循环肿瘤细胞在进展期胃癌中的临床应用

doi:10.16139/j.1007-9610.2024.06.16

摘要/Abstract

摘要：

胃癌（GC）是全球常见的肿瘤之一，其三高三低（发病率高、转移率高、死亡率高，早期诊断率低、切除治愈率低、5年生存率低）的特点严重影响了临床治疗和预后。循环肿瘤细胞（CTC）指离开实体瘤病灶并进入血流的癌细胞，其扩散和迁移是造成远处转移的重要原因，其计数在一些实体瘤中已作为总生存（OS）、复发风险、无进展生存（PFS）和化疗有效性的替代指标。遗憾的是，对GC中CTC的研究并不充分。本文收集相关文献，阐述CTC对于GC 病人特别是进展期胃癌（AGC）病人的临床意义，从 CTC 的生物学、检测方法、临床应用等方面，讨论该领域面临的挑战，并阐述未来前景。

关键词: 循环肿瘤细胞, 胃癌, 化疗, 靶向治疗, 免疫治疗

Abstract:

Gastric cancer (GC) is one of the common malignant tumors globally. Its characteristics of high morbidity and mortality, high metastasis, low early diagnosis rate, low radical resection rate and low 5-year survival rate have seriously affected clinical treatment and patients’ prognosis. Circulating tumor cells (CTCs) are cancer cells that leave a solid tumor lesion and enter the bloodstream. Its diffusion and migration are important reasons for distant metastasis. In some solid tumors, enumeration of CTC has served as surrogate markers for overall survival (OS), progression-free survival (PFS) and chemotherapy effectiveness, and risk factors of relapse. Unfortunately, the study of CTC in GC is not sufficient. In this review, we collected relevant literatures and described the clinical significance of CTC for the patients with GC, especially advanced gastric cancer (AGC), including the biology, detection methods, and clinical applications of CTC, discussed the challenges and the future prospects in this field.

Key words: Circulating tumor cell (CTC), Gastric cancer (GC), Chemotherapy, Targeted therapy, Immunotherapy

中图分类号:

R735.2

汪逸舟, 韦琪, 金惠敏, 陈磊, 梁海滨, 周韵澜. 循环肿瘤细胞在进展期胃癌中的临床应用[J]. 外科理论与实践, 2024, 29(06): 549-554.

WANG Yizhou, WEI Qi, JIN Huimin, CHEH Lei, LIANG Haibin, ZHOU Yunlan. Clinical application of circulating tumor cell in advanced gastric cancer[J]. Journal of Surgery Concepts & Practice, 2024, 29(06): 549-554.

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