Abstract: Objective To observe the efficacy of dexmedetomidine combined with dezocine-assisted ultrasound-guided brachial plexus block anesthesia in the treatment of upper limb fracture surgery. Methods A total of 60 patients with upper limb fracture were enrolled in this study, who were treated from January 2017 to March 2019. All the patients were randomly divided into the experimental group and the control group, with 30 cases in each group. Patients in the experimental group were anesthetized with dexmedetomidine combined with dezocine for ultrasound-guided brachial plexus block, while patients in the control group were anesthetized with dezocine for ultrasound-guided brachial plexus block. Blood pressure, heart rate,oxygen saturation and Ramsay sedation scores were compared between the two groups during the perioperative period. The incidence of intraoperative adverse reactions and the VAS scores after operation were compared between the two groups.Results The oxygen saturation of the two groups were stable at each time point during the perioperative period with no significant difference(P>0.05). The blood pressure and heart rate of the experimental group were stable at each time point during the perioperative period with no significant difference(P >0.05). The blood pressure and heart rate fluctuated significantly in the control group during the perioperative period(P 0.05). Ramsay sedation scores immediately after nerve block,10 minutes after anesthesia, 5 minutes after operation, 30 minutes after operation and at the end of operation in the experimental group were all significantly higher than those in the control group with statistical significance(P0.05), and there were no serious adverse reactions in both groups. Postoperative VAS score showed that the VAS of the experimental group and the control group were(1.6 ±0.5) and(2.0 ±0.6) respectively, with no statistical significance(P >0.05). Conclusion Dexmedetomidine combined with Dizosin assisted ultrasound-guided brachial plexus block anesthe sia is safe and effective with better sedative and analgesic effect in the treatment of upper limb fracture surgery.

Key words: Dexmedetomidine, Dizocine, Brachial plexus block, Ultrasound, Upper limb fracture