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    Journal of Internal Medicine Concepts & Practice    2019, 14 (02): 116-120.   DOI: 10.16138/j.1673-6087.a0135
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    Research progress of Hashimoto thyroiditis
    TIAN Limin, FENG Jing
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 217-223.   DOI: 10.16138/j.1673-6087.2024.04.01
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    Hashimoto thyroiditis (HT) is a very common organic autoimmune thyroid disease, and its incidence is increasing year by year. It not only causes hypothyroidism in clinical practice, but also has many connections with a variety of immune diseases, endocrine diseases, rheumatic diseases and thyroid cancer. Although the exact etiology of HT has not been fully clarified, the mainstream treatment is still based on management and alternative treatment of hypothyroidism. However, as the research further deepens, more clinical variants have been gradually discovered, more and more factors have been found to be related to the onset of HT, and new discoveries have been made in treatment methods. This article reviews the research progress on clinical manifestations, pathological features, diagnosis, pathogenesis, relationship with other diseases and treatment of HT.

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    Journal of Internal Medicine Concepts & Practice    2008, 3 (01): 63-.   DOI: 10.16138/j.1673-6087.a0060
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    Research progress on agranulocytosis caused by antithyroid drugs
    TIAN Ruochen, LI Jing
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 264-268.   DOI: 10.16138/j.1673-6087.2024.04.09
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    In China, antithyroid drugs are the first choice of treatment for hyperthyroidism. However, their side effects may result in agranulocytosis, which has an insidious onset and requires urgent treatment. Up to date,the mechanisms of agranulocytosis caused by antithyroid drugs is still unclear. Herein, the article reviewed the direct toxic activities, the immune effects, and the genetic susceptibility of antithyroid drugs, which may be helpful to provide better clinical treatment options and improve the prognosis of agranulocytosis caused by the drugs.

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    Journal of Internal Medicine Concepts & Practice    2022, 17 (02): 123-126.   DOI: 10.16138/j.1673-6087.2022.02.005
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    Study on efficacy and safety of Dioscorea bublifera L. in treatment of Graves disease
    CUI Yifan, ZHANG Ruixiang, WEI Xiao, LIU Chao
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 273-277.   DOI: 10.16138/j.1673-6087.2024.04.11
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    Hyperthyroidism is most common in Graves disease (GD), and traditional antithyroid medicine are often difficult to achieve satisfactory efficacy, and high recurrence rate and long course of treatment are the most prominent problems. Huangyaozi(Dioscorea bublifera L.), a traditional Chinese medicine, has the effect of “Xiao Ying” and has been widely used in the treatment of GD in recent years, but long-term use may cause liver and kidney damage. Therefore, more research on the efficacy and safety of Huangyaozi need to be done in the treatment of GD.

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    Recent advances in diagnosis and treatment of subacute thyroiditis
    LI Yajie, CUI Dai
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 259-263.   DOI: 10.16138/j.1673-6087.2024.04.08
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    Subacute thyroiditis (SAT) is a common thyroid inflammatory disease that is frequently prone to misdiagnosis or underdiagnosis, which impact the quality of life for patients adversely. In this review, we summarize the pathogenesis, clinical manifestations, diagnosis, and treatment of SAT, aiming to improve clinician’s understanding of the disease.

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    Journal of Internal Medicine Concepts & Practice    2013, 8 (01): 24-28.   DOI: 10.16138/j.1673-6087.a1189
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    Expert consensus on diagnosing and evaluating sacroiliitis using magnetic resonance imaging
    DAI Shengming, BAO Chunde, ZOU Hejian, et al
    Journal of Internal Medicine Concepts & Practice    2023, 18 (02): 65-69.   DOI: 10.16138/j.1673-6087.2023.02.001
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    Journal of Internal Medicine Concepts & Practice    2015, 10 (06): 397-402.   DOI: 10.16138/j.1673-6087.a0851
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    Journal of Internal Medicine Concepts & Practice    2019, 14 (06): 391-394.   DOI: 10.16138/j.1673-6087.a0766
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    Research progress on pathogenesis of diabetic nephropathy
    BI Liming, WANG Zhaohui
    Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 201-205.   DOI: 10.16138/j.1673-6087.2023.03.014
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    Ultrasound features and clinical manifestations of two cases of thyroid metastatic cancer: pay attention to abnormal thyroid ultrasound spectrum
    LI Yuanyuan, DING Wenbo, JIANG Ziyu, CHEN Xi, LIU Binbin, CHEN Guofang, LIU Chao
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 254-258.   DOI: 10.16138/j.1673-6087.2024.04.07
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    Ultrasonography plays an important role in early screening of thyroid cancer. This article introduced two cases of thyroid metastatic carcinoma secondary to renal clear cell carcinoma and cervical squamous cell carcinoma respectively, analyzed their clinical diagnosis and treatment process, ultrasound characteristics, and prognosis, as well as reviewed the related literature. As atypical thyroid lesions were detected through the ultrasound spectrum in patients with a history of malignant tumors, it should be alert to the possibility of metastatic cancer. Ultrasound-guided core-needle biopsy combined with immunohistochemical testing can help early diagnosis and timely treatment.

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    Journal of Internal Medicine Concepts & Practice    2018, 13 (03): 153-157.   DOI: 10.16138/j.1673-6087.a0303
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    Journal of Internal Medicine Concepts & Practice    2017, 12 (05): 314-317.   DOI: 10.16138/j.1673-6087.a0496
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    Reliability and validity of the ultra-brief screening scale for depression and anxiety in outpatients clinics of community healthcare centers
    QIAN Jie, JIANG Minmin, CHEN Chen, CHEN Yujiao, YU Dehua, LI Chunbo
    Journal of Internal Medicine Concepts & Practice    2021, 16 (02): 116-120.   DOI: 10.16138/j.1673-6087.2021.02.010
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    Objective To preliminary evaluate the reliability and validity of the ultra-brief screening scale for depression and anxiety [patient health questionnaire 4 (PHQ-4)] in outpatients clinics of community healthcare centers. Methods Totally 313 patients were randomly selected from two community healthcare centers in Shanghai. The patients were asked to complete the PHQ-4 following the prescribed instruction with assistance of a psychiatrist and two physicians, and then were evaluated according Hamilton depression scale(HAMD) and the Hamilton anxiety scale(HAMA) followed by a mini international neuropsychiatric interview(MINI). Out of subjects screened, 50 patients were randomly selected to retest the PHQ-4. The reliability coefficients, retest reliability and criterion validity sensitivity and specificity were calculated. The receiver operating characteristic(ROC) analysis was performed to determine the best cut-off value, and the sensitivity and specificity accordingly. Results The Cronbach’α coefficient of PHQ-4 was 0.833, the Spearman-Brown coefficient of the split-half reliability was 0.835. For the test-retest reliability, the intraclass correlation coefficient (ICC) was 0.969. The correlation coefficients of generalized anxiety disorder 7(GAD-7) with HAMD and HAMA were 0.391 and 0.407 respectively, both statistically significant (P<0.01). ROC analysis showed that the area under curve(AUC) was 0.919, and the best cut-off value was 3, the sensitivity and specificity of PHQ-4 were 87.1% and 82.6% respectively. Conclusions The Chinese version of the PHQ-4 maintains high reliability and validity in outpatient clinics of community healthcare centers, and is suitable for the screening of depression and anxiety.

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    Journal of Internal Medicine Concepts & Practice    2007, 2 (02): 106-108.   DOI: 10.16138/j.1673-6087.a0461
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    Journal of Internal Medicine Concepts & Practice    2010, 5 (05): 400-402.   DOI: 10.16138/j.1673-6087.a0663
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    Journal of Internal Medicine Concepts & Practice    2015, 10 (04): 272-275.   DOI: 10.16138/j.1673-6087.a0898
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    Journal of Internal Medicine Concepts & Practice    2017, 12 (05): 344-350.   DOI: 10.16138/j.1673-6087.a0069
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