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Bioinformatics analysis and identification of cuproptosis characteristic genes for acute pancreatitis by machine learning WANG Zhuoxin, HUANG Xinyang, JIN Yixun, WANG Lifu Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 224-230.   DOI: 10.16138/j.1673-6087.2024.04.02 Abstract （199）   HTML （14）    PDF（pc） （1760KB）（720）       Knowledge map    Save Objective To discover the characteristic genes of cuproptosis in acute pancreatitis (AP). Methods The expression of cuproptosis-related genes (CRG) in the GSE1943 dataset was extracted and performed differential analysis and immune cell correlation analysis. The different subtypes were classified according to the expression of CRG, and metabolic pathway enrichment was performed using gene set variation analysis. Four machine learning algorithms, including generalized linear models, random forest, support vector machine and extreme gradient boosting were used to screen disease characteristic genes. Results A total of 13 CRG were differentially expressed in AP (P<0.05), and CRG were not only correlated to each other in different degrees, but also had correlation with multiple immune cells (P<0.05). There were four immune-related pathways among the two subtypes obtained by cluster analysis, in which the T-cell receptor signaling pathway was noteworthy. Further analysis revealed significant difference between the two subtypes of multiple T cells (P<0.05). Each machine learning algorithm screened out five characteristic genes, and dihydrolipoamide dehydrogenase (DLD) was obtained as the next target of research. Conclusions CRG-based machine learning and bioinformatics analyses could be used to explore CRG in AP to discover potential biomarkers. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Progress in treatment of adult acute lymphoblastic leukemia LIU Wenhui, WU Tao, ZHANG Xi Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 201-206.   DOI: 10.16138/j.1673-6087.2024.03.10 Abstract （292）   HTML （9）    PDF（pc） （917KB）（671）       Knowledge map    Save Acute lymphoblastic leukemia (ALL) is a hematological malignancy with abnormal proliferation of primitive naive lymphocytes and inhibition of normal hematopoiesis. It originates from B-lineage or T-lineage lymphoid progenitor cells, accounting for 20%-30% of adult acute leukemia. Although the complete remission rate of newly diagnosed adult ALL patients after multi-drug combination chemotherapy can reach more than 80%, most of the patients still show relapse and refractory. The 5-year long term survival rate in the patients is only 20%-40% and the clinical characteristics and prognosis are quite different. In recent years, with the advent of targeted drugs, immunotherapy, and chimeric antigen receptor (CAR) -T cell therapy, the clinical outcomes of adult ALL patients have been greatly improved. This article reviews the current progress of new therapeutic drugs for adult ALL in detail. Reference | Related Articles | Metrics | Comments（0）

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Therapeutic effect of theta burst transcranial magnetic stimulation combined with speech training on aphasia after stroke ZENG Zhen, LU Chunhua, WANG Kai, ZHANG Qin Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 231-235.   DOI: 10.16138/j.1673-6087.2024.04.03 Abstract （124）   HTML （2）    PDF（pc） （3195KB）（613）       Knowledge map    Save Objective Analyzing the clinical treatment efficacy of continuous theta burst stimulation (cTBS), theta burst stimulation (TBS) combined with speech training on post stroke aphasia (PSA). Methods In this study, 90 PSA patients admitted to our hospital from February 2022 to January 2023 were divided into three groups according to different treatment methods, each 30 cases in each group. The basic group was given speech training, the observation group 1 was given cTBS combined speech training, and the observation group 2 was given iTBS combined speech training. The clinical efficacy, western aphasia battery (WAB) score, view naming test results, Boston diagnostic aphasia examination (BDAE) rating, stroke aphasia quality of life scale (SAQOL-39g) score were compared among the three groups. Results The total clinical effective rate (96.67%, 93.33%) in observation group 1 and observation group 2 were higher than that in basic group (60.00%) (P<0.05). After treatment, WAB score and correct number of view naming test in observation group 1 and observation group 2 were higher than those in basic group (P<0.05). The reaction time of view naming test in observation group 1 and observation group 2 were shorter than that in basic group (P<0.05). The improvement degree of BDAE grade in observation group 1 and observation group 2 after treatment were better than that in basic group (P<0.05). The SAQOL-39g score in observation group 1 and observation group 2 after treatment was higher than that in basic group (P<0.05). The total clinical response rate, WAB score after treatment, correct number of view naming tests, response time, improvement effect of BDAE classification, and SAQOL-39g score didn’t show significant difference between observation group 1 and group 2 (P>0.05). Conclusions Both cTBS and iTBS combined speech training can improve aphasia symptoms, view naming ability and quality of life in PSA patients. The clinical efficacy of them is comparable, and both are better than single speech training. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Interaction of bile acids with the gut microbiota and their effects on sepsis YANG Jin, WEI Yao, JIN Jun Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 207-211.   DOI: 10.16138/j.1673-6087.2024.03.11 Abstract （333）   HTML （5）    PDF（pc） （850KB）（466）       Knowledge map    Save Numerous microorganisms inhabit the human intestine, participate in the digestion and absorption of nutrients, and produce a large number of metabolites, participate in regulating functions and protect the host from disease damage. Bile acids are produced by cholesterol metabolism and metabolized by the gut microbiota into secondary bile acids. Bile acids facilitate lipid digestion and absorption and interact with the gut microbiota. The composition and quantity of the gut microbiota also regulate bile acid metabolism. As sepsis occurs, the poor prognosis of the disease is associated with disturbances of the gut microbiota and bile acid metabolism. This paper reviews the metabolic process of bile acids, the interaction between bile acids and the gut microbiota, and the changes of gut microbiota and bile acids during sepsis, to provide new ideas for the prevention and treatment of sepsis. Reference | Related Articles | Metrics | Comments（0）

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Salt diet assessment in community residents with salt-sensitive hypertension YUAN Xinyan, GONG Yanchun Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 197-200.   DOI: 10.16138/j.1673-6087.2024.03.09 Abstract （215）   HTML （3）    PDF（pc） （839KB）（415）       Knowledge map    Save Salt sensitivity has been proven to be closely related to the occurrence and development of hypertension, and high salt intake is one of the important risk factors for hypertension in community residents. This article provides a literature review of domestical and international research, introducing the relationship between salt sensitivity and hypertension, the current state of salt intake in the diet of community residents, application and effect of a salt-restricted dietary pattern, the different evaluation method of salt intake, and the application of multiple theoretical models in the assessment of salt intake. The article points out the importance of salt restriction dietary behavior of community residents in the prevention and treatment of hypertension. Therefore, it is crucial to investigate and evaluate the current status of salt-restricted diets in order to help to form a good habit and promote healthy behaviors among community residents. Reference | Related Articles | Metrics | Comments（0）

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Study on efficacy and safety of Dioscorea bublifera L. in treatment of Graves disease CUI Yifan, ZHANG Ruixiang, WEI Xiao, LIU Chao Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 273-277.   DOI: 10.16138/j.1673-6087.2024.04.11 Abstract （1426）   HTML （1）    PDF（pc） （955KB）（367）       Knowledge map    Save Hyperthyroidism is most common in Graves disease (GD), and traditional antithyroid medicine are often difficult to achieve satisfactory efficacy, and high recurrence rate and long course of treatment are the most prominent problems. Huangyaozi（Dioscorea bublifera L.）, a traditional Chinese medicine, has the effect of “Xiao Ying” and has been widely used in the treatment of GD in recent years, but long-term use may cause liver and kidney damage. Therefore, more research on the efficacy and safety of Huangyaozi need to be done in the treatment of GD. Reference | Related Articles | Metrics | Comments（0）

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Research progress of Hashimoto thyroiditis TIAN Limin, FENG Jing Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 217-223.   DOI: 10.16138/j.1673-6087.2024.04.01 Abstract （2053）   HTML （32）    PDF（pc） （973KB）（317）       Knowledge map    Save Hashimoto thyroiditis (HT) is a very common organic autoimmune thyroid disease, and its incidence is increasing year by year. It not only causes hypothyroidism in clinical practice, but also has many connections with a variety of immune diseases, endocrine diseases, rheumatic diseases and thyroid cancer. Although the exact etiology of HT has not been fully clarified, the mainstream treatment is still based on management and alternative treatment of hypothyroidism. However, as the research further deepens, more clinical variants have been gradually discovered, more and more factors have been found to be related to the onset of HT, and new discoveries have been made in treatment methods. This article reviews the research progress on clinical manifestations, pathological features, diagnosis, pathogenesis, relationship with other diseases and treatment of HT. Reference | Related Articles | Metrics | Comments（0）

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Value of peripheral perfusion index combined with APACHEⅡ score in predicting 28-day prognosis of patients with septic shock GONG Hao, CHI Cheng, ZHANG Xiaoxia Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 174-179.   DOI: 10.16138/j.1673-6087.2024.03.04 Abstract （167）   HTML （1）    PDF（pc） （967KB）（252）       Knowledge map    Save Objective To study the value of peripheral perfusion index (PPI) combined with acute physiology and chronic evaluation Ⅱ(APACHEⅡ) score in predicting prognosis of septic shock patients. Methods A total of 200 patients diagnosed as septic shock in the emergency department of Xinjiang Medical University First Affiliated Hospital from January to August 2023 were prospectively included. The patients were divided into survival group (84 cases) and death group (116 cases) according to their 28-day prognosis. The patients’ information including name, age, gender, vital signs after admission, Glasgow coma scale(GCS), sepsis-related organ failure assessment(SOFA), APACHEⅡ, infection site, fluid intake within 24 h of admission, antibiotic use, past medical history, types and 24 h doses of vasopressors used, mechanical ventilation status, complete blood count, liver function, renal function, coagulation indicators, onset time, and 28-day prognosis outcomes were recorded. The lactate and PPI values of the two groups of patients were measured at the time of admission (0 h), 6 h after admission, and 12 h after admission, and the lactate clearance rate at 0-6 h and 0-12 h was calculated. Cox regression was used to screen independent factors for predicting the prognosis of septic shock patients, and the area under the ROC curve(AUC) was plotted. PPI parameter combined with APACHEⅡ score were analyzed in predicting AUC, which represented patients’ prognosis. Results Compared with the death group, the survival group had higher GCS score, 0 hPPI, 6 hPPI, 12 hPPI, 0-12 h lactic acid clearance rate, and lower in age, SOFA score, APACHEⅡ score, 0 h lactic acid, 12 h lactic acid (all P<0.05). COX regression showed that 12 hPPI was an independent predictor of the prognosis of patients with septic shock, and the AUC for predicting the prognosis of patients with septic shock was 0.945, and the 12 hPPI combined with APACHEⅡ score for predicting AUC as the prognosis of patients with was 0.996. Conclusions 12 hPPI combined with APACHEⅡ score after admission has good prognostic value for 28-day prognosis of patients with septic shock. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Study on the role of charged multivesicular body proteins 5 in regulating pyroptosis of vascular endothelial cells SUN Junnan, ZHANG Jiaojiao, WANG Hairong Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 159-166.   DOI: 10.16138/j.1673-6087.2024.03.02 Abstract （216）   HTML （6）    PDF（pc） （7711KB）（246）       Knowledge map    Save Objective To investigate the expression of charged multivesicular body proteins 5(CHMP5) in pyroptosis of human umbilical vein endothelial cell (HUVEC) and the effect of knocking down CHMP5 on HUVEC pyroptosis. Methods Using polyinosinic-polycytidylic acid (Poly I:C) to stimulate HUVEC to establish an in vitro model of double-stranded RNA (dsRNA) induced HUVEC injury in viral sepsis. HUVEC were randomly divided into control, Lipo, Poly I:C, siNC and siCHMP5+Poly I:C groups, and the expression of CHMP5 in each group was detected by real-time fluorescent quantitative PCR (qRT-PCR) to verify the transfection efficiency. Lactate dehydrogenase (LDH) cytotoxicity assay kit was used to detect the release rate of LDH, ELISA was used to detect the secretion of interleukin-1β(IL-1β) and transmission electron microscopy (TEM) was used to detect the ultrastructure of HUVEC to observe the integrity of the cell membrane, and Western blotting was used to detect the expression level of the cleaved caspase-3(Casp-3) and gasdermin E N-terminal(GSDME-N), and immunofluorescence staining was used to detect the expression and localization of the related proteins in each group of cells. Results In comparison with the control group, the HUVEC in the Poly I:C group were swollen and showed multiple cell membrane ruptures, and cleaved Casp-3, GSDME-N and CHMP5 protein expression was up-regulated. Compared with the control group and the siNC group, knocking down CHMP5 by RNAi technology resulted in increased release of LDH and IL-1β, up-regulation of the expression level of pyroptosis-related proteins, alteration of the distribution of GSDME protein recruitment, and significant aggravation of endothelial cell pyroptosis in the siCHMP5+Poly I:C group. Conclusions The CHMP5 is highly expressed in HUVEC pyroptosis. Knockdown of CHMP5 can enhances HUVEC cellular pyroptosis, which may be related to the inhibition of membrane repair and promoting secondary cellular pyroptosis induced by cleavage of GSDME and GSDMD proteins. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Research progress of the association between intra-pancreatic fat deposition and atherosclerosis LI Chenxi, HU Yun, WU Wenjun Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 278-282.   DOI: 10.16138/j.1673-6087.2024.04.12 Abstract （158）   HTML （2）    PDF（pc） （881KB）（234）       Knowledge map    Save Intra-pancreatic fat deposition (IPFD) is the most common disease of pancreas in our country. In recent years, there has been increasing evidence that IPFD is closely related to atherosclerosis. However, some studies do not support the correlation between them, which may be affected by differences in study population, atherosclerosis detection methods, and IPFD diagnostic criteria. Therefore, large-sample prospective studies are urgently needed to further clarify the correlation between IPFD and atherosclerosis. The mechanisms involved in correlation between them may be related to inflammation, oxidative stress, hypoadiponectinemia and glucose metabolism. There is currently no specific treatment for IPFD, while weight loss has been shown to significantly reduce the amount of fat deposited in the pancreas. In addition to the treatment of IPFD itself, clinicians should also pay attention to the assessment of the risk of cardiovascular disease in IPFD patients to facilitate early diagnosis and early intervention. Reference | Related Articles | Metrics | Comments（0）

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Effect of Shenfu injection on immune function in elderly patients with sepsis LIU Di, QÜ Hongping, XÜ Zhihong, CAO Jiumei, ZHENG Lan, BAI Tingting Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 153-158.   DOI: 10.16138/j.1673-6087.2024.03.01 Abstract （179）   HTML （13）    PDF（pc） （1022KB）（221）       Knowledge map    Save Objective To explore the effect of Shenfu injection on immune function in elderly patients with sepsis. Methods This study was a retrospective analysis. The elderly patients(n=126) with sepsis admitted to 4 hospitals including Shanghai Ruijin Hospital from January 2019 to December 2020 were divided into two groups according to whether Shenfu injection was used (61 cases in Shenfu group, 65 cases in control group). Basic data, comorbidities, relevant test results (including inflammatory factors, humoral immune indicators, cellular immune indicators, etc.), disease severity score, mortality rate, etc., were collected for statistical analysis. Results After seven days of Shenfu injection treatment, the indexes including the mean artery pressure (MAP), lactate (Lac), C-reactive protein (CRP), procalcitonin (PCT), prothrombin time (PT), activated partial thromboplastin time (APTT), interleukin-6(IL-6), IL-10, tumor necrosis factor-α(TNF-α), CD3 count, CD4 count, CD8 count, IgG, IgA and IgM of patients in 2 groups were significantly improved (all P<0.05). Compared with the control group, MAP(P=0.034), and the absolute count of CD3(P=0.002) and CD4(P=0.002) were significantly increased in the Shenfu treated group. Conclusions Shenfu injection combined with standard bundled regimen can improve the immune function and reduce inflammation in elderly patients with sepsis. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Acute myeloid leukemia with CEBPA double mutation combined with GATA2 germline mutation: one case report AN Huihui, WU Tao, LI Yunyun, LIU Wenhui, TIAN Sirui, LIU Yang, GAO Mingmin Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 185-187.   DOI: 10.16138/j.1673-6087.2024.03.06 Abstract （251）   HTML （4）    PDF（pc） （913KB）（210）       Knowledge map    Save The patient was diagnosed as acute myeloid leukaemia with CEBPA double mutation, GATA2 and IKZF1 mutation in 2021, and relapsed after giving two courses of IA treatment (idarubicin, cytosine arabinoside). There was transient remission after four additional courses of azacitidine combined with venetoclax. The patient relapsed again due to lack of regular treatment. This paper mainly analyses the therapeutic and prognostic role of CEBPA double mutation combined with GATA2 germline mutation in acute myeloid leukaemia. Reference | Related Articles | Metrics | Comments（0）

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Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 287-288.   Abstract （66）      PDF（pc） （789KB）（189）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Research progress on agranulocytosis caused by antithyroid drugs TIAN Ruochen, LI Jing Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 264-268.   DOI: 10.16138/j.1673-6087.2024.04.09 Abstract （1588）   HTML （5）    PDF（pc） （970KB）（161）       Knowledge map    Save In China, antithyroid drugs are the first choice of treatment for hyperthyroidism. However, their side effects may result in agranulocytosis, which has an insidious onset and requires urgent treatment. Up to date，the mechanisms of agranulocytosis caused by antithyroid drugs is still unclear. Herein, the article reviewed the direct toxic activities, the immune effects, and the genetic susceptibility of antithyroid drugs, which may be helpful to provide better clinical treatment options and improve the prognosis of agranulocytosis caused by the drugs. Reference | Related Articles | Metrics | Comments（0）

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Recent advances in diagnosis and treatment of subacute thyroiditis LI Yajie, CUI Dai Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 259-263.   DOI: 10.16138/j.1673-6087.2024.04.08 Abstract （1381）   HTML （24）    PDF（pc） （939KB）（132）       Knowledge map    Save Subacute thyroiditis (SAT) is a common thyroid inflammatory disease that is frequently prone to misdiagnosis or underdiagnosis, which impact the quality of life for patients adversely. In this review, we summarize the pathogenesis, clinical manifestations, diagnosis, and treatment of SAT, aiming to improve clinician’s understanding of the disease. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Rehabilitation efficacy of aerobic exercise on patients with overlap syndrome of chronic obstructive pulmonary disease and obstructive sleep apnea LIU Jie, ZHANG Yin, XU Yiming, REN Lei, SHEN Honghua Journal of Internal Medicine Concepts & Practice    2024, 19 (05): 295-302.   DOI: 10.16138/j.1673-6087.2024.05.02 Abstract （181）   HTML （2）    PDF（pc） （939KB）（123）       Knowledge map    Save Objective To evaluate the rehabilitation efficacy of moderate intensity aerobic exercise on patients with chronic obstructive pulmonary disease (COPD)-obstructive sleep apnea (OSA) overlap syndrome. Methods A retrospective cohort study was used in the study. The patients who were diagnosed with COPD-OSA overlap syndrome and applied positive airway pressure (PAP) from January 2021 to December 2023 were selected in the Department of Respiratory Rehabilitation, at the Fourth Rehabilitation Hospital of Shanghai. A total of 29 patients [aged (62.2±5.9) years, male 65.5%] with overlap syndrome received moderate intensity aerobic training for 20 weeks were enrolled as the intervention group (IG). At the same time, 29 patients [(64.6±6.9) years, male 62.1%] with overlap syndrome who didn’t receive aerobic training were selected as the control group (CG). The differences in motor function, daily living abilities, body composition, respiratory function, psychological state and sleep parameters between two cohorts of patients before and after treatment were compared. Results After 20 weeks of aerobic exercise, the various parameters of IG demonstrated significant improvement compared with those before treatment: a notable increase in the 6 min walk distance (6MWD) [(268.62±47.02) m vs (316.97±58.44) m], quadriceps muscle strength [22.40 (20.40, 27.45) kg vs 25.40 (20.00, 30.45) kg], Barthel index (BI) scores [(66.03±12.42) vs (76.72±11.82)], a reduction in the 5 times sit-to-stand test (5TSTS) [19.50 (15.94, 31.10) s vs 13.50 (11.75, 18.50) s], body mass index (BMI) [(25.16±3.17) kg/m2 vs (22.31±2.16) kg/m2] and fat mass (FM) [(24.13±9.22) kg vs (20.47±8.32) kg]. Additionally, there were significant enhancements observed in PSG parameters, blood gas analysis results, Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) scores after training in IG (all P<0.05). In contrast, the CG exhibited improvements in quadriceps muscle strength and the modified Medical Research Council (mMRC) as well as PSG parameters and psychological state; while there was an FM increase in this group (all P<0.05). Compared with the CG, the 6MWD [(316.97±58.44) m vs 239.93±37.80) m], quadriceps muscle strength [25.40 (20.00, 30.45) kg vs 23.70 (20.50, 25.60) kg], 5TSTS [13.50 (11.75, 18.50) s vs 19.50 (17.60, 23.12) s], BI [(76.72±11.82) vs （67.59±10.74)], mMRC, pH, PaO2, TS90%, BMI [(22.31±2.16) kg/m2 vs（26.17±3.83) kg/m2], FM, HAMD, HAMA of the IG patients showed significant improvement (all P<0.05). However, there were no significant differences observed between the two groups in terms of percentage of predicted forced expiratory volume in one second (FEV1%） (43.72%±9.49% vs 43.97%±7.22%), PaCO2, apnea hypopnea index, pulse oxygen saturation （L-SpO2）%, fat free mass and fat free mass index (P>0.05). Conclusions The combination of a 20-week moderate-intensity aerobic training and PAP demonstrates significant improvements in motor function, reduction in body fat, alleviation of hypoxia and respiratory difficulties, enhancement of psychological state and daily life abilities. This intervention may be considered suitable for patients with COPD-OSA overlap syndrome. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Discussion on understanding of the essence of chronic obstructive pulmonary disease from the definitions of chronic obstructive pulmonary disease in GOLD over the years HE Quanying Journal of Internal Medicine Concepts & Practice    2024, 19 (05): 289-294.   DOI: 10.16138/j.1673-6087.2024.05.01 Abstract （143）   HTML （3）    PDF（pc） （887KB）（108）       Knowledge map    Save This article reviewed the definition of chronic obstructive pulmonary disease (COPD) in Global Initiative for Chronic Obstructive Lung Disease (GOLD) over the years, from which it can be seen that our understanding of the nature of COPD has gradually deepened and comprehensively. However, there are still some deficiencies in definition of COPD, including airway inflammation, etiology, disease heterogeneity, etc. The comorbid diagnosis and intervention of COPD requires multidisciplinary collaboration. Reference | Related Articles | Metrics | Comments（0）

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Current situation of knowledge of hypertension management among general practice residents and improvement strategies WANG Zhenzhen, TONG Jianjing, ZHANG Chenli, JIANG Jie Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 180-184.   DOI: 10.16138/j.1673-6087.2024.03.05 Abstract （178）   HTML （1）    PDF（pc） （883KB）（86）       Knowledge map    Save Objective To evaluate the ability of general practice residents in diagnosing and treating hypertension and managing chronic diseases, identify existing deficiencies, and provide a basis for improving standardized training. Methods A questionnaire survey and assessment on hypertension-related knowledge were conducted among 34 general practice residents participating in standardized training at our hospital. The assessment covered five aspects: hypertension diagnosis, risk stratification, conditions for community referral, follow-up requirements, blood pressure management and non-pharmacological interventions. The influence of different factors on the assessment results was analyzed, including gender, year of rotation, and participation in rotation training in hypertension-related departments. Results The overall pass rate for the assessment among the 34 general practice residents was 76.5%. However, only 23.5% of the residents met the passing criteria in the blood pressure management and non-pharmacological interventions section, and the mean score (12.18±1.42) was significantly lower than the diagnostic criteria (14.24±1.69), risk stratification (15.00±3.79), community referral (14.00±3.48) and follow-up (13.65±3.17) (F=4.441, P=0.002). There was no significant difference between different genders, rotation years and related departments. Conclusions General practice residents have already acquired basic professional skills in the diagnosis and treatment of hypertension, but showed significant deficiencies in chronic disease management, particularly in non-pharmacological interventions. General practitioners still need further training and improvement on long-term chronic disease management and comprehensive intervention strategy to better serve for community and patients. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Ultrasound features and clinical manifestations of two cases of thyroid metastatic cancer: pay attention to abnormal thyroid ultrasound spectrum LI Yuanyuan, DING Wenbo, JIANG Ziyu, CHEN Xi, LIU Binbin, CHEN Guofang, LIU Chao Journal of Internal Medicine Concepts & Practice    2024, 19 (04): 254-258.   DOI: 10.16138/j.1673-6087.2024.04.07 Abstract （1160）   HTML （18）    PDF（pc） （8859KB）（70）       Knowledge map    Save Ultrasonography plays an important role in early screening of thyroid cancer. This article introduced two cases of thyroid metastatic carcinoma secondary to renal clear cell carcinoma and cervical squamous cell carcinoma respectively, analyzed their clinical diagnosis and treatment process, ultrasound characteristics, and prognosis, as well as reviewed the related literature. As atypical thyroid lesions were detected through the ultrasound spectrum in patients with a history of malignant tumors, it should be alert to the possibility of metastatic cancer. Ultrasound-guided core-needle biopsy combined with immunohistochemical testing can help early diagnosis and timely treatment. Table and Figures | Reference | Related Articles | Metrics | Comments（0）

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Journal of Internal Medicine Concepts & Practice    2024, 19 (03): 187-187.   Abstract （171）      PDF（pc） （695KB）（68）       Knowledge map    Save Related Articles | Metrics | Comments（0）