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Table of Content

    23 July 2020, Volume 10 Issue 4 Previous Issue    Next Issue
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    Original article
    The Influence of Propranolol on VEGF, bFGF, MMP-9 in Serum Samples in the Treatment Proliferative Hemangioma
    WU Shanying,WANG Biao,CHEN Lifen,HUANG Zugen,HUANG Xunlei,WANG Meishui
    2014, 10 (4):  181-186.  DOI: 10.3969/j.issn.1673-0364.2014.04.001
    Abstract ( 416 )  
    Objective To investigate the influence of propranolol on VEGF, bFGF and MMP-9 in serum samples in the treatment of proliferative hemangioma. Methods Forty children with proliferative hemangioma were enrolled and treated with propranolol. The VEGF, bFGF and MMP-9 in serum samples were detected with ELISA assay before and 8 weeks after propranolol treatment. Results After 8 weeks of treatment, the concentration levels of VEGF, bFGF and MMP-9 in serum were obviously decreased, and the differences were significant. Conclusion The decrease on the expression of VEGF, bFGF and MMP-9 may play an important role in the treatment of proliferative hemangioma.
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    Retrospective Analysis of the Management of Periorbital Hemangioma with Intralesional Glucocorticoids Injection and Systemic Propranolol
    XU Yekai,YUAN Siming,GUO Yao,CUI Lei,HONG Zhijian,JIANG Huiqing
    2014, 10 (4):  183-186.  DOI: 10.3969/j.issn.1673-0364.2014.04.002
    Abstract ( 437 )  
    Objective To analyze and compare the management of periorbital hemangioma by intralesional glucocorticoids injection and systemic propranolol. Methods From Jan. 2006 to Dec. 2013, twenty-five children with periorbital hemangioma were enrolled into this study. Among them, sixteen children accepted intralesional injection of compound betamethasone preparation. Eight children accepted systemic propranolol. One child accepted both of the two treatments. Results The follow-up period ranged from 6 months to 60 months. In the patients treated with intralesional glucocorticoids injection, the tumors of 13 patients involuted completely, and the tumors of the other 3 patients didn't involute completely at the end of follow-up. In the patients treated with systemic propranolol, the tumors of all the patients involuted almost completely. One patient didn’t respond to intralesional glucocorticoids injection, and was switched to systemic propranolol, which lead to the involution of tumor finally. The adverse effects in the patients treated with intralesional glucocorticoids included local soft tissue atrophy, local ulcer, and Cushing-like manifestations, which occurred in three patients respectively. In the patients treated with systemic propranolol, mild diarrhoea occurred in one child. Conclusion Both of intralesional glucocorticoids injection and systemic propranolol can achieve good results in the management of periorbital hemangioma. Systemic propranolol shows superiority in efficacy and safety. Systemic propranolol should be recommend as the first-choise therapy. However, for the children who can’t tolerate systemic propranolol, intralesional glucocorticoids injection is still a feasible choice.
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    Propranolol for Superficial Infantile Hemangiomas in 56 Cases
    FU Shizhang,HUANG Heping,HUANG Linling
    2014, 10 (4):  187-190.  DOI: 10.3969/j.issn.1673-0364.2014.04.003
    Abstract ( 541 )  
    Objective To explore the efficacy, safety and appropriate method of oral propranolol for superficial infantile hemangiomas. Methods From January 2010 to January 2013, 56 cases with infantile hemangiomas in superficial body were treated with oral propranolol. These lesions ranged from 0.8 cm ×0.6 cm to 4.0 cm ×4.5 cm. Propranolol was administered orally twice a day after meal. The initial dose was 0.5 mg/Kg·d, and was added 0.2 mg/Kg every day till it added up to 1.5 mg/Kg·d only if complications were not occurred in the cases. After treated for 4 months, the dose was decreased by 0.2 mg/Kg every day to withdrawal. Follow-up was conducted every month during treatment. The response to therapy after 6 months of propranolol withdrawal was evaluated using Achauer system. Results Fifty-three cases took propranolol for 4 months, 1 case gave up therapy because of obvious fatigue during the first month of treatment, and 2 cases ended treatment as they had gotten cured almostly after taking propranolol for 3 months. Most hemangiomas decreased distinctly in size and color, and some even disappeared completely when treatment ended. According to Achauer system, 2 cases were scale Ⅰ(including 1 recurrence), 6 cases were scaleⅡ (including 5 recurrence), 17 cases were scale Ⅲand 31 cases were scaleⅣafter six months of propranolol withdrawal. Recurrence of lesion was noticed in six cases after propranolol withdrawal. No other adverse reaction was observed during taking medication except obvious fatigue in 1 case and intermittent diarrhea without affecting diet and therapy in 6 cases. Conclusion Oral propranolol is one of the effective methods for treating infantile hemangiomas located in superficial body, both the efficacy and safety are probably relative to its dose and usage.
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    Microultrasound in Monitoring the Evolution of Infantile Hemangioma after Propranolol Treatment
    CHANG Lei,QIU Yajing,MA Gang,JIN Yunbo,CHEN Hui,YU Wenxin,YANG Xi,HU Xiaojie,LIN Xiaoxi
    2014, 10 (4):  191-195.  DOI: 10.3969/j.issn.1673-0364.2014.04.004
    Abstract ( 350 )  
    Objective To evaluate changes in parotid infantile hemangioma by using microultrasound before and after propranolol therapy. Methods Medical records and image studies of parotid hemangioma treated with propranolol were identified in a database. Evaluation criterion included the depth, vessel density and resisting index of focus. Student t test was used to evaluate changes before and after hemangioma treatment. Results The depth, vessel density were decreased and resisting index were increased after propranolol treatment. Conclusion Propranolol can treat infantile hemangioma effectively. Microultrasound can monitor the evolution of infantile hemangioma effectively.
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    Propranolol in Combination with Pingyangmycin for the Treatment of Infantile Hemangioma
    LU Yan,ZHANG Xinxia,XIANG Yan,GUO Aidi
    2014, 10 (4):  193-195.  DOI: 10.3969/j.issn.1673-0364.2014.04.005
    Abstract ( 438 )  
    Objective To explore the clinical efficacy of propranolol in combination with pingyangmycin for the treatment of infantile hemangioma. Methods Sixty patients with infantile hemangioma were injected with pingyangmycin (injection dose: 0.3-0.5 mg/cm2), and treated with propranolol for oral administration (1.0~2.0 mg/Kg·d) at the meantime. All the patients were followed and the clinical efficacy were observed. Results With the time extention, the hemangioma reduced, the color became shallow, the tumor and the bloodshot on its surface gradually faded. The effective rate was 93.7%. Conclusion Propranolol combined with pingyangmycin may act synergistically to improve the curative effect in treating infantile hemangioma.
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    Efficacy and Safety of Sclerotherapy with Polidocanol Foam for Superficial Venous Malformation
    HU Li,HUANG Huizhen,MA Gang,QIU Yajing,CHEN Hui,JIN Yunbo,HU Xiaojie,LIN Xiaoxi,LI Wei
    2014, 10 (4):  196-198.  DOI: 10.3969/j.issn.1673-0364.2014.04.006
    Abstract ( 545 )  
    Objective To investigate the efficacy and safety of sclerotherapy with polidocanol foam in the treatment of superficial venous malformation (VM). Methods From January 2013 to April 2014, 17 superficial VM patients were treated by sclerotherapy. The polidocanol foam was produced by Tessari ’s method (liquid∶air=1∶4). The concentration of polidocanol used was 1%. Sclerotherapy was repeated at an interval of 4 weeks. Therapeutic outcomes were evaluated by color and size of lesions. Side-effects were both recorded during treatment and after treatment. Results The average number of sessions was 3.06. The results were excellent in 5 cases, good in 7 cases, fair in 3 cases and poor in 2 cases. Side effects including swelling, pain and transient hyperpigmentation were observed. Conclusion Sclerotherapy with polidocanol foam for superficial venous malformation is effective and safe without severe side effects.
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    Clinical Analysis of Intralesional Lauromacrogol Injection for Venous Malformation of Glans Penis in 15 Cases
    LI Kelei,TAI Maozhong,GE Chunxiao,QIN Zhongping
    2014, 10 (4):  199-206.  DOI: 10.3969/j.issn.1673-0364.2014.04.007
    Abstract ( 537 )  
    Objective To evaluate the therapeutic effect and safety of intralesional lauromacrogol injection in the treat-ment of venous malformation of glans penis. Methods From Jan 2011 to May 2013, 15 patients with venous malformation of the glans penis were treated with percutaneous intralesional injection of lauromacrogol. Injections were administrated under epidural anesthesia at a dose of 0.5-2.0 mL. Patients were treated once 2 months for 1 to 4 times. Results All the patients experienced transient erythema and edema without bleeding and infection, whereas local diabrosis occurred in only 1 patient. There were 2 patients complained of light pain after treatment. After followed up for 12 months to 3 years, all patients were cured without pigment alteration, abnormalities and erectile dysfunction. Conclusion It is considerd that intralesional in-jection with lauromacrogol is a safe and effective method for the treatment of venous malformation of the glans penis with no influence on appearance and function, which can be carried out easily and shows a low postoperative infection rate, so that it should be suggested as first choice of venous malformation in glans penis.
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    The Application of STAE in the Treatment of Auricular Arteriovenous Malformations
    HUANG Zugen,XIONG Shuyuan,WANG Biao,ZHUANG Fulian,HUANG Xunlei,WU Shanying,WANG Meishui,ZHEN Houbin
    2014, 10 (4):  201-224.  DOI: 10.3969/j.issn.1673-0364.2014.04.008
    Abstract ( 481 )  
    Objective To explore the effect of superselective transcatheter artery embolization (STAE) in the treatment of auricular arteriovenous malformations (AVM). Methods The clinical results in the treatment of auricular AVM of 14 cases during the past 7 years were reviewed. The different treatments including operation, STAE and combined therapy were compared. Results Operation resulted in severe trauma and large amount of bleeding but with low recurrent rate. While operation after STAE shorted operation time and extremely decreased the blood loss with clear operation field and less complications. The STAE might obtain better results with the advanced embolism drugs and modified technique, although the early recurrence was common recently. Conclusion STAE is playing more and more important role in the treatment of auricular AVM and should be recommended as an important treatment method.
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    Effect of Timolol Maleate Gel-forming Solution in the Treatment of Superficial Infantile Hemangiomas:a Prospective, Randomized, Double-Blind, Controlled Trial
    QIU Yajing,CHEN Minyan,CHANG Lei,MA Gang,HU Xiaojie,JIN Yunbo,CHEN Hui,LIN Xiaoxi
    2014, 10 (4):  203-206.  DOI: 10.3969/j.issn.1673-0364.2014.04.009
    Abstract ( 833 )  
    Objective To investigate the efficacy and safety of timolol maleate gel-forming solution with different concentrations for the treatment of superficial infantile hemangiomas (IHs). Methods From July 2012 to February 2013, patients aged from 1 to 6 months with superficial infantile hemangiomas were enrolled onto this study:a prospective, randomized, double-blind, controlled trial. Participants were randomly divided into 3 groups according to different concentration of timolol maleate gel-forming solution:group 1 (0.25%timolol gel), group 2 (0.5%timolol gel) and group 3 (1.0%timolol gel). Adverse effects and duration of the treatments were recorded. A visual analogue scale (VAS) was used to evaluate the efficacy of the drugs. Multiple logistic regression analysis was used to determine the independent correlation of each factor (e.g. age, gender, tumors location, the thickness of tumor, drug concentration, application frequency and duration of the treatment) and the efficacy. Results The mean VAS score was 30.94±32.97 for the patients treated by timolol gels with a total clinical efficacy of 62.3%. There were significant correlations between the VAS scores and the frequency&the duration of treatment (P<0.05). The main side effects were local skin reactions (2.9%) and mild wheezing (0.97%). Conclusion Timolol gel is safe and effective in the treatment for superficial IHs. Concentrations are not relevant for the treatment effect.
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    Establish ment and Biocompatibility of a Small Diameter Tubular Scaffold of Electrospun Poly (L-lactide-co-ε-caprolactone)/fibrinogen Blended Fibers
    FANG Zhengdong,HU Hejie,DONG Zhihui,WANG Xiaotian,SUN Xiaojie,GE Xinbao
    2014, 10 (4):  207-210.  DOI: 10.3969/j.issn.1673-0364.2014.04.010
    Abstract ( 536 )  
    Objective To fabricate a small diameter tubular scaffold of P (LLA-CL)/fibrinogen by electrospinning fiber technique, to evaluate the biocompatibility of the P (LLA-CL)/fibrinogen scaffold and its feasibility for vascular tissue engineering. Methods A small diameter tubular scaffold was fabricated by co-electrospinning blend of P (LLA-CL) and Fibrinogen. Gross morphology of the scaffold was observed and the 3-dimensional structure was observed by scanning electron microscope (SEM). Biocompatibilities of the tubular scaffold were evaluated in vivo and in vitro by acute hemolysis test, cytotoxicity test, and short-term test of subcutanous implantation. Results A randomly oriented nanofibrous structure with a well interconnected network of pores was observed. The diameter of the fiber at the outer surface was 318 ±56 nm and the average pore diameter was 4.56 ±1.23 μm; Hemolysis rate was 2.87%±0.49%; There was no significant difference of cytotoxicity between the P (LLA-CL)/fibrinogen tubular scaffold and negative control group (P>0.05). After the placement in rat subcutaneous pouches, the scaffolds were gradually biodegraded with little inflammatory reaction. Conclusion The P (LLA-CL)/fibrinogen tubular scaffold can be fabricated by electrospinning fiber technique. It has good biocompatibility and could be potentially used as vascular tissue engineering scaffold material.
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    Biomechanical Analysis of a Modification of Tang Method and Its Application on Flexor Tendon Repair in Zone Ⅱ
    SONG Nan,MAO Hailei,YANG Xi,XU Qiming,JIANG Yongkang,ZHOU Shengbo,NI Feng,WANG Bin
    2014, 10 (4):  211-214.  DOI: 10.3969/j.issn.1673-0364.2014.04.011
    Abstract ( 1667 )  
    Objective To investigate the biomechanical properties and preliminary application of a new suture method, modification of Tang's method, for flexor tendon repair. Methods Thirty-six fresh porcine flexor tendons were divided and repaired with either the modified Tang or the original Tang method. The tendons were subjected to linear or 90 ° angular loading in an Instron tensile testing machine. 2 mm gap formation force and ultimate strength were recorded. M-Tang method was performed in repairing 96 human flexor tendons in zone Ⅱ, and protected passive and active motion protocol were used in eash case after the operation. Strickland TAM classification was applied to evaluate the function postopertively. Results Under linear tension mode, M-Tang was similar to Tang method with its 2 mm gap formation force at (46.2 ±5.2) N, ultimate strength at (61.9 ±6.0) N; Under angular tension mode, M-Tang was similar to Tang with its 2 mm gap formation force at (35.9±3.6) N, but superior to Tang with its ultimate strength at (57.0±4.5) N. No tendon rupture was observed in any of the repaired fingers. Strickland TAM classification showed excellent in 78 cases, good in 10 cases, fair in 8 cases, and the total good rate was 91.6%. Conclusion M-Tang method maintained the biomechanical characters of the original Tang method which can fulfill the requirements for early motion protocol. With fewer suture and knots and easy to operate, M-Tang method was one of the first choice in repairing flexor tendons in zone Ⅱ.
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    Treatment Experience for Acute Injuries of Parotid Gland and Facial Nerve
    HAO Dongyue,LIU Chaohua,HE lin,SUN feng,SONG Baoqiang,XIA Wensen
    2014, 10 (4):  215-217.  DOI: 10.3969/j.issn.1673-0364.2014.04.012
    Abstract ( 292 )  
    Objective To explore the diagnosis and treatment for acute injuries of parotid and facial nerve. Methods From June 2012 to June 2013, 21 cases with parotid and facial nerve injury were performed actively emergency treatment. After sufficient preoperative preparation, the parotid gland and facial nerves were actively treated. Injury in parotid gland, parotid duct, or facial nerve were differently treated. Parotid gland ruptures were repaired instantly, and the parotid duct and facial nerve were anastomosed instantly. Results 93% of the patients with parotid gland and parotid duct injury were completely healed, while the other 7% cases had parotid gland fistula. All of the 7% patients were cured after giving anticholinergics and pressure dressing. 66% of the patients with facial nerve injury were completely cured, the other 24%cases were partly cured, and remained 10% cases were not cured. Conclusion Strict examination should be given to the patients with acute injuries of parotid gland and facial nerve, then the diagnosis and treatment could be given instantly.
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    Review
    Research Progress of Vascular Abnormalities in NF1
    Gao Yang,HU Jiaojie,LIN Xiaoxi
    2014, 10 (4):  218-221.  DOI: 10.3969/j.issn.1673-0364.2014.04.013
    Abstract ( 402 )  
    Neurofibromatosis type 1 is a common autosomal dominant condition caused by heterozygous mutations of the NF1 gene. The most frequent clinical manifestations are alterations of skin pigmentation and benign neurofibromas, but patients with NF1 may also develop nervous system tumors, skeletal abnormalities, or vascular disease. Vascular abnormalities is a common complication of NF1 and may lead to a high morbidity and mortality. The new findings of vascular abnormalities NF1were reviewed in this paper.
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    The Mechanism of Perictes in the Fading of Infantile Hemangioma
    ZHAO Zheyuan,GUO Liang
    2014, 10 (4):  222-224.  DOI: 10.3969/j.issn.1673-0364.2014.04.014
    Abstract ( 388 )  
    As the most common benign tumor of infancy, infantile hemangioma has its special evolution process. En-dotheile cells, as well as perictes play important roles in the occurrence, development and resolution of the infantile heman-gioma. In this article, by summarizing the source and diferentitation of perictes, and its relationship with endotheile cells, the mechanism of perictes in the fading of infantile hemangioma was reviewed.
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    Progress in the Treatment of Venous Malformations
    QIU Shengda,CHEN Hui,LIN Xiaoxi
    2014, 10 (4):  225-227.  DOI: 10.3969/j.issn.1673-0364.2014.04.015
    Abstract ( 356 )  
    Venous malformations (VMs) is one the most common congenital vascular malformation, and the exact cause of the disease is not very clear. The clinical treatment is always various according to the extent of the disease and affected organs. Up to now, there is no single method for treatment. The treatment strategy should be individualized and multidisciplinary for complicated cases, in order to achieve effective results. Endovascular therapy for VMs is found to be safe and effective, which may be the main technique in the treatment of VMs. In this paper, the current progress in the treatment, diagnosis and therapeutic management of VMs were reviewed.
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    Research Progress of Diagnosis and Treatment of Peripheral Venous Malformations
    HUANG Huizhen,LI Wei
    2014, 10 (4):  228-231.  DOI: 10.3969/j.issn.1673-0364.2014.04.016
    Abstract ( 326 )  
    Peripheral venous malformations are blue-purple color vascular dysplasia lesions at skin which located in head and neck, trunk or limbs of a man, subcutaneous tissue, mucosa or muscle. Although peripheral venous malformations are benign vascular malformation disease, they grow synchronously with physical development and can ’t regress spontaneously. What’s more, they always lead to appearance defects and dysfunction. Owing to the reasons above, peripheral venous malformations should be diagnosed and treated actively. In this paper, the diagnosis and treatment of peripheral venous malformations were reviewed.
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    Research Progress of Photodynamic Therapy for Port-Wine Stain
    WANG Tianyou,LIN Xiaoxi
    2014, 10 (4):  232-235.  DOI: 10.3969/j.issn.1673-0364.2014.04.017
    Abstract ( 525 )  
    Photodynamic therapy (PDT) was firstly applied for treating port-wine stain (PWS) in the 1990s in China. PDT is composed of two major factors, photo sensitizer and excitation light source. PDT can kill cells directly, destroy vessels of le-sions, trigger apoptosis and play a role in immunoregulation by its phototoxic effect. It is currently used for the treatment of skin diseases, tumors in eyes, nose, mouth and respiratory, gastrointestinal, genitourinary tract, and other cavity owing to its high selectivity. In this article, PDT application and its research progress in the treatment of port-wine stain were reviewed.
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    The Role of Adipose-derived Stem Cells in Skin Aging Treatment
    LIU Meichen,LIU Xia,XIAO Ran,CAO Yilin
    2014, 10 (4):  236-239.  DOI: 10.3969/j.issn.1673-0364.2014.04.018
    Abstract ( 424 )  
    Adipose-derived stem cells (ADSC), cating in fat tissue, pluripotent mesenchymal stem cells which display the ability of self-renewal and multi-lineage differentiation and can secrete a variety of biological activity factors, having broad application prospects in regenerative medicine. Recently, diverse rejuvenation effects of ADSCs on skin have been demonstrated. The role of ADSCs in anti-wrinkle, whitening, promoting hair regeneration, improving the ability of tissue repair were reviewed in this paper.
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