痴呆及相关认知障碍的神经影像学诊断专家共识（2023年版）

doi:10.16150/j.1671-2870.2024.01.005

摘要/Abstract

摘要：

临床医师面对以认知障碍为主要临床表现的患者，首先应完善结构MRI（或CT替代）检查，以明确其颅内病变和脑萎缩情况。对于伴有特定临床表现的患者，推荐加行特定MRI序列扫描进一步辅助诊断。对于疑似AD源性认知障碍的患者，推荐加行斜冠状位T1加权成像（T1-weighted imaging，T1W1）序列扫描，进行海马内侧颞叶萎缩评分。对于疑似血管性因素或特殊感染（朊蛋白）导致的认知障碍患者，建议加选弥散加权成像（diffusion-weighted imaging，DWI）序列。对于疑似合并锥体外系症状和（或）小血管病变患者，尤其是脑淀粉样血管病及并发糖尿病的认知障碍患者，建议加选磁敏感加权成像序列。常规MRI检查发现可疑占位时，可选用增强MRI和磁共振波谱分析。对于疑似合并肌萎缩侧索硬化的认知障碍患者，可选用弥散张量成像序列。对于怀疑神经变性病导致的痴呆，推荐完善¹⁸F-FDG PET和Aβ-PET或tau-PET检查。Aβ-PET显像和tau-PET显像可实现脑内病理蛋白沉积程度和范围的可视化，对于痴呆具有重要的预测和诊断价值，并可用于痴呆的鉴别诊断以及疾病进展评估。此外，静息态功能性MRI、近红外脑功能成像以及一些新兴的影像检查手段，如相位对比脑脊液电影MRI、类淋巴显像已经在认知障碍疾病中开展研究，期待未来能用于临床，更好地辅助认知障碍相关疾病的诊断和鉴别诊断。需要注意的是，神经影像学结果并不能代表疾病的完整诊断和临床症状，必须慎重解读和分析。

关键词: 痴呆, 认知障碍, 阿尔茨海默病, 神经影像, 专家共识

Abstract:

For patients with cognitive impairment as the main clinical manifestation, structural MRI (or CT instead) should be performed first to clarify intracranial lesions and brain atrophy. For patients with specific clinical manifestations, specific MRI sequences is recommended to further assist diagnosis. If the patient is suspected of AD, it is recommended to perform oblique coronal T1WI for MTA grading to score medial temporal lobe atrophy. If the patient is suspected to be caused by vascular factors or special infections (prion proteins), it is recommended to perform diffusion-weighted imaging. If the patient has extrapyramidal symptoms or small vessel disease, especially cerebral amyloid angiopathy or cognitive impairment complicated by diabetes, it is recommended to perform susceptibility-weighted imaging. If a mass is suspicious on MRI, contrast-enhanced MR imaging and MR spectroscopy should be performed. If the patient has amyotrophic lateral sclerosis, it is recommended to perform diffusion tensor imaging. If the patient is suspected to be caused by neurodegenerative diseases, it is recommended to perform ¹⁸F-FDG PET and Aβ-PET or tau-PET. Aβ-PET imaging and tau-PET imaging can visualize the degree and scope of pathological protein deposition in the brain, which has important predictive and diagnostic value for dementia and can be used for the differential diagnosis of dementia and staging the disease progression. In addition, resting-state functional magnetic resonance imaging, near-infrared spectroscopy, and some emerging imaging techniques such as cine phase-contrast magnetic resonance imaging, and diffusion tensor image analysis along the perivascular space have been studied in patients with cognitive impairment. It is expected that these technologies can be used in the future to better assist the diagnosis and differential diagnosis of cognitive impairment. It should be noted that neuroimaging does not represent the complete diagnosis and clinical symptoms of the disease and must be interpreted with caution.

Key words: Dementia, Cognitive impairment, Alzheimer’s disease, Neuroimaging, Expert Consensus

中图分类号:

2030脑与类脑计划变性病痴呆多模影像诊断标准及分子影像技术研究课题组, 上海市衰老与退行性疾病学会衰老与认知障碍分会. 痴呆及相关认知障碍的神经影像学诊断专家共识（2023年版）[J]. 诊断学理论与实践, 2024, 23(01): 30-39.

Aging and Cognitive Impairment Branch of Shanghai Society of Aging and Degenerative Diseases. Expert consensus on neuroimaging diagnosis of dementia and cognitive impairment (2023)[J]. Journal of Diagnostics Concepts & Practice, 2024, 23(01): 30-39.

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	推荐加做序列	推荐人群	推荐依据
所有可疑认知障碍患者需完善T₁WI、T₂WI、FLAIR像（水平位+海马冠状位）	斜冠状位T1W1	疑似AD患者	从认知正常人群中鉴别出AD源性痴呆的MTA界值分别是，50-64岁≥1.0（灵敏度和特异度分别为 92.3% 和 68.4%），65~74岁≥1.5（灵敏度和特异度分别为 90.4% 和 85.2%），75~84岁≥2.0（灵敏度和特异度分别为70.8%和82.3%）^[6]。
	弥散加权成像	疑似血管性因素或特殊感染（朊蛋白）导致的认知障碍患者	对于朊蛋白病的诊断能力，灵敏度为90%~95%，特异度为90% 到 100%^[8]。
	磁敏感加权成像	疑似合并锥体外系症状和（或）小血管病变，尤其是CAA及并发糖尿病的认知障碍患者	在CAA病例中，评估者在SWI序列上评估微出血的评估者之间的可靠性良好（组内r=0.87）^[9]。
	增强MRI和MRS	常规MRI发现关键脑结构可疑占位的患者	利用Cho峰和NAA峰可将肿瘤和非肿瘤鉴别，其AUC为0.94，特异度86%，灵敏度90%^[10]。
	DTI	疑似合并ALS的认知障碍患者，如bvFTD	一项荟萃分析纳入8项研究143例ALS患者和145名健康对照，发现ALS额叶白质，扣带回以及内囊后肢的FA减少^[11]。