Most Down Articles

Published in last 1 year | In last 2 years| In last 3 years| All| Most Downloaded in Recent Month | Most Downloaded in Recent Year|

In last 2 years

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Value of serum N-terminal pro-brain natriuretic peptide levels in primary screening peritoneal dialysis patients with volume overload LI Hua, HUANG Xiaomin, ZHANG Chunyan, DU Lu, REN Hong, XU Tian Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 157-164.   DOI: 10.16138/j.1673-6087.2023.03.005 Abstract （705）   HTML （1）    PDF（pc） （845KB）（1447）       Knowledge map    Save Objective To explore the relationship between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level and hydration status and cardiac function indexes in the patients receiving peritoneal dialysis(PD) treatment，and to further analyze the factors affecting the level of NT-proBNP. Methods A total of 111 patients with PD who were followed up in the PD Center of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from May 2019 to January 2022 were enrolled and the data was analyzed retrospectively. According to the results of multi-frequency bioelectrical impedance body composition monitor (BCM), relative hydration status (DHS), the ratio obtained through dividing extracellular water (ECW) by overhydration (OH), the patients were divided into normal volume group (OH/ECW≤15%) and overhydration group (OH/ECW>15%). The relationship between serum NT-proBNP level and hydration status in two groups was compared, and the related factors affecting the level of NT-proBNP were further analyzed and discussed. Using BCM result as the“gold standard”, the receiver operator characteristic curve(ROC curve) determined the optimal threshold of NT-proBNP as the capacity was overloaded. The patients were divided into two groups according to NT-proBNP and their clinical data were compared. Results The indexes including systolic blood pressure, urine volume, urea clearance index (Kt/V), creatinine clearance rate(CCr), dialysate to plasma ratio for urea at 4 hours(4hD/PCr), types of antihypertensive drugs, type of diuretic, hemoglobin, serum albumin, log2(NT-proBNP), interventricular septal thickness (IVST), left ventricular posterior wall thickness(LVPWT), left atrial diameter(LAD), OH, TBW, ECW, OH/TBW, ECW/TBW and ECW/ICW were detected in volume overload group and normal volume group, and showed statistically significant (all P<0.05). log2(NT-proBNP) level was correlated with systolic blood pressure, dialysis duration, ultrafiltration volume, dialysis dose, antihypertensive drug group, IVST, LVPWT, LAD, left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic dimension (LVEDD), OH, OH/ECW were positively correlated (all P<0.05). It was negatively correlated with urine volume, Kt/V, CCr, normalized protein catabolic rate (nPCR), hemoglobin, serum albumin and LVEF (all P<0.05). NT-proBNP 4 896 ng/L could be used as the critical value of initial screening capacity overload and was applied to divide the patients into two groups, and the systolic blood pressure, urine volume, ultrafiltration volume, Kt/V, CCr, IVST, LVPWT, OH/ECW indicators showed significant differences (all P<0.05) in two groups. Conclusions The level of NT-proBNP in PD patients is generally increased, and it indicates volume overload as its value is greater than 4 896 ng/L, which can be used as a simple monitoring index for the preliminary judgment of volume overload in PD patients. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Advances in human respiratory microbiome and detection techniques WU Wenjuan, TIAN Wenjie Journal of Internal Medicine Concepts & Practice    2024, 19 (01): 37-42.   DOI: 10.16138/j.1673-6087.2024.01.07 Abstract （239）   HTML （6）    PDF（pc） （909KB）（1308）       Knowledge map    Save Human respiratory microbiome has great diversity and heterogeneity in healthy and diseased states, rapid and accurate microbial detection is the key to distinguish respiratory tract infection from non-infection. In recent years, new detection technologies represented by metagenomic technology have developed rapidly in the field of pathogen diagnosis, which improves the detection rate of pathogenic microorganisms, and also makes great breakthroughs in analyzing human host reaction and predicting drug resistance. This article reviews the research progress and achievements of molecular technology in the respiratory microbiome, inspiring readers to think about the development and clinical transformation of new technologies in the future, aiming to explore therapeutic strategies for respiratory diseases based on the respiratory microbiome. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Research progress on pathogenesis of diabetic nephropathy BI Liming, WANG Zhaohui Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 201-205.   DOI: 10.16138/j.1673-6087.2023.03.014 Abstract （1183）   HTML （34）    PDF（pc） （501KB）（822）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

Select

Advances in study of PCSK9 inhibitors in treatment of non-alcoholic fatty liver disease SHEN Yun, XU Yijiao, WEI Xiao, ZHANG Ruixiang, LIU Chao Journal of Internal Medicine Concepts & Practice    2024, 19 (02): 136-139.   DOI: 10.16138/j.1673-6087.2024.02.09 Abstract （229）   HTML （8）    PDF（pc） （842KB）（775）       Knowledge map    Save Non-alcoholic fatty liver disease (NAFLD) is the chronic liver disease with the highest incidence rate, and its main cause is due to disorders of lipid metabolism and damage to the liver caused by ectopic fat deposition. Proprotein convertase bacillus subtilis/ kexin type 9 (PCSK9), as a lipid-regulating protease in vivo, plays a key role in abnormal lipid metabolism. Dyslipidemia levels can be significantly improved by inhibiting PCSK9 binding to receptors circulating in vivo. Therefore, PCSK9 inhibitors may improve the condition of NAFLD patients and achieve therapeutic effects. Reference | Related Articles | Metrics | Comments（0）

Select

Bioinformatics analysis and identification of cuproptosis characteristic genes for acute pancreatitis by machine learning WANG Zhuoxin, HUANG Xinyang, JIN Yixun, WANG Lifu Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 224-230.   DOI: 10.16138/j.1673-6087.2024.04.02 Abstract （199）   HTML （14）    PDF（pc） （1760KB）（720）       Knowledge map    Save Objective To discover the characteristic genes of cuproptosis in acute pancreatitis (AP). Methods The expression of cuproptosis-related genes (CRG) in the GSE1943 dataset was extracted and performed differential analysis and immune cell correlation analysis. The different subtypes were classified according to the expression of CRG, and metabolic pathway enrichment was performed using gene set variation analysis. Four machine learning algorithms, including generalized linear models, random forest, support vector machine and extreme gradient boosting were used to screen disease characteristic genes. Results A total of 13 CRG were differentially expressed in AP (P<0.05), and CRG were not only correlated to each other in different degrees, but also had correlation with multiple immune cells (P<0.05). There were four immune-related pathways among the two subtypes obtained by cluster analysis, in which the T-cell receptor signaling pathway was noteworthy. Further analysis revealed significant difference between the two subtypes of multiple T cells (P<0.05). Each machine learning algorithm screened out five characteristic genes, and dihydrolipoamide dehydrogenase (DLD) was obtained as the next target of research. Conclusions CRG-based machine learning and bioinformatics analyses could be used to explore CRG in AP to discover potential biomarkers. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Progress in treatment of adult acute lymphoblastic leukemia LIU Wenhui, WU Tao, ZHANG Xi Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 201-206.   DOI: 10.16138/j.1673-6087.2024.03.10 Abstract （292）   HTML （9）    PDF（pc） （917KB）（671）       Knowledge map    Save Acute lymphoblastic leukemia (ALL) is a hematological malignancy with abnormal proliferation of primitive naive lymphocytes and inhibition of normal hematopoiesis. It originates from B-lineage or T-lineage lymphoid progenitor cells, accounting for 20%-30% of adult acute leukemia. Although the complete remission rate of newly diagnosed adult ALL patients after multi-drug combination chemotherapy can reach more than 80%, most of the patients still show relapse and refractory. The 5-year long term survival rate in the patients is only 20%-40% and the clinical characteristics and prognosis are quite different. In recent years, with the advent of targeted drugs, immunotherapy, and chimeric antigen receptor (CAR) -T cell therapy, the clinical outcomes of adult ALL patients have been greatly improved. This article reviews the current progress of new therapeutic drugs for adult ALL in detail. Reference | Related Articles | Metrics | Comments（0）

Select

Therapeutic effect of theta burst transcranial magnetic stimulation combined with speech training on aphasia after stroke ZENG Zhen, LU Chunhua, WANG Kai, ZHANG Qin Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 231-235.   DOI: 10.16138/j.1673-6087.2024.04.03 Abstract （124）   HTML （2）    PDF（pc） （3195KB）（613）       Knowledge map    Save Objective Analyzing the clinical treatment efficacy of continuous theta burst stimulation (cTBS), theta burst stimulation (TBS) combined with speech training on post stroke aphasia (PSA). Methods In this study, 90 PSA patients admitted to our hospital from February 2022 to January 2023 were divided into three groups according to different treatment methods, each 30 cases in each group. The basic group was given speech training, the observation group 1 was given cTBS combined speech training, and the observation group 2 was given iTBS combined speech training. The clinical efficacy, western aphasia battery (WAB) score, view naming test results, Boston diagnostic aphasia examination (BDAE) rating, stroke aphasia quality of life scale (SAQOL-39g) score were compared among the three groups. Results The total clinical effective rate (96.67%, 93.33%) in observation group 1 and observation group 2 were higher than that in basic group (60.00%) (P<0.05). After treatment, WAB score and correct number of view naming test in observation group 1 and observation group 2 were higher than those in basic group (P<0.05). The reaction time of view naming test in observation group 1 and observation group 2 were shorter than that in basic group (P<0.05). The improvement degree of BDAE grade in observation group 1 and observation group 2 after treatment were better than that in basic group (P<0.05). The SAQOL-39g score in observation group 1 and observation group 2 after treatment was higher than that in basic group (P<0.05). The total clinical response rate, WAB score after treatment, correct number of view naming tests, response time, improvement effect of BDAE classification, and SAQOL-39g score didn’t show significant difference between observation group 1 and group 2 (P>0.05). Conclusions Both cTBS and iTBS combined speech training can improve aphasia symptoms, view naming ability and quality of life in PSA patients. The clinical efficacy of them is comparable, and both are better than single speech training. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

An update on complement targeted treatment of IgA nephropathy ZHANG Huijian, LI Guisen Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 197-200.   DOI: 10.16138/j.1673-6087.2023.03.013 Abstract （743）   HTML （16）    PDF（pc） （481KB）（557）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Research progress of chronic kidney injury in primary aldosteronism LAI Liqin, GONG Yanchun Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 211-214.   DOI: 10.16138/j.1673-6087.2023.03.016 Abstract （544）   HTML （9）    PDF（pc） （423KB）（556）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

Select

Progress in treatment of activated phosphoinositide 3-kinase δ syndrome WU Tao, LIU Wenhui Journal of Internal Medicine Concepts & Practice    2024, 19 (02): 140-143.   DOI: 10.16138/j.1673-6087.2024.02.10 Abstract （269）   HTML （3）    PDF（pc） （904KB）（550）       Knowledge map    Save Phosphoinositide 3-kinase δ (PI3Kδ) activated phosphoinositide 3-kinase δ syndrome (APDS) was first reported in 2013. APDS is an autosomal dominant primary immunodeficiency disease (PID) caused by mutations in the PIK3CD gene or PIK3R1 gene. The clinical manifestations of APDS are recurrent respiratory tract infection, non-neoplastic lymphoid hyperplasia, autoimmune diseases and lymphoma. In this paper, the treatment of APDS is introduced in detail. In addition to conventional treatment for immunodeficiency, treatment such as antimicrobial prophylaxis, immunoglobulin replacement therapy and hematopoietic stem cell transplantation were reviewed, and more specific mammalian target of rapamycin (mTOR) inhibitors and PI3Kδ inhibitors were also discussed. Reference | Related Articles | Metrics | Comments（0）

Select

Is severe pneumonia ARDS? HE Quanying Journal of Internal Medicine Concepts & Practice    2024, 19 (01): 19-24.   DOI: 10.16138/j.1673-6087.2024.01.04 Abstract （292）   HTML （14）    PDF（pc） （853KB）（517）       Knowledge map    Save The acute respiratory distress syndrome (ARDS) is an acute hypoxic respiratory insufficiency caused by severe infection, shock, trauma and burns. It is easily confused with severe pneumonia combined with hypoxemia and severe COVID-19 pneumonia. In this paper, the concept, pathogenesis, pathological changes, pathophysiology and definition of ARDS were discussed, and the similarities and differences between ARDS and severe pneumonia combined with hypoxemia or severe COVID-19 pneumonia were analyzed and conducted in-depth interpretation. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Discussion on management models in patients with chronic respiratory diseases YANG Linglin, CHEN Yujie, WANG Yi, et al Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 192-196.   DOI: 10.16138/j.1673-6087.2023.03.012 Abstract （307）   HTML （2）    PDF（pc） （725KB）（481）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Interaction of bile acids with the gut microbiota and their effects on sepsis YANG Jin, WEI Yao, JIN Jun Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 207-211.   DOI: 10.16138/j.1673-6087.2024.03.11 Abstract （333）   HTML （5）    PDF（pc） （850KB）（466）       Knowledge map    Save Numerous microorganisms inhabit the human intestine, participate in the digestion and absorption of nutrients, and produce a large number of metabolites, participate in regulating functions and protect the host from disease damage. Bile acids are produced by cholesterol metabolism and metabolized by the gut microbiota into secondary bile acids. Bile acids facilitate lipid digestion and absorption and interact with the gut microbiota. The composition and quantity of the gut microbiota also regulate bile acid metabolism. As sepsis occurs, the poor prognosis of the disease is associated with disturbances of the gut microbiota and bile acid metabolism. This paper reviews the metabolic process of bile acids, the interaction between bile acids and the gut microbiota, and the changes of gut microbiota and bile acids during sepsis, to provide new ideas for the prevention and treatment of sepsis. Reference | Related Articles | Metrics | Comments（0）

Select

Progress in diagnosis and treatment of obliterated bronchiolitis after lung transplantation ZHU Haixing, ZHOU Min Journal of Internal Medicine Concepts & Practice    2024, 19 (01): 72-76.   DOI: 10.16138/j.1673-6087.2024.01.13 Abstract （275）   HTML （3）    PDF（pc） （922KB）（445）       Knowledge map    Save Bronchiolitis obliterans syndrome（BOS） is the most common non-infectious form of chronic lung allograft dysfunction. In recent years, diagnosis methods such as screening studies of lung function in the early 0p stage of the disease, small airway reconstruction techniques with thin-layer CT scan images, 3He-MRI and other imaging examination technique, and bronchoalveolar lavage-derived biomarkers are used, to make the understanding BOS to improve a lot. In terms of therapeutic strategies, many promising treatment modalities such as prophylactic azithromycin use, lung re-transplantation, and umbilical cord blood-derived mesenchymal stem cells have been applied. These advances in diagnostic methods and therapeutic strategies for occlusive bronchiolitis obliterans syndromes provide more theoretical references and insights into the early monitoring and management of the development of the disease. Reference | Related Articles | Metrics | Comments（0）

Select

Clinical significance of plasma peak concentration determination of compound sulfamethoxazole in treatment of Pneumocystis jirovecii pneumonia in patients with non-human immunodeficiency virus infection SHU Yang, HE Xiaoshuang, $\boxed{\hbox{CHEN Hong}}$, SHI Guochao, FANG Jie Journal of Internal Medicine Concepts & Practice    2024, 19 (01): 51-56.   DOI: 10.16138/j.1673-6087.2024.01.09 Abstract （244）   HTML （10）    PDF（pc） （982KB）（420）       Knowledge map    Save Objective To explore the significance of monitoring the blood peak concentration of sulfamethoxazole (SMZ) to learn the efficacy and safety of compound SMZ (SMZco) tablets in the treatment of Pneumocystis jirovecii pneumonia (PJP) in patients with non-human immunodeficiency virus (HIV). Methods Clinical data of PJP infected patients with non-HIV hospitalized in Ruijin Hospital, from January 2019 to May 2023 were enrollled, and the relationship between the peak plasma concentration of SMZ and the efficacy and occurrence of adverse reactions was retrospectively analyzed. Results A total of 47 patients were included in this study. The peak plasma concentration of SMZ ranged from 87.49 mg/L to 334.31 mg/L, the median (interquartile distance) was 168.62 (79.72) mg/L, and the peak plasma concentration in 64% of patients was >150 mg/L. The 30-day all-cause mortality of the patients was 28%，and the positive response rate was 66%. Among them, there was no statistical difference in 30-day all-cause death and treatment positive response rate between the patients with peak concentration ≤150 mg/L and the patients with peak concentration of SMZ >150 mg/L. In terms of safety, a total of 29 (62%) patients showed adverse reactions. The incidence of thrombocytopenia (40% vs 6%, P=0.025), decreased hemoglobin (37% vs 0, P=0.013) and serious adverse reactions (43% vs 12%, P=0.026) were higher in the patients with SMZ peak concentration >150 mg/L than those in the patients with SMZ peak concentration <150 mg/L. The incidence of serious adverse reactions was higher in the patients with a peak concentration of SMZco >150 mg/L. Conclusions The results of the study showed that as SMZco tablets were used in the treatment of non-HIV patients infected with PJP, those with a peak plasma concentration ≤150 mg/L of SMZ could achieve comparable efficacy, and their risk of serious adverse reactions was less than that of the patients with a peak plasma concentration >150 mg/L. It is suggested that the plasma peak concentration of SMZ should be monitored regularly. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Salt diet assessment in community residents with salt-sensitive hypertension YUAN Xinyan, GONG Yanchun Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 197-200.   DOI: 10.16138/j.1673-6087.2024.03.09 Abstract （215）   HTML （3）    PDF（pc） （839KB）（415）       Knowledge map    Save Salt sensitivity has been proven to be closely related to the occurrence and development of hypertension, and high salt intake is one of the important risk factors for hypertension in community residents. This article provides a literature review of domestical and international research, introducing the relationship between salt sensitivity and hypertension, the current state of salt intake in the diet of community residents, application and effect of a salt-restricted dietary pattern, the different evaluation method of salt intake, and the application of multiple theoretical models in the assessment of salt intake. The article points out the importance of salt restriction dietary behavior of community residents in the prevention and treatment of hypertension. Therefore, it is crucial to investigate and evaluate the current status of salt-restricted diets in order to help to form a good habit and promote healthy behaviors among community residents. Reference | Related Articles | Metrics | Comments（0）

Select

Application of lipid-modulating drugs in treatment of non-alcoholic fatty liver disease ZHANG Ruixiang, SUN Shuoshuo, WEI Xiao, et al Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 215-220.   DOI: 10.16138/j.1673-6087.2023.03.017 Abstract （309）   HTML （8）    PDF（pc） （710KB）（411）       Knowledge map    Save Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Importance of drug monitoring for compound sulfamethoxazole therapy in patients with Pneumocystis jiroveci pneumonia FANG Jie, CHEN Chao, ZHOU Min Journal of Internal Medicine Concepts & Practice    2024, 19 (01): 31-35.   DOI: 10.16138/j.1673-6087.2024.01.06 Abstract （377）   HTML （8）    PDF（pc） （1413KB）（402）       Knowledge map    Save Pneumocystis jiroveci pneumonia (PJP) is one of the more common and serious opportunistic infections in patients with human immunodeficiency virus (HIV). With the use of immunosuppressants and chemotherapy drugs, most PJP cases reported in China are non-HIV immunosuppressed patients. Compound sulfamethoxazole (SMZco) is the first-line drug for the treatment of PJP, and there are wide individual differences in its pharmacokinetics. Through citing a PJP case treated with SMZco under drug monitoring, a systematic review was conducted from the aspects of SMZco pharmacokinetics, dose-related adverse reactions, and optimal therapeutic dose research. It aims to demonstrate the importance of drug monitoring for sulfamethoxazole therapy, which ensures the drug reaches effective therapeutic concentrations and the occurrence of its’ adverse reactions was reduced. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Investigation of serum uric acid level in adult patients and analysis of related influencing factors LUO Yadan, YUAN Liying, LU Yide, WANG Ziqiu, WANG Zhaohui Journal of Internal Medicine Concepts & Practice    2023, 18 (03): 141-145.   DOI: 10.16138/j.1673-6087.2023.03.002 Abstract （768）   HTML （17）    PDF（pc） （567KB）（400）       Knowledge map    Save Objective To investigate the distribution characteristics of hyperuricemia(HUA) and related influencing factors among the adult patients in Ruijin Hospital, and provide the clinical reference for prevention and treatment of HUA. Methods A retrospective study of serum uric acid was carried out on 47 100 people in Ruijin Hospital in June 2018, who were over 18 years old. Among them, 27 091 were males and 20 009 were females. The value of serum uric acid and distribution in different gender, age groups and clinical departments were studied. Results The total detection rate of HUA was 20.26%; it was 22.82% in male, and it was 16.88% in females. The serum uric acid level was negatively correlated with age in males, and females (≤50 years) (P<0.05), while it was positively correlated with female over 50 years (P<0.05). The high incidence age groups were 18-30 years in male, and in women over 71 years(P<0.05). Three departments with the highest HUA detection rate were the departments of nephrology, cardiac surgery outpatient and hypertension outpatient. Conclusions The detection rate of HUA in the study was high. The overall blood uric acid level in men was higher than that in women. The blood uric acid level in men gradually decreased with age, and the blood uric acid level in women showed a trend of decreasing and then increasing. Learning the distribution characteristics of uric acid in population could give help in strengthening education and prevention work in the susceptible population. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

Select

Clinical efficacy of venetoclax combined with azacytidine in treatment of newly treated elderly patients with acute myeloid leukemia who were intolerant to intensive chemotherapy ZHAO Huijin, JIN Zhen, ZHANG Yunxiang, WU Min, ZHENG Yu, WU Wen, SHEN Yang, CHEN Qiusheng, LI Junmin, CHEN Yu Journal of Internal Medicine Concepts & Practice    2024, 19 (02): 89-94.   DOI: 10.16138/j.1673-6087.2024.02.01 Abstract （462）   HTML （13）    PDF（pc） （996KB）（368）       Knowledge map    Save Objective To investigate the clinical characteristics of 35 elderly patients with acute myeloid leukemia (AML) who were newly treated and intolerant to intensive chemotherapy and evaluate treatment efficacy and safety of venetoclax combined with azacytidine (VEN+AZA). Methods Between February 2021 and March 2022, 35 AML elderly patients who were intolerant to intensive therapy were enrolled in the study. They received VEN+AZA induction therapy. The disease characteristics, VEN+AZA induced remission and treatment safety were retrospectively analyzed and reported. Results The median age of enrolled patients was 68 year old, and there were 9 cases diagnosed with secondary AML. All patients completed bone marrow cytogenetic and molecular biology evaluation and were stratified by European LeukemiaNet (ELN) genetic risk classification. Thirty-five patients were classified as low risk group (10 of 35 cases), intermediate risk group (12 of 35 cases) and high risk group (13 of 35 cases). Common genetic mutations included DNA methyltransferase 3A (DNMT3A) (n=11), isocitrate dehydrogenase (IDH) 1/2 (n=11), ten-eleven translocation 2 (TET2) (n=9), NPM1 (n=8) and Fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) (n=6). The overall complete remission (CR) rate of treatment was 65.7% (n=23), and the CR rate of patients with mutation of NPM1, FLT3-ITD, IDH1/2 were 87.5%, 66.7% and 72.7%, respectively. The total negative rate of minimal residual disease (MRD) among CR patients was 73.9%, the median follow-up time was 10.1 months and median event-free survival (EFS) was 11.3 months. Among remission patients, MRD-negative patients had longer EFS and overall survival than MRD-positive patients（P<0.05）. The early mortality rate was 5.7%. The most common adverse reaction during treatment was hematological toxicity (treatment-induced grade 3-4 neutropenia 31.4%, grade 3-4 thrombocytopenia 25.7%, febrile neutropenia 48.6%) and pulmonary infection (17.1%). Conclusions Our results showed that VEN+AZA has a higher overall response rate in newly treatment elderly AML who were intolerant to intensive chemotherapy, which was similar with the clinical trial results. NPM1 mutation might indicate higher CR rate. The EFS and OS of MRD-negative patients were longer than those of MRD-positive patients, and the risk of death was reduced. In summary, VEN+AZA regime was currently one of the most promising strategies for newly treated elderly AML who couldn’t tolerate intensive chemotherapy. Table and Figures | Reference | Related Articles | Metrics | Comments（0）