外科理论与实践

外科理论与实践 ›› 2020, Vol. 25 ›› Issue (01): 56-59.doi: 10.16139/j.1007-9610.2020.01.012

• 论著 • 上一篇    下一篇

循环肿瘤细胞与胃癌病理分期相关性的初探

严晓伟1, 刘坤1, 胡皆乐1, 姜松耀1, 项明2()   

  1. 1.上海交通大学医学院附属瑞金医院北院普外科,上海 201801
    2.上海交通大学医学院附属瑞金医院外科,上海 200025
  • 收稿日期:2018-05-21 出版日期:2020-01-25 发布日期:2020-02-25
  • 通讯作者: 项明 E-mail:xm@medmail.com.cn
  • 基金资助:
    上海申康医院发展中心临床科技创新项目(SHDC12015909)

Study on correlationship between circulating tumor cells and pathological staging of gastric cancer

YAN Xiaowei1, LIU Kun1, HU Jiele1, JIANG Songyao1, XIANG Ming2()   

  1. 1. Department of General Surgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, China
    2. Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2018-05-21 Online:2020-01-25 Published:2020-02-25
  • Contact: XIANG Ming E-mail:xm@medmail.com.cn

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摘要：

目的： 研究术前循环肿瘤细胞（circulating tumor cell,CTC）检测与胃癌病理分期的相关性,探讨CTC检测在预测胃癌病理分期中的应用价值。方法： 收集上海交通大学医学院附属瑞金医院北院2016年1月至2017年12月诊断为胃癌并进行根治性手术的30例病人资料。所有病人术前进行CTC检测。分析其数量和表型与术后病理分期之间的关系。结果： 术前CTC数量和亚型与N分期有一定的相关性,但与T分期无相关性。间质型CTC的数量与胃癌的TNM分期和N分期密切相关。结论： 术前CTC与术后病理分期有一定的相关性,有助于临床预后预测。

关键词: 胃癌, 循环肿瘤细胞, TNM分期

Abstract:

Objective To study the correlationship between circulating tumor cell (CTC) detected preoperatively and pathological staging of gastric cancer and the effect of detection of CTC on prediction of pathological staging. Methods The data of 30 cases with gastric cancer subjected to radical surgery in Ruijin Hospital North from January 2016 to December 2017 were collected. All cases had the detection of CTC preoperatively. The correlationship between the amount with subtype of CTC and pathological staging postoperatively were analyzed. Results The amount and subtype of CTC detected preoperatively were correlated with N stage of gastric cancer, however, which were not correlated with T stage. The amount of interstitial CTC was correlated with both TNM stage and N stage of gastric cancer closely. Conclusions The preoperative CTC was correlated with the postoperative pathological staging of gastric cancer which would be helpful to predict the clinical prognosis of gastric cancer.

Key words: Gastric cancer, Circulating tumor cell, TNM stage

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