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Table of Content

    28 February 2025, Volume 20 Issue 01 Previous Issue   
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    Original article
    Efficacy analysis of Shuangbai tablets and irbesartan in treatment of proteinuria in chronic glomerulonephritis
    CHEN Zijin, YU Haijin, WANG Zhaohui, MA Jun, WANG Zhiyu, WANG Jie, XU Yaowen, ZHENG Lan, CHEN Xiaonong
    2025, 20 (01):  1-6.  DOI: 10.16138/j.1673-6087.2025.01.01
    Abstract ( 9 )   HTML ( 1 )   PDF (1307KB) ( 0 )  

    Objective To compare the efficacy and safety of Shuangbai tablets and irbesartan in the treatment of proteinuria. Methods A retrospective analysis was conducted on patients with chronic glomerulonephritis who visited the outpatient department of Ruijin Hospital from January 2016 to February 2018. All the patients received irbesartan or Shuangbai tablets as monotherapy and were classified with syndrome differentiation of traditional Chinese medicine(TCM). Their clinical information, blood pressure and laboratory test were performed at 0, 4, 8, 12, and 24 weeks. Results One-hundred and nineteen patients were enrolled in the study, in which 54 cases were in the irbesartan group and 65 cases were in the Shuangbai tablet group. In all patients, the main TCM types were “pifeixiqu” type (56.3%), “pishenyangxu” type (20.2%), and “qiyinliangxu” type (21.8%). The 24-hour urinary protein of baseline level in the irbesartan group was 704 (448,1 090) mg/d, and it was significantly decreased to 456 (300,660), 428 (288,793), 510 (327,949), and 446 (273,801) mg/d at 4, 8, 12, and 24 weeks, respectively. The 24-hour urine protein level of baseline in the Shuangbai tablet group was 571 (390,1 049) mg/d, and it was significantly decreased to 491 (200,861), 432 (252,925), 478 (267,858) mg/d and 420 (175,742) mg/d at 4, 8, 12, and 24 weeks, respectively. There was no significant difference in proteinuria between the two groups. There was no statistical difference in the therapeutic effect among patients with different TCM syndrome types. The symptoms of lower back pain (59.3% vs 13.8%, P<0.001) and dry mouth and throat (24.1% vs 6.2%, P=0.005) in the Shuangbai tablet treatment group were significantly improved compared to those in the irbesartan group. The blood pressure of patients in the irbesartan treatment group decreased significantly at 12 and 24 weeks compared to it at enrollment. There were no significant adverse reactions in the Shuangbai tablet treatment group. Conclusions Shuangbai tablets can effectively reduce the urine protein level in chronic glomerulonephritis patients. It can also significantly improve the symptoms of lower back pain, dry mouth and throat in patients. Shuangbai tablet treatment showed a lower incidence of adverse reactions and can be used as an alternative medicine for patients with normal blood pressure, angiotensin-converting enzyme inhibitor(ACEI)/angiotensin receptor blocker(ARB) intolerance, or chronic glomerulonephritis without renal biopsy.

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    Fuzheng Xiaoji granules combined with frontline chemotherapy in colorectal cancer patients with stasis and toxin internal obstruction syndrome
    LYU Lingling, XU Yumin, XU Cheng, ZHENG Lan
    2025, 20 (01):  7-13.  DOI: 10.16138/j.1673-6087.2025.01.02
    Abstract ( 4 )   HTML ( 2 )   PDF (3273KB) ( 0 )  

    Objective To observe the clinical efficacy of Fuzheng Xiaoji granules combined with first-line chemotherapy in colorectal cancer patients with stasis toxin internal obstruction syndrome and the influence of gut microbiota in them. Methods A total of 100 stage Ⅳ colorectal cancer patients with stasis toxin internal obstruction syndrome admitted to Ruijin Hospital,Shanghai Jiao Tong University School of Medicine from January 1, 2019 to December 31, 2023 were selected as the study subjects. They were randomly divided into a control group and a treatment group using a random number table method, with 50 cases in each group. The control group received standard Western medicine chemotherapy, and the treatment group was given modified oral Fuzheng Xiaoji granules combined with chemotherapy. Six months later, the traditional Chinese medicine syndrome scores and Kanofsky performance score (KPS) of the two groups before, during, and after treatment were compared between the two groups, and the gut microbiota were compared between the two groups. Results Before treatment, the traditional Chinese medicine syndrome scores and KPS of the two groups were similar, and the difference was not statistically significant (both P>0.05). After treatment, the scores of depression, anxiety, and fatigue in the treatment group decreased compared to those before treatment (all P<0.05). Tingling, localized pain, refusal to press, depression and anxiety, and fatigue in the treatment group decreased compared with those in the control group (all P<0.01). The symptoms in the control group were similar, and the difference was not statistically significant (all P>0.05). The results of two groups of gut microbiota showed a slight increase in the abundance of gut microbiota in the control group compared to the treatment group. The differential microbiota with linear discriminant analysis (LDA) values>2 in the two groups were Actinobacteria, Ruminococcus, Clostridium, Campylobacter, Abiotrophya, Chloroplast, and Pseudomonas in the control group, and Aeromonas in the treatment group. Conclusions The combination of Fuzheng Xiaoji granules and first-line chemotherapy can improve the quality of life of colorectal cancer patients with stasis toxin internal obstruction syndrome, regulate the patient's gut microbiota, and improve traditional Chinese medicine symptoms.

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    Clinical effect of Kou Chuang San in treating oral mucositis associated with chemotherapy in malignant hematologic patient after autologous stem cell transplantation
    TANG Wei, CAI Mingci, SHEN Yige, ZHANG Shoujie, GE Jian, ZHAO Weili
    2025, 20 (01):  14-17.  DOI: 10.16138/j.1673-6087.2025.01.03
    Abstract ( 2 )   HTML ( 1 )   PDF (995KB) ( 0 )  

    Objective To study clinical effect with Kou Chuang San in oral mucositis associated with chemotherapy in malignant hematologic patient during autologous stem cell transplantation. Methods From April 2016 to December 2021,149 patients with oral mucositis who received autologous hematopoietic stem cell transplantation in the Department of Hematology in Ruijin hospital were enrolled and divided into two groups according to receiving Kou Chuang San treatment or not. The treatment group was applied to Kou Chuang San on the first day after stem cell transplantation, while the patients who did not receive Kou Chuang San treatment belonged to the control group. Oral mucositis grading and therapeutic effects were compared between the two groups. Results The incidence of oral mucositis in the treatment group was significantly lower than that in the control group (87.18% vs 6.25%, P<0.001). Conclusions The Kou Chuang San is effective and safe in treating patients with oral mucositis after autologous hematopoietic stem cell transplantation.

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    Exploring the mechanism of Huhuang decoction promoting diabetic wound healing based on network pharmaco-logy and transcriptomics
    ZHANG Jie, XU Shun, LIU Yan, SHI Yan
    2025, 20 (01):  18-23.  DOI: 10.16138/j.1673-6087.2025.01.04
    Abstract ( 5 )   HTML ( 1 )   PDF (3929KB) ( 0 )  

    Objective To investigate the effect and mechanism of Huhuang decoction on diabetic wound healing.Methods The active ingredients and target genes of each component of Huhuang decoction were queried through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database. The gene targets of diabetic foot ulcer were screened through the Comparative Toxicogenomics Database (CTD) and GeneCards database. The component-target interaction network was drawn using Cytoscape software draw and gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was performed using DAVID. The wound tissue of diabetic rats was collected to undergo transcriptomic sequencing analysis. The effect of Huhuang decoction on wound healing of diabetic rats was verified in vivo, and the expressions of inflammatory factors interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and IL-1β in wound tissue were detected by enzyme-linked immunosorbent assay (ELISA). Results Network pharmacology and transcriptomic sequencing analysis showed that the potential targets of Huhuang decoction were closely related to inflammatory regulation. Local application of Huhuang decoction on the wound surface could promote the healing of diabetic wounds. Hematoxylin and eosin (HE) staining results displayed that Huhuang decoction promoted epithelialization of diabetic wounds.ELISA test results showed that Huhuang decoction could inhibit the expression of inflammatory factors IL-6, TNF-α and IL-1β in wound tissue. Conclusions Huhuang decoction could inhibit inflammation of diabetic wounds and promote wound healing.

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    Study on efficacy and transcriptomics characteristics of Fuzheng Xiaoji recipe based on subcutaneous transplanted tumor model in mice
    LYU Lingling, WU Zhiyuan, WANG Shenjie, HUANG Yuqing, LI Yuxi, ZHENG Lan, NING Guang
    2025, 20 (01):  24-29.  DOI: 10.16138/j.1673-6087.2025.01.05
    Abstract ( 3 )   HTML ( 1 )   PDF (2726KB) ( 0 )  

    Objective To explore the efficacy and safety of Fuzheng Xiaoji recipe in the treatment of colorectal cancer based on the subcutaneous transplanted tumor model in mice. Methods The subcutaneous tumor transplantation mouse model was established and the mice received Fuzheng Xiaoji recipe treatment, which could strengthen the body resistance and eliminate stagnation. The high-throughput transcriptome sequencing technology was used to evaluate treatment effect. The differentially expressed genes were annotated through Ensembl, gene oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases, and the related biological functions of abnormally expressed genes were compared and analyzed. Hematonylin and eosin (HE) staining was used to observe the effect of Fuzheng Xiaoji recipe on liver and kidney of tumor-bearing mice. Results Tumor volume and weight in both the low-dose and high-dose groups of Fuzheng Xiaoji treatment were significantly lower than those in the control group (P<0.001). Transcriptomic analysis revealed 166 upregulated and 328 downregulated genes in the tumor tissues after Fuzheng Xiaoji recipe treatment. Hierarchical clustering analysis, based on transcripts per million (TPM) values, demonstrated significant differences in gene expression between the treatment group and control groups. KEGG pathway analysis indicated that the top 20 enriched metabolic pathways included the calcium signaling pathway, cyclic guanosine monophosphate (cGMP)-protein kinase G signaling pathway, and cyclic adenosine monophosphate (cAMP) signaling pathway (P<0.05). HE staining results showed there were no significant hepatotoxicity or nephrotoxicity in Fuzheng Xiaoji recipe treated mice. Conclusions Fuzheng Xiaoji recipe could reduce the growth of CT26 subcutaneous transplanted tumors in a dose-dependent manner in mice, and it didn’t show obvious hepatorenal toxicity. Transcriptome analysis showed that the therapeutic effect of Fuzheng Xiaoji recipe on colorectal cancer may relate to regulating the proliferation of colorectal cancer, inducing apoptosis of colorectal cancer cells and inhibiting tumor migration and invasion.

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    Case report
    Two cases of staged treatment of non-small cell lung cancer with traditional Chinese medicine
    CHENG Dongfeng, ZHOU Ziyi, XU Rongzhong, FANG Zhihong
    2025, 20 (01):  30-33.  DOI: 10.16138/j.1673-6087.2025.01.06
    Abstract ( 10 )   HTML ( 1 )   PDF (2482KB) ( 0 )  

    Lung cancer is one of the malignant tumors with the highest incidence and mortality rates globally. The prognosis of advanced lung cancer is poor, and drug resistance and toxic side effects limit clinical efficacy on it, and new treatment strategies are urgently needed. Traditional Chinese medicine (TCM) regards lung cancer as “lung accumulation”,which belonging to “general deficiency and local excess”, and the treatment emphasizes strengthening the body and eliminating pathogens. The TCM treatment of lung cancer is divided into three phases: postoperative support and nurturing, TCM combined with chemotherapy to enhance efficacy and reduce toxicity, and prevention of recurrence and metastasis. Based on this, professor Fang Zhihong mentioned that lung cancer was fundamentally characterized as deficiency of both qi and yin, with symptoms of qi stagnation, blood stasis, phlegm coagulation and toxin accumulation. He advocated the ideas of combination of disease differentiation, syndrome differentiation, and stage differentiation during the disease treatment, emphasized strengthening the spleen and stomach, cultivate righteous qi, and eliminating evil toxins. This article presents two case studies demonstrating the effectiveness of individualized staged treatment with TCM. Case 1 (stage Ⅲ B) was treated with TCM to strengthen body and eliminate pathogens after receiving targeted therapy and chemotherapy. The lesion had been stable for nearly 3 years and a total survival time was nearly 6 years; Case 2 (stage Ⅱ A) underwent postoperative TCM-assisted chemotherapy, and the survival time exceeded 8 years, and achieved clinical cure. The therapeutic effect was significant in 2 cases after using TCM methods to tonify qi and nourish yin, clear heat and detoxify, strengthen the spleen and resolve phlegm.

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    Review
    Research progress on treatment of orthostatic hypotension in Parkinson disease with integrated traditional Chinese and Western medicine
    ZHANG Fengjuan, YANG Zhao
    2025, 20 (01):  34-37.  DOI: 10.16138/j.1673-6087.2025.01.07
    Abstract ( 6 )   HTML ( 1 )   PDF (1037KB) ( 0 )  

    From the perspective of interdisciplinary integration of traditional Chinese and Western medicine, this article systematically reviews the research trends and progress on treatment of orthostatic hypotension in Parkinson disease, aiming to provide solid theoretical support for clinical medical practice. Orthostatic hypotension, as a prominent non-motor symptom in Parkinson disease, often poses risks of syncope and falls, and becomes adverse factor affecting patient prognosis. Therefore, a comprehensive understanding of the etiology, pathogenesis analysis, diagnostic methods, and treatment methods of orthostatic hypotension in Parkinson disease from both traditional Chinese and Western medicine perspectives is of immeasurable importance to clinical medical workers. This in-depth understanding will not only enhance the understanding and treatment skills of the disease but will also help to provide patients with more comprehensive, accurate, and effective diagnosis and treatment strategies.

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    Current research status on mechanism of action of traditional Chinese medicine in improving interstitial fibrosis of diabetes kidney disease
    YAN Jiayi, MA Jun, ZHONG Yifei, ZHANG Xianwen
    2025, 20 (01):  38-45.  DOI: 10.16138/j.1673-6087.2025.01.08
    Abstract ( 2 )   HTML ( 1 )   PDF (1080KB) ( 0 )  

    Diabetes kidney disease (DKD) is a chronic kidney disease caused by hyperglycemia, which is one of the common microvascular complications of diabetes. As one of the significant pathological features, interstitial fibrosis is a key factor leading to renal dysfunction. Its pathological evolution involves multiple mechanisms such as metabolic abnormalities, hemodynamic disorders, inflammatory responses, activation of cellular signaling pathways, epigenetic regulation, and cellular autophagy. This article sorted and analyzed the relevant research on the mechanism of action of traditional Chinese medicine (TCM) in improving interstitial fibrosis of DKD through searching multiple databases (Pubmed, Web of Science, CNKI, WANFANG, VIP databases, etc.). Studies have shown that treatment of TCM may delay DKD interstitial fibrosis through its multi-component, multi-target and multi pathway. In the future, with further in-depth research on the pathogenesis of DKD interstitial fibrosis and continuous clarification of the mechanism of action of TCM, TCM is expected to provide more effective strategies for the prevention and treatment of DKD.

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    Research progress on Chaiqi decoction in treatment of metabolic syndrome
    WANG Zhenzhen, TONG Jianjing, LIU Zixiong, ZHU Hui, JIANG Jie
    2025, 20 (01):  46-49.  DOI: 10.16138/j.1673-6087.2025.01.09
    Abstract ( 6 )   HTML ( 1 )   PDF (1020KB) ( 0 )  

    Chaiqi decoction, a classic traditional Chinese medicine formula, has demonstrated significant clinical efficacy and safety in treating metabolic syndrome. This paper summarizes the recent research progress on Chaiqi decoction in the treatment of metabolic syndrome, especially the clinical research and pharmacological mechanism of improving glucose and lipid metabolism, reducing insulin resistance, and protecting multi-organs such as cardiovascular system, liver, kidneys, and intestine, revealing the potential and value of Chaiqi decoction in the comprehensive management and prevention of metabolic syndrome.

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    Research progress on treatment of Parkinson disease-related pain with traditional Chinese and Western medicine
    SUN Qian, LIN Shiyu, XIA Mengjie, ZHOU Haiyan, WANG Xiuwei
    2025, 20 (01):  50-53.  DOI: 10.16138/j.1673-6087.2025.01.10
    Abstract ( 4 )   HTML ( 1 )   PDF (1052KB) ( 0 )  

    Pain is one of the most common non-motor symptoms of Parkinson disease, with complex pathogenesis and clinical classification. The current treatment in Western medicine for pain in Parkinson disease mainly focuses on dopamine replacement therapy, which can only solve a portion of the pain issues. However, long-term use of Western medications inevitably leads to motor complications and drug side effects, making the effect of treatment often insufficient. Traditional Chinese medicine has unique advantages in pain management. Therefore, this article summarizes recent literature on the treatment of Parkinson disease pain with Western and traditional Chinese medicine, aiming to provide scientific references and therapeutic strategies for the integrated treatment of the disease with traditional Chinese and Western medicine.

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    Research progress on pathogenesis and treatment of refractory asthma in traditional Chinese medicine
    DU Wei, LIU Hongwei, ZHANG Yada, CHEN Yiren, TANG Binqing
    2025, 20 (01):  54-58.  DOI: 10.16138/j.1673-6087.2025.01.11
    Abstract ( 4 )   HTML ( 1 )   PDF (980KB) ( 0 )  

    The article focuses on research and treatment of refractory asthma as it responds poorly to conventional Chinese medicine treatments, which suggests that the disease has unique pathogenesis in traditional Chinese medicine. Exploring its specific pathogenesis will help develop more targeted treatments to improve clinical efficacy. This article systematically summarizes the views and treatments method of various scholars from three aspects: pathogenic factors, vital qi, and location of the disease. It aims to fully reveal the underlying pathogenic mechanisms of the disease and provide a basis and guidance for clinical practice and research.

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    Treatment of hypertensive patients with insulin resistance from the spleen
    LI Hua, YANG Hua
    2025, 20 (01):  59-62.  DOI: 10.16138/j.1673-6087.2025.01.12
    Abstract ( 6 )   HTML ( 1 )   PDF (1002KB) ( 0 )  

    Insulin resistance is the common pathological basis for various metabolic-related diseases, including hypertension, and is a root cause of the metabolic syndrome. In traditional Chinese medicine, the core pathogenesis of insulin resistance is considered as spleen deficiency. The hypertensive patients with insulin resistance are more likely to be the type of stagnation of phlegm dampness. Through treating hypertensive patients with insulin resistance from the spleen, the various components of metabolic syndrome can be managed in the same disease category. The research on correlation between intestinal flora imbalance and mitochondrial dysfunction provides a theoretical basis for the treatment of the patients from spleen.

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    Research progress of traditional Chinese and Western medicine used in respiratory rehabilitation of COVID-19
    LIU Jialin, ZHANG Li
    2025, 20 (01):  63-66.  DOI: 10.16138/j.1673-6087.2025.01.13
    Abstract ( 5 )   HTML ( 1 )   PDF (1068KB) ( 0 )  

    Decreased respiratory function is the major problem in patients with coronavirus disease 2019(COVID-19) during the acute phase of infection and long-term recovery process. It manifests as dyspnea, fatigue and other symptoms, and leads to affect normal life. It attracted a lot attention from clinicians. This article reviews the relevant domestic and international literature on Western medicine and traditional Chinese medicine therapeutic methods used in respiratory rehabilitation of COVID-19 and summarizes the experience of it. Using the method of syndrome differentiation and treatment, modern Western medical rehabilitation methods can be combined with traditional Chinese medicine pulmonary rehabilitation to enhance physical function through traditional Chinese medicine exercises. The integrated respiratory rehabilitation treatment of traditional Chinese medicine and Western medicine may have a certain therapeutic effect in improving the respiratory function of COVID-19 patients. The integration of traditional Chinese and Western medicine in respiratory rehabilitation treatment may help the long-term recovery of COVID-19 patients and improves their quality of life.

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    Explore mechanism and progress of kidney-tonifying method on middle-aged and elderly essential hypertension based on traditional Chinese medicine theory of “tonifying kidney and resisting aging”
    XU Tingyan, ZHANG Jin, GU Yun
    2025, 20 (01):  67-70.  DOI: 10.16138/j.1673-6087.2025.01.14
    Abstract ( 5 )   HTML ( 1 )   PDF (1077KB) ( 0 )  

    Hypertension is a common disease and the most important risk factor for cardiovascular diseases (CVD). Lowering blood pressure effectively and stably is the key to reduce CVD. Unlike single-mechanism drugs, traditional Chinese medicine (TCM) has the synergistic effect of multi-target and multi-mechanism on the treatment of essential hypertension. According to the theory of TCM, kidney essence deficiency and liver-yang hyperactivity are the characteristics and pathogenesis of hypertension. The method of tonifying kidney has a long history in treating hypertension, and it embodies the basic concept ‘treat disease, cure must seek the root cause’ in TCM. The article reviews the clinical studies on various kidney-tonifying methods, explores the mechanisms and summarizes the research progress, to provide reference for the clinical treatment of hypertension with the combination of traditional Chinese and Western medicine.

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    Research progress of combining Chinese and Western medicine to improve malnutrition in tumor patients
    YIN Huijun, JIANG Yongmei, GAO Xiaodong, SHI Yongmei
    2025, 20 (01):  71-75.  DOI: 10.16138/j.1673-6087.2025.01.15
    Abstract ( 4 )   HTML ( 1 )   PDF (971KB) ( 0 )  

    Malnutrition is a serious problem for patients with malignant tumors, severely affecting their survival rate and quality of life. The combination of traditional Chinese medicine and Western medicine has unique advantage in the prevention and treatment of malnutrition in malignant tumors. It can not only ameliorate the symptoms and appetite of patients, reduce the side effects of radiotherapy and chemotherapy, but also improve the nutritional indexes, treatment efficacy and quality of life. The article aims to review the therapeutic strategies and effect of combining traditional Chinese medicine and Western medicine to improve malnutrition in patients with malignant tumors, and to provide new ideas for the study of malnutrition treatment.

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    Research progress of polydatin in treatment of digestive system diseases
    WU Chao, ZHUANG Lei, MA Junjun, HE Zirui, SUN Yongshun
    2025, 20 (01):  76-80.  DOI: 10.16138/j.1673-6087.2025.01.16
    Abstract ( 3 )   HTML ( 1 )   PDF (1042KB) ( 0 )  

    Polydatin is the main active ingredient extracted from the traditional Chinese herbal medicine Polygonum cuspidatum, which has multiple pharmacological effects such as anti-inflammation, antioxidant and apoptosis regulation. Its application in the treatment of liver disease, inflammatory bowel disease and other digestive system diseases has gradually attracted attention. This article reviews therapeutic progress of polydatin in benign and malignant diseases of the digestive system (liver, gallbladder, pancreas and gastrointestinal tract), analyzes the potential mechanism of polydatin in the treatment of digestive disorders. We hope to provide new ideas for in-depth research on application of polydatin in digestive disorders.

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    Progress in treatment of premature ventricular contraction in children with traditional Chinese medicine
    TIAN Lei
    2025, 20 (01):  81-83.  DOI: 10.16138/j.1673-6087.2025.01.17
    Abstract ( 2 )   HTML ( 0 )   PDF (913KB) ( 0 )  

    Ventricular premature contraction is a common arrhythmia in children. Western medicine treatment including propafenone and radiofrequency ablation surgery have been shown good efficacy for ventricular premature contraction, but it has limitation such as adverse medicine reactions and limited indications. Traditional Chinese medicine has unique advantages in ventricular premature contractions treatment. This article reviews the related theory of ventricular premature contraction in traditional Chinese medicine, analyzes the Chinese patent medicine commonly used in clinical treatment of ventricular premature contractions in children, and summarizes their therapeutic effects.

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    Progress in diagnosis and treatment of oral ulcer with traditional Chinese medicine and Western medicine
    WU Jingyi, WANG Xiaoli, CHEN Jie, ZHENG Lan
    2025, 20 (01):  84-88.  DOI: 10.16138/j.1673-6087.2025.01.18
    Abstract ( 9 )   HTML ( 0 )   PDF (997KB) ( 0 )  

    Oral ulcer is a common oral mucosal disease, the pathogenesis of it is complex. It may relate to genetics, immune disorders, nutritional deficiency, infection, drug response and psychological factors, while currently there is no specific treatment for the disease. In recent years, the research on the treatment of oral ulcers with traditional Chinese medicine has gradually increased, especially the combination of traditional Chinese medicine and Western medicine has showed a good application prospect. The article reviews the diagnosis and treatment of oral ulcer with traditional Chinese medicine and Western medicine to explore new ideas for further promotion relevant clinical research.

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    Progress in conservative treatment of knee osteoarthritis with traditional Chinese medicine
    ZONG Ya, JIA Jinxuan, XIE Qing, XIANG Jing, LI Qinghai
    2025, 20 (01):  89-93.  DOI: 10.16138/j.1673-6087.2025.01.19
    Abstract ( 5 )   HTML ( 1 )   PDF (1083KB) ( 0 )  

    The knee osteoarthritis is a common chronic degenerative joint disease in clinical practice, with high disability and recurrence rates. Long-term clinical practice and research have shown that the treatment of patients with mild to moderate knee osteoarthritis tends to use conservative therapies such as oral medications, rehabilitation training, and traditional Chinese medicine (TCM) therapies (acupuncture and massage). The patients with moderate or severe disease need surgical treatment while conservative treatments are ineffective. TCM conservative treatments of knee osteoarthritis show the advantages of significant efficacy, simple operation, few adverse effects, and high patient acceptance. The paper reviews the research progress of knee osteoarthritis treatment from the perspective of TCM, including acupuncture, moxibustion, massage, small needle knife, acupoint injection, Chinese medicine, and the integration of TCM and Western medicine. It aims to provide a multidimensional diagnostic and treatment approach for clinical management of knee osteoarthritis, enrich and optimize treatment plans, and improve clinical outcomes.

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    Theory of “kidneys storing essence and dominating bones” and male osteoporosis
    SHEN Shizhong, SUI Liang, CHEN Kang, SHI Xiao, SHI Dan
    2025, 20 (01):  94-100.  DOI: 10.16138/j.1673-6087.2025.01.20
    Abstract ( 2 )   HTML ( 0 )   PDF (1183KB) ( 0 )  

    Male osteoporosis (MOP) is often not taken seriously by the public, while MOP may cause more severe consequence compared with female osteoporosis. Based on the theory of “kidney storing the essence and dominating the bones” in traditional Chinese medicine (TCM), it was believed that the concurrence of MOP is related to kidney’s physiological function in TCM. It is proposed that “kidney essence deficiency, marrow loss and bone atrophy” is the core pathogenesis of MOP, which is related to the pathogenesis of various osteoporosis in modern medicine. In terms of treatment, both ancient and modern TCM doctors have mostly adopted the methods of tonifying kidney, strengthening bone and replenishing the essence and nourishing the marrow to effectively prevent and treat osteoporosis.

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