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    Journal of Internal Medicine Concepts & Practice    2021, 16 (03): 220-224.   DOI: 10.16138/j.1673-6087.2021.03.018
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    Research progress of miRNA-206 on lung diseases
    ZHANG Lulu, WU Qiannan, HUO Rujie, et al
    Journal of Internal Medicine Concepts & Practice    2022, 17 (05): 413-417.   DOI: 10.16138/j.1673-6087.2022.05.014
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    Value of serum N-terminal pro-brain natriuretic peptide levels in primary screening peritoneal dialysis patients with volume overload
    LI Hua, HUANG Xiaomin, ZHANG Chunyan, DU Lu, REN Hong, XU Tian
    Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 157-164.   DOI: 10.16138/j.1673-6087.2023.03.005
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    Objective To explore the relationship between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level and hydration status and cardiac function indexes in the patients receiving peritoneal dialysis(PD) treatment,and to further analyze the factors affecting the level of NT-proBNP. Methods A total of 111 patients with PD who were followed up in the PD Center of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from May 2019 to January 2022 were enrolled and the data was analyzed retrospectively. According to the results of multi-frequency bioelectrical impedance body composition monitor (BCM), relative hydration status (DHS), the ratio obtained through dividing extracellular water (ECW) by overhydration (OH), the patients were divided into normal volume group (OH/ECW≤15%) and overhydration group (OH/ECW>15%). The relationship between serum NT-proBNP level and hydration status in two groups was compared, and the related factors affecting the level of NT-proBNP were further analyzed and discussed. Using BCM result as the“gold standard”, the receiver operator characteristic curve(ROC curve) determined the optimal threshold of NT-proBNP as the capacity was overloaded. The patients were divided into two groups according to NT-proBNP and their clinical data were compared. Results The indexes including systolic blood pressure, urine volume, urea clearance index (Kt/V), creatinine clearance rate(CCr), dialysate to plasma ratio for urea at 4 hours(4hD/PCr), types of antihypertensive drugs, type of diuretic, hemoglobin, serum albumin, log2(NT-proBNP), interventricular septal thickness (IVST), left ventricular posterior wall thickness(LVPWT), left atrial diameter(LAD), OH, TBW, ECW, OH/TBW, ECW/TBW and ECW/ICW were detected in volume overload group and normal volume group, and showed statistically significant (all P<0.05). log2(NT-proBNP) level was correlated with systolic blood pressure, dialysis duration, ultrafiltration volume, dialysis dose, antihypertensive drug group, IVST, LVPWT, LAD, left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic dimension (LVEDD), OH, OH/ECW were positively correlated (all P<0.05). It was negatively correlated with urine volume, Kt/V, CCr, normalized protein catabolic rate (nPCR), hemoglobin, serum albumin and LVEF (all P<0.05). NT-proBNP 4 896 ng/L could be used as the critical value of initial screening capacity overload and was applied to divide the patients into two groups, and the systolic blood pressure, urine volume, ultrafiltration volume, Kt/V, CCr, IVST, LVPWT, OH/ECW indicators showed significant differences (all P<0.05) in two groups. Conclusions The level of NT-proBNP in PD patients is generally increased, and it indicates volume overload as its value is greater than 4 896 ng/L, which can be used as a simple monitoring index for the preliminary judgment of volume overload in PD patients.

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    Novel coronavirus infection: a new challenge for the management of thyroid disease
    XIANG Pingping, LIU Chao
    Journal of Internal Medicine Concepts & Practice    2022, 17 (06): 486-490.   DOI: 10.16138/j.1673-6087.2022.06.013
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    COVID-19 vaccine induced thyroid disease: challenges and strategies
    YUAN Li, XIANG Pingping, CHEN Guofang, et al
    Journal of Internal Medicine Concepts & Practice    2023, 18 (02): 121-123.   DOI: 10.16138/j.1673-6087.2023.02.012
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (04): 344-348.   DOI: 10.16138/j.1673-6087.2022.04.015
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    Journal of Internal Medicine Concepts & Practice    2021, 16 (06): 438-441.   DOI: 10.16138/j.1673-6087.2021.06.015
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    Journal of Internal Medicine Concepts & Practice    2021, 16 (01): 53-59.   DOI: 10.16138/j.1673-6087.2021.01.012
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (03): 258-261.   DOI: 10.16138/j.1673-6087.2022.03.017
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    Journal of Internal Medicine Concepts & Practice    2021, 16 (05): 289-293.   DOI: 10.16138/j.1673-6087.2021.05.001
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (03): 202-207.   DOI: 10.16138/j.1673-6087.2022.03.006
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    Geometric deep learning and computational medicine research prospects of “preventing disease” in pre diabete
    RUAN Ming, HOU Tianzhichao, WANG Haiyan, et al
    Journal of Internal Medicine Concepts & Practice    2022, 17 (06): 475-481.   DOI: 10.16138/j.1673-6087.2022.06.011
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (01): 92-96.   DOI: 10.16138/j.1673-6087.2022.01.018
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    Progress in clinical application of leadless pacemaker
    TANG Baopeng, ZHANG Jianghua, GUO Yankai
    Journal of Internal Medicine Concepts & Practice    2022, 17 (05): 365-368.   DOI: 10.16138/j.1673-6087.2022.05.003
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (02): 117-122.   DOI: 10.16138/j.1673-6087.2022.02.004
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    Study on the relationship between vitamin D deficiency and Hashimoto’s thyroiditis
    FU Jiawen, LI Xiaohua, ZHANG Hongli, XU Yanhong, ZHU Yi
    Journal of Internal Medicine Concepts & Practice    2021, 16 (01): 27-31.   DOI: 10.16138/j.1673-6087.2021.01.007
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    Objective To evaluate the relationship between Hashimoto’s thyroiditis (HT) and 25-hydroxy vitamin D. Methods A total of 334 HT patients were enrolled from the endocrine department of our hospital from January 2017 to December 2019, and 300 non-HT patients were selected as the control. There was no significant difference in gender and age composition between the two groups(P>0.05). The indexes of liver function, renal function, blood glucose, blood lipid, electrolyte level, thyroid function, thyroid antibody and vitamin D level of the two groups were collected and analyzed. Results Compared with the control group, there was no significant difference in vitamin D level and vitamin D deficiency rate between the HT group and the control group (P>0.05), while the thyroid stimulating hormone (TSH) level and the incidence of subclinical hypothyroidism in the HT group was significantly higher than that in the control group(P<0.05). The vitamin D level of female HT patients was lower and the cases of subclinical hypothyroidism were more(P<0.05). The HT patients with vitamin D deficiency were more likely to show subclinical hypothyroidism than the HT patients with normal vitamin D. Serum free triiodothyronine(FT3) was a protective factor for 25-hydroxy vitamin D[odds ratio(OR)=0.958, P=0.002], serum TSH(OR=1.080, P=0.002) and female(OR=1.167, P=0.001) were risk factors for 25-hydroxy vitamin D. Conclusions The vitamin D deficiency is prevalent in the population, especially in female. Vitamin D deficiency can lead to higher TSH level and increase the incidence of subclinical hypothyroidism in HT patients.

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    Application of pulsed electric field ablation in atrial fibrillation
    ZHANG Zhi, TANG Xuechao, HUANG Xinmiao, et al
    Journal of Internal Medicine Concepts & Practice    2022, 17 (05): 400-404.   DOI: 10.16138/j.1673-6087.2022.05.011
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (01): 15-23.   DOI: 10.16138/j.1673-6087.2022.01.004
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    Reliability and validity of the ultra-brief screening scale for depression and anxiety in outpatients clinics of community healthcare centers
    QIAN Jie, JIANG Minmin, CHEN Chen, CHEN Yujiao, YU Dehua, LI Chunbo
    Journal of Internal Medicine Concepts & Practice    2021, 16 (02): 116-120.   DOI: 10.16138/j.1673-6087.2021.02.010
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    Objective To preliminary evaluate the reliability and validity of the ultra-brief screening scale for depression and anxiety [patient health questionnaire 4 (PHQ-4)] in outpatients clinics of community healthcare centers. Methods Totally 313 patients were randomly selected from two community healthcare centers in Shanghai. The patients were asked to complete the PHQ-4 following the prescribed instruction with assistance of a psychiatrist and two physicians, and then were evaluated according Hamilton depression scale(HAMD) and the Hamilton anxiety scale(HAMA) followed by a mini international neuropsychiatric interview(MINI). Out of subjects screened, 50 patients were randomly selected to retest the PHQ-4. The reliability coefficients, retest reliability and criterion validity sensitivity and specificity were calculated. The receiver operating characteristic(ROC) analysis was performed to determine the best cut-off value, and the sensitivity and specificity accordingly. Results The Cronbach’α coefficient of PHQ-4 was 0.833, the Spearman-Brown coefficient of the split-half reliability was 0.835. For the test-retest reliability, the intraclass correlation coefficient (ICC) was 0.969. The correlation coefficients of generalized anxiety disorder 7(GAD-7) with HAMD and HAMA were 0.391 and 0.407 respectively, both statistically significant (P<0.01). ROC analysis showed that the area under curve(AUC) was 0.919, and the best cut-off value was 3, the sensitivity and specificity of PHQ-4 were 87.1% and 82.6% respectively. Conclusions The Chinese version of the PHQ-4 maintains high reliability and validity in outpatient clinics of community healthcare centers, and is suitable for the screening of depression and anxiety.

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    Research progress on pathogenesis of diabetic nephropathy
    BI Liming, WANG Zhaohui
    Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 201-205.   DOI: 10.16138/j.1673-6087.2023.03.014
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