DNA甲基化基因DNMT3A在急性髓系白血病M4和M5发病机制的研究进展

doi:10.16150/j.1671-2870.2017.04.022

摘要/Abstract

关键词: 急性髓系白血病, DNA甲基化基因, DNMT3A基因, 机制

中图分类号:

R735

马娟, 沈立松. DNA甲基化基因DNMT3A在急性髓系白血病M₄和M₅发病机制的研究进展[J]. 诊断学理论与实践, 2017, 16(04): 446-448.

[1] Burnett A, Wetzler M, Löwenberg B.Therapeutic advances in acute myeloid leukemia[J]. J Clin Oncol,2011, 29(5):487-494.
[2] Stein EM.Molecularly targeted therapies for acute myeloid leukemia[J]. Hematology Am Soc Hematol Educ Program,2015:579-583.
[3] Kelly LM, Gilliland DG.Genetics of myeloid leukemias[J]. Annu Rev Genomics Hum Genet,2002,3:179-198.
[4] Shen H, Laird PW.Interplay between the cancer genome and epigenome[J]. Cell,2013,153(1):38-55.
[5] Cancer Genome Atlas Research Network, Ley TJ, Miller C, et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia[J]. N Engl J Med,2013, 368(22):2059-2074.
[6] Figueroa ME, Lugthart S, Li Y, et al.DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia[J]. Cancer Cell,2010,17(1): 13-27.
[7] Shen Y, Zhu YM, Fan X, et al.Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia[J]. Blood,2011,118(20):5593-5603.
[8] Bullinger L, Ehrich M, Döhner K, et al.Quantitative DNA methylation predicts survival in adult acute myeloid leukemia[J]. Blood,2010,115(3):636-642.
[9] Rice KL, Hormaeche I, Licht JD.Epigenetic regulation of normal and malignant hematopoiesis[J]. Oncogene,2007, 26(47):6697-6714.
[10] Yang L, Rau R, Goodell MA.DNMT3A in haematological malignancies[J]. Nat Rev Cancer,2015,15(3):152-165.
[11] Challen GA, Sun D, Jeong M,et al.Dnmt3a is essential for hematopoietic stem cell differentiation[J]. Nat Genet,2011,44(1):23-31.
[12] Mayle A, Yang L, Rodriguez B, et al.Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation[J]. Blood,2015,125(4):629-638.
[13] Shlush LI, Zandi S, Mitchell A, et al.Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia[J]. Nature,2014,506(7488):328-333.
[14] Ley TJ, Ding L, Walter MJ, et al.DNMT3A mutations in acute myeloid leukemia[J]. N Engl J Med, 2010,363(25):2424-2433.
[15] Yan XJ, Xu J, Gu ZH, et al.Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia[J]. Nat Genet,2011, 43(4):309-315.
[16] Hou HA, Kuo YY, Liu CY, et al.DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications[J]. Blood,2012,119(2):559-568.
[17] Russler-Germain DA, Spencer DH, Young MA, et al.The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers[J]. Cancer Cell,2014,25(4):442-454.
[18] Holz-Schietinger C, Matje DM, Reich NO.Mutations in DNA methyltransferase(DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation[J]. J Biol Chem,2012,287(37):30941-30951.
[19] Schoch C, Schnittger S, Klaus M, et al.AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases[J]. Blood,2003,102(7):2395-2402.
[20] Zhao X, Chen A, Yan X, et al.Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal[J]. Blood,2014,123(211):1729-1738.
[21] Weidner CI, Walenda T, Lin Q, et al.Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture[J]. Sci Rep,2013, 3:3372.
[22] Zhou J, Wu J, Li B, et al.PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway[J]. Leukemia,2014,28(7):1436-1448.
[23] Papaemmanuil E, Gerstung M, Bullinger L, et al.Genomic classification and prognosis in acute myeloid Leukemia[J]. N Engl J Med,2016,374(23):2209-2221.
[24] Arber DA, Orazi A, Hasserjian R, et al.The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia[J]. Blood,2016, 127(20):2391-2405.
[25] Friedman AD.Transcriptional control of granulocyte and monocyte development[J]. Oncogene,2007,26(47):6816-6828.
[26] 沈志祥. 我国急性髓系白血病(非M3)的诊治现状[J]. 诊断学理论与实践,2017,16(1):1-3.

DNA甲基化基因DNMT3A在急性髓系白血病M₄和M₅发病机制的研究进展

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	陈宏, 沈银忠. 人类免疫缺陷病毒感染/艾滋病合并结核病的诊治进展[J]. 诊断学理论与实践, 2022, 21(04): 530-534.
[2]	汤建平, 龚邦东. 干燥综合征的诊治现状、挑战和思考[J]. 诊断学理论与实践, 2022, 21(03): 291-298.
[3]	罗雅方, 徐倩玥, 余红. 尘螨在特应性皮炎中的致病机制及相关免疫治疗应用研究进展[J]. 诊断学理论与实践, 2021, 20(06): 592-595.
[4]	苏长青. 从基础研究到临床转化应用谈肝癌的诊治进展[J]. 诊断学理论与实践, 2021, 20(05): 427-433.
[5]	章淼滢, 罗飞宏. 儿童单基因糖尿病诊治进展及诊断策略[J]. 诊断学理论与实践, 2021, 20(03): 229-232.
[6]	徐兆平, 王浩飞. ZNF692基因在肾透明细胞癌中的表达及其与患者预后间关系的研究[J]. 诊断学理论与实践, 2020, 19(03): 292-296.
[7]	余红, 王一飞, 陈佳, 陈洁, 李斌. 青蒿素及其衍生物在皮肤疾病中的作用机制研究及临床应用[J]. 诊断学理论与实践, 2019, 18(2): 233-236.
[8]	魏坚, 高平进, 韩卫青. α7烟碱型乙酰胆碱受体激动剂对TGF-β1介导的血管外膜成纤维细胞表型转化影响的体外研究[J]. 诊断学理论与实践, 2019, 18(1): 56-60.
[9]	房莹, 吴东, 常春康. 癌基因与抑癌基因在伯基特淋巴瘤发生发展中的研究进展[J]. 诊断学理论与实践, 2019, 18(06): 630-633.
[10]	徐婷婷, 张文. 感染与中性粒细胞胞质抗体相关性血管炎间相关性的研究进展[J]. 诊断学理论与实践, 2019, 18(06): 698-703.
[11]	刘海霞, 瞿介明. 肺部微生态及其与肺癌关系的研究进展[J]. 诊断学理论与实践, 2019, 18(05): 496-502.
[12]	蔡业冰, 任家俊, 郝风节, 叶枫, 杨宇尘, 龚笑勇, 马迪, 王俊青, 陈拥军. 人类假基因在以肝癌为主的肿瘤中的作用及研究进展[J]. 诊断学理论与实践, 2019, 18(05): 590-594.
[13]	周敏, 张秋蕊. 呼吸道、肠道微生物菌群对慢性阻塞性肺疾病的发病及治疗的影响[J]. 诊断学理论与实践, 2019, 18(03): 246-249.
[14]	时国朝, 黄春容. 呼吸道及肠道微生物菌群与支气管哮喘的发病及治疗[J]. 诊断学理论与实践, 2019, 18(03): 241-245.
[15]	蒋晓飞, 周迎. 碳青霉烯耐药肺炎克雷伯菌的耐药与传播机制研究进展及对策[J]. 诊断学理论与实践, 2018, 17(06): 623-629.