巨滤泡型甲状腺乳头状癌（附3例报告）

doi:10.16139/j.1007-9610.2018.01.013

外科理论与实践 ›› 2018, Vol. 23 ›› Issue (01): 57-61.doi: 10.16139/j.1007-9610.2018.01.013

巨滤泡型甲状腺乳头状癌（附3例报告）

于起春^1a, 殷剑光^1b, 尚艳红^1a, 邱伟华², 谈坚^1b

1.民航上海医院-瑞金医院古北分院,a. 病理科,b. 普外科,上海 200336;
2.上海交通大学医学院附属瑞金医院外科,上海 200025

收稿日期:2017-12-01 出版日期:2018-01-25 发布日期:2020-07-25
通讯作者: 谈坚,E-mail: tjwpp687@sina.com
基金资助:
国家自然科学基金（81772558）; 上海市长宁区医疗卫生专项课题（CNKW2017Y30）

Macrofollicular variant of papillary thyroid carcinoma: a report of 3 cases

YU Qichun^1a, YIN Jianguang^1b, SHANG Yanhong^1a, QIU Weihua², TAN Jian^1b

1a. Department of Pathology, 1b. Department of General Surgery, Shanghai Hospital of Civil Aviation Gubei Branch of Ruijin Hospital, Shanghai 200336, China;
2. Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2017-12-01 Online:2018-01-25 Published:2020-07-25

摘要/Abstract

摘要： 目的探讨巨滤泡型甲状腺乳头状癌（macrofollicular variant of papillary thyroid carcinoma,MFPTC）的临床病理特点。方法回顾分析3例MFPTC病人临床资料、病理形态学及免疫组织化学检测结果。结果 MFPTC超声检查主要表现为不规则强回声,血流丰富。显微镜下可见巨大滤泡,腔内富含胶质。滤泡上皮细胞核被挤压呈立方至扁平状。免疫组织化学显示与其他类型PTC相同。MFPTC的肿瘤上皮细胞CK19、galectin-3、HBME-1呈弥漫或部分阳性。结论 MFPTC在临床病理诊断中容易漏诊。结合临床资料,独特的组织学形态以及免疫组织化学检查有助于明确诊断。

关键词: 甲状腺肿瘤, 巨滤泡型, 乳头状癌, 免疫组织化学

Abstract: Objective To investigate the clinicopathologic features of macrofollicular variant of papillary thyroid carcinoma (MFPTC). Methods Three cases with MFPTC were analyzed retrospectively for the clinical data, pathological morphology and the results by immunohistochemical detection. Results The ultrasonic examination showed MFPTC mostly as irregular strong hyperechoic nodules with abundant blood flow. Under the microscope, huge follicles could be observed and there was rich of colloid in the cavity of follicles. The nucleus of the follicular epithelium was extruded into a cubic or flattened form. MFPTC could be diagnosed similar to the other PTC by immunohistochemistry. The diffusive or partial distribution of positive expression of CK19, galectin-3, and HBME-1 was shown in the epithelium of MFPEC. Conclusions MFPTC was inclined to be miss-diagnosed in the clinics and pathology. With clinical data and the histomorphologic feature combined with immunohistochemical examination, MFPTC could be confirmed pathologically.

Key words: Thyroid tumor, Macrofollicular variant, Papillary carcinoma, Immunohistochemistry

中图分类号:

R736.1

于起春, 殷剑光, 尚艳红, 邱伟华, 谈坚. 巨滤泡型甲状腺乳头状癌（附3例报告）[J]. 外科理论与实践, 2018, 23(01): 57-61.

YU Qichun, YIN Jianguang, SHANG Yanhong, QIU Weihua, TAN Jian. Macrofollicular variant of papillary thyroid carcinoma: a report of 3 cases[J]. Journal of Surgery Concepts & Practice, 2018, 23(01): 57-61.

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巨滤泡型甲状腺乳头状癌（附3例报告）

Macrofollicular variant of papillary thyroid carcinoma: a report of 3 cases

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