Interaction of bile acids with the gut microbiota and their effects on sepsis

doi:10.16138/j.1673-6087.2024.03.11

Abstract

Abstract:

Numerous microorganisms inhabit the human intestine, participate in the digestion and absorption of nutrients, and produce a large number of metabolites, participate in regulating functions and protect the host from disease damage. Bile acids are produced by cholesterol metabolism and metabolized by the gut microbiota into secondary bile acids. Bile acids facilitate lipid digestion and absorption and interact with the gut microbiota. The composition and quantity of the gut microbiota also regulate bile acid metabolism. As sepsis occurs, the poor prognosis of the disease is associated with disturbances of the gut microbiota and bile acid metabolism. This paper reviews the metabolic process of bile acids, the interaction between bile acids and the gut microbiota, and the changes of gut microbiota and bile acids during sepsis, to provide new ideas for the prevention and treatment of sepsis.

Key words: Bile acids, Gut microbiota, Sepsis, Metabolomics, Cytokine

CLC Number:

R575
R631

YANG Jin, WEI Yao, JIN Jun. Interaction of bile acids with the gut microbiota and their effects on sepsis[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(03): 207-211.

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