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Effects of FAK SiRNA On the Expression of Integrinα1,TGF-βR,FAK and α-SMA in Hypertrophic Scar Fibroblasts In Vitro
CHEN Rui,FAN Zhihong,FU Mingang,WANG Ling,PING Ping
2008, 4 (6):
320-322.
DOI: 10.3969/j.issn.1673-0364.2008.06.006
Objective Explore the effects of FAK SiRNA on the expression of integrin α1, TGF-βR, focal adhesive kinase (FAK) and α-smooth muscle actin (α-SMA) of hypertrophic scar fibroblasts. Methods After hypertrophic scar fibroblasts were transfected by FAK SiRNA, FQ-PCR assay was applied to detect the mRNA expression of integrin α1, TGF-βR, FAK, α-SMA. Results 48 hours after transfection the mRNA expression of integrin α1, TGF-βR, FAK, α-SMA was significantly lower than before transfection (P<0.05). Conclusion F...
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