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Bibliometric Analysis of Journal of Tissue Engineering and Reconstructive Surgery from 2019 to 2022 PAN Xian, XU Qi Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (6): 570-.   Abstract （56）      PDF（pc） （840KB）（255）       Knowledge map    Save Objective　To analyze the change of the main bibliometrics indexes of Journal of Tissue Engineering and Reconstructive Surgery in recent 4 years, and to compare with other journals of cosmetic and plastic surgery. Methods　Based on the statistical data from the Chinese S&T Journal Citation Reports (Core Version), the main bibliometric indicators of Tissue Engineering and Reconstructive Surgery, including total cites, impact factor, fund paper ratio, other-citing rate and other citing indexes, were statistically and longitudinal analyzed, and horizontal comparisons were made with 5 cosmetic and plastic surgery journals with similar publication backgrounds. Results　In the past four years, the total cites and published article numbers in Tissue Engineering and Reconstructive Surgery increased steadily, while the impact factor, fund paper ratio, and comprehensive evaluation scores showed a downward trend, and the other-citing rate remained at about 0.9. Compared with other journals of cosmetic and plastic surgery, the total cites, impact factor and published article numbers of our journal ranked at the bottom, but the other-citing rate, fund paper ratio, and comprehensive evaluation scores ranked at the top. Conclusion　The short-term goal and direction of the journal is to organize high-quality papers and enhance the scope of the journal. Related Articles | Metrics | Comments（0）

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fficacy analysis and patient satisfaction study of postoperative elect beam radiotherapy for refractory keloid ZHAO Min, LI Li, ZHAO Ruidong, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (6): 544-.   Abstract （60）      PDF（pc） （1162KB）（55）       Knowledge map    Save Objective　To explore the therapeutic effect of postoperative electron beam radiotherapy for intractable keloid and the influencing factors of recurrence, and to evaluate patients’ satisfaction with the therapeutic effect. Methods　From 2019 to 2021, 37 patients with refractory keloids, including 40 keloids, were treated with electron beam irradiation after operation. The radiotherapy was conducted with 6-9 MeV electron beam irradiation from the skin, and the irradiation dose was 20 Gy/5 Gy/4 F. The general clinical data of patients were collected and followed up regularly after operation. After the observation, questionnaires were distributed to all patients to evaluate their satisfaction. The treatment effect and adverse reactions of patients were analyzed, and the factors affecting recurrence were analyzed by Logistic regression. Results　Among the 40 scars, 4 cases (10%) recurred after treatment, and 5 cases (12.5%) had no obvious change after treatment, and the effective rate was 77.5%. The main adverse reactions were skin pigmentation and incision expansion. Univariate analysis showed that sex, past history, time interval from operation to radiotherapy, continuous irradiation and plasma fibrinogen content were related to recurrence. Multivariate analysis showed that the interval between operation and radiotherapy for more than 24 hours was an independent risk factor for recurrence, and continuous irradiation was an independent protective factor. Recurrence, incision expansion and pigmentation were the main reasons for patients’ dissatisfaction. Conclusion　Surgery combined with electron beam radiotherapy is an effective method for the treatment of refractory keloid. The time from operation to radiotherapy and continuous irradiation are independent prognostic factors affecting the recurrence of keloid, and the subjective evaluation of patients is not completely consistent with their clinical manifestations and examinations. Related Articles | Metrics | Comments（0）

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Research progress of the effect of radiotherapy on breast reconstruction with prosthesis and autologous tissue after breast cancer surgery REN Yanxin, YU Yan, XU Kexin, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 511-.   Abstract （81）      PDF（pc） （903KB）（161）       Knowledge map    Save 　Breast integrity and beauty affect women’s physical and mental health. Immediate breast reconstruction after breast cancer mastectomy can significantly increase women’s self-confidence and improve women’s quality of life. As a conventional treatment for breast cancer, radiotherapy can reduce the local recurrence rate and disease-free survival rate of breast cancer. However, radiotherapy can increase the complication rate and failure rate of breast reconstruction immediately after breast cancer surgery. The two most commonly performed breast reconstruction procedures are breast reconstruction with autologous tissue and breast reconstruction with prosthesis. In this paper, the effects of radiotherapy on autologous tissue breast reconstruction and prosthesis breast reconstruction were reviewed. Related Articles | Metrics | Comments（0）

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Effect of pressure therapy on hypertrophic scar based on body surface pressure sensor monitoring XU Jia, HAN Dong, SU Weijie, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 229-.   Abstract （111）      PDF（pc） （2025KB）（231）       Knowledge map    Save Objective　To investigate the effects of strontium-β-tricalcium phosphate (SR-β-TCP) on the biological activ ity and osteogenic differentiation of rabbit adipose derived stem cells (ADSCs). Methods　rADSCs were isolated and cultured from subcutaneous fat of interscapular region of New Zealand white rabbits, and the third generation rADSCs were selected for osteogenic induction. β-TCP materials and Sr-β-TCP materials were prepared, and the β-TCP materials and Sr-β-TCP materi als were co-cultured with osteogenic induced rADSCs, respectively, and divided into 1% Sr-β-TCP group, 3% Sr-β-TCP group, 5% Sr-β-TCP group, β-TCP group and control group (osteogenic induction medium). The proliferation of rADSCs was detected by MTT colorimetric assay, and the activity of Alkaline phosphatase (ALP) and calcium ion content were detected. The osteogen ic related proteins of rADSCs were detected by Western blot (WB). Results　Compared with the control group and 3% Sr-β- TCP group, the optical density (OD) value of β-TCP group, 1% and 5% Sr-β-TCP group decreased on the 1st, 3rd, 6th and 8th day (P<0.05). The OD value of 5% Sr-β-TCP group was lower than that of β-TCP group and 1% Sr-β-TCP group on the 3rd, 6th and 8th day (P<0.05). OD values of all groups were increased with the extension of time (P<0.05). Compared with the control group and β-TCP group, the calcium ion content, ALP activity, Notch3, pFAK, pERK1/2 and RhoA expression of 1% and 3%  Sr-β- TCP groups were increased, while the calcium ion content, ALP activity, Notch3, pFAK, pERK1/2 and RhoA expression of 5% Sr-β-TCP group were decreased (P<0.05). The calcium ion content, ALP activity, Notch3, pFAK, pERK1/2 and RhoA expression of 3% Sr-β-TCP group were higher than those of 1% and 5% Sr-β-TCP group (P<0.05). Conclusion　3% Sr-β-TCP can improve the biological activity and osteogenic differentiation of rADSCs, which may be related to Notch3/FAK/ERK1/2 signaling pathway. Related Articles | Metrics | Comments（0）

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The incidence and risk factors of breast cancer-related lymphedema ZHANG Yingying, LI Hua, GUAN Jiaqin, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 242-.   Abstract （184）      PDF（pc） （1127KB）（429）       Knowledge map    Save Objective　To explore the incidence rate, severity and risk factors of breast cancer-related lymphedema (BCRL) among breast cancer survivors. Methods　Data collected from 128 patients underwent breast cancer operation during September 1 to December 31, 2019. All the patients were female, aging (49.0±6.8) years (29-81 years). The Norman questionnaire and arm circumference measurement were used to evaluate the BCRL status and treatment status of breast cancer patients from subjective and objective perspectives at 6, 12, 24 and 36 months after surgery separately. The influence of the correlation factors on BRCL occurrence was analyzed by Logistic analysis. Results　BRCL incidences were 9.4%, 25%, 23.4% and 23.4% at 6, 12, 24, 36 months according to arm circumference measurement, while 12.5%, 26.6%, 25.0% and 25.0% by Norman questionnaire. Among the 128 patients, 30 were diagnosed with BCRL after breast cancer surgery, among which the incidence of stage Ⅰ lymphedema, stage Ⅱ lymphedema and stage Ⅲ lymphedema were 15.6%, 6.3% and 1.6%, respectively. Age, body mass index (BMI)  radiotherapy, the number of positive lymph nodes and surgery method showed differences between the the BCRL group and control group. Both CDT or LVA showed improvement for the BCRL patients. Conclusion　BCRL is a common complication for breast cancer patients after surgery. It can be fairly diagnosed in the first year after surgery without the increasing incidence of BCRL over time throughout 3 years. BMI, radiotherapy were found to be independent risk factors in the development of BCRL in this study. Related Articles | Metrics | Comments（0）

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Analysis of mutation type and clinical significance of congenital melanocytic nevi ZHAO Yifei, ZOU Yun, CHEN Hui, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 258-.   Abstract （143）      PDF（pc） （843KB）（395）       Knowledge map    Save Objective To explore the molecular characteristics of giant congenital melanocytic nevi (GCMN) and their clinical significance. Methods The samples of patients diagnosed with GCMN were subjected whole-exome sequencing and bio-information analysis to clarify the pathogenic genes and distribution patterns. Results In 50 samples (25 pairs of tissues and blood) from 25 patients, 21 patients had somatic mutations, including NRAS gene (19 cases) and BRAF gene (1 case). New mutations were detected in 2 patients’ lesions and blood, and the mutant genes were MET gene and IDH1 gene. In addition, no causative mutation was detected in 4 patients. There was no statistic difference between GCMN genotype and phenotype. Conclusion NRAS somatic mutation is the most common mutation in GCMN, and BRAF gene has also been detected. Potential new mutated IDH1 and MET genes were also found. Related Articles | Metrics | Comments（0）

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Efficacy analysis of‘core stripping’keloid thinning surgery combined with radiotherapy WU Xiaoli, BAN Yaolin, CHEN Libin, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (1): 22-.   Abstract （187）      PDF（pc） （9318KB）（76）       Knowledge map    Save Objective　To explore the effect of "core stripping" keloid thinning surgery combined with radiotherapy in the treatment of keloid. Methods　From January 2020 to December 2020, 43 patients with slope keloid and 326 keloid lesions were selected by retrospective study and self-control. The "core stripping" keloid thinning surgery was used to separate and remove the core tissue of keloid while retaining the scar skin with a thickness of about 1 mm. The reticular dermis was retained, and the scar skin was sutured and fixed by the "modified mattress suture method". After surgery, 6 Mev electron radiotherapy was performed twice. The first radiotherapy was completed within 24 hours after operation, and the second radiotherapy was performed 7 days later. The single dose of radiotherapy was 9 Gy. Follow-up was performed at 6 months, 12 months and 18 months after the end of treatment. The patient and observer scar scale (POSAS) was used to analyze the treatment outcomes, and  the treatment response rate and patients' satisfaction at 18 months after treatment were statistically analyzed. Results　The total score of POSAS, total score of patients, and total score of observers were significantly lower after treatment than before treatment. Some patients had different degrees of hyperpigmentation, hypopigmentation, local hair loss, transient dermatitis and neuritis, which improved spontaneously. The total recurrence rate at 18 months after treatment was 30.23%. Among 43 keloid patients, 17 patients (39.53%) were very satisfied with the treatment outcome, 22 patients (51.62%) were satisfied, and 4 patients (9.3%) were not satisfied. The overall satisfaction rate was 90.7%. Conclusion　The "core stripping" keloid thinning surgery is a rapid and effective keloid volume reduction surgery, which has a good therapeutic effect when combined with postoperative radiotherapy. Related Articles | Metrics | Comments（0）

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Effect of non-ablative fractional laser combined with asiaticoside ointmenton hypertrophic scar of rabbit ear CHEN Xi, HAN Xiaofeng, XIAO Sha, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (1): 28-.   Abstract （149）      PDF（pc） （27469KB）（144）       Knowledge map    Save Objective　To explore the effect and mechanism of non-ablative fractional laser combined with asiaticoside ointment on hypertrophic scar (HS) in rabbit ear. Methods　Rabbit ear HS model was established and divided into control group (no modeling), model group (no intervention), combination group (1 565 nm non-ablative fractional laser combined with snow side treatment), fractional group (1 565 nm non-ablative fractional laser treatment) and asiaticoside group (asiaticoside treatment) according to different intervention methods. Gross observation, HE staining and MASSON staining were conducted to assess HS improvement, fibroblast apoptosis was detected by TUNEL method. The expressions of type Ⅰ and type Ⅲ collagen, TGF-β1, Smads, IL-6 were detected by real-time PCR and Western blot. Results　After the intervention of the modeling group, gross observation, HE staining and MASSON staining showed that scar hyperplasia was reduced in the combination group. TUNEL showed that apoptotic cells were significantly increased in the combination group. Real-time and Western blot results showed the mRNA and protein levels of type Ⅰ collagen and type Ⅲ collagen, TGF-β1, IL-6 and Smad 2 in combination group increased, while the expression of Smad 7 decreased. Conclusion　1 565 nm non-ablative fractional laser combined with asiaticoside has significant effect in the treatment of HS, and is significantly better than that of laser or asiaticoside alone. Its mechanism is related to the increased expression of TGF- β1, IL-6 and Smad 2, and the decreased expression of Smad 7. Related Articles | Metrics | Comments（0）

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Research progress of mediating factors affecting the formation of foreign body giant cell LIU Yu, WANG Rui, LI Shijie, et al Journal of Tissue Engineering and Reconstructive Surgery    2022, 18 (6): 527-.   Abstract （385）      PDF（pc） （453KB）（201）       Knowledge map    Save Foreign body giant cell (Foreign body giant cell, FBGC) is a prominent cell type formed after the implantation of biomedical materials. It is formed by the fusion of macrophages. It is a hallmark histological feature in chronic inflammation caused by persistent microbial infection or non-phagocytosis of foreign bodies. FBGC is related to the degradation and failure of implanted biomaterials, and is the key cell of foreign body reaction. Controlling the formation of FBGC is considered the key to preventing implantation failure. Therefore, FBGC has always been a research hotspot. Although the molecular mechanism that promotes the adhesion and development of macrophages and supports the formation of FBGC has not yet been elucidated, many mediating factors affecting its formation have also been discovered. In this paper, the relevant domestic and foreign literatures from the three aspects of FBGC formation process, structure and function, and influencing factors were summarized to further understand the mechanism of foreign body giant cell formation and provide enlightenment for finding other possible mediating factors. Related Articles | Metrics | Comments（0）