组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2019, Vol. 15 ›› Issue (3): 191-193.doi: 10.3969/j.issn.1673-0364.2019.03.017

• 论著 • 上一篇    下一篇

ALA光动力疗法治疗面部中重度痤疮的疗效和安全性分析

李晓庆，徐素平，孔迎辉，李鹤，徐漫远，江明，孙卫国   

  1. 南京医科大学附属淮安第一医院皮肤科
  • 收稿日期:2019-01-19 修回日期:2019-03-10 出版日期:2019-06-20 发布日期:2019-06-20

Efficacy and Safety of ALA Photodynamic Therapy for Moderate to Severe Facial Acne

LI Xiaoqing,XU Suping,KONG Yinghui,LI He,XU Manyuan,JIANG Ming,SUN Weiguo   

  • Received:2019-01-19 Revised:2019-03-10 Online:2019-06-20 Published:2019-06-20

摘要： 目的 探索5-氨基酮戊酸光动力疗法(Aminolevulinic acid photodynamic therapy,ALA-PDT)治疗面部中重度痤疮的疗效和安全性。方法 2015年10月至2017年6月,94例中重度痤疮患者随机分为观察组(n=47)和对照组(n=47)。观察组采用ALA-PDT治疗,对照组采用红蓝光照射治疗。对比两组患者的疗效、血清TNF-α、IL-8水平变化及不良反应发生情况。结果 治疗后2、4、8周,观察组有效率明显高于对照组(P0.05)。结论 ALAPDT治疗面部中重度痤疮的疗效优于红蓝光照射,且无明显副作用,值得临床推广。

关键词: 痤疮, 5-氨基酮戊酸, 光动力

Abstract: Objective To explore the efficacy and safety of 5-aminolevulinic acid photodynamic therapy for moderate to severe facial acne.Methods A total of 94 cases of moderately severe acne were selected from October 2015 to June 2017,and were divided into control group(n=47)and observation group(n=47).The patients in control group were treated with red and blue light,while the patients in observation group were treated with 5-aminolevulinic acid photodynamic therapy.Clinical curative effect,serum TNF-αand IL-8 levels and adverse reactions of the two groups were compared.Results After treatment for 2,4 and 8 weeks,the effective rates of the observation group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).Serum TNF-αand IL-8 level of observation group after treatment was lower than that of the control group(P<0.05).The incidence of adverse reactions was 12.77%in the observation group and 8.51%in the control group.There was no significant difference between the two groups(P>0.05).Conclusion The efficacy of ALA-PDT in the treatment of moderate to severe acne was significantly better than red and blue light treatment,and the recurrence rate was low,it is worthy of clinical application.

Key words: Acne, 5-aminolevulinic acid, Photodynamic

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