Trop2基因与三阴性乳腺癌的研究进展

doi:10.16139/j.1007-9610.2022.05.018

摘要/Abstract

摘要：

Trop2基因在多种恶性肿瘤的发生、发展中起重要作用。三阴性乳腺癌（triple-negative breast cancer, TNBC）的滋养层细胞表面抗原2（trophoblast cell-surface antigen 2, Trop2）基因能调控周期蛋白D₁（cyclin D₁）及上皮钙黏素的表达，进而促进TNBC转移及侵袭。本文对Trop2基因的结构、功能、作用机制及在TNBC中的表达和治疗进行综述，以期找到TNBC的治疗靶点，探索新疗法。

关键词: 三阴性乳腺癌, Trop2基因, 靶向治疗

Abstract:

Trophoblast cell-surface antigen 2(Trop2) gene plays an important role in the development of various malignant tumors. Trop2 gene regulates the expression of cyclin D₁ and E-cadherin in triple-negative breast cancer (TNBC), and promote the metastasis and invasion of TNBC. In this study, the structure, function, mechanism of action, the expression of Trop2 gene and treatment of TNBC were reviewed to find therapeutic targets for TNBC and explore new therapy.

Key words: Triple-negative breast cancer, Trop2 gene, Targeted therapy

中图分类号:

R737.9

王杰强综述, 马德奎审校. Trop2基因与三阴性乳腺癌的研究进展[J]. 外科理论与实践, 2022, 27(05): 473-477.

WANG Jieqiang, MA Dekui. Study on trophoblast cell-surface antigen 2 gene and triple-negative breast cancer[J]. Journal of Surgery Concepts & Practice, 2022, 27(05): 473-477.

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