et al. COVID-19 vaccination and glomerulonephritis[J]. Kidney Int Rep, 2021, 6(12): 2969-2978. doi: 10.1016/j.ekir.2021.09.008 pmid: 34632166
[22]	de Vriese AS, Sethi S, Nath KA, et al. Differentiating primary, genetic, and secondary FSGS in adults[J]. J Am Soc Nephrol, 2018, 29(3): 759-774. doi: 10.1681/ASN.2017090958 pmid: 29321142
[23]	Markowitz GS, Appel GB, Fine PL, et al. Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate[J]. J Am Soc Nephrol, 2001, 12(6): 1164-1172. doi: 10.1681/ASN.V1261164 pmid: 11373339
[24]	Kriz W, Lemley KV. A potential role for mechanical forces in the detachment of podocytes and the progression of CKD[J]. J Am Soc Nephrol, 2015, 26(2): 258-269. doi: 10.1681/ASN.2014030278 pmid: 25060060
[25]	Zhuo L, Huang L, Yang Z, et al. A comprehensive analysis of NPHS1 gene mutations in patients with sporadic focal segmental glomerulosclerosis[J]. BMC Med Genet, 2019, 20(1): 111. doi: 10.1186/s12881-019-0845-4
[26]	Nandlal L, Winkler CA, Bhimma R, et al. Causal and putative pathogenic mutations identified in 39% of children with primary steroid-resistant nephrotic syndrome in South Africa[J]. Eur J Pediatr, 2022, 181(10): 3595-3606. doi: 10.1007/s00431-022-04581-x pmid: 35920919
[27]	Polat OK, Uno M, Maruyama T, et al. Contribution of coiled-coil assembly to Ca²⁺/calmodulin-dependent inac-tivation of TRPC6 channel and its impacts on FSGS-associated phenotypes[J]. J Am Soc Nephrol, 2019, 30(9):1587-1603. doi: 10.1681/ASN.2018070756 pmid: 31266820
[28]	Husain S, Ginawi I, Bashir AI, et al. Focal and segmental glomerulosclerosis in murine models: a histological and ultrastructural characterization with immunohistochemistry correlation of glomerular CD44 and WT1 expression[J]. Ultrastruct Pathol, 2018, 42(5): 430-439. doi: 10.1080/01913123.2018.1501125 pmid: 30285525
[29]	Ammar S, Kanoun H, Kammoun K, et al. Next-generation sequencing in patients with familial FSGS: first report of collagen gene mutations in Tunisian patients[J]. J Hum Genet, 2021, 66(8): 795-803. doi: 10.1038/s10038-021-00912-2 pmid: 33654185
[30]	Feng D, Notbohm J, Benjamin A, et al. Disease-causing mutation in α-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch[J]. Proc Natl Acad Sci U S A, 2018, 115(7): 1517-1522. doi: 10.1073/pnas.1717870115 URL
[31]	Sanchez-Ares M, Garcia-Vidal M, Antucho EE, et al. A novel mutation, outside of the candidate region for diagnosis, in the inverted formin 2 gene can cause focal segmental glomerulosclerosis[J]. Kidney Int. 2013 Jan; 83(1):153-159. doi: 10.1038/ki.2012.325 pmid: 22971997
[32]	Vijayan P, Hack S, Yao T, et al. LAMA2 and LOXL4 are candidate FSGS genes[J]. BMC Nephrol, 2021, 22(1): 320. doi: 10.1186/s12882-021-02524-6 pmid: 34565340
[33]	Gast C, Pengelly RJ, Lyon M, et al. Collagen(COL4A) mutations are the most frequent mutations underlying adult focal segmental glomerulosclerosis[J]. Nephrol Dial Transplant, 2016, 31(6): 961-970. doi: 10.1093/ndt/gfv325 URL
[34]	Duchateau PN, Pullinger CR, Orellana RE, et al. Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L[J]. J Biol Chem, 1997, 272(41): 25576-25582. doi: 10.1074/jbc.272.41.25576 pmid: 9325276
[35]	Boersma V, Moatti N, Segura-Bayona S, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5’ end resection[J]. Nature, 2015, 521(7553):537-540. doi: 10.1038/nature14216
[36]	Connaughton DM, Kennedy C, Shril S, et al. Monogenic causes of chronic kidney disease in adults[J]. Kidney Int, 2019, 95(4): 914-928. doi: S0085-2538(18)30839-1 pmid: 30773290
[37]	Liu W, Peng L, Tian W, et al. Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis[J]. Dis Model Mech, 2021, 14(6): dmm048777. doi: 10.1242/dmm.048777 URL
[38]	Rovin BH, Adler SG, Barratt J, et al. Executive summary of the KDIGO 2021 guideline for the management of glomerular diseases[J]. Kidney Int, 2021, 100(4): 753-779. doi: 10.1016/j.kint.2021.05.015 pmid: 34556300
[39]	Rydel JJ, Korbet SM, Borok RZ, et al. Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment[J]. Am J Kidney Dis, 1995, 25(4):534-542. doi: 10.1016/0272-6386(95)90120-5 pmid: 7702047
[40]	孙良忠, 王海燕, 李敏, 等. WT1基因变异相关肾脏病临床、病理特点与基因变异类型的临床研究[J]. 中华儿科杂志, 2018, 56(10): 769-774.
[41]	Soliman AR, Maamoun H, Soliman H, et al. Steroid resistant focal segmental glomerulosclerosis: effect of arterial hyalinosis on outcome: single center study[J]. Rom J Intern Med, 2021, 59(2): 127-133.
[42]	Santín S, Bullich G, Tazón-Vega B, et al. Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome[J]. Clin J Am Soc Nephrol, 2011, 6(5): 1139-1148. doi: 10.2215/CJN.05260610 URL
[43]	Yu CC, Fornoni A, Weins A, et al. Abatacept in B7-1-positive proteinuric kidney disease[J]. N Engl J Med, 2013, 369(25): 2416-2423. doi: 10.1056/NEJMoa1304572 URL
[44]	ElSayed NA, Aleppo G, Aroda VR, et al. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2019[J]. Diabetes care, 2019, 42 Suppl 1: S90-S102.
[45]	Vallon V, Thomson SC. Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition[J]. Diabetologia, 2017, 60(2): 215-225. doi: 10.1007/s00125-016-4157-3 pmid: 27878313
[46]	Trachtman H, Nelson P, Adler S, et al. DUET: a phase 2 study evaluating the efficacy and safety of sparsentan in patients with FSGS[J]. J Am Soc Nephrol, 2018, 29(11):2745-2754. doi: 10.1681/ASN.2018010091 pmid: 30361325
[47]	Sinha A, Mathew G, Arushi A, et al. Sequential rituximab therapy sustains remission of nephrotic syndrome but carries high risk of adverse effects[J]. Nephrol Dial Transplant, 2023, 38(4): 939-949. doi: 10.1093/ndt/gfac228 URL
[48]	Ravani P, Ponticelli A, Siciliano C, et al. Rituximab is a safe and effective long-term treatment for children with steroid and calcineurin inhibitor-dependent idiopathic nephrotic syndrome[J]. Kidney Int, 2013, 84(5): 1025-1033. doi: 10.1038/ki.2013.211 pmid: 23739238
[49]	Osterholt T, Todorova P, Kühne L, et al. Repetitive administration of rituximab can achieve and maintain clinical remission in patients with MCD or FSGS[J]. Sci Rep, 2023, 13(1): 6980. doi: 10.1038/s41598-023-32576-7 pmid: 37117201

Progress in the pathogenesis and treatment of focal segmental glomerulosclerosis

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 49

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	ZHOU Liyang, ZHANG Chunli, DING Qiulan, LI Ya. Genetic diagnosis and clinical analysis of congenital dysfibrinogenemia with polycystic disease: a case report and literature review [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(05): 328-333.
[2]	ZHANG Yu, WANG Zhihong, DONG Cui, KUAI Tingting, YOU Lianlian, LIU Shuxin. Comparison of ordinary calcium-containing dialysate segmented regional citrate anticoagulation hemodialysis and heparin-free hemodialysis in patients with high risk of bleeding [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(05): 322-327.
[3]	WANG Weiming. Interpretation of Chinese expert consensus on understanding and management of renal anemia in diabetic kidney disease [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(03): 137-140.
[4]	LUO Yadan, YUAN Liying, LU Yide, WANG Ziqiu, WANG Zhaohui. Investigation of serum uric acid level in adult patients and analysis of related influencing factors [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(03): 141-145.
[5]	ZHANG Huijian, LI Guisen. An update on complement targeted treatment of IgA nephropathy [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(03): 197-200.
[6]	OUYANG Yan, CHEN Zijin, ZHANG Qianying, et al. Ruijin Hospital recommendations for diagnosis and treatment of novel coronavirus infection in chronic kidney disease population (2023) [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(01): 28-33.
[7]	ZHANG Xiaoyan, XU Jing, QU Bin. Effect of serum vitamin D level on renal function in elderly patients with chronic kidney disease [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(04): 307-312.
[8]	ZHANG Chunli, XU Jing, PAN Xiaoxia, HU Xiaofan, LI Ya. Analysis of clinical and histological features of IgG4-related kidney disease [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(03): 214-219.
[9]	. [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(05): 366-370.
[10]	XUAN Yingli, CHEN Feihong, QIN Li, HE Ruibin, PANG Shiqing, YUAN Jiangzi. Correlation analysis of vitamin D and nocturnal blood pressure in the patients with chronic kidney disease [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(04): 246-250.
[11]	. [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(01): 49-52.
[12]	. [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(01): 4-9.
[13]	WANG Xuejie, CHEN Zijin, DU Wen, GU Feifei, YU Haijin, ZHANG Wen, CHEN Xiaonong. Risk factors of acute kidney injury in the patients with bloodstream infection caused by different pathogens [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(01): 22-26.
[14]	. [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(01): 15-17.
[15]	. [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(01): 10-14.