外科理论与实践

外科理论与实践 ›› 2019, Vol. 24 ›› Issue (02): 149-154.doi: 10.16139/j.1007-9610.2019.02.013

• 论著 • 上一篇    下一篇

唾液肿瘤标志物诊断胰腺癌的研究

赵治锋1, 谢荣理2, 沈东杰2, 张俊1, 许志伟1, 程东峰1, 费健1, 邓侠兴1, 沈柏用1, 彭承宏1   

  1. 1.上海交通大学医学院附属瑞金医院外科,上海 200025;
    2.上海交通大学医学院附属瑞金医院卢湾分院外科,上海 200020
  • 收稿日期:2019-01-11 出版日期:2019-03-25 发布日期:2019-04-25
  • 通讯作者: 费健,E-mail: feijian@hotmail.com
  • 基金资助:
    国家自然科学基金（81670581）

Study on salivary tumor markers in diagnosis of pancreatic cancer

ZHAO Zhifeng1, XIE Rongli2, SHEN Dongjie2, ZHANG Jun1, XU Zhiwei1, CHENG Dongfeng1, FEI Jian1, DENG Xiaxing1, SHEN Baiyong1, PENG Chenghong1   

  1. 1. Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
    2. Department of Surgery, Luwan Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
  • Received:2019-01-11 Online:2019-03-25 Published:2019-04-25

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摘要： 目的 分析唾液肿瘤标志物在胰腺癌中的诊断及评估。方法 选取胰腺癌病人26例、胰腺良性肿瘤9例、健康对照16例。比较3组唾液肿瘤标志物的浓度,包括AFP、CEA、CA125、CA19-9、CA724、CA242。筛选出其中有诊断作用的标志物,分析其与胰腺癌的诊断、局部进展及预后的关系。结果 胰腺癌病人唾液AFP、CEA、CA125、CA724浓度高于胰腺良性病变组和健康对照组,胰腺癌组与健康对照组差异存在统计学意义（P<0.05）。唾液CEA和CA125诊断胰腺癌的曲线下面积分别为0.91、0.94,灵敏度和特异度均为92.31%、84.62%。唾液CEA和CA125浓度与生存期<半年以及局部进展有关联（P<0.05）。结论 唾液CEA及CA125对胰腺癌具有一定的诊断意义,有待今后进一步研究。

关键词: 胰腺癌, 肿瘤标志物, 唾液, 诊断

Abstract: Objective To analyze salivary tumor markers in diagnosis and evaluation of pancreatic cancer. Methods Twenty-six patients with pancreatic cancer, 9 patients with benign pancreatic tumor and 16 healthy controls were involved. We compared the concentrations of salivary tumor markers including AFP, CEA, CA125, CA19-9, CA724 and CA242 in three groups to find the tumor marker to diagnose pancreatic cancer and the biomarker associated with the patients of local advanced pancreatic cancer. The tumor marker associated with survival of pancreatic cancer was also studied. Results Salivary AFP, CEA, CA125 and CA724 in the patients with pancreatic cancer were higher when compared those in patients with benign pancreatic tumor and in healthy controls. The difference of salivary tumor markers was present significantly between pancreatic cancer group and control group (P< 0.05). Salivary CEA and CA125 to diagnose pancreatic cancer had area under curve 0.91 and 0.94, respectively. Both tumor markers got same sensitivity 92.31% and same specificity 84.62%. Salivary CEA and CA125 were associated with the patients of survival less half year and with the patients of locally advanced pancreatic cancer significantly (P< 0.05). Conclusions The results showed that salivary tumor markers CEA and CA125 could be used in diagnosis of pancreatic cancer at some extent and further study is needed.

Key words: Pancreatic cancer, Tumor marker, Saliva, Diagnosis

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