Role of gut microbiota in mediating metabolic and cardiovascular abnormalities in patients with obstructive sleep apnea and related mechanisms

doi:10.16138/j.1673-6087.2024.02.08

Abstract

Abstract:

Obstructive sleep apnea (OSA) is a common sleep disorder characterized by intermittent hypoxia and sleep fragmentation, which is closely associated with the development of hypertension, atherosclerosis, insulin resistance and other metabolic diseases. A lot of studies have found that OSA can cause the disturbance of gut microbiota and affect human health. This paper reviews the possible mechanisms of gut microbiota disturbance and related metabolic and cardiovascular changes caused by OSA in clinical trials and animal models, and the new complementary therapies derived from them. The aim of the paper is to use gut microbiota as an entry point to re-understand the relationship between OSA and metabolic and cardiovascular abnormalities, and provides new ideas for early intervention of OSA and related complications.

Key words: Obstructive sleep apnea, Gut microbiota, Hypertension, Atherosclerosis, Diabetes mellitus

CLC Number:

R563.5

ZHU Xiaowen, WANG Hongchao, WU Wenjun. Role of gut microbiota in mediating metabolic and cardiovascular abnormalities in patients with obstructive sleep apnea and related mechanisms[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(02): 130-135.

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