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    Research progress of Hashimoto thyroiditis
    TIAN Limin, FENG Jing
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 217-223.   DOI: 10.16138/j.1673-6087.2024.04.01
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    Hashimoto thyroiditis (HT) is a very common organic autoimmune thyroid disease, and its incidence is increasing year by year. It not only causes hypothyroidism in clinical practice, but also has many connections with a variety of immune diseases, endocrine diseases, rheumatic diseases and thyroid cancer. Although the exact etiology of HT has not been fully clarified, the mainstream treatment is still based on management and alternative treatment of hypothyroidism. However, as the research further deepens, more clinical variants have been gradually discovered, more and more factors have been found to be related to the onset of HT, and new discoveries have been made in treatment methods. This article reviews the research progress on clinical manifestations, pathological features, diagnosis, pathogenesis, relationship with other diseases and treatment of HT.

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    Research progress on agranulocytosis caused by antithyroid drugs
    TIAN Ruochen, LI Jing
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 264-268.   DOI: 10.16138/j.1673-6087.2024.04.09
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    In China, antithyroid drugs are the first choice of treatment for hyperthyroidism. However, their side effects may result in agranulocytosis, which has an insidious onset and requires urgent treatment. Up to date,the mechanisms of agranulocytosis caused by antithyroid drugs is still unclear. Herein, the article reviewed the direct toxic activities, the immune effects, and the genetic susceptibility of antithyroid drugs, which may be helpful to provide better clinical treatment options and improve the prognosis of agranulocytosis caused by the drugs.

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    Study on efficacy and safety of Dioscorea bublifera L. in treatment of Graves disease
    CUI Yifan, ZHANG Ruixiang, WEI Xiao, LIU Chao
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 273-277.   DOI: 10.16138/j.1673-6087.2024.04.11
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    Hyperthyroidism is most common in Graves disease (GD), and traditional antithyroid medicine are often difficult to achieve satisfactory efficacy, and high recurrence rate and long course of treatment are the most prominent problems. Huangyaozi(Dioscorea bublifera L.), a traditional Chinese medicine, has the effect of “Xiao Ying” and has been widely used in the treatment of GD in recent years, but long-term use may cause liver and kidney damage. Therefore, more research on the efficacy and safety of Huangyaozi need to be done in the treatment of GD.

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    Recent advances in diagnosis and treatment of subacute thyroiditis
    LI Yajie, CUI Dai
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 259-263.   DOI: 10.16138/j.1673-6087.2024.04.08
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    Subacute thyroiditis (SAT) is a common thyroid inflammatory disease that is frequently prone to misdiagnosis or underdiagnosis, which impact the quality of life for patients adversely. In this review, we summarize the pathogenesis, clinical manifestations, diagnosis, and treatment of SAT, aiming to improve clinician’s understanding of the disease.

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    Ultrasound features and clinical manifestations of two cases of thyroid metastatic cancer: pay attention to abnormal thyroid ultrasound spectrum
    LI Yuanyuan, DING Wenbo, JIANG Ziyu, CHEN Xi, LIU Binbin, CHEN Guofang, LIU Chao
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 254-258.   DOI: 10.16138/j.1673-6087.2024.04.07
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    Ultrasonography plays an important role in early screening of thyroid cancer. This article introduced two cases of thyroid metastatic carcinoma secondary to renal clear cell carcinoma and cervical squamous cell carcinoma respectively, analyzed their clinical diagnosis and treatment process, ultrasound characteristics, and prognosis, as well as reviewed the related literature. As atypical thyroid lesions were detected through the ultrasound spectrum in patients with a history of malignant tumors, it should be alert to the possibility of metastatic cancer. Ultrasound-guided core-needle biopsy combined with immunohistochemical testing can help early diagnosis and timely treatment.

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    Impact of maternal hyperthyroidism during pregnancy on neurological and psychiatric development of offspring
    YANG Ao, ZHANG Peiheng, ZHANG Yang, GAO Ying
    Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 269-272.   DOI: 10.16138/j.1673-6087.2024.04.10
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    Gestational hyperthyroidism can significantly increase health risks to both mother and fetal. However, there are few reports on its impact on the neuropsychological development of offspring. This article reviews the literature related to the effect of hyperthyroidism during pregnancy on brain structure, intelligence quotient (IQ) and neuropsychiatric disorders of offsprings. It was found that hyperthyroidism during pregnancy may be associated with reduced brain volume and cortical gray matter volume, lower IQ, and increase the risk of depression in offspring. However, its’ relationship with other mental and emotional well-being disorder of the offspring is unclear.

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    Molecular study of benign and malignant thyroid nodules
    LI Haorong, HAN Rulai, YU Danyan, YE Lei
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 266-269.   DOI: 10.16138/j.1673-6087.2023.04.011
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    Objective To establish a next-generation sequencing panel for the molecular diagnosis of thyroid nodules. Methods The panel, named ThyNod Panel, was designed to detect single nucleotide variant(SNV), indel, fusion, copy number variant (CNV) and RNA expression levels in 112 thyroid nodules associated genes, including benign and malignant molecular markers, thyroid differentiation or function genes and cell identity marker genes. Results The ThyNod Panel was successfully constructed and applied, and 856 benign or malignant thyroid nodules were completed sequencing. Totally 676 (79.0%) thyroid nodules were detected mutations. In 627 thyroid nodules with definite pathological diagnosis, 17.6% were benign nodules and 82.4% were malignant ones, in which malignant pathological types included classical papillary carcinoma, follicular variant papillary carcinoma, and medullary carcinoma. The most common mutant genes detected were BRAF (n=426), followed by RET (n=68), RET/PTC fusion (n=68), DICER1 (n=35), telomerase reverse transcriptase (TERT) (n=35), HRAS (n=24), NRAS (n=23), neurotrophin receptor kinase (NTRK3) fusion (n=19), and eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX) (n=11). The malignant percentage was counted for the detected mutations, and the malignant related variants such as BRAF V600E and RET fusion were higher than 90.0%, while the overall malignant percentage of RAS-like variants was only 18.9%. Conclusions ThyNod Panel can efficiently identify genetic characteristics in thyroid nodules and be applied in the molecular diagnosis of thyroid nodules.

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    Clinical and basic research on adrenal cortical carcinoma
    WU Luming, WANG Weiqing
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 234-238.   DOI: 10.16138/j.1673-6087.2023.04.004
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    Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 166-166.  
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    Diagnosis and treatment of primary hyperparathyroidism
    YANG Yuying, SUN Lihao, LIU Jianmin
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 297-300.   DOI: 10.16138/j.1673-6087.2023.04.018
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    Clinical diagnosis and treatment progress of hypoglycemia caused by non-islet cell tumors
    ZHANG Jie, LU Jieli
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 256-260.   DOI: 10.16138/j.1673-6087.2023.04.009
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    Relationship between serum uric acid and cognitive impairment
    LIN Weizhi, FU Yang, LUO Qi, CHEN Jie, MA Jianfang
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 278-283.   DOI: 10.16138/j.1673-6087.2023.04.013
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    Objective To explore the relationship between serum uric acid and cognitive impairment. Methods This was a community-based prospective study. The baseline population(2011) was enrolled from a cohort(≥50 years old) of normal people in Wuliqiao and Malu community in Shanghai. The endpoint was the cognitive function assessment results of the last follow-up (2016). Cognitive assessment was performed using mini-mental status examination(MMSE). The uric acid level of the study population was divided into four quartiles from low to high score (Q1-Q4) in both male and female. Logistic regression was used to analyze the relationship between serum uric acid and cognitive impairment. Results A total of 312 people with an average age of (68.36±6.45) years old were enrolled, and there were 124 males (39.7%). During 5-year follow-up, the total people with cognitive impairments was 43, and the incidence rate was 13.8%. After adjusting age, gender and other related risk factors, multivariate Logistic regression analysis showed that people with higher uric acid level (Q3) had higher risk of cognitive impairment than those with low uric acid level (Q1), with an odds ratio(OR) of 2.53 [95% confidence interval (CI): 0.91-7.02]. After age stratification (50-70 years old; 70-90 years old), no positive results were found. However, stratified by gender, it was found that men with the highest uric acid level(Q4) had a higher risk of cognitive impairment than those with the lowest uric acid level (Q1)(OR=18.60,95%CI: 1.26-274.13), while no positive results were found in women. Conclusions Higher uric acid levels, especially in men, might increase the risk of cognitive impairment in people over 50 years.

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    Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 158-158.  
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    Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 179-179.  
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    Research progress on molecular mechanism of primary aldosteronism
    JIANG Yiran, WANG Weiqing
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 261-265.   DOI: 10.16138/j.1673-6087.2023.04.010
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    New understanding of mechanism of Cushing’s disease
    ZHOU Weiwei, ZHENG Sichang, WANG Weiqing
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 247-250.   DOI: 10.16138/j.1673-6087.2023.04.007
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    Clinical efficacy of venetoclax combined with azacytidine in treatment of newly treated elderly patients with acute myeloid leukemia who were intolerant to intensive chemotherapy
    ZHAO Huijin, JIN Zhen, ZHANG Yunxiang, WU Min, ZHENG Yu, WU Wen, SHEN Yang, CHEN Qiusheng, LI Junmin, CHEN Yu
    Journal of Internal Medicine Concepts & Practice    2024, 19 (02): 89-94.   DOI: 10.16138/j.1673-6087.2024.02.01
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    Objective To investigate the clinical characteristics of 35 elderly patients with acute myeloid leukemia (AML) who were newly treated and intolerant to intensive chemotherapy and evaluate treatment efficacy and safety of venetoclax combined with azacytidine (VEN+AZA). Methods Between February 2021 and March 2022, 35 AML elderly patients who were intolerant to intensive therapy were enrolled in the study. They received VEN+AZA induction therapy. The disease characteristics, VEN+AZA induced remission and treatment safety were retrospectively analyzed and reported. Results The median age of enrolled patients was 68 year old, and there were 9 cases diagnosed with secondary AML. All patients completed bone marrow cytogenetic and molecular biology evaluation and were stratified by European LeukemiaNet (ELN) genetic risk classification. Thirty-five patients were classified as low risk group (10 of 35 cases), intermediate risk group (12 of 35 cases) and high risk group (13 of 35 cases). Common genetic mutations included DNA methyltransferase 3A (DNMT3A) (n=11), isocitrate dehydrogenase (IDH) 1/2 (n=11), ten-eleven translocation 2 (TET2) (n=9), NPM1 (n=8) and Fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) (n=6). The overall complete remission (CR) rate of treatment was 65.7% (n=23), and the CR rate of patients with mutation of NPM1, FLT3-ITD, IDH1/2 were 87.5%, 66.7% and 72.7%, respectively. The total negative rate of minimal residual disease (MRD) among CR patients was 73.9%, the median follow-up time was 10.1 months and median event-free survival (EFS) was 11.3 months. Among remission patients, MRD-negative patients had longer EFS and overall survival than MRD-positive patients(P<0.05). The early mortality rate was 5.7%. The most common adverse reaction during treatment was hematological toxicity (treatment-induced grade 3-4 neutropenia 31.4%, grade 3-4 thrombocytopenia 25.7%, febrile neutropenia 48.6%) and pulmonary infection (17.1%). Conclusions Our results showed that VEN+AZA has a higher overall response rate in newly treatment elderly AML who were intolerant to intensive chemotherapy, which was similar with the clinical trial results. NPM1 mutation might indicate higher CR rate. The EFS and OS of MRD-negative patients were longer than those of MRD-positive patients, and the risk of death was reduced. In summary, VEN+AZA regime was currently one of the most promising strategies for newly treated elderly AML who couldn’t tolerate intensive chemotherapy.

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    Therapy progress for acromegaly
    ZHENG Sichang, ZHOU Weiwei, WANG Weiqing
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 292-296.   DOI: 10.16138/j.1673-6087.2023.04.017
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    Research progress of cardiovascular damage in primary aldosteronism
    KE Yuya, GONG Yanchun
    Journal of Internal Medicine Concepts & Practice    2023, 18 (04): 301-304.   DOI: 10.16138/j.1673-6087.2023.04.019
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    Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 184-184.  
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