Journal of Surgery Concepts & Practice ›› 2021, Vol. 26 ›› Issue (03): 249-253.doi: 10.16139/j.1007-9610.2021.03.015
• Original article • Previous Articles Next Articles
WU Chengxiao1, FANG Jie2a, ZHOU Jichuan2a, XIAO Yongsheng2b, ZHANG Xiaoguang1,2a()
Received:
2020-04-14
Online:
2021-05-25
Published:
2022-08-03
CLC Number:
WU Chengxiao, FANG Jie, ZHOU Jichuan, XIAO Yongsheng, ZHANG Xiaoguang. Expression of microRNA-324-5p in hepatocellular carcinoma based on the Cancer Genome Atlas (TCGA) database and analysis of prognosis risk factor[J]. Journal of Surgery Concepts & Practice, 2021, 26(03): 249-253.
项目 | miR-324-5p 低表达 | miR-324-5p 高表达 | P值 |
---|---|---|---|
病例(n) | 187 | 188 | |
年龄 | 0.178 | ||
≤60 | 82 (21.9) | 96 (25.7) | |
>60 NAa) | 105 (28.1) 0 | 91 (24.3) 1 | |
性别 | 0.683 | ||
女 | 57 (15.2) | 62 (16.5) | |
男 | 130 (34.7) | 126 (33.6) | |
T分期 | 0.937 | ||
T1 | 95 (25.5) | 89 (23.9) | |
T2 | 46 (12.4) | 49 (13.2) | |
T3 | 39 (10.5) | 41 (11) | |
T4 NAa) | 6 (1.6) 1 | 7 (1.9) 2 | |
N分期 | 0.357 | ||
N0 | 123 (47.3) | 133 (51.2) | |
N1 NAa) | 3 (1.2) 61 | 1 (0.4) 54 | |
M分期 | 1.000 | ||
M0 | 130 (47.3) | 141 (51.3) | |
M1 NAa) | 2 (0.7) 55 | 2 (0.7) 45 | |
病理分期 | 0.898 | ||
Ⅰ | 88 (25.1) | 86 (24.5) | |
Ⅱ | 42 (12) | 45 (12.8) | |
Ⅲ | 40 (11.4) | 45 (12.8) | |
Ⅳ NAa) | 3 (0.9) 14 | 2 (0.6) 10 | |
甲胎蛋白(μg/L) | <0.001b) | ||
≤400 | 127 (44.9) | 91 (32.2) | |
>400 NAa) | 17 (6.0) 43 | 48 (17.0) 49 | |
Child-Pugh分级 | 0.258 | ||
A | 115 (47.1) | 107 (43.9) | |
B | 8 (3.3) | 13 (5.3) | |
C NAa) | 1 (0.4) 63 | 0 68 | |
Ishak评分 | 0.830 | ||
0 | 43 (19.7) | 33 (15.1) | |
1/2 | 16 (7.3) | 14 (6.4) | |
3/4 | 14 (6.4) | 16 (7.3) | |
5/6 NAa) | 45 (20.6) 69 | 37 (17.0) 88 | |
血管侵犯 | 0.598 | ||
无 | 110 (4.4) | 98 (30.6) | |
有 NAa) | 55 (17.2) 22 | 57 (17.8) 33 |
项目 | 单因素分析 | 多因素分析 | |||
---|---|---|---|---|---|
HR (95%CI) | P值 | HR (95%CI) | P值 | ||
年龄 | 1.222 (0.860~1.738) | 0.263 | |||
性别 | 1.252 (0.875~1.792) | 0.219 | |||
T分期 | 2.617 (1.834~3.736) | <0.001a) | 1.696 (0.233~12.356) | 0.602 | |
N分期 | 2.051 (0.503~8.372) | 0.317 | |||
病理分期 | 2.519 (1.731~3.665) | <0.001a) | 1.541 (0.213~11.142) | 0.668 | |
甲胎蛋白 | 1.090 (0.667~1.784) | 0.730 | |||
Child-Pugh分级 | 1.672 (0.825~3.391) | 0.154 | |||
Ishak评分 | 0.764 (0.461~1.267) | 0.297 | |||
血管侵犯 | 1.337 (0.882~2.028) | 0.172 | |||
miR-324-5p表达 | 1.428 (1.006~2.026) | 0.046a) | 1.537 (1.058~2.233) | 0.024a) |
[1] | 郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志, 2019, 41(1):19-28. |
[2] |
Dai M, Chen S, Wei X, et al. Diagnosis, prognosis and bioinformatics analysis of lncRNAs in hepatocellular carcinoma[J]. Oncotarget, 2017, 8(56):95799-95809.
doi: 10.18632/oncotarget.21329 URL |
[3] |
Jiang Y, Sun A, Zhao Y, et al. Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma[J]. Nature, 2019, 567(7747):257-261.
doi: 10.1038/s41586-019-0987-8 URL |
[4] |
Liu YR, Tang RX, Huang WT, et al. Long noncoding RNAs in hepatocellular carcinoma: novel insights into their mechanism[J]. World J Hepatol, 2015, 7(28):2781-2791.
doi: 10.4254/wjh.v7.i28.2781 URL |
[5] |
Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers[J]. Nature, 2005, 435(7043):834-838.
doi: 10.1038/nature03702 URL |
[6] |
Farazi TA, Spitzer JI, Morozov P, et al. miRNAs in human cancer[J]. J Pathol, 2011, 223(2):102-115.
doi: 10.1002/path.2806 URL |
[7] |
Gu C, Zhang M, Sun W, et al. Upregulation of miR-324-5p inhibits proliferation and invasion of colorectal cancer cells by targeting ELAVL1[J]. Oncol Res, 2019, 27(5):515-524.
doi: 10.3727/096504018X15166183598572 URL |
[8] |
Wan Y, Luo H, Yang M, et al. miR-324-5p contributes to cell proliferation and apoptosis in pancreatic cancer by targeting KLF3[J]. Mol Ther Oncolytics, 2020, 18:432-442.
doi: 10.1016/j.omto.2020.07.011 URL |
[9] | Xu HS, Zong HL, Shang M, et al. MiR-324-5p inhibits proliferation of glioma by target regulation of GLI1[J]. Eur Rev Med Pharmacol Sci, 2014, 18(6):828-832. |
[10] |
Ishak K, Baptista A, Bianchi L, et al. Histological gra-ding and staging of chronic hepatitis[J]. J Hepatol, 1995, 22(6):696-699.
pmid: 7560864 |
[11] |
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2):281-297.
doi: 10.1016/s0092-8674(04)00045-5 pmid: 14744438 |
[12] |
Kent OA, Mendell JT. A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes[J]. Oncogene, 2006, 25(46):6188-6196.
pmid: 17028598 |
[13] |
Murakami Y, Yasuda T, Saigo K, et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues[J]. Oncogene, 2006, 25(17):2537-2545.
pmid: 16331254 |
[14] |
Mao B, Wang G. MicroRNAs involved with hepatocellular carcinoma(Review)[J]. Oncol Rep, 2015, 34(6):2811-2820.
doi: 10.3892/or.2015.4275 URL |
[15] |
Kuo WT, Yu SY, Li SC, et al. MicroRNA-324 in human cancer: miR-324-5p and miR-324-3p have distinct biological functions in human cancer[J]. Anticancer Res, 2016, 36(10):5189-5196.
doi: 10.21873/anticanres.11089 URL |
[16] | Bamodu OA, Yang CK, Cheng WH, et al. 4-acetyl-antroquinonol B suppresses SOD2-enhanced cancer stem cell-like phenotypes and chemoresistance of colorectal cancer cells by inducing hsa-mir-324 re-expression[J]. Cancers(Basel), 2018, 10(8):269. |
[17] |
Zheng Z, Li J, An J, et al. High miR-324-5p expression predicts unfavorable prognosis of gastric cancer and faci-litates tumor progression in tumor cells[J]. Diagn Pathol, 2021, 16(1):5.
doi: 10.1186/s13000-020-01063-2 URL |
[18] |
Rong Z, Wang Z, Wang X, et al. Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression[J]. J Exp Clin Cancer Res, 2020, 39(1):61.
doi: 10.1186/s13046-020-01551-9 URL |
[19] |
Huang X, Sun L, Wen S, et al. RNA sequencing of plasma exosomes revealed novel functional long noncoding RNAs in hepatocellular carcinoma[J]. Cancer Sci, 2020, 111(9):3338-3349.
doi: 10.1111/cas.14516 URL |
[1] | ZHAO Hui (赵晖),WEN Baiqing (文柏清),KANG Yani*(康亚妮). Gene Expression Profiling Identifies Potential Biomarkers for Colorectal Cancer Using NanoString nCounter Assay [J]. J Shanghai Jiaotong Univ Sci, 2023, 28(4): 432-. |
[2] | JIA Jingyil (贾菁怡),LI Zhengyi1,2 (李正裔),PENG Linjing1 (彭琳晶),YAO Yifeil* (姚怡飞). Early Detection Methods of Deep Tissue Pressure Injuries: A Systematic Review [J]. J Shanghai Jiaotong Univ Sci, 2023, 28(4): 526-. |
[3] | CHEN Guoqun, CAI Jiaodi. Interpretation of the Clinical Practice Guidelines for Non-small Lung Cancer (version 4 and version 5) of 2022 National Comprehensive Cancer Nerwork(NCCN) [J]. Journal of Diagnostics Concepts & Practice, 2023, 22(01): 8-13. |
[4] | REN Xinping, LI Junjian, ZHANG Jie, ZHAN Weiwei. Advances in the application of contrast-enhanced ultrasound in the diagnosis and treatment of focal liver lesions [J]. Journal of Diagnostics Concepts & Practice, 2022, 21(06): 684-690. |
[5] | WU Dongdong, CHEN Yuhui, LIU Fang, LIU Yinhong, JIANG Jingwen. Study progress on cerebral small vessel disease complicated with neurodegenerative disorders in central nervous system [J]. Journal of Diagnostics Concepts & Practice, 2022, 21(05): 644-649. |
[6] | ZHOU Sifeng, XU Haishu, FAN Xinsheng. Application of metabolomics of different biological samples in study of OSAHS biomarkers [J]. Journal of Diagnostics Concepts & Practice, 2022, 21(04): 535-540. |
[7] | YANG Ling, ZHA Qing, ZHANG Qianru, YE Jiawen, YANG Ke, LIU Yan. Biomarker-based predictive model for calcific aortic valve disease [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(04): 324-329. |
[8] | ZHANG Xihao, ZHANG Xinyun, CAO Manqing, ZHANG Jinliang, WANG Huaqi, ZHANG Su, FU Zhou, WANG Lu, ZHANG Ti. Both anti-angiogenesis and immunotherapy combined with interventional therapy in treatment of hepatocellular carcinoma: effect of hepatic artery infusion chemotherapy compared with hepatic artery chemoembolization [J]. Journal of Surgery Concepts & Practice, 2022, 27(02): 152-157. |
[9] | GUAN Tao, ZHANG Ti, WANG Lu. Pulmonary metastasis of hepatocellular carcinoma: pathogenesis and therapeutic advances [J]. Journal of Surgery Concepts & Practice, 2022, 27(02): 180-184. |
[10] | WANG Zetian, WU Chunrong, QI Yue, XU Dan, SUN Keyuan, TANG Jianguo. Proteomics analysis of exosome in mice with Candida albicans infection for biomarker [J]. Journal of Surgery Concepts & Practice, 2021, 26(03): 262-268. |
[11] | TONG Hui, CHEN Peng, ZHANG Jiaqiang, XIE Junjie, LI Tao, ZHU Zhecheng, PENG Chenghong. Enhanced recovery after liver transplantation for patients with hepatocellular carcinoma [J]. Journal of Surgery Concepts & Practice, 2020, 25(01): 45-49. |
[12] | YE Feng, MA Di, GONG Xiaoyong, YANG Yuchen, CHEN Yongjun. Risk factor and prediction of spontaneous rupture of Barcelona Clinic Liver Cancer stage A primary hepatocellular carcinoma [J]. Journal of Surgery Concepts & Practice, 2020, 25(01): 40-44. |
[13] | ZHU Di, ZHU Xiaona, YANG Shuo, HE Ping, SHEN Shaoming, YU Yun. Study on ANP32B expression in hepatocellular carcinoma and its significance [J]. Journal of Diagnostics Concepts & Practice, 2019, 18(2): 170-176. |
[14] | CAO Lichen, TIAN Baoxing, QU Feilin, ZHANG Qinghua, GUO Shanyu. Study on serum exosome proteins in metastatic breast cancer patients [J]. Journal of Surgery Concepts & Practice, 2019, 24(02): 141-148. |
[15] | YAO Jiejie, ZHU Ying, ZHAN Weiwei, CHEN Xiaosong, FEI Xiaochun. Correlation of sonographic features of non-mass ductal carcinoma in situ with clinicopathological findings and biomarkers [J]. Journal of Diagnostics Concepts & Practice, 2018, 17(06): 676-681. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||