Analysis of long non-coding RNA TUG1 expression in colorectal cancer

doi:10.16139/j.1007-9610.2018.04.020

Abstract

Abstract: Objective To investigate the expression of long non-coding RNA TUG1 (taurine upregulated gene 1) in co-lorectal cancer tissues and the correlation between TUG1 expression and clinicopathological factors in patients with colorectal cancer. Methods Real-time quantitative polymerase chain reaction was used to detect TUG1 expression in cancer tissues and paracancerous tissues (>5 cm from the edge of cancer tissues) of 106 patients with colorectal cancer. The correlations between TUG1 expression and clinicopathological factors, and between TUG1 expression and the survivals of patients with colorectal cancer were analyzed. The patients were followed up from 3 to 60 months. Results In comparison with the expression of TUG1 in adjacent normal tissues, the expression of TUG1 in colorectal cancer tissues was significantly higher (P=0.003). We found that high expression of TUG1 related with tumor diameter (P<0.001), serum CEA (P=0.049) and TNM stage (P=0.005) significantly. Higher expression of TUG1 in patients with colorectal cancer had shorter overall survival times compared with the patients with lower expression of PUG1 (P=0.0025). Multivariate regression analysis showed that TUG1 expression could be an independent prognostic factor in patients with colorectal cancer. Conclusions TUG1 might play an important role in the development of colorectal cancer and may be used as predictor of prognosis for colorectal cancer.

Key words: Colorectal cancer, Taurine upregulated gene 1, Real-time quantitative polymerase chain reaction, Prognosis

CLC Number:

ZHOU Yong, CUI Rong, SHI Xingyao. Analysis of long non-coding RNA TUG1 expression in colorectal cancer[J]. Journal of Surgery Concepts & Practice, 2018, 23(04): 374-378.

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