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    Journal of Internal Medicine Concepts & Practice    2021, 16 (03): 220-224.   DOI: 10.16138/j.1673-6087.2021.03.018
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    Journal of Internal Medicine Concepts & Practice    2021, 16 (05): 289-293.   DOI: 10.16138/j.1673-6087.2021.05.001
    Abstract270)   HTML6)    PDF (662KB)(427)      
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    Novel coronavirus infection: a new challenge for the management of thyroid disease
    XIANG Pingping, LIU Chao
    Journal of Internal Medicine Concepts & Practice    2022, 17 (06): 486-490.   DOI: 10.16138/j.1673-6087.2022.06.013
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (03): 202-207.   DOI: 10.16138/j.1673-6087.2022.03.006
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    Journal of Internal Medicine Concepts & Practice    2021, 16 (06): 438-441.   DOI: 10.16138/j.1673-6087.2021.06.015
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    Progress in clinical application of leadless pacemaker
    TANG Baopeng, ZHANG Jianghua, GUO Yankai
    Journal of Internal Medicine Concepts & Practice    2022, 17 (05): 365-368.   DOI: 10.16138/j.1673-6087.2022.05.003
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (02): 117-122.   DOI: 10.16138/j.1673-6087.2022.02.004
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    Application of pulsed electric field ablation in atrial fibrillation
    ZHANG Zhi, TANG Xuechao, HUANG Xinmiao, et al
    Journal of Internal Medicine Concepts & Practice    2022, 17 (05): 400-404.   DOI: 10.16138/j.1673-6087.2022.05.011
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    Expert consensus on diagnosing and evaluating sacroiliitis using magnetic resonance imaging
    DAI Shengming, BAO Chunde, ZOU Hejian, et al
    Journal of Internal Medicine Concepts & Practice    2023, 18 (02): 65-69.   DOI: 10.16138/j.1673-6087.2023.02.001
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (04): 344-348.   DOI: 10.16138/j.1673-6087.2022.04.015
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    Journal of Internal Medicine Concepts & Practice    2021, 16 (03): 141-144.   DOI: 10.16138/j.1673-6087.2021.03.001
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (03): 198-201.   DOI: 10.16138/j.1673-6087.2022.03.005
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (02): 109-111.   DOI: 10.16138/j.1673-6087.2022.02.001
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    Research progress of thyroid hormone on organ function maintenance in sepsis
    ZHOU Yi, CHEN Ying, CHEN Erzhen
    Journal of Internal Medicine Concepts & Practice    2022, 17 (05): 408-412.   DOI: 10.16138/j.1673-6087.2022.05.013
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (01): 15-23.   DOI: 10.16138/j.1673-6087.2022.01.004
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    Effects of activin A on migration and aerobic glycolysis of gastric cancer cells
    ZHAO Liqin, GUO Weijian, YU Nuoya, WU Junwei, ZHANG Jun
    Journal of Internal Medicine Concepts & Practice    2022, 17 (04): 317-323.   DOI: 10.16138/j.1673-6087.2022.04.009
    Abstract165)   HTML2)    PDF (1217KB)(137)      

    Objective To investigate the role of activin A, a member of transforming growth factor-β superfamily cytokine, in regulating migration and aerobic glycolysis of gastric cancer cells, and the prognostic value of the expression of its coding gene inhibin βA(INHBA) in survival of gastric cancer patients. Methods The gastric cells were first titrated with various concentration of activin A and the expression of pSmad2/3 was examined by Western blot(WB) to determine the concentration range of activin A used in the study. The effect of activin A on the migration of gastric cancer cells was monitored by transwell and wound healing assays. The lactate production and glucose uptake of gastric cancer cells were followed to evaluate the role of activin A on the regulation of aerobic glycolysis. The association between activin A and epithelial mesenchymal transformation(EMT)/glycolysis related genes was analyzed in the Cancer Genome Atlas (TCGA) gastric cancer database, and further validated by WB studies. The expression of INHBA in gastric cancer and normal mucosa tissue were analyzed in TCGA, Gene Expression Omnibus(GEO) and other publicly available databases to explore the association of INHBA expression level with patients’ survival. Results The activin A at 20 ng/mL sufficiently upregulate the level of pSmad2/3, and the concentration was thus used in the study. Activin A promoted migration and aerobic glycolysis of gastric cancer cells. There was a significant positive correlation between the expression of INHBA and several EMT related genes, hypoxia inducible factor-1 α(HIF1A), glucose transporter 3 (GLUT3) [SNAI1: r=0.47, P=0;SNAI2: r=0.51, P=0; VIM: r=0.37, P=2.1×10-14; matrix metalloproteinase(MMP)2: r=0.64, P=0; MMP9: r=0.27, P=2.8×10-8; HIF1A: r=0.45, P=0; SLC2A3: r=0.42, P=0]. After treatment with activin A, the expression of snail, slug, vimentin, MMP2 and GLUT3 increased significantly(P<0.05). The expression of INHBA in gastric cancer was significantly higher than that in normal gastric mucosa tissue, and the prognosis of patients with higher expression of INHBA was poor. Conclusions Activin A can promote migration and aerobic glycolysis, which might attribute to its upregulation of EMT related genes and GLUT3. High level of INHBA is indicative of prognosis for gastric cancer patients.

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    Journal of Internal Medicine Concepts & Practice    2022, 17 (04): 353-355.   DOI: 10.16138/j.1673-6087.2022.04.017
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    Greatness in simplicity—new technology of pulmonary vein isolation
    WU Liqun
    Journal of Internal Medicine Concepts & Practice    2022, 17 (05): 357-359.   DOI: 10.16138/j.1673-6087.2022.05.001
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (02): 123-126.   DOI: 10.16138/j.1673-6087.2022.02.005
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    Journal of Internal Medicine Concepts & Practice    2022, 17 (03): 267-272.   DOI: 10.16138/j.1673-6087.2022.03.019
    Abstract91)   HTML4)    PDF (549KB)(126)      
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