Table of Content

25 April 2017, Volume 16 Issue 02 Previous Issue    Next Issue

For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

Original articles

Select

Study of nigrosome-1 degeneration on imaging by quantitative susceptibility mapping in Parkinson's disease patients HE Naying, XU Hongmin, HUANG Pei, CHEN Shengdi, YAN Fuhua, LING Huawei 2017, 16 (02):  147-151.  DOI: 10.16150/j.1671-2870.2017.02.005 Abstract ( 398 )   PDF (631KB) ( 63 )   Objectives: To assess the diagnostic performance of nigrosome-1 degeneration on imaging by quantitative susceptibility mapping (QSM) for Parkinson's Disease (PD). Methods: Two cohorts (Cohort Ⅰ and Cohort Ⅱ) of patients were analyzed retrospectively in this study. For Cohort Ⅰ, forty-four early idiopathic PD patients and 35 age-and gender- matched healthy controls were recruited,and a three-dimensional 8-echo GRE sequence was acquired on a 3T MR scanner. For Cohort Ⅱ, 43 patients with idiopathic PD and 48 healthy gender- and age-matched controls were recruited. For each subject, a three-dimensional 16-echo GRE sequence was scanned. Then QSM was reconstructed from GRE data for all the subjects. Two neuro-radiologists who were blind to the diagnosis evaluated separately the visibility of nigrosome-1 on quantitative susceptibility mapping. There were three presenting types: present, possible present, and absent. Then all the subjects were classified into three groups based on the visibility of nigrosome-1: normal group, PD group, and non-diagnostic group. Clinical diagnosis was taken as the gold standard, and diagnostic performance of QSM for PD was assessed. Results: For Cohort Ⅰ, 42/44 PD and 10/35 controls were correctly classified, while there were 42/43 PD and 29/48 controls correctly classified in Cohort Ⅱ. Sensitivity of nigrosome-1 degeneration on imaging by QSM for diagnosing PD was 95.5%, specificity was 28.6%, positive predictive value (PPV) was 65.6%, negative predictive value (NPV) was 100% and accuracy rate was 66.0% in Cohort Ⅰ. While for cohort Ⅱ, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate were 97.7%, 60.4%, 75.0%, 100 % and 78.0%, respectively. Conclusions: QSM imaging could be used as a diagnostic tool for PD, which is feasible to assess the nigrosome-1 degeneration with a high negative predictive value. References | Related Articles | Metrics

Select

Detection of residual neuronal function in vegetative state patients after traumatic brain injury by using 11C-FMZ PET BAO Weiqi, GUAN Yihui, WU Xuehai, ZHANG Zhengwei, ZHANG Huiwei 2017, 16 (02):  152-156.  DOI: 10.16150/j.1671-2870.2017.02.006 Abstract ( 334 )   PDF (882KB) ( 103 )   Objective: To study the use of 11C-FMZ PET in detecting residual neuronal function in vegetative state patients after traumatic brain injury. Methods: Four cases of vegetative state patients after traumatic brain injury were enrolled,and 7 normal volunteers were served as controls. 11C-FMZ PET was performed to detect the standardized uptake value（SUV） of cortex of both hemispheres. SUV ratio (SUVR ) was obtained when SUV of the cerebral hemispheres was divided by SUV value of reference tissue, the pons. SUVRs of affected side and unaffected side were compared, as well as between patients and volunteers. Results: SUVRs of cerebral cortex of affected side were significantly lower than those of unaffected side and those of normal controls (P<0.05): frontal lobe (4.70 vs. 5.08, 7.23); temporal lobe (4.56 vs. 4.88, 7.05); parietal lobe (4.80 vs. 5.13, 6.81); occipital lobe (4.97 vs. 5.38, 7.42); cerebral hemisphere (4.75 vs. 5.12, 7.12). Conclusions: 11C-FMZ PET can be used to observe the residual neuronal function in vegetative state patients after traumatic brain injury. References | Related Articles | Metrics

Select

Detection of electrode position in deep brain stimulation therapy in patients with Parkinson′s disease: A retrospective analysis WANG Tao, ZHANG Chencheng, SUN Bomin, LI Dianyou 2017, 16 (02):  157-161.  DOI: 10.16150/j.1671-2870.2017.02.007 Abstract ( 227 )   PDF (791KB) ( 50 )   Objective: To assess the value of two methods for the verification of electrode position in deep brain sti-mulation (DBS) therapy of Parkinson′s disease (PD). Compare the accuracy of electrode position detection in images acquired by merging the short-term (within 1 week after the procedure) computed tomography (CT) with preoperative MRI and the long-term (1-12 month or more after the procedure) magnetic resonance imaging (MRI). Methods: The position of DBS electrode tip was detected under direct vision in fusion images of CT and preoperative 3.0T MRI images as well as in postoperative 1.5T MRI images only. Differences in the two methods were statistically analyzed. Results: Fifty-three fusion images and 14 MRI images showed no significant differences with regard to the position of electrode tips detected, the difference ranging from 0.42 mm to 0.89 mm. Conclusions: The fusion of preoperative MRI and postoperative CT image within 1 week is an effective and efficient approach for detection of DBS electrode position. References | Related Articles | Metrics

Select

Identification of mutated gene in two pedigrees with aniridia WEI Xiwei, YIN Haitao, CHEN Lei, YANG Wenlei, TAO Chen, GU Mingmin 2017, 16 (02):  162-165.  DOI: 10.16150/j.1671-2870.2017.02.008 Abstract ( 106 )   PDF (523KB) ( 39 )   Objective: To study the clinical features of two pedigrees of families with autosomal dominant aniridia, and to identify the pathogenic genes of the 2 families. Methods: All affected members underwent interrogation and ophthalmological examinations. Screening for PAX6 gene mutations was carried out in the 2 families. Family 2 in which no mutation was detected was also detected by exon capture and whole exome sequencing. Results: The patients of Family 1 pedigrees were completely consistent with the clinical features of aniridia, and the patients of Family 2 also had furthermore the phenotype of ptosis. Mutation screening showed that there was a known PAX6 gene mutation c.718C>T (p.Arg240*) in Family 1, but no mutation of PAX6 gene and other known genes were detected in Family 2. Conclusions: A PAX6 gene mutation (p.Arg240*) is detected in pedigrees of Family 1, but no disease-causing gene is yet detected in pedigrees of Family 2, denoting there is a novel genetic heterogeneity in aniridia. References | Related Articles | Metrics

Select

Relationship between HER2 expression and clinicopathological features in advanced gastric cancer QIAO Changting, LI Lei, WU Anni, YUAN Fei 2017, 16 (02):  166-170.  DOI: 10.16150/j.1671-2870.2017.02.009 Abstract ( 100 )   PDF (714KB) ( 52 )   Objective: To investigate the expression of human epidermal growth factor receptor-2 (HER2) in advanced gastric cancer and the correlation between HER2 expression and clinicopathological features. Methods: A total of 542 consecutive patients with gastric cancer from 2011 to 2015 were enrolled, and all the patients received resection of the tumor at Ruijin Hospital. HER2 expression in tumor tissue was detected by immunohistochemistry in accordance with the Hoffmann scoring system. Correlation between HER2 expression and clinicopathological features was statistically analyzed. Results: One hundred and forty-one cases (26%) were scored as strongly positive for HER2 membrane staining (3+). HER2 positivity was statistically associated with local invasion (P=0.002), lymph node metastasis (P< 0.001), and TNM staging (P=0.030), respectively. HER2 overexpression was more frequently detected in intestinal (30.5%) than that in diffuse (16.1%) type of tumor according to Lauren's classification. Similarly, HER2 overexpression was more frequently detected in well or moderate differentiated (43.0%) than in poor or undifferentiated (22.8%) tumor according to WHO classification. Conclusions: An accurate standardized scoring system for HER2 expression in gastric cancer patients is important for selecting patients for trastuzumab treatment. This study indicates that patients with intestinal type, well differen-tiated and late staging hare a high rate of HER2 expression, and they were the candidates for targeted therapy using trastuzumab. References | Related Articles | Metrics

Select

Optimization of screening potential candidates for use of aspirin as primary prevention in health check-up male subjects aged 50-59 years based on the results of endoscopy WU Chao, XU Chenying, XU Qingling, TANG Chenyue, YU Lifen 2017, 16 (02):  171-177.  DOI: 10.16150/j.1671-2870.2017.02.010 Abstract ( 368 )   PDF (898KB) ( 55 )   Objective: To optimize screening potential candidates for use of aspirin as primary prevention. Methods: Male subjects undergoing endoscopic examination at the endoscopic center of Shanghai Ruijin Hospital were enrolled. According to the endoscopic findings and biopsy result, upper and lower gastrointestinal (GI) lesions were classified. Information of gender, age, race, total cholesterol, HDL-cholesterol, systolic blood pressure, treatment for hypertension, status of diabetes and smoking was collected and 10-year atherosclerotic cardiovascular disease (ASCVD) risk estimation was calculated by the ASCVD Estimator. Results: A total of 5 772 subjects underwent endoscopy under light anesthesia, and 32.7% (1 885) of them were aged 50-59 years, and 839 were male. Endoscopic upper GI mucosal lesions were observed in 33.5% (281/839), and these subjects should be directly excluded because long-term use of aspirin might increase the risk of GI bleeding. One hundred and seven (12.8%) subjects who had high risk of colorectal cancer, 10-year ASCVD risk≥; 10% and had no obvious lesions in upper GI mucosa were the potential candidates for use of aspirin as primary prevention. Among them, 40 male smokers (25.2%) aged 50-59 years with colorectal adenoma or polyps might have better compliance for long-term prophylactic use of aspirin. Conclusions: Endoscopic examination under light anesthesia has optimization effects on screening potential candidates for use of aspirin as primary prevention,with which the risk of GI bleeding induced by long-term use of aspirin might be reduced, and the compliance might be improved because of the understanding of baseline status of GI mucosa. References | Related Articles | Metrics

Select

Correlation of blood pressure level with development and progression of chronic kidney disease in Chinese community diabetes patients LIN Anhua, WANG Chenxiu, HUO Yanan, CHEN Zhixiong, SONG Wei, LIU Jingdong, HU Yaqin 2017, 16 (02):  178-182.  DOI: 10.16150/j.1671-2870.2017.02.011 Abstract ( 289 )   PDF (547KB) ( 61 )   Objective: To investigate the correlation between blood pressure level and development and progression of chronic kidney disease (CKD) in Chinese community diabetes (DM) patients. Methods: Questionnaires and physical examination were performed in 1 349 diabetic patients over 40 years old in a community in Nanchang. The laboratory examinations included blood sugar and blood lipids, and the estimated glomerular filtration rate (estimated GFR, eGFR) was calculated. Patients were grouped by blood pressure level on the basis for every 10 mmHg. Logistic regression was used to evaluate the correlation between different groups. Results: The prevalence of CKD in community DM patients was 28.97%（376/1298）, and the prevalence of CKD in subjects with hypertension was 83.51%（314/376）. The treated rate of hypertension was 95.21%（299/314）, and the hypertension control rate was 49.33%（155/314）. Non-conditional logistic regression analysis showed that age, BMI, duration of diabetes, glycosylated hemoglobin, systolic blood pressure, low density lipoprotein cholesterol(LDL-C), smoking, taking meals at restaurant weekly were correlated with CKD in community diabetic patients. The prevalence of CKD in community patients with DM increased with the elder age, longer duration of dia-betes, higher glycated hemoglobin, larger body mass index, higher LDL-C, smoking, and higher frequency of taking meals at restaurant weekly. CKD staging was different between systolic blood pressure≥; 130 mmHg and<; 130 mmHg, as well as between systolic blood pressure ≥; 140 mmHg and <; 140 mmHg. There was also significant difference in progress of renal disease between patients having diastolic blood pressure <; 80 mmHg and ≥; 80 mmHg. Conclusions: CKD is a common complication of DM, and CKD is associated with a high prevalence rate and low control rate of hypertension. Age, duration of diabetes, glycosylated hemoglobin, body mass index(BMI), LDL-C, smoking and taking meals at restaurant weekly are correlated with the stage and progress of chronic kidney disease (CKD) and control of hypertension. References | Related Articles | Metrics

Select

Clinicopathological features of primary renal angiosarcoma: report of 3 cases and review of literature HAN Dongyan, LI Qianyu, JIANG Hongwei, XI Hao, WEI Qing 2017, 16 (02):  183-187.  DOI: 10.16150/j.1671-2870.2017.02.012 Abstract ( 235 )   PDF (1241KB) ( 133 )   Objective: To study the clinnicopathological features, differential diagnosis and prognosis of primary renal angiosarcoma. Methods: Tumor specimens from 3 cases of primary renal angiosarcoma were observed under light microscope. Immunohistochemistry examination was performed and relevant literatures were reviewed. Results: The lesions didn't have a clear boundary between tumor and normal tissue, and multiple irregular anastomosing vascular spaces or channels which were lined by discrete and large endothelial cells with variable degrees of nuclear atypia were observed. Two cases had epithelioid characteristics. Immunohistochemical study showed that tumor cells were positive for vimentin, CD31, CD34. Tumor cells of Case 2 were also partially positive for EMA. Tumor cells of Case 3 were strongly and diffusely positive for AE1/AE3, CK8/18. Tumor cells of Case 1 were negative for AE1/AE3, EMA. Conclusions: Primary renal angiosarcoma is extremely rare, and imaging examination does not allow for specific diagnosis of the tumor. Histopathology and immunohistochemistry are of great importance for diagnosis of the tumor. Whole intact tumor resection is the most effective treatment for primary renal angiosarcoma. References | Related Articles | Metrics

Select

Pulmonary sclerosing pneumocytoma: a clinicopathologic analysis of 23 cases GU Bin, WANG Chaofu, JIN Xiaolong, YUAN Fei, ZHANG Jing, XU Haimin, REN Jingli, CHEN Xiaoyan 2017, 16 (02):  188-194.  DOI: 10.16150/j.1671-2870.2017.02.013 Abstract ( 170 )   PDF (2105KB) ( 249 )   Objective: To investigate the clinical manifestations, imaging characteristics and pathological features of pulmonary sclerosing pneumocytoma（PSP）. Methods: A total of 23 cases of PSP were enrolled,and the clinical and pathologic features, imaging findings and immunophenotype were collected and analyzed retrospectively. The associated literature was reviewed. Results: PSP was more common in adult females than male, most patients were symptom-free（13/23,56.5%）. Of the 23 cases, 3 cases（3/23, 13.0%）were preoperatively diagnosed as PSP by imaging, and 13 cases were diagnosed as PSP（13/23, 56.5%）by frozen section examination at operation and the diagnostic rate was low. Gross examination revealed that PSP presented with a well-circumscribed mass, with no capsule or pseudocapsule,and a grey to tan color cut surface, 7 cases had focal dark red hemorrhage area. Microscopic examination revealed that PSP showed four histological patterns (solid, papillary, hemorrhagic and sclerotic) and two types of tumor cells（cuboidal surface cells and round or polygon stromal cells）. For immunophenotype, TTF-1 was strongly expressed on both surface cells and stromal cells. AE1/AE3, CAM5.2 and EMA were strongly expressed on the cell membrane and cytoplasm of surface cells, while weakly expressed on the cell cytoplasm of only a minority of stromal cells. NapsinA and SP-A were only expressed on surface cells, and Vimentin on stromal cells. All the 23 patients were followed up from 4 to 50 months, one case was found having contralateral pulmonary nodule of 1.5 cm on CT at 9 months after surgery, and radiographic surveillance was to be continued. The other 22 patients had no recurrence or metastasis. Conclusions: PSP lacks special clinical and imaging manifestations and having a high misdiagnosis rate of frozen section pathology examination. The pathological diagnosis depends on the morphologic characteristics of paraffin-embedded tissue sections and immunohistochemical staining. References | Related Articles | Metrics

Select

Significance of detection of p16 and Ki-67 in diagnosis of cervical intraepithelial lesions LIU Jingwen, WU Qiu-liang 2017, 16 (02):  195-198.  DOI: 10.16150/j.1671-2870.2017.02.014 Abstract ( 523 )   PDF (745KB) ( 259 )   Objective: To assess the value of detection of p16 and Ki-67 in diagnosis of cervical intraepithelial lesions for providing a basis for its clinical application. Methods: Two hundred cases of cervical intraepithelial lesion selec-ted from January 2015 to June 2016 were served as the object of this study. The biopsy paraffin sections after appropriate antigen retrieval were used for detection of p16 and Ki-67 immunohistochemically and the value of detection of p16 and Ki-67 in diagnosis of cervical intraepithelial lesion was analyzed. Results: The positive expression rates of p16 and Ki-67 in cervical squamous intraepithelial lesion (SIL) were significantly higher than those in atrophic cervix and cervical squamous epithelial metaplasia (P< 0.05). The positive expression rates of p16 and Ki-67 in high grade squamous intraepithelial lesion (HSIL) were significantly higher than those in low grade squamous intraepithelial lesion (LSIL) (P< 0.05). In cervical intraepithelial lesion, the expressions of p16 and Ki-67 were in good consistency, and was statistically significant (P< 0.05). The p16, Ki67 positive cells extended to 2/3 layer or whole layer in HSIL, and the positive expression rate was significantly higher than that in LSIL (P< 0.05). Conclusions: Detection of p16 and Ki-67 can be used as an important indicator for cervical intraepithelial lesion and has high diagnostic value clinically. References | Related Articles | Metrics

Select

Study on correlation of serum level of C1q tumor necrosis factor-related protein 1（CTRP1) with coronary atherosclerotic heart disease LING Yuan, WANG Shuhong, LIANG Wei, SHEN Linhui 2017, 16 (02):  199-203.  DOI: 10.16150/j.1671-2870.2017.02.015 Abstract ( 198 )   PDF (566KB) ( 63 )   Objective: To investigate the correlation between C1q tumor necrosis factor-related protein 1（CTRP1) and coronary atherosclerotic heart disease（CHD）. Methods: A total of 203 patients with suspected CHD were divided into two groups based on the results of coronary angiography: CHD group(n=103) and control group(n=100). The serum levels of CTRP1, adiponectin（APN）, tumor necrosis factor-α（TNF-α）, IL-6, IL-8, intracellular adhesion molecule 1（ICAM-1）, vascular cell adhesion molecule-1（VCAM-1）and monocyte chemotactic protein-1（MCP-1）were detected by ELISA. SPSS19.0 statistical software was used to analyze the data obtained. Results: The serum level of CTRP1 in CHD group was significantly higher than those in control group [(16.68±; 12.10) ng/mL vs (10.27±; 5.68) ng/mL, P< 0.001 ). After adjusted for gender, age, fasting plasma glucose (FPG) and HbA1c, CTRP1 level in CHD group was correlated with Gensini score（r=0.279, P=0.015）. Based on the quartile of Gensini score, CTRP1 level in the top quartile group was significantly higher than the other three groups [(23.45±; 18.87） ng/mL vs（11.27±; 5.88） ng/mL, （15.15±; 9.12） ng/mL, （17.00±; 7.82） ng/mL, all P< 0.05)]. After adjusted for gender, age, FPG and HbA1c, correlation analysis revealed that CTRP1 was positively correlated with TNF-α, IL-6, ICAM-1, MCP-1（r=0.260, 0.448, 0.362, 0.287, all P< 0.05）. Logistic regression analysis indicated that FPG（OR: 1.740, 95% CI: 1.027-2.880, P< 0.05）, HbA1c（OR: 2.714, 95% CI: 1.133-6.499, P< 0.05）, IL-8（OR: 1.041, 95% CI: 1.008-1.073, P< 0.05）, CTRP1（OR: 1.136, 95% CI:1.060-1.218, P< 0.05） were the risk factors for CHD. Conclusions: Serum CTRP1 level are significantly increased in patients with CHD and are positively correlated with the severity of coronary artery lesion, which suggested that CTRP1 might be used as an efficient indicator for evaluating the severity of CHD. References | Related Articles | Metrics

Select

Clinical value of prenatal ultrasonography in diagnosis of fetal hepatic space occupying lesion YANG Zexuan, ZHOU Liuying, DENG Ying 2017, 16 (02):  204-207.  DOI: 10.16150/j.1671-2870.2017.02.016 Abstract ( 313 )   PDF (761KB) ( 197 )   Objective: To investigate the value of prenatal ultrasonography in the diagnosis of fetal hepatic space occupying lesion. Methods: A total of 68 cases of fetal liver space occupying lesion diagnosed by prenatal ultrasonography from July 2011 to December 2015 were enrolled, and the gestational age, position and size of lesion, ultrasonic imaging characteristics, initial prenatal diagnosis, associated malformation and secondary change, as well as the clinical outcome were analyzed. Results: Among the 59 139 cases receiving prenatal ultrasonography, 68 cases were diagnosed as having fetal hepatic space occupying lesion by prenatal ultrasonography, in which 28 cases showing cystic lesion, 24 cases revealing hyperechogenic space occupying lesion, 12 cases showing mixed type space occupying lesion, and 4 cases showing low echogenic space occupying lesion. By imaging or pathologic examination, 23 cases were diagnosed as hepatic cyst, 1 case as biliary atresia, 4 cases as cystic dilatation in bile duct, 18 cases as hepatic calcification, 4 cases as meconium peritonitis, 13 cases as hepatic hemangioma, 1 case as hepatoblastoma, 2 cases as focal nodular hyperplasia, and 2 cases with no confirmed diagnosis. Clinical outcomes included intrauterine death in 2 cases, abortion in 3 cases, neonatal death in 1 case, survival in 61 cases, and lost tracking in 1 case. Conclusions: Prenatal ultrasonography is an important and efficient approach for detection and diagnosis of fetal hepatic space occupying lesion, it might provide a valuable direction for perinatal management of cases with fetal hepatic space occupying lesion. References | Related Articles | Metrics

Select

Comparison of pregnancy outcome of frozen-thawed embryo plantation with two different endometrial preparation in patients with history of ectopic pregnancy DU Tong, LYU Qifeng 2017, 16 (02):  208-212.  DOI: 10.16150/j.1671-2870.2017.02.017 Abstract ( 243 )   PDF (476KB) ( 55 )   Objective: To evaluate the effect of different endometrial preparation on outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) frozen-thawed embryo plantation in patients with history of ectopic pregnancy. Methods: Data from 914 patients with history of ectopic pregnancy who underwent IVF/ICSI frozen-thawed embryo plantation from January 2012 to December 2014 were collected. Patients undergoing natural cycles and those undergoing artificial cycles were matched into 379 pairs by propensity score matching. Pregnancy outcomes were compared between the two matched groups of patients. Results: The basic characteristics including maternal age, body mass index, full-term birth history, primary or secondary infertility, previous tubal surgery history, infertility diagnosis, endometrial thickness on embryo plantation day, number and stage of embryos planted, and year of treatment were not significantly different between the two groups (P>; 0.05). As for pregnancy outcome, the ectopic pregnancy rate of the two groups was not significantly different (5.2% vs.7.5%, P>; 0.05). Moreover, biochemical pregnancy rate, clinical pregnancy rate, delivery rate, miscarriage rate, and multiple pregnancy rate of the two groups were also not significantly different (P>; 0.05). Conclusions: In IVF/ICSI frozen-thawed embryo plantation, natural cycles and artificial cycles have similar effect on recurrence risk of ectopic pregnancy, and have comparable pregnancy outcome. References | Related Articles | Metrics

Select

Prenatal serological screening for Down's syndrome in second trimester of pregnancy ZHANG Bin, YUE Chaoyan, YING Chunmei 2017, 16 (02):  213-216.  DOI: 10.16150/j.1671-2870.2017.02.018 Abstract ( 380 )   PDF (468KB) ( 181 )   Objective: To investigate the value of second trimester prenatal serological screening for Down's syndrome by analyzing the positive rate of serological screening and the detection rate of Down's syndrome. Methods: From January to December 2014, prenatal serological screening for Down's syndrome was performed in 19 718 pregnant women in 14-21 weeks of pregnancy. Combined detection of alpha fetoprotein (AFP), β-human chorionic gonadotropin (β-hCG) and unconjugated estriol(uE3) was performed on Beckman Access 2 Automatic Chemiluminescence Analyzer. Calculated the multiples of median (MoM) of above three indices and in coordinating with maternal age, body weight and weeks of pregnancy to predict the risk of 21-trisomy, open spine bifida (OSB), 18-Trisomy, and the pregnancy outcome was followed. Results: In the 19 718 pregnant women, serological triple screening revealed that 1 264 pregnant women were in high risk and had a positive screening rate of 6.41%. Among 18 660 pregnant women under 35 years old, 1 015 were in high risk and had a positive screening rate of 5.44%;; while for 1 058 pregnant women over 35 years old, 249 cases were in high risk and had a positive screening rate of 23.53%. Follow-up study showed that 11 pregnant women had baby with Down's syndrome, including 9 with screening positive and 2 with screening negative. The detection rate of 21-Trisomy was 82%. Follow-up also confirmed 2 cases of 18-Trisomy and 6 cases of other deformities. Conclusions: In considering the detection rate, economic aspect and operability of laboratory, serological screening in second trimester is still an important approach for screening Down′s syndrome, besides, 18-Trisomy, OSB and some other deformities can also been screened. References | Related Articles | Metrics

Select

Analysis of Gesell Developmental Schedules test in 200 late premature infants ZHANG Shi, HE Huijing, WAN Guobin 2017, 16 (02):  217-220.  DOI: 10.16150/j.1671-2870.2017.02.019 Abstract ( 710 )   PDF (444KB) ( 128 )   Objective: To investigate the intelligent development of late preterm infants and its influencing factors, and to provide a theoretical basis for early intervention. Methods: Two hundred late preterm infants were enrolled, and 100 full term infants were served as controls. The intelligence development level was assessed by Gesell development schedules test, and the risk factors for influencing the development of intelligence were analyzed. Results: The average developmental quotient score of 200 late preterm infants was 94.5+6.7, and the abnormal rates of gross motor development, fine movement, verbal skills, social behavior and adaptability were 9.00%, 10.00%, 8.50%, 8.50%, and 9.00%, respectively. Multi factor logistic regression analsis showed that, very low birth weight (OR=2.235), low blood glucose (OR=2.002) and parental education level (OR=0.750) were associated with mental development in late preterm infants(P< 0.05). Conclusions: The late preterm infants are at high risk for mental development, abnormal rates are significantly associated with very low birth weight, low blood glucose and low parental education level. References | Related Articles | Metrics

Select

Magnetic resonance imaging in evaluating the therapeutic efficacy of uterine artery embolization for uterine leiomyoma YU Wuxia, YAO Weiwu, QIAN Zhaoxia 2017, 16 (02):  221-226.  DOI: 10.16150/j.1671-2870.2017.02.020 Abstract ( 263 )   PDF (757KB) ( 65 )   Objective: To evaluate the therapeutic efficacy of uterine artery embolization for leiomyoma by MRI. Methods: Seventeen patients with leiomyoma (39 leiomyomas) undergone uterine artery embolization with Seldinger′s method were enrolled and the indices of uterine leiomyoma were recorded, including volume, major axis, number, signals and ADC on magnetic resonance imaging before and 3 months,6 months after the procedure as well as the clinical symptoms. Results: The average volume of 39 leiomyomas was reduced by 79.72%. Meanwhile, the average of total major axis was reduced by 44.92%. And the symptoms of 9 patients with menorrhagia improved markedly, the symptoms of 7 of the 9 patients with severe dysmenorrhea relieved dramatically. After treatment, signal intensity on T1WI imaging was increased in 84.62% lesions, while ADC values were decreased in 82.05% lesions. Conclusions: MRI is a preferable approach to evaluate the efficacy of uterine artery embolization. References | Related Articles | Metrics

Medical education

Select

An investigation on present teaching situation of hematology JIN Xiaomu, JIN Shiwei, FAN Qingye, WU Ping, MI Jianqing 2017, 16 (02):  236-240.  DOI: 10.16150/j.1671-2870.2017.02.023 Abstract ( 177 )   PDF (491KB) ( 96 )   Objective: To investigate the current teaching situation of hematology, and to explore the teaching metho-ds for improving the efficacy of teaching effect, thereby providing the theoretical basis for teaching reform. Methods: A questionnaire of present teaching situation of hematology was designed and medical students were recruited and surveyed. The software SPSS 23.0 was used to analyze the statistics. Results: Overall 72.0% of students realized the importance of learning hematology; 47.0% of students were interested in hematology, while 41.2% of students complained difficulty to understand hematology; 71.4% of students showed satisfactions in hematology teaching. More 5-year program students were interested in learning hematology than 8-year program students. Conclusions: The majority of students expressed satisfaction with current hematology teaching. However, it is important to improve the way of teaching and combing theories with clinical practice for achieving better teaching effectiveness, stimulating students' interest in learning hematology, and promoting independent self-learning. References | Related Articles | Metrics