Journal of Diagnostics Concepts & Practice ›› 2023, Vol. 22 ›› Issue (05): 413-420.doi: 10.16150/j.1671-2870.2023.05.001
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Received:
2023-10-23
Online:
2023-10-25
Published:
2024-03-15
CLC Number:
WANG Shukui, GU Xinliang. Advances in the study of tsRNA as diagnostic and prognostic biomarkers in cancer[J]. Journal of Diagnostics Concepts & Practice, 2023, 22(05): 413-420.
Table 1
Dysregulation of tsRNA in cancer and its related roles
tsRNA名称 | 癌症类型 | 表达 | 功能作用 | 参考文献 |
---|---|---|---|---|
5'tiRNA-His-GTG | 结直肠癌 | 上调 | 靶向LATS2抑制Hippo信号通路,促进增殖和抗凋亡相关基因的表达,促进结直肠癌进展 | [ |
5′-tiRNA-Val | 结直肠癌 | 上调 | 参与了血管生成素促进结直肠癌转移的过程 | [ |
tRF-20-MEJB5Y13 | 结直肠癌 | 上调 | 在缺氧条件下由Dicer1诱导产生,增强结直肠癌细胞的迁移和侵袭能力 | [ |
tRF-3022b | 结直肠癌 | 上调 | 与半乳糖凝集素1和巨噬细胞迁移抑制因子结合,通过调节M2巨噬细胞中的MIF降低极化并影响结直肠癌的生长 | [ |
tRF-19-3L7L73JD | 胃癌 | 下调 | 将胃癌细胞周期阻滞在G0/G1期,诱导细胞凋亡,抑制胃癌细胞增殖和迁移 | [ |
tRF-24-V29K9UV3IU | 胃癌 | 下调 | 调控Wnt信号通路,抑制胃癌细胞的增殖和转移能力 | [ |
tRF-5026a | 胃癌 | 下调 | 调节PTEN/PI3K/AKT信号通路,上调tRF-5026a可以抑制胃癌细胞的增殖和转移 | [ |
tRF-Val | 胃癌 | 上调 | 与EEF1A1结合,介导其转运入核,促进其与一种特异性的p53 E3泛素连接酶相互作用,从而抑制p53下游分子通路,促进胃癌的恶性进展 | [ |
缺氧应激诱导产生的tRF | 乳腺癌 | 下调 | 与YBX1结合,降低YBX1内源性致癌转录本的稳定性,抑制乳腺癌的进展 | [ |
5'-tiRNAVal | 乳腺癌 | 下调 | 与FZD3结合,抑制FZD3/Wnt/β-Catenin信号通路,抑制乳腺癌的进展 | [ |
tRFdb-5024a、5P_tRNA-Leu-CAA-4-1 和 ts-49 | 乳腺癌 | 下调 | 促进乳腺癌的免疫治疗,为乳腺癌治疗提供新的靶点,提高乳腺癌中免疫治疗的水平 | [ |
ts-34 和 ts-58 | 上调 |
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