外科理论与实践 ›› 2024, Vol. 29 ›› Issue (03): 264-269.doi: 10.16139/j.1007-9610.2024.03.14

• 综述 • 上一篇    下一篇

结肠直肠癌肿瘤疫苗研究现状及展望

贾文清 综述, 张弢, 赵任 审校()   

  1. 上海交通大学医学院附属瑞金医院普外科 上海市消化外科研究所,上海 200025
  • 收稿日期:2024-06-11 出版日期:2024-05-25 发布日期:2024-09-03
  • 通讯作者: 赵任,E-mail: zhaorensurgeon@aliyun.com
  • 基金资助:
    国家自然科学基金(82202839);上海申康中心促进市级医院临床技能与临床创新三年行动计划(SHDC2020CR1026B)

Research status and prospects of colorectal cancer vaccine

JIA Wenqing, ZHANG Tao, ZHAO Ren()   

  1. Department of General Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2024-06-11 Online:2024-05-25 Published:2024-09-03

摘要:

结肠直肠癌(CRC)是全球发病率排名第3、但死亡率排名第2的恶性肿瘤。肿瘤疫苗是一种新型免疫治疗方式,向机体递呈肿瘤抗原,诱导抗肿瘤免疫应答,以形成长期免疫记忆。本文综述不同类型CRC疫苗近5年代表性临床/基础研究进展并展望未来。

关键词: 肿瘤疫苗, 结肠直肠癌, 新生抗原, 纳米疫苗

Abstract:

Colorectal cancer(CRC) ranks in third place in terms of incidence but second in terms of mortality. Cancer vaccine, as a novel immunotherapy, presents tumor antigens to human immune system and further elicits anti-tumor immune response, leading to long-term immune memory. This review summarized representative research progress in both clinical and basic scenario of past five years, and prospected the future of CRC vaccine.

Key words: Cancer vaccine, Colorectal cancer(CRC), Neoantigen, Nanovaccine

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