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New advances in the study of scaffold materials for cartilage tissue engineering YUE Guangren, WANG Ximei, LI Yu Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 408-413.   Abstract （176）      PDF（pc） （875KB）（302）       Knowledge map    Save Lacking blood vessels and nerve nourishment, cartilage has limited ability to repair and regenerate. Combining scaffolds, cells and active factors, tissue engineering has been considered as an important new direction for repairing cartilage injury. Scaffold plays an important role in the cartilage regeneration process, not only providing a support site for cell adhesion, but also improving the local microenvironment and affecting cell proliferation and differentiation. Many materials have been used to make biodegradable scaffolds: natural materials, synthetic materials and composite materials. In this paper, the materials that have been relatively widely used in cartilage tissue engineering were reviewed so as to provide valuable reference for researchers in this field. Related Articles | Metrics | Comments（0）

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Evaluation of facial injection filling materials for medical aesthetics ZHAO Chenyu, LI Chongchong, SUN Xue, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 517-.   Abstract （175）      PDF（pc） （874KB）（851）       Knowledge map    Save With economic development and technological progress, the demand for medical aesthetics has increased sig nificantly, and medical biomaterials are widely used. It is necessary to further improve the evaluation of their effectiveness and safety. At present, the evaluation of its physicochemical properties and biology is adopted in China. However, the clinical effec tiveness is a multi-faceted evaluation without unified criteria. Most of the evaluation mainly adopts objective indicators for quan titative analysis, while subjective feelings are secondary criteria. In this paper, the main facial fillers and the evaluation methods of their physicochemical properties were reviewed. Related Articles | Metrics | Comments（0）

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Clinical observation of the effect of JianpiQushi Fang on the treatment of keloid in patients with phlegm-damp/damp-heat TCM constitution TANG Renyan, XIA Lingling, CAO Zhengdong, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 376-379.   Abstract （174）      PDF（pc） （889KB）（110）       Knowledge map    Save Objective　To explore the clinical effect of Traditional Chinese Medicine (TCM) formula “JianpiQushi Fang” in the treatment of keloid in patients with phlegm-damp/damp-heat TCM constitution, and to provide preliminary clinical evidence for TCM systemic treatment of keloid. Methods　Twenty-five keloid cases were diagnosed as phlegm-dampness/damp heat constitution by TCM constitution criteria. The patients were treated with“JianpiQushi” decoction with 1 dose daily (half dose twice a day) and continued for 4 weeks as a course of treatment. Physique score, local scar pain/pruritus symptoms, and Vancouver scar scale (VSS) score were compared before and after the treatment. Results　Compared with before treatment, the physique score, scar local pain score and pruritus symptom score were significantly improved after treatment (P<0.05), while the scar VSS score had no significant change (P>0.05). Conclusion　“JianpiQushi Fang” can effectively reduce the symptoms of keloid in patients with phlegm-damp/damp-heat TCM constitution, but its effect on improving the appearance and texture of scar is limited, suggesting that it should be combined with local surgical treatment. Related Articles | Metrics | Comments（0）

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Akkermansia muciniphila outer membrane protein 1100 promotes wound healing in diabetic rats LIN Weiyi, GE Chengwang, TANG Xiaowei, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 358-.   Abstract （96）      PDF（pc） （2047KB）（108）       Knowledge map    Save Objective　To investigate the effects of Akkermansia muciniphila outer membrane protein 1100 (Amuc_1100) on wound inflammation and collagen fiber synthesis in diabetic rats. Methods　Twenty male SD rats were induced into diabeticrats by intraperitoneal injection of streptozotocin. The defective wound model of full-thickness back skin was constructed and the rats were divided into two groups, control group and Amuc_1100 group. The Amuc_1100 group was injected locally with 300 μL Amuc_1100 solution with a concentration of 333 μg/mL, the control group was injected with the same amount of normal saline. Wounds were photographed and the wound healing rate were compared on day 0, 3, 7, 10 and 14, respectively. Five rats in each group were sacrificed and harvested on day 7 and 14. Hematoxylin-eosin (HE) staining was used to evaluate inflammatory cellinfiltration and histological morphology of the wound. Masson three-color staining was used to evaluate collagen fiber deposition. The mRNA expression levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), collagen fiber 1A1 (Col1A1) and collagen fiber 3A1 (Col3A1) were compared by real-time quantitative polymerase chain reaction (RT-PCR). Results　The wound healing rate in Amuc_1100 group was higher than that in control group on day 3, 7, 10 and 14 (P<0.05). HE staining showed that the Amuc_1100 group had less inflammatory cells and more collagen fiber deposition in wound tissue. Masson three-color staining showed that the collagen in the Amuc_1100 group was thicker, deeper dyed and more compact than control group. RT-PCR showed that the relative mRNA expressions of TNF-α and IL-6 were significantly decreased in Amuc_1100 group compared with the control group (P<0.05), and the relative mRNA expressions of IL-10, Col1A1 and Col3A1 were significantly increased compared with the control group (P<0.05). Conclusion　Amuc_1100 can improve the wound healing rate of diabetic rats, and the mechanism may be related to reducing local inflammatory response and increasing collagen fiber synthesis. Related Articles | Metrics | Comments（0）

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Curcumin-loaded nanofilm stabilize in vivo chondrogenesis of stem cellengineered cartilage using an encapsulation model HU Doudou, XU Yong, JIA Wei Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 329-335.   Abstract （94）      PDF（pc） （1500KB）（60）       Knowledge map    Save Objective　To explore the feasibility of a curcumin-loaded nanofilm using an encapsulation model to stabilize in vivo chondrogenesis of stem cell-engineered cartilage. Methods　Curcumin (CUR) with anti-angiogenic activities was loaded into poly(L-lactide-co-caprolactone) (PLCL) and underwent electrospun process to produce a CUR/PLCL nanofilm, and a PLCL nanofilm was identically prepared as a control group. The morphologies of PLCL and CUR/PLCL nanofilms were observed using SLR camera and scanning electron microscope. The anti-angiogenic activity of CUR/PLCL nanofilm was evaluated through the in vitro co-culture with human umbilical vein endothelial cells for 6 hours. In addition, rabbit-derived bone marrow stem cells (BMSCs) were seeded into a porous gelatin scaffold and underwent chondrogenic culture for 3 weeks. The BMSC engineered cartilage was evaluated using SLR camera and histological staining. Finally, the BMSC engineered cartilage was embedded using  the CUR/PLCL nanofilm and implanted into nude mice subcutaneously for 6 weeks. The achieved samples were evaluated using SLR camera, micro-CT, and histological staining examinations, aiming to distinguish chondrogenesis and ossification conditions. Results　In contrast to the white PLCL nanofilm, the CUR/PLCL nanofilm showed yellow color, whereas both nanofilms exhibited similar nano-scaled structure. The in vitro tube formation assay suggested that the CUR/PLCL nanofilm possessed enhanced anti-angiogenic activity than PLCL nanofilm. A BMSC engineered cartilage tissue was successfully achieved via in vitro chon drogenic culture of the BMSC-gelatin construct for 3 weeks, as evidenced by cartilage-like appearance in photograph, typical lacunar structure and cartilage-specific extracellular matrix formation in HE staining, and positive stained glycosaminoglycan in safranin-O staining. After subcutaneously implanted into nude mice for 6 weeks, the gross images indicated that the PLCL group was obvious vascularized whereas the CUR/PLCL group was absent from vascular invasion. The micro-CT images suggested that the PLCL group exhibited abundant bone trabecular structure but not in the CUR/PLCL group. The HE and saf-O/FG staining further confirmed that the PLCL group showed typical bone trabecular structure and bone-specific matrix, and the CUR/PLCL group displayed typical mature lacuna and cartilage-specific extracellular matrix. Conclusion　CUR/PCL nanofilm could stabilize in vivo chondrogenesis of stem cell-engineered cartilage using an encapsulation model. Related Articles | Metrics | Comments（0）

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Mechanism research of adipose-derived mesenchymal stem cell-derived exosomes in wound healing of full-thickness skin defect in rats FU Wen, WANG Xiangchen, WANG Yangui, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 342-.   Abstract （93）      PDF（pc） （2604KB）（122）       Knowledge map    Save Objective　To explore the mechanism of adipose-derived mesenchymal stem cell-derived exosomes (hADSC-Exo) on wound healing of full-thickness skin defect in rats. Methods　hADSC and hADSC-Exo were isolated and identified. Human microvascular endothelial cells (hMECs) were divided into control group, positive control group (treated with 200 μg/L recombinant human epidermal growth factor) and hADSC-Exo group (treated with 100 μg/mL hADSC-Exo). The proliferation, migration and angiogenesis of hMECs were detected by CCK-8, scratch and angiogenesis experiments. A total of 60 rats were randomly divided into control group, positive control group, hADSC group and hADSC-Exo group, 15 rats in each group. Full-layer skin defect wounds were prepared on the back of all rats. Each group was injected with 200 μL 1×PBS, 100 μg/kg recombinant human epidermal growth factor, 200 μL 1×PBS containing 1×106 hADSC and 200 μL 1×PBS containing 200 μg hADSC-Exo, re spectively. Three rats were randomly reserved in each group. The wound images were taken and the wound area was calculated on the 0, 3, 7, 10 and 12 days respectively. The rest of the rats in each group were randomly divided into 4 groups, with 3 rats in each group. The unhealed wound tissues were collected on the 3, 7, 10 and 12 days respectively, and tissue samples were prepared into paraffin sections. HE and Masson staining were used to observe the wound healing. The expression of proteins related to inflammation and wound healing was detected by immunohistochemistry. Results　The results of cell experiment showed that compared with the control group, the cell proliferation activity, cell migration rate, lumen length and the number of branching points increased in the positive control group and hADSC-Exo group (P<0.05). Compared with the positive control group, the cell proliferation activity, cell migration rate, lumen length and the number of branching points in hADSC-Exo group were further increased (P<0.05). The results of animal test showed that compared with the control group, the wound healing rate and the expression levels of CD206, Collagen Ⅰ , Collagen Ⅲ and Aquaporin 3 (AQP3) in the positive control group, hADSC group and hADSC-Exo group increased (P<0.05), while the expression levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, CD68, keratin 1 (KRT1) and the ratio of Collagen Ⅰ /Collagen Ⅲ decreased (P<0.05), the new epidermis was more intact and thicker, the proliferation of fibroblasts and the deposition of new collagen in the wound were significantly increased. Compared with the positive control group, the expression levels of CD206, Collagen Ⅰ , Collagen Ⅲ and AQP3 in hADSC group and hADSC-Exo group were further increased (P<0.05), while the expression levels of TNF-α, IL-6, CD68, KRT1 were further decreased (P<0.05). Conclusion　hADSCs-Exos can enhance the proliferation, migration and angiogenesis of hMECs, reduce the level of wound inflammation, promote the proliferation of wound cells, collagen remodeling, and accelerate wound healing, which has the potential to be used as a treatment drug for skin wounds. Related Articles | Metrics | Comments（0）

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Research progress of the effect of radiotherapy on breast reconstruction with prosthesis and autologous tissue after breast cancer surgery REN Yanxin, YU Yan, XU Kexin, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 511-.   Abstract （90）      PDF（pc） （903KB）（167）       Knowledge map    Save 　Breast integrity and beauty affect women’s physical and mental health. Immediate breast reconstruction after breast cancer mastectomy can significantly increase women’s self-confidence and improve women’s quality of life. As a conventional treatment for breast cancer, radiotherapy can reduce the local recurrence rate and disease-free survival rate of breast cancer. However, radiotherapy can increase the complication rate and failure rate of breast reconstruction immediately after breast cancer surgery. The two most commonly performed breast reconstruction procedures are breast reconstruction with autologous tissue and breast reconstruction with prosthesis. In this paper, the effects of radiotherapy on autologous tissue breast reconstruction and prosthesis breast reconstruction were reviewed. Related Articles | Metrics | Comments（0）

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Research progress of NOTCH signaling pathway and endothelial-to-mesenchymal transition in infantile hemangioma SUN Xiaoting, MA Xiaorong Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 414-.   Abstract （85）      PDF（pc） （854KB）（123）       Knowledge map    Save Infantile hemangioma (IH) is a benign tumor that occurs in infants and childhood. The pathogenesis of IH has not been fully elucidated. Although the course of the disease is self-limiting, partial patients may have sequelae that affect the aesthetics or normal function. NOTCH signaling is an evolutionarily conserved signaling pathway, that plays vital roles in many physiological and pathological processes, such as cell differentiation, embryonic vascular development, tissue itself-renewal, the occurrence of tumor and inflammation, and regulation of vascular function. Endothelial-to-mesenchymal transition (EndMT) is a mechanism in which endothelial cells (ECs) lose their unique properties and acquire mesenchymal and stem cell-like characteristics under the influence of multiple factors. EndMT can be involved in a variety of pathologies, including embryonic development, malignant tumor invasion, and fibrotic disease. Recent findings have shown that inhibition of the NOTCH signaling pathway might accelerate the regression of IH and interfere with disease progression caused by EndMT. In this paper, the progression of endothelial-to-mesenchymal transition and NOTCH signaling pathway in IH were reviewed Related Articles | Metrics | Comments（0）

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Clinical application of TAPAS flap in face reconstruction YANG Jifan, FAN Jincai Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 425-.   Abstract （80）      PDF（pc） （810KB）（110）       Knowledge map    Save 　Temporal artery postauricular skin flap, also known as TAPSA flap, is a technique for transposition of posterior auricular island flap, by pedicled with superficial temporal artery. Island TAPAS flap has been used in clinic practice since 1980s. After continuous innovation and combined with new technologies such as prefabricated flap, it has developed into a flap that could carry a variety of tissues at the same time for complex reconstruction. It has been used in the repair of organs such as nose, eyelid and periorbital reconstruction, which represents indispensable medical and aesthetic significance. In this paper, the clinical application of TAPAS flap in face reconstruction was reviewed. Related Articles | Metrics | Comments（0）

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Application of multipoint injection indocyanine green lymphography in lymphaticovenular anastomosis of lower limbs ZHOU Xuchuan, LIU Bin, WANG Wenfei, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 459-.   Abstract （80）      PDF（pc） （1122KB）（115）       Knowledge map    Save Objective　To explore the application of multipoint injection indocyanine green (ICG) lymphography in lymphaticovenular anastomosis (LVA) of lower limbs and analyze the advantages of the improved lymphography. Methods　From December 2020 to June 2022, 57 patients with lower limb lymphedema were selected as the study subjects and were divided into the single injection group (n=25) and the multi-injection group (n=32). In the single injection group, ICG was injected into the first toe web. In the multi-point injection group, ICG was injected preoperatively at the first web, medial malleolus, lateral malleolus, medial knee and lateral knee. The linear pattern was observed by ICG lymphography and LVA was performed in both groups. The number of lymphatic vessels anastomosed and the time of surgery were compared. Lower extremity lymphedema index (LELI) was used as the prognostic index, the symptom relief of lymphedema half a year after LVA was evaluated in both groups. Results　The number of anastomotic lymphatic vessels in the multi-injection group was higher than that in the single injection group, and the surgery time was lower than that in the single injection group (P<0.05). The LELI of the multi-injection group and the single injection group half a year after LVA were lower than that before operation (P<0.05). The circumference of the affected limb was reduced in both groups after operation, the reduction of LELI in the multi-point injection group was higher than that in the single injection group (P<0.05). Conclusion　Multipoint injection indocyanine green lymphography can find more pattern before operation and shorten the time of looking for lymphatic vessels, which has high clinical application value. Related Articles | Metrics | Comments（0）

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Research on the application of 3D printing technology in personalized customization of neck functional stents for#br# scar patients#br# NI Xiaojun, ZHUANG Leilan, SHEN Lei, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 397-.   Abstract （78）      PDF（pc） （826KB）（52）       Knowledge map    Save Objective　To explore the application effect of 3D printing technology in personalized customization of neck functional stents for scar patients. Methods　Fifty patients who underwent neck scar treatment in our hospital from March 2021 to August 2021 were selected and randomly divided into two groups according to the random number table method. On the basis of conventional anti-scar drug treatment, the control group was treated with a conventional size neck brace for pressure treatment, andthe observation group was treated with a personalized neck functional stent made by 3D printing technology for pressure treatment. The patients were followed up for 12 months and assessed by the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS). Results　A total of 43 patients completed the whole course of treatment. The time for the observation group to reach the target pressure value was significantly shorter than the control group (P<0.05); All indicators of VSS scores were better than the control group (P<0.05); Multiple indicators of POSAS scores were better than the control group (P<0.05). Conclusion　Implementing 3D printing technology to customize personalized functional stents for neck scar patients is beneficial for maintaining stable pressure treatment effects and improving scar treatment efficacy Related Articles | Metrics | Comments（0）

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Analysis of time window and influencing factors of various complications after breast reconstruction with prosthesis implantation GAO Qiang Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 464-.   Abstract （76）      PDF（pc） （942KB）（44）       Knowledge map    Save Objective　To evaluate and analyze the time window and influencing factors of various complications in breast cancer (BC) patients undergoing implant-based breast reconstruction (IBBR). Methods　The retrospective study method was used in this study. Extract the data to be analyzed from the inpatient medical records. The onset time of complications after breast reconstruction in BC patients was described and summarized, and the related factors influencing the onset of complications were analyzed by COX. Results　There were 129 cases of acute and long-term complications in 395 cases of breast reconstruction surgery, and the incidence rate of complications was 32.66%. Among them, 73 patients (104 breasts) had at least one complication. Chemotherapy was the protective factor of postoperative hematoma (P<0.05). The indications of therapeutic mastectomy, tissue expander implantation, prosthesis implantation in the anterior plane of pectoral muscle, preoperative radiotherapy for IBBR, obesity and smoking were the risk factors for postoperative seroma (P<0.05). Preoperative radiation therapy was a risk factor for postoperative necrosis of nipple areola/skin flap in patients with IBBR (P<0.05). The indication of therapeutic mastectomy and axillary lymph node dissection were the risk factors for postoperative infection in the surgical area (P<0.05). Preoperative radiotherapy, obesity, axillary lymph node dissection, and reconstruction support material Vicryl mesh were the risk factors for prosthetic loss in patients with IBBR (P<0.05). Prosthesis implantation in the anterior plane of pectoral muscle, preoperative radiotherapy for IBBR, chemotherapy and obesity were the risk factors for postoperative ripple/wrinkle (P<0.05). Radiotherapy before IBBR and axillary lymph node dissection were the risk factors of capsular contracture (P<0.05). Conclusion　Postop erative complications of IBBR in BC patients show discrete time distribution. These findings have a certain value in guiding the postoperative treatment, follow-up and clinical trial design of patients. Related Articles | Metrics | Comments（0）

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Discussion on application and related issues of skin soft tissue expansion in treatment of congenital giant nevus WEI Siming, YAO Wende, WANG Na, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 450-.   Abstract （74）      PDF（pc） （1081KB）（34）       Knowledge map    Save Objective　To summarize the curative effect of congenital giant nevus after transcutaneous soft tissue expansion. Methods　In the past 9 years (July 2010 to September 2019), 28 patients with congenital giant nevus were treated and repaired by single/multiple one-stage expansion of head, trunk and limbs followed by two-stage flap repair. The expander was placed in stage I, and when the skin and soft tissue were fully expanded, the expander was removed, and the giant nevus on the head, face, trunk and limbs was removed. Skin flaps were designed according to the size and shape of the giant nevus to completely repair the defect. Results　In 28 cases, the area of giant nevus was about 13 cm×12 cm to 43 cm×33 cm, all of which were com pletely resected. One case of hematoma and three cases of infection were improved after active treatment, and the flap transfer was not affected. After follow-up for more than half a year, all the flaps survived well and no obvious contracture was observed. The color was similar to normal skin, and no recurrence was observed. Conclusion　Congenital giant nevus treated by skin soft tissue expansion is satisfactory and worthy of promotion. Related Articles | Metrics | Comments（0）

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Research progress on rehabilitation effect of respiratory training on breast cancer-related lymphedema LI Hui, YIN Yu, LI Chunxiao, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 430-.   Abstract （73）      PDF（pc） （839KB）（108）       Knowledge map    Save 　Breast cancer-related lymphedema (BCRL) is one of the common postoperative complications of breast cancer. At present, there is no effective method to cure BCRL at home and abroad. Respiratory training, as a simple and easy training program, can improve the lymphedema of patients through a variety of mechanisms, improve the quality of life, and may provide a potential rehabilitation treatment for BCRL. Related Articles | Metrics | Comments（0）

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The lymphatic endothelial microchannel in the renal cortex of the rat MA Qiaoying, PAN Weiren, ZENG Fanqiang, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 435-.   Abstract （71）      PDF（pc） （2150KB）（55）       Knowledge map    Save Objective　To explore the endothelial microchannel and ultrastructure of the lymphatic vessel in the renal cortex of the rat. Methods　Twelve kidneys were obtained from six rats. Eight of them were examined by histological section, Haema toxylin Eosin (HE) and Immunohistochemical (IHC) staining. The other four were examined by scanning electron microscopy af ter tissues were pre-prepared. Results　Lymphatic vessels were hardly recognized in the HE staining section of the rat kidney, but could be detected by IHC staining of LYVE-1. They had irregular and thin walls with varying shapes and sizes. Some nuclei of the endothelial were protruded into the lumen. The scanning electron microscope showed that scattered entrances of the endo thelial microchannel were seen on the lymphatic vessel in the renal cortex of the rat, which contained a semicircular“roof” and a flat“floor”. Metabolites were scattered around or gathered at the entrance. Conclusion　This study introduces the morpholog ical structure of endothelial microchannels of the lymphatic vessel in the renal cortex of the rat. The result can provide a morpho logical theoretical basis of experimental animals for further basic scientific research, tissue engineering, 3D tissue printing, and clinical applications. Related Articles | Metrics | Comments（0）

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Establishment and application of the patient safety smart warning system based on 5G Internet of things technology#br# in Plastic and Reconstructive Surgery nursing #br# ZHANG Yongmei, WANG Ping, BIAN Weiwei, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 402-.   Abstract （68）      PDF（pc） （857KB）（110）       Knowledge map    Save Objective　To develop the patient safety smart warning system based on 5G internet of things technology, and to explore its application effect in the Plastic and Reconstructive Surgery nursing. Methods　The patient safety smart warning system was constructed based on research group establishing, literature research and Delphi study, then patient safety warning indicators were screened and modules were built. Based on 5G network, the patient safety indicators and the connected equipment involved were integrated with the system. Then the system was applied in plastic and reconstructive surgery ward after staff training. Two months before and after the application of the system, the postoperative complications, incidence of adverse events and discovery rate of potential complications in patients were calculated, and graded care quality was scored. Medical staff’s application satisfaction was investigated using self-designed questionnaire. Results　After the application of the patient safety smart warning system, the discovery rate of potential complications in patients was increased significantly (P<0.05). The incidence of postoperative complications and adverse events decreased with no significant difference (P>0.05). The score of graded care quality improved from 97 to 99 after the application of the system. The overall satisfaction score of medical staff to patient safety smart warning system was 4.59±0.49. Conclusion　Application of the patient safety smart warning system based on 5G Internet of things technology can improve the discovery rate of potential complications in patients, enhance the predictability of  patients’safety risks and the awareness of safety risk management of medical staff, promote the timely follow-up of clinical intervention measures, and ensure the safety of patients. Related Articles | Metrics | Comments（0）

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The application of pedicled vastus lateralis-myocutaneous flap in the repair of complex wounds in the lower limbs#br# LIU Jiayue, CHEN Yong, WANG Qian, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 440-.   Abstract （67）      PDF（pc） （2961KB）（80）       Knowledge map    Save Objective　To investigate the efficacy of pedicled vastus lateralis-myocutaneous flap in repairing complex wounds of the lower limbs. Methods　From Jan. 2016 to Dec. 2021, pedicled vastus lateralis-myocutaneous flap were used to repair complex wounds in the lower limbs in 9 cases, including 4 cases of anterograde flap and 5 cases of retrograde flap. The wounds were caused by traffic accident in 4 cases, burn in 1 case and the excision of malignant tumor in 4 cases. The defect ranged from 6.0 cm×4.0 cm to 20.0 cm×8.0 cm, and the harvested flaps ranged from 5.0 cm×5.0 cm to 23.0 cm×7.0 cm. The donor sites were sutured directly or repaired by skin-grafting. Results　All the flaps survived well and both the donor and recipient sites were primarily healed. After 3-12 months, the myocutaneous flap or muscle flap combined with skin-grafting had good texture, and the recovery of function was good. Cases with direct suture in donor area had good appearance, but cases with skin-grafting had poor appearance. Conclusion　The pedicled vastus lateralis-myocutaneous flap has large area, reliable blood supply and can be transferred flexibly. This flap is a good choice for repairing complex wounds in the thigh and upper legs. Related Articles | Metrics | Comments（0）

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Application of IPACK (interspace between the popliteal artery and the capsule of the posterior knee blocks) combined with adductor canal block and sciatic nerve block combined with adductor canal block in analgesia after total knee arthroplasty in elderly people JIN Hao, FU Qiang Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 480-.   Abstract （63）      PDF（pc） （917KB）（55）       Knowledge map    Save Objective　To investigate the effect of ultrasound-guided interspace between popliteal artery and capsule of the posterior knee (IPACK) blocks combined with adductor canal block and sciatic nerve block combined with adductor canal block in elderly patients undergoing total knee arthroplasty (TKA). Methods　This study was a prospective study. The clinical data of 108 elderly patients undergoing unilateral TKA were included. The patients were randomly divided into two groups: the observation group received IPACK combined with adductor canal block, the control group received sciatic nerve block combined with adductor canal block, with 54 cases in each group. Outcome measures including: Changes of vital signs, recovery time, incidence of related adverse reactions; Expression levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), matrix metalloproteinase 3 (MMP3), high sensitivity C-reactive protein (hs-CRP) at 6, 12, 24 h after operation; Numerical rating scale (NRS) pain score and substance P (SP) at 6, 12, 24 h after operation; Lysholm score and WOMAC score at 48 h after operation were  compared. Results　The changes of vital signs in the two groups were compared, the systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) in the observation group were lower than those in the control group (P<0.05); The recovery time, recovery time of postoperative spontaneous respiration, and PACU stay time of the observation group were shorter than those of the control group (P<0.05); The incidence of adverse reactions including nausea, vomiting and hypoxemia in the observation group were lower than those in the control group (P<0.05); The levels of IL-6, IL-1β, MMP3 and hs-CRP in the observation group at 6, 12, 24 h after operation were lower than those in the control group (P<0.05); The resting and exercise NRS pain scores and substance P in the observation group were significantly lower than those in the control group (P<0.05); The Lysholm scores in the observation group at 48 h after operation were higher than those in the control group, but the WOMAC scores in the observation group at 48 h after operation were lower than those in the control group (P<0.05). Conclusion　IPACK combined with adductor canal block for elderly patients undergoing TKA surgery has a good analgesic effect, it can help the patients to reduce their recovery time, maintain the stability of hemodynamics, alleviate inflammatory response, improve the pain control and reduce the occurrence of adverse reaction, which is better than the sciatic nerve block combined with adductor canal block. Related Articles | Metrics | Comments（0）

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Research progress in the treatment of hypertrophic port-wine stain GAO Qianqian, LI Yangqun Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 507-.   Abstract （63）      PDF（pc） （821KB）（51）       Knowledge map    Save 　Port-wine stain (PWS) is a congenital, progressive capillary malformation that does not recede spontaneously. The incidence of PWS in the newborn is about 0.3% to 0.5%. The early clinical manifestations are pink spots or plaques, which are more common on the face. With age, the color of the lesions deepens. Also, most patients will develop hypertrophy during their adult life, which increases the difficulty of treatment, and adversely influence patients’ psychology and quality of life. The treatment of hypertrophic PWS was reviewed in this paper. Related Articles | Metrics | Comments（0）

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Treatment of cicatricial cryptotia and utilization of para-auricular scar flap DONG Liwei, TANG Yinke, CHU Feifei, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 366-.   Abstract （61）      PDF（pc） （1758KB）（47）       Knowledge map    Save Objective　To explore the treatment of cicatricial cryptotia and utilization of para-auricular scar flap. Methods 　From 2014 to 2018, 12 cases of cicatricial cryptotia were treated. The correction of cicatricial cryptotia deformity was per formed by releasing the superior auricular scar adhesion, correcting the deformed auricular cartilage, reshaping the antihelix. A local scar flap was designed and transferred to reconstruct cranioauricular groove, and the skin defects of the superior- and dorsal- part of the auricle were repaired as well. Results　All the cicatricial cryptotia were corrected by scar adhesion releasing, deformed auricular cartilage remodeling and the utilization of a para-auricular scar flap. Follow-up ranged from 3 months to 4 years, and all the patients had significant improvement and stabilized appearance of the auricle. Conclusion　Scar adhesion releasing, auricular cartilage remodeling and the para-auricular scar tissue repair could be served as the reliable method of de formity correction, and significant improvement could be obtained without additional donor site compromise. Related Articles | Metrics | Comments（0）