胆汁酸与肠道菌群的相互作用及对脓毒症的影响

doi:10.16138/j.1673-6087.2024.03.11

摘要/Abstract

摘要：

大量微生物寄居在人体肠道内，参与营养物质的消化和吸收，并产生大量代谢产物，参与调解宿主功能，保护宿主免受疾病损伤。胆汁酸由胆固醇代谢产生，经肠道菌群代谢转化为次级胆汁酸。胆汁酸有助于脂质消化吸收，与肠道菌群相互作用，同时肠道菌群的组成和数量也调控胆汁酸代谢。在脓毒症发生时，肠道菌群和胆汁酸代谢紊乱，与脓毒症的不良预后相关。本文阐述了胆汁酸的代谢过程、胆汁酸与肠道菌群的相互作用、脓毒症期间肠道菌群与胆汁酸的变化，为脓毒症的防治提供新思路。

关键词: 胆汁酸, 肠道菌群, 脓毒症, 代谢组学, 细胞因子

Abstract:

Numerous microorganisms inhabit the human intestine, participate in the digestion and absorption of nutrients, and produce a large number of metabolites, participate in regulating functions and protect the host from disease damage. Bile acids are produced by cholesterol metabolism and metabolized by the gut microbiota into secondary bile acids. Bile acids facilitate lipid digestion and absorption and interact with the gut microbiota. The composition and quantity of the gut microbiota also regulate bile acid metabolism. As sepsis occurs, the poor prognosis of the disease is associated with disturbances of the gut microbiota and bile acid metabolism. This paper reviews the metabolic process of bile acids, the interaction between bile acids and the gut microbiota, and the changes of gut microbiota and bile acids during sepsis, to provide new ideas for the prevention and treatment of sepsis.

Key words: Bile acids, Gut microbiota, Sepsis, Metabolomics, Cytokine

中图分类号:

R575
R631

杨瑾, 韦瑶, 金钧. 胆汁酸与肠道菌群的相互作用及对脓毒症的影响[J]. 内科理论与实践, 2024, 19(03): 207-211.

YANG Jin, WEI Yao, JIN Jun. Interaction of bile acids with the gut microbiota and their effects on sepsis[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(03): 207-211.

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