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    Journal of Diagnostics Concepts & Practice    2021, 20 (04): 317-337.   DOI: 10.16150/j.1671-2870.2021.04.001
    Abstract11560)   HTML612)    PDF(pc) (3337KB)(10273)       Save
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    Effects of Peer Feedback on EFL Learners' Pragmatic Acquisition
    WEI Ran
    Contemporary Foreign Languages Studies    2017, 17 (03): 96-102.   DOI: 10.3969/j.issn.1674-8921.2017.03.017
    Abstract367)      PDF(pc) (1262KB)(6378)       Save
    This study investigated the effects of two types of peer feedback, i.e., peer prompts and peer recasts, on the acquisition of request speech act, i.e., comprehensive and productive acquisition, by 102 non-English majors. Through the experimental design of pretest, posttest, and delayed posttest, it revealed that, peer prompts and peer recasts facilitated learners' pragmatic acquisition in which both experimental groups significantly improved pragmatic comprehensive competence, irrespective of feedback type, while peer prompts group performed significantly better than peer recasts group in pragmatic production. In terms of effect durability, both of them were durable for pragmatic comprehension, but the effect of peer recasts faded away in pragmatic production compared with that of peer prompts.
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    Global Structural Strength Analysis Methodology of a Typical TLP
    Yang LI, Zhong-min SHI, Bin XIE, Wen-hui XIE
    Ocean Engineering Equipment and Technology    2014, 1 (1): 3-13.  
    Abstract478)   HTML2)    PDF(pc) (3686KB)(6142)       Save

    We focus on the global structure strength analysis of a typical tension leg platform (TLP). The objective of the TLP global structural analysis is to check the hull global structural integrity under design environmental conditions. Firstly, a global finite element model of the entire TLP is established, the hull structure is modeled in detail, whilst the deck structure is represented through a simplified deck beam model. A hydrodynamic analysis for operation and extreme conditions is conducted to get the design wave parameters for critical wave loads. After that, wave loads are mapped to the global structure finite element model, and the tendons are modeled as spring element which represents 6 degrees of freedom and rotations. Finally, the maximum stress and its distribution trends, together with the control elements, are obtained by finite element analysis according to critical wave heading, wave periods, wave heights and wave positions. Results and the TLP analysis method proposed can be used as reference for strength analysis of other offshore platforms.

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    Journal of Tissue Engineering and Reconstructive Surgery    2021, 17 (6): 1-.  
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    Interpretation on the report of global stroke data 2022
    TANG Chunhua, GUO Lu, LI Qiong, ZHANG Lili
    Journal of Diagnostics Concepts & Practice    2023, 22 (03): 238-246.   DOI: 10.16150/j.1671-2870.2023.03.06
    Abstract5924)   HTML242)    PDF(pc) (2270KB)(4733)       Save

    In 2022, the World Stroke Organization released two new reports regarding global stroke statistics in the International Journal of Stroke. The reports updated the global incidence and mortality of stroke, evaluated the effects of gender and geographic factors, and provided updated statistics on attributable risk factors associated with stroke. This article briefly interprets the two reports in the context of stroke prevalence and disease burden in China. 2019 Global Burden of Disease Study findings show that stroke remains the second-leading cause of death and the third-leading cause of death and disability combined in the world. From 1990 to 2019, the burden (in terms of the absolute number of cases) increased substantially, with the bulk of the global stroke burden residing in lower-income and lower-middle-income countries. Moreover, people under 70-year-old were observed to have significant increases in stroke prevalence and incidence. The five major risks for stroke globally include high systolic blood pressure, high body mass index, high fasting glucose, environmental particulate matter pollution, and smoking. Stroke prevention and treatment in China are facing great challenges. Stroke has become the leading cause of death and disability among Chinese adults, as well as the leading cause of disability adjusted life year lost. The incidence, prevalence and mortality of stroke in China are geographically high in the north, low in the south and prominent in the central part of the country; the prevalence is higher in rural areas than that in urban areas; the morbidity and mortality rates are higher in men than those in women; the average age of onset is lower than in developed countries; the overall disease burden of ischemic stroke is on the rise, but that of hemorrhagic stroke is on the decline. The awareness of stroke prevention and treatment was low. In conclusion, it is of strategic importance to actively establish a graded stroke prevention and control system that meets the national conditions.

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    China Alzheimer Report 2024
    WANG Gang, QI Jinlei, LIU Xinya, REN Rujing, LIN Shaohui, HU Yisong, LI Haixia, XIE Xinyi, WANG Jintao, LI Jianping, ZHU Yikang, GAO Mengyi, YANG Junjie, WANG Yiran, JING Yurong, GENG Jieli, ZHI Nan, CAO Wenwei, XU Qun, YU Xiaoping, ZHU Yuan, ZHOU Ying, WANG Lin, GAO Chao, LI Binyin, CHEN Shengdi, YUAN Fang, DOU Ronghua, LIU Xiaoyun, LI Xuena, YIN Yafu, CHANG Yan, XU Gang, XIN Jiawei, ZHONG Yanting, LI Chunbo, WANG Ying, ZHOU Maigeng, CHEN Xiaochun, representing the China Alzheimer's Disease Report Writing Group
    Journal of Diagnostics Concepts & Practice    2024, 23 (03): 219-256.   DOI: 10.16150/j.1671-2870.2024.03.001
    Abstract7452)   HTML519)    PDF(pc) (3339KB)(4658)       Save

    With the sustained growth of economy and significant changes in social demographics, the issue of elderly-related diseases has increasingly drawn attention particularly. Alzheimer's disease (AD),as a representative disease of neurodegenerative diseases has become a major challenge, affecting the health and quality of life among the elderly population severely. In recent years, the incidence, prevalence, and mortality rate of AD increase in China, imposing substantial economic burdens on families, society, and the entire healthcare system. To proactively address this challenge and respond to the national 'Healthy China Action' initiative, leading experts from Renji Hospital, Shanghai Jiao Tong University School of Medicine,and Chinese Center for Disease Control and Prevention Chronic Non-communicable Disease Control Center, Fudan University School of Public Health, Shanghai Mental Health Center, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Fujian Medical University, and other authoritative institutions, have jointly authored the 'China Alzheimer Disease Report 2024'. Building upon previous editions of 2021, 2022, and 2023, this report updates epidemiological data on AD in China, thoroughly analyzes the latest economic burdens of the disease, and comprehensively evaluates the current status of AD diagnosis and treatment services, as well as the allocation of public health resources in our country. The release of the 'China Alzheimer Disease Report 2024' not only reflects China's progress and efforts in AD research and prevention, but also underscores the social heightened concern for elderly health issues. It aims to provide scientific and technical guidance and robust data support for the prevention, diagnosis, and treatment of AD, offering a professional basis for the government and relevant departments to formulate targeted health policies and intervention measures. Furthermore, it serves as a platform for promoting academic exchanges and cooperation in this field domestically and internationally. Through the dissemination and application of this report, we anticipate it will not only serve as a reference for professionals but also enhance public awareness of AD, promote active participation across various sectors of society, and jointly advance the development of elderly health care in China, empowering us towards achieving 'healthy aging'.

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    Journal of Diagnostics Concepts & Practice    2021, 20 (04): 401-406.   DOI: 10.16150/j.1671-2870.2021.04.014
    Abstract308)   HTML5)    PDF(pc) (551KB)(4574)       Save
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    Chinese interpretation of Japanese Gastric Cancer Treatment Guidelines 2021 (6th edition) and Ruijin clinical practice
    YAN Chao, LU Sheng, YAN Min, ZHU Zhenggang
    Journal of Surgery Concepts & Practice    2023, 28 (04): 326-354.   DOI: 10.16139/j.1007-9610.2023.04.010
    Abstract1473)   HTML33)    PDF(pc) (4954KB)(4024)       Save

    “Japanese Gastric Cancer Treatment Guidelines” have been important guidelines for the treatment of gastric cancer in Japan and worldwide. The English version “Japanese Gastric Cancer Treatment Guidelines 2021 (6th Edition)” published in January 2023 consists of two parts. The first part includes diagnostic and treatment methods, such as surgery, endoscopic resection, chemotherapy, follow-up. The second part addresses clinical issues, including recommendations and explanations for clinical hot topics. This article will provide a Chinese interpretation of the guidelines and briefly introduce our hospital's clinical practice in the diagnosis and treatment of gastric cancer.

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    Interpretation of Multiple Myeloma Guidelines update (version 2, 2023) of National Comprehensive Cancer Network (NCCN)
    TAO Yi, MI Jianqing
    Journal of Diagnostics Concepts & Practice    2023, 22 (02): 121-126.   DOI: 10.16150/j.1671-2870.2023.02.003
    Abstract2226)   HTML71)    PDF(pc) (1042KB)(4024)       Save

    Multiple myeloma (MM) is the second most common hematological malignancy. With the continuous advent of new drugs, the survival of MM patients has been significantly improved, with a median survival of 7-10 years. However, the overall survival of high-risk MM patients is still less than 3 years, and extending the survival of high-risk MM has always been a hot topic in this field. The National Comprehensive Cancer Network (NCCN) released the 2nd version of the MM guidelines for 2023 (2023. v2). Compared with the 5th edition of the MM guidelines for 2022, the update of this guideline in diagnosis is mainly reflected in the detailed description of high-risk MM in tabular form, including both cytogenetic high-risk factors containing 1q21 gain/amplification and clinical high-risk factors, such as extramedullary disease, renal failure and weakness. In terms of treatment, the updated guideline still emphasizes the importance of autologous hematopoietic stem cell transplantation in the era of new drugs, and indicates that the judgment of whether patients are suitable for transplantation needs to be dynamically adjusted based on the patients’ condition after initial treatment. 2023. v2 upgrades the recommendation of the new generation proteasome inhibitor carfilzomib in initial induction and CD38 monoclonal antibody in maintenance therapy. The combinations of these new drugs with immunomodulatory drug pomalidomide are also listed as the preferred regimens in relapsed patients. The diagnostic techniques for distinguishing high-risk MM and new drugs recommended in the updated guideline are currently available in China, Which greatly enhanc our confidence in the “clinical cure” of MM. A comprehensive interpretation of the 2023. v2 of the guidelines is expected to improve the diagnostic and therapeutic level of clinicians, and further improve the prognosis of China’s MM patient population, especially high-risk patients.

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    Interpretation of the Global Tuberculosis Report 2022 by World Health Organization
    LIANG Chen, YU Jiajia, TANG Shenjie
    Journal of Diagnostics Concepts & Practice    2023, 22 (01): 21-30.   DOI: 10.16150/j.1671-2870.2023.01.004
    Abstract1880)   HTML53)    PDF(pc) (1105KB)(3964)       Save

    Global Tuberculosis Report 2022 (hereafter referred to as “report”), newly published by the World Health Organization (WHO), states that the coronavirus (COVID-19) pandemic has increased the tuberculosis (TB) disease burden and severely affected global TB prevention and control. In 2021, WHO approved a total of six molecular diagnostic technologies for TB diagnosis and anti-TB drug resistance detection, and three new TB antigen-based skin tests for TB screening were recommended. To reduce the burden on patients and the health system, WHO recommends a 4-month regimen for drug-susceptible TB and four shorter regimens for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). In addition, there were 26 drugs for TB treatment in clinical trials, and at least 22 clinical trials evaluating drugs and drug regimens for TB treatment were underway. In 2021, the TB epidemic remains severe in China, with the number of newly diagnosed cases ranking third among the 30 countries. In 2021, a total of 639 548 TB cases and 1 763 deaths were reported nationwide, with an incidence of 45.37/100 000 and a mortality of 0.13/100 000. China has the fourth largest number of MDR/RR-TB patients in the world. However, it is necessary to verify whether the regimens for MDR/RR-TB treatment recommended by WHO are suitable for patients in China.

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    Detection rate of gastric polyps and its clinical characteristics in 36 857 subjects in Shanghai
    ZHOU Yufen, WONG Bokai, LUO Fangxiu, XU Ying, DING Yanfei, YUAN Xiaoqin, CHEN Ping, WU Yunlin
    Journal of Diagnostics Concepts & Practice    2020, 19 (04): 420-425.   DOI: 10.16150/j.1671-2870.2020.04.018
    Abstract380)   HTML0)    PDF(pc) (632KB)(3661)       Save

    Objective: To explore the detection rate of gastric polyp (GP) in Shanghai and analyze its clinical characteristics. Methods: A total of 36 857 subjects undergone gastroscopy during December 2012 to May 2019 were enrolled, and the detection rate of GP and related pathologic data were analyzed. Results: It revealed that 3 858 patients had GP, with a detection rate of 10.47%. In patients over 60 years old, 1 534 patients were diagnosed as having GP, with a detection rate of 14.75%. Compared with patients in other age groups (<30, 30-39, 40-49, 50-59 years), the constituent ratio of patients with GP diameter ≥2.0 was higher(1.8%)(P<0.05), so was with adenomatous polyps (1.9%) and with intraepithelial neoplasia (2.9%)(P<0.05). The only three cases with high-grade intraepithelial neoplasia were all ≥60 years old. Besides, the constituent ratio of patients ≥60 years old with atrophic gastritis and with intestinal metaplasia were 22.4% and 34.0%, respectively,which were higher than those of patients <60 years old. In contrast, GP patients ≥60 years old had a lower constituent ratio of Helicobacter pylori infection (15.1%), lower than that of patients under 60 years old (P<0.01). Conclusions: In comparison with the population <60 years old, population ≥60 had a higher detection rate of GP. GP patients of ≥60 years old had higher proportion of polyps diameter greater than 2 cm, adenomatous polyps, intraepithelial neoplasia, atrophic gastritis, and intestinal metaplasia. Therefore, more attention should be paid to the detection and pathology examination of GP in elderly patients.

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    Interpretation of the 2022 edition of “guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis in China”
    XU Bojin, PENG Wenfang, HUANG Shan
    Journal of Surgery Concepts & Practice    2023, 28 (06): 512-519.   DOI: 10.16139/j.1007-9610.2023.06.05
    Abstract1280)   HTML8)    PDF(pc) (889KB)(3574)       Save

    “Guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis in China” (2022) (referred to as the “guidelines”) was officially published in August 2022 in the Chinese Journal of Endocrine Metabolism. These guidelines have been extensively updated from the 2007 version, with 15 sections covering the etiology, clinical manifestations, diagnosis, evaluation, and treatment of hyperthyroidism, as well as the management of specific types of thyrotoxicosis. The new version guidelines proposed 107 recommended opinions supported by stronger evidence, offering comprehensive and reliable guidance for clinical doctors and medical professionals dealing with thyrotoxicosis. This article aimed to extract the key points and recommended strategies from the guidelines to help clinical doctors better understand and apply the latest guiding principles.

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    Interpretation of clinical practice guidelines for myelodysplastic syndrome (version 1, 2023) of National Comprehensive Cancer Nerwork(NCCN)
    SONG Luqian, CHANG Chunkang
    Journal of Diagnostics Concepts & Practice    2023, 22 (02): 116-120.   DOI: 10.16150/j.1671-2870.2023.02.002
    Abstract651)   HTML31)    PDF(pc) (904KB)(3413)       Save

    Myelodysplastic syndrome (MDS) is a diverse and common group of myeloid malignant clonal diseases in the hematologic system, with different classification and grouping, clinical manifestations and natural course, and the iteration of different classification systems and versions in history, resulting distress in the correct diagnosis, classification and treatment options. The National Comprehensive Cancer Network (NCCN) released the first version (2023) of Clinical Practice Guidelines for MDS in September 2022. The guideline is based on the clinical practice and standards of high-level evidence and the latest research progress, and its attracts wide attention from clinicians worldwide. Currently, many clinicians in China have insufficient understanding of MDS, and there is still a certain gap with the international diagnosis and treatment level of MDS. This paper interprets the content of the new guidelines, and compares it with the previous guidelines, in order to provide a reference for the standardized diagnosis and treatment of MDS at the current stage in China.

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    Can Research with Chinese Characteristics be Universally Accessible?
    QU Weiguo
    Contemporary Foreign Languages Studies    2020, 20 (4): 13-26.   DOI: 10.3969/j.issn.1674-8921.2020.04.002
    Abstract304)   HTML1)    PDF(pc) (2000KB)(3386)       Save
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    Interpretation of the Clinical Practice Guidelines for Non-small Lung Cancer (version 4 and version 5) of 2022 National Comprehensive Cancer Nerwork(NCCN)
    CHEN Guoqun, CAI Jiaodi
    Journal of Diagnostics Concepts & Practice    2023, 22 (01): 8-13.   DOI: 10.16150/j.1671-2870.2023.01.002
    Abstract1283)   HTML32)    PDF(pc) (900KB)(3186)       Save

    Lung cancer is the leading cause of cancer-related deaths worldwide, with approximately 1.8 million patients dying of lung cancer each year, accounting for 18.0% of all cancer deaths. Non-small cell lung cancer (NSCLC) is the main type of lung cancer and accounts for more than 85% of all lung cancer patients. In China, more than 700 000 new cases of lung cancer are diagnosed each year, and more than 600 000 patients die of lung cancer, accounting for 21.7% of all cancer deaths. In 2022, the National Comprehensive Cancer Network (NCCN) updated the guidelines for clinical diagnosis and treatment of lung cancer. Compared with the third edition of the guidelines, the fourth edition of the guidelines added the reference significance of ERBB2 (HER2) mutation in the diagnosis and treatment of (NSCLC). The updated content was mainly focused on the detection of HER2 mutation as a standard biomarker and the treatment of patients with HER2 mutation. The detection of HER2 mutation is recommended for patients with metastatic NSCLC. Fam-trastuzumab deruxtecan and trastuzumab emtansine are recommended as second-line treatment options for patients with HER2 mutation. However, both are in clinical trials in China. The treatment strategies for NSCLC patients with HER2 mutations need to be considered comprehensively in light of the actual situation, and more data from domestic trials are needed. The fifth edition of the guidelines expanded the use of nivolumab, marking new progress in the study of immune checkpoint inhibitors.

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    Time-Varying Delay and Quantization Error
    LI Bin (李 斌), WAN Yi-ming (万一鸣), YE Hao (叶 昊)
    Journal of shanghai Jiaotong University (Science)    2011, 16 (5): 513-518.   DOI: 10.1007/s12204-011-1181-9
    Abstract1961)      PDF(pc) (303KB)(3085)       Save
    Abstract:  Problems related to fault detection of
    networked control systems (NCSs) with both uncertain time-varying
    delay and quantization error are studied in this paper. A novel
    model with the form of polytopic uncertainty is given to represent
    the influences of both the time-varying delay and the quantization
    error, and then the reference model based method is used to design
    the residual generator that is robust to both unknown
    network-induced delay and unknown inputs. A numerical example is
    also given to illustrate the merits of the presented method. The
    proposed method can be regarded as an extension of the
    authors' former work, which can only deal with time-varying delay.
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    Development of IT Industry in China in the New Age
    JIANG Ze-min
    Journal of Shanghai Jiaotong University   
    Abstract17255)            Save
    The article explains the role and future trend of IT industry, and states that information technology represented by the internet and computers has brought about the third industrial revolution in history. An important impetus for economic growth in modern times, the IT industry has greatly promoted sustainable development and is profoundly changing mankind’s way of life and production. In discussing the development trend of world IT industry, the article suggests that with potential new breakthroughs in IT technology, the trend of agglomeration and integration of industries has become increasingly obvious, competition of intellectual properties and strandards is intensifying and ubiquitous networks is taking shape. It points out that China should bring into better play the role of IT industry as an “amplifier” in economic growth, a “transformer” in development mode and a “propeller” in industrial upgrading. It is important to follow a policy that emphasizes indepandent innovation, marketdriven approach, open and compatible technologies, integrated and comprehensive application, and serving both military and civil purposes, so that a quantum leap of IT industry will be achieved. China should advance industrialization with IT technologles and promote the IT industry in the course of industrialization in an effort to build an IT industry with Chinese characteristics. Greater efforts should be made to develop such core sectors as microelectronics, computer, software, key components and materials, as well as sectors with international competitiveness, including broadband mobile communication, nextgeneration network and information services. Continued improvement should be made in the policies guiding the development of IT industry with a view to making China a country with a strong IT industry by 2020.
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    Fault Detection in Power Distribution Systems Based on Gated Recurrent Attention Network
    CHEN Haolan, JIN Bingying, LIU Yadong, QIAN Qinglin, WANG Peng, CHEN Yanxia, YU Xijuan, YAN Yingjie
    Journal of Shanghai Jiao Tong University    2024, 58 (3): 295-303.   DOI: 10.16183/j.cnki.jsjtu.2022.091
    Abstract238)   HTML12)    PDF(pc) (2938KB)(2980)       Save

    To improve fault identification accuracy in power distribution systems, a model named gated recurrent attention network is proposed. First, a higher weight is put on the key cycles of fault phase based on the attention mechanism, making the model focus more on these key messages by weight assignment. Then, the gated recurrent network is adopted, which controls the memory transmission with gate signal and constructs the relationship between input waveform and probability of events at different stages to process the waveform sequence, thereby improving recognition accuracy. Experiments based on both simulation and field data show that the proposed method, under the small-sample-learning condition, is much better than other commonly-used classification models, such as support vector machine, gradient boosting decision tree, and convolutional neural network, providing new insights into fault identification technology in power distribution systems.

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    Evaluation of facial injection filling materials for medical aesthetics
    ZHAO Chenyu, LI Chongchong, SUN Xue, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 517-.  
    Abstract376)      PDF(pc) (874KB)(2931)       Save
    With economic development and technological progress, the demand for medical aesthetics has increased sig
    nificantly, and medical biomaterials are widely used. It is necessary to further improve the evaluation of their effectiveness and
    safety. At present, the evaluation of its physicochemical properties and biology is adopted in China. However, the clinical effec
    tiveness is a multi-faceted evaluation without unified criteria. Most of the evaluation mainly adopts objective indicators for quan
    titative analysis, while subjective feelings are secondary criteria. In this paper, the main facial fillers and the evaluation methods
    of their physicochemical properties were reviewed.
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    Report on diagnosis and treatment of hemophilia in China 2023
    XUE Feng, DAI Jing, CHEN Lixia, LIU Wei, ZHANG Houqiang, WU Runhui, SUN Jing, ZHANG Xinsheng, WU Jingsheng, ZHAO Yongqiang, WANG Xuefeng, YANG Renchi
    Journal of Diagnostics Concepts & Practice    2023, 22 (02): 89-115.   DOI: 10.16150/j.1671-2870.2023.02.001
    Abstract3066)   HTML89)    PDF(pc) (1494KB)(2810)       Save

    In recent years, China attaches great importance to the prevention and treatment of rare diseases. As one of the representative diseases of rare diseases, management of Hemophilia has made great progress in China. From 1986 to 1989, the National Hemophilia Cooperative Group conducted China's hemophilia epidemiological survey according to the unified method and standard, and the results showed that the prevalence of hemophilia was 2.73/100 000, and there was no statistical difference in prevalence among different regions. In 2014, Meta-analysis showed that the prevalence of hemophilia in China was 2.8/100 000, and in 2018, based on the data of the urban population of Tianjin, the local prevalence of hemophilia was estimated to be 3.09/100 000. With the comprehensive promotion of the construction of hemophilia hierarchical diagnosis and treatment system, China requires that hospitals applying for hemophilia comprehensive management centers and diagnosis and treatment centers must be able to independently carry out screening tests and confirmatory tests related to hemophilia diagnosis. For diagnosis of hemophilia, most laboratories in China usually adopt the one-stage method (coagulation method) based on the activated partial thromboplastin time (APTT) for the determination of coagulation factor activity, but it should be noted that more than two activity detection methods are required for some special types of hemophilia. The types of each mutation in the F8 gene of patients in China are similar to those reported in international data, and the mutations in the F9 gene of our patients are mainly single base point mutations, with no mutation hotspots found. As of June 2023, a total of more than 40 000 cases with inherited bleeding disorders registered in 261 centers in China (including hemophilia), through the National Hemophilia Registration System. The history of hemophilia treatment in China has been explored through inadequate on-demand and low-dose prophylaxis, and is now moving towards higher-dose prophylaxis and individualized prophylaxis with higher efficacy. Based on the above registry data and literature, this report comprehensively summarizes the progress of basic and clinical research and medical protection in the field of hemophilia in China, and analyzes the shortcomings for further improvement of hemophilia diagnosis and treatment in China.

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    New knowledge of prophylaxis and treatment about cancer-associated thrombosis
    DING Yongjie, ZHANG Liu, LI Qingyun
    Journal of Diagnostics Concepts & Practice    2023, 22 (04): 323-331.   DOI: 10.16150/j.1671-2870.2023.04.001
    Abstract422)   HTML20)    PDF(pc) (946KB)(2763)       Save

    Cancer-associated thrombosis (CAT) is the second leading cause of death in cancer patients, second only to the progression of the tumor. It leads to extended hospitalization and re-hospitalization, resulting in a serious social medical burden. Tumor-specific gene mutations such as JAK2, ALK, and KRAS mutations are closely related to the risk of CAT in patients with solid tumors. Patients treated with immune checkpoint inhibitors have a high risk of CAT, with a 1-year cumulative incidence rate of 10.86%. Therefore, accurate risk assessment is important. The Khorana risk score (KRS) is the first model to assess CAT risk and has been validated in several studies. The new generation models are based on the improvement of KRS, but they have not yet undergone large-scale external verification, such as the Vienna CAT model, PROTECHT model, and CONKO model. Due to the strong correlation between tumors and CAT, several CAT-related prevention guidelines have been established domestically and abroad. All of these guidelines recommend that patients undergo preventive anticoagulation therapy after tumor surgery. Low molecular weight heparin (LMWH) is the most widely used anticoagulant drug to prevent CAT. New oral anticoagulants (NOAC) are also used to prevent CAT, despite the incidence of hemorrhaging increases, the overall benefits to patients outweigh the risks. The strategy for treating CAT is complex. For patients with non-gastrointestinal tumors, NOAC can be used as a first-line drug, while LMWH is recommended for anticoagulation in patients with gastrointestinal tumors. Since CAT patients receive anticoagulation and anti-tumor therapy at the same time, drug interactions need to be considered to avoid drug-induced bleeding, especially the impact of combined medication on NOAC pharmacokinetics. The ideal length of anticoagulation therapy for CAT remains unclear. Guidelines recommend that patients with CAT should indefinitely continue the anticoagulation therapy after completing 3 to 6 months of initial anticoagulation therapy. Therefore, when determining the course of anticoagulation therapy for cancer patients, physicians should evaluate the risk of recurrence of thrombosis and bleeding, and optimize the treatment plan.

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    Advances in surgical treatment of hepatocellular carcinoma
    HUANG Jiwei, QIU Guoteng, ZENG Yong
    Journal of Surgery Concepts & Practice    2022, 27 (02): 113-118.   DOI: 10.16139/j.1007-9610.2022.02.005
    Abstract271)   HTML2)    PDF(pc) (554KB)(2556)       Save
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    The fifth edition of WHO classification of digestive system tumors: update and progress on biliary system tumors
    LUO Fangxiu, MA Qianchen, YUAN Fei
    Journal of Surgery Concepts & Practice    2023, 28 (02): 124-131.   DOI: 10.16139/j.1007-9610.2023.02.08
    Abstract1007)   HTML20)    PDF(pc) (3365KB)(2529)       Save

    Overall, there was little change in biliary system tumors of the 5th edition of WHO classification of digestive system tumors after update. The three-tiered classification of biliary intraepithelial neoplasia changed to two-tiered system: high-grade and low-grade, in the section of benign tumors and precancerous lesions. And both intracholecystic and intraductal papillary tumors associated with invasive carcinoma were added. The classification of intrahepatic bile duct tumors introduced parts of bile duct adenoma and bile duct adenofibroma, which were mentioned previously in the differential diagnosis with bile duct carcinoma. Intrahepatic cholangiocarcinoma was divided into small bile duct subtype and large bile duct subtype in the 5th edition of WHO classification, and the names of cholangiocellular carcinoma and cholangiole cell carcinoma were no longer recommended to use. Extrahepatic cholangiocarcinoma was listed as a separate part for the first time, including squamous cell carcinoma, adenosquamous carcinoma and undifferentiated carcinoma in addition to common histological types. Some new contents of molecular pathology in the 5th edition of WHO classification were added, which provided the basis for precise classification and diagnosis of tumors in biliary system.

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    Joint Policy Optimization of Quality Control, Condition-Based Maintenance and Spare Ordering for a Degradation System
    HAN Mengying, MA Shugang, YANG Jianhua, LI Wei, MA Zhichao
    Journal of Shanghai Jiao Tong University    2024, 58 (3): 361-370.   DOI: 10.16183/j.cnki.jsjtu.2022.356
    Abstract181)   HTML8)    PDF(pc) (5697KB)(2449)       Save

    A joint policy of quality control, condition-based maintenance and spare ordering is proposed for a degradation system subject to the delay time concept. First, considering the fact that product quality is largely dependent on system state, a two-stage inspection policy is proposed, in which the system state is detected during the initial deterioration process, but the product quality is checked after the defective state is found by an inspection. Then, based on the condition inspection information, quality information and failure information, the corresponding maintenance activity is chosen. Combining the state of the spare part when the system replacement is required, all possible events during an inspection interval are discussed and then a mathematical model of average cost rate is established. Afterwards, a simulation-based optimization approach coupling discrete event simulation and response surface methodology is devised to obtain a near optimal joint policy. Finally, a numerical example is provided to demonstrate the effectiveness and applicability of the proposed policy by comparing it with the comparative policy.

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    Review of Equipment Effectiveness Evaluation and Supporting Technologies
    SU Hongjia, LUO Yucheng, LIU Fei
    Air & Space Defense    2023, 6 (3): 29-38.  
    Abstract688)      PDF(pc) (619KB)(2381)       Save
    Operational effectiveness evaluation has been widely used in various weapon and equipment validation studies to assess the capability of specific operational mission objectives. This paper has provided a summarized analysis of the current problems and challenges. Then, it reviewed three categories of equipment system operational effectiveness evaluation methods: multi-attribute decision-making, complex networks, and machine learning algorithms. The research status of the above approaches was analyzed. In addition, this paper has summarized the supporting technologies for equipment system operational effectiveness evaluation, respectively, indicator reduction and optimization. Finally, according to the current research progress, expected research directions for future evaluation are proposed.
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    Clinical characteristics and risk factor analysis of 118 patients with cerebral venous sinus thrombosis
    LI Lei, WU Xi, DAI Jing, WU Wenman, DING Qiulan, WANG Xuefeng
    Journal of Diagnostics Concepts & Practice    2023, 22 (03): 261-269.   DOI: 10.16150/j.1671-2870.2023.03.09
    Abstract221)   HTML10)    PDF(pc) (991KB)(2372)       Save

    Objective: To analyze the clinical characteristics and thrombotic risk factors of cerebral venous sinus thrombosis (CVST) in Chinese population, in order to provide reference for the clinical diagnosis, prevention and treatment of CVST. Methods: A total of 118 CVST patients who visited the Thrombosis and Hemostasis Clinic of Ruijin Hospital from January in 2015 to December in 2022 were enrolled. The clinical data, imaging characteristics, and thrombotic gene panel were collected, and independent risk factors for thrombosis, recurrence, and multi-site thrombosis in CVST patients were studied through univariate and multivariate logistic regression. Results: Among 118 CVST patients, 88.1% (104/118) patients firstly developed CVST at age younger than 45 years old.It revealed that 57.6% patients (68/118) only suffered CVST once,and 33.1% patients (39/118) experienced thrombotic events at least twice, while 37.3% patients (44/118) suffered multi-site venous thromboembolism (VTE). The superior sagittal sinus was the most common venous sinus to form thrombosis (77/118), and multi-sites of venous sinus were involved simultaneously in 54.2% patients (64/118). The risk factor screening for thrombophilia showed that 70.3% patients (83/118) carried at least one thrombotic risk factor, including 53.3% patients (63/118) with inherited risk factors and 32.2% patients (38/118) with acquired risk factors. The main risk factors for males were anticoagulant protein deficiency (35/66) and antiphospholipid syndrome (5/66), while the risk factors for females mainly included anticoagulant protein deficiency (20/52), pregnancy/postpartum period (11/47), and contraceptive use (5/47). Among 35 patients with unknown risk factors, more than 30% of them experienced recurrent or multi-site thrombosis, and the underlying etiology in these patients still need to be further investigated. Univariate and multivariate logistic regression analysis showed that both inherited risk factors (odds ratio, OR=21.643, 95% confidence interval, CI 9.455-49.544, P<0.0001) and acquired risk factors (OR=10.836, 95% CI 4.306-27.270, P<0.0001) were independent risk factors for the occurrence of CVST. Genetic risk factor (OR=2.270, 95% CI 1.021-5.048, P=0.044) was an independent risk factor for recurrent thrombosis in CVST patients. Conclusions: In Chinese population, CVST is more common in middle-aged and young populations.,with 70.3% patients carrying at least one thrombotic risk factor. Genetic risk factors are the main cause of CVST in China and the detectable rate is 53.3%, which is significantly higher than that (22%) reported abroad. The patients with genetic risk factors have a significantly increased risk of developing CVST or recurrent thrombosis. Identification of thrombotic risk factors, prevention, diagnosis and treatment should be carried out earlier for individuals with high-risk CVST.

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    Development of Light Photoelectric Guided Missile
    LI Jiatai, CHEN Guoliang, MA Shanbin, WU Zhipeng, WANG Qinchao
    Air & Space Defense    2021, 4 (4): 37-43.  
    Abstract523)      PDF(pc) (5173KB)(2158)       Save
    With the rapid development of new photodetectors, optical materials, signal processing and MEMS techno-logy, the photoelectric precision guidance technology has gradually become one of the most important technologies in the field of precision guidance today, and also lays the foundation for the development of a new generation of light photoelectric guided missile. In this paper, the typical models of light photoelectric guided missile in foreign military are summarized, and the technology development status is introduced. The key technologies in missile overall design technology, detection guidance and control technology, fuse-warhead coordination technology, and motor system technology are analyzed in detail. Finally, the paper envisages the development trend of light photoelectric guided missile.
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    AC loss study on a 3-phase HTS 1 MVA transformer coupled with a three-limb iron core
    Yue Wu, Shuangrong You, Jin Fang, Rodney A. Badcock, Nicholas J. Long, Zhenan Jiang
    Superconductivity    2024, 10 (0): 100095-.   DOI: 10.1016/j.supcon.2024.100095
    Abstract26)   HTML18)    PDF(pc) (4938KB)(2115)       Save

    High-temperature superconducting (HTS) technology provides an alternative approach to achieve compact transformers. Addressing AC loss in the HTS winding is crucial for HTS transformer applications. Most numerical AC loss studies on HTS transformers have neglected the influence of iron cores. This work carries out an AC loss study to explore the impact of an iron core on the HTS windings in a 3-phase HTS 1 MVA transformer coupled with it. AC loss simulations for the transformer winding both with and without the iron core are conducted by adopting the three-dimensional (3D) T-A homogenization method. When the iron core is incorporated, the saturation magnetic fields of iron materials, flux diverters (FDs) with different geometries, and variations in turn spacings in the LV winding composed of Roebel cables are considered to investigate their influence on the AC loss of the transformer winding. The inclusion of the iron core leads to a 1.2% increase in AC loss for the transformer winding while simulating at the rated current. We attribute this slight difference to the non-inductive winding structure of the transformer winding, where a strong magnetic field generated in the space between the LV and HV windings effectively shields the influence of the iron core.

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    Journal of Diagnostics Concepts & Practice    2021, 20 (04): 349-355.   DOI: 10.16150/j.1671-2870.2021.04.004
    Abstract1082)   HTML31)    PDF(pc) (766KB)(2093)       Save
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    Lung cancer worldwide and in China from 1990 to 2020: prevalence and prevention measures
    WANG Zezhou, ZHENG Ying
    Journal of Diagnostics Concepts & Practice    2023, 22 (01): 1-7.   DOI: 10.16150/j.1671-2870.2023.01.001
    Abstract1794)   HTML52)    PDF(pc) (946KB)(2085)       Save

    From 1990 to 2020, the number of newly diagnosed cases of lung cancer in the world continued to grow, but the prevalence remained stable. As time went, the incidence (world standard incidence, adjusted with age structure of world population) of lung cancer changed in gender, region, age, and histological type. The difference between male and female in incidence continued to narrow, with male incidence declining by 12.5% and female incidence rising by 22.3%. There were obvious regional differences in the incidence of lung cancer. From 1998 to 2012, the incidence of male lung cancer in Europe, Asia and North America showed a downward trend (the average annual change percentages were -1.6%, -0.6% and -2.5%, respectively), while the incidence of female lung cancer showed a upward trend except North America. From 1998 to 2012, the average age of lung cancer patients in all regions of the world showed a trend of increasing year by year. The average age at diagnosis of lung cancer in Asian men increased from 67.21 years in 1998 to 69.14 years in 2012. Patterns of histological types of lung cancer have also changed. Since the early 1980s, the proportion of squamous cell lung cancer has declined. Since 2004, adenocarcinoma has become the most common histological type of lung cancer in the world. In 2020, China had the largest cases of newly diagnosed lung cancer in the world. From 1989 to 2008, urban-rural ratio of lung cancer incidence dropped from 2.07 to 1.14. In economically underdeveloped areas, the incidence of lung cancer was also rising, and the situation in some areas with high incidence of lung cancer had been controlled. China, as the largest tobacco producer and consumer country, has to be serious with the control of tobacco. Risk of lung cancer caused by environmental pollution is gradually lower. Controlling occupational exposure is also the key to preventing lung cancer in China, and establishing a mornitoring network for risk factors is the direction in future.

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    Global Space Security Situation Analysis and Development Proposal
    CHEN Ying, WEI Guoning, TANG Shengyong, KANG Zhiyu
    Air & Space Defense    2021, 4 (3): 99-104.  
    Abstract1659)      PDF(pc) (5925KB)(2058)       Save
    As a new frontier of human activity, space is threatened by asteroid, space debris and military contest, and space security is closely related to the common interests of all mankind. Focusing on the topic of space security situation, a new definition of space security is proposed in this paper from the perspective of space domain and application scenario. In addition, considering both man-made threats and natural threats, current situation and near future development of space security is analyzed. And then, the main challenges of space security situation are discussed, such as asteroid defense, debris removal and outer space arms control. Lastly, four proposals about the big issue of global space security improvement are presented, from the point of view of diplomacy, law, technology, culture.
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    Association between 24-h ambulatory blood pressure variability and cardiac structure and function
    XU Tingyan, YANG Yan, LI Jingjing, ZHANG Dongyan, WANG Ying, WANG Jiguang, LI Yan
    Journal of Diagnostics Concepts & Practice    2019, 18 (2): 193-198.   DOI: 10.16150/j.1671-2870.2019.02.014
    Abstract530)   HTML1)    PDF(pc) (605KB)(2047)       Save

    Objective: To investigate the association between 24-h ambulatory blood pressure variability and cardiac structure and function in untreated patients. Methods: The association between 24-hour ambulatory blood pressure (BP) recordings and echocardiography in 80 untreated patients referred to a hypertension clinic was assessed. BP variability indices were standard deviation (SD), coefficient of variation (CV), variability independent of the mean (VIM), maximum-minimum difference (MMD), and average real variability (ARV). Effect sizes (standardized β)and partial coefficient of determination were computed using multivariable regression models. Results: Left ventricular mass index(LVMI) (systolic BP: β=6.8—8.0, P<0.01; diastolic BP: β=6.7—7.8, P<0.01), longitudinal strain(LS) (systolic BP: β=-0.76—-0.71, P<0.05; diastolic BP: β=-0.81—-0.71, P<0.05) and septal E/e' (systolic BP: β=0.44—0.57, P<0.05) were associated independently with BP, whereas the association with BP variability was not significant except for those of LVMI with systolic BP CV and VIM ( β=3.3, P=0.048, β=3.4, P=0.049), and of septal E/e' with diastolic BP MMD ( β=0.46, P=0.034). Conclusion: Short-term 24-h blood pressure variability is associated with cardiac structure and function, but blood pressure might be a major factor affecting these cardiac indices.

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    The Overall Approach to Studying Translator Groups:A Review of A Study on English Translators of Jiangsu Classic Literature
    FENG Quangong
    Contemporary Foreign Languages Studies    2022, 22 (1): 153-160.   DOI: 10.3969/j.issn.1674-8921.2022.01.013
    Abstract375)   HTML24)    PDF(pc) (1396KB)(1983)       Save

    Nowadays translator studies are greatly emphasized and a large number of relevant research achievements are produced. However, studies on translator groups are relatively few, which should be strengthened in the future. Xu Duo’s monograph A Study on English Translators of Jiangsu Classic Literature, as a typical achievement of studies on translator groups, investigates the translation views, cultural position, translation motives, translation selection and translation features of five translators of Jiangsu classic literature like David Hawkes, John Minford, Moss Roberts, Sidney Shapiro and Yang Xianyi. This paper discusses the overall approach on the study of translator groups mainly by analyzing and commenting on Xu Duo’s monograph, such as the selection of research object and methods, the progression of research blueprint, the realization of research conclusion and so on. It is suggested that emphasis be placed on the investigation of shared features of translator groups and the light shed by translator group studies on current translation practice.

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    Pressurization, intercalation, doping, and elements: An empirical study of superconductivity near perturbation onsets
    Shermane M. Benjamin
    Superconductivity    2024, 10 (0): 100098-.   DOI: 10.1016/j.supcon.2024.100098
    Abstract28)   HTML27)    PDF(pc) (1976KB)(1901)       Save

    Superconductivity is a phenomenon arising from cooperative electron behavior. However, correlations among (1) the minimum tuning parameter required for emergence, (2) the superconducting transition temperature resulting from minimal tuning, and (3) the host's physical/chemical properties still elude the scientific community. Recent empirical investigations, such as those revealing ideal gas-like correlations at the onset of superconductivity in intercalated superconductors, motivate this study. Our investigation reports similar findings in systems (>170 compounds) exhibiting superconductivity through other perturbative means, such as single-element doping. In general, statistical measures, including distance correlation analyses (≠ linear regression fit) of thermodynamic variables, indicate the presence of empirical relationships near the superconducting onset of systematically tuned compounds. These relations involve unit cell volume (V), the number of valence electrons (N), and the superconducting transition temperature (Tc). Note: The author's primary aim is not to validate or challenge BCS theory; it is instead to focus on leveraging methodology led by available data to enhance the exploration and development of innovative and cost-effective superconductors.

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    Interpretation of guidelines for the diagnosis and treatment of primary osteoporosis (2022 version) in China: essential introduction
    ZHANG Zhenlin, YUE Hua, LI Mei, XIA Weibo
    Journal of Diagnostics Concepts & Practice    2023, 22 (03): 230-233.   DOI: 10.16150/j.1671-2870.2023.03.04
    Abstract690)   HTML13)    PDF(pc) (913KB)(1891)       Save

    China is now witnessing an accelerated aging process,and active reaction is an important issue that we are facing. Osteoporosis and the resulting fractures are particularly noteworthy. In order to further standardize the diagnosis and treatment of primary osteoporosis, the Osteoporosis and Bone Mineral Disease Branch of the Chinese Medical Association has developed and released the “Guidelines for the Diagnosis and Treatment of Primary Osteoporosis (2022 Version)” based on the epidemiological characteristics and pathogenesis of the Chinese population, which combined high-quality medical research evidence from both domestic and foreign sources. Based on evidence-based medicine evidence, and clinical practice in China, this article will focus on the interpretation of two key clinical issues in the new version of the guidelines, namely “fracture risk stratification and treatment selection” and “treatment course of anti-osteoporosis drugs”. Regarding the risk of fractures, this guideline divides it into high and extremely high fracture risks, cancels the classification of low and medium risks, and for one of the extremely high fracture risk indicators “recent brittle fractures”,defines “recent” as “24 months”.Given that the FRAX model underestimates the fracture risk of Chinese patients, it is proposed to develop a highly operational fracture risk stratification criteria in clinical practice. Regarding drug treatment, patients who use bisphosphonates should be fully evaluated before entering the medication holiday, and regular follow-up is still required. Although the Food and Drug Administration (FDA) of the United States has lifted the warning of osteosarcoma and 24- month treatment limit for terlipide, the user manual of the drug in China still suggests a treatment period of 24 months. This guideline is based on high-quality evidence-based medical evidence both domestically and internationally, and may provide reference and research directions for clinical practice.

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    Research progress on the mechanism of skin aging caused by ultraviolet radiation
    CHEN Heng, WANG Jue, ZHOU Xu
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 382-.  
    Abstract164)      PDF(pc) (992KB)(1878)       Save
    Skin exposed to sunlight for a long period of time will have impaired function and even genetic material
    alteration, which is manifested by aging characteristics such as water loss, elasticity loss, wrinkle growth, melanin
    deposition and dryness. There are many ways to cause skin photoaging and the mechanism is complex, the ultraviolet light in
    sunlight has a particularly obvious effect on skin aging, the ultraviolet light that can act on the skin is divided into two kinds:
    UVA and UVB. They mainly act on the skin through five mechanisms that lead to photoaging: oxidative stress, damaging
    genetic material, changing the epidermal microbial community, destroying the function and structure of organelles, and
    reshaping the extracellular matrix (ECM).In this paper, these five mechanisms were reviewed, and research directions and
    prospects in this field were proposed.
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    Superconducting nanostrip single photon detectors fabricated of aluminum thin-films
    Yuting Jiang, Xingyu Zhang, Hui Zhou, Xiaofu Zhang, Hao Li, Lixing You
    Superconductivity    2024, 10 (0): 100096-.   DOI: 10.1016/j.supcon.2024.100096
    Abstract19)   HTML19)    PDF(pc) (1122KB)(1856)       Save

    We systematically investigated the detection performance of Al nanostrips for single photons at various wavelengths. The Al films were deposited using magnetron sputtering, and the sophisticated nanostructures and morphology of the deposited films were revealed through high-resolution transmission electron microscopy. The fabricated Al meander nanostrips, with a thickness of 4.2 nm and a width of 178 nm, exhibited a superconducting transition temperature of 2.4 K and a critical current of approximately 5 μA at 0.85 K. While the Al nanostrips demonstrated a saturated internal quantum efficiency for 405-nm photons, the internal detection efficiency exhibited an exponential dependence on bias current without any saturation tendency for 1550-nm photons. This behavior can be attributed to the relatively large diffusion coefficient and coherence length of the Al films. By further narrowing the nanostrip width, the Al-SNSPDs remain capable of effectively detecting single telecom photons to facilitate practical applications.

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    Research Review of Hypervelocity Projectile by Electromagnetic Launch at Home and Abroad
    MA Xiaoping, LIAO Xin, CHEN Bing
    Air & Space Defense    2021, 4 (2): 87-.  
    Abstract575)      PDF(pc) (1615KB)(1850)       Save
    In light of new-type weapon equipment in terminal defense-hypervelocity projectile (HVP) by electromagnetic launch, this paper first overviews the concept of electromagnetic rail gun, its system and working principle. Then the features of HVP by electromagnetic launch are analyzed. Based on this, foreign and domestic research status is reviewed. Besides, the key technologies to promote product serialization are discussed, among which includes multi-mode combined guidance, electromagnetic compatibility, etc. Finally, based on research achievements analysis related to HVP at home and abroad, this paper indicates that HVP will develop towards systemization, intellectualization, networking and coordination from product lifecycle management and general development model.
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    Numerical modelling of electromechanical coupling behaviors in HTS coil with implementation of H formulation in FE software
    Huadong Yong, Dong Wei, Yunkai Tang, Donghui Liu
    Superconductivity    2024, 10 (0): 100097-.   DOI: 10.1016/j.supcon.2024.100097
    Abstract17)   HTML12)    PDF(pc) (3029KB)(1816)       Save

    (Re)Ba2Cu3O7-x (REBCO) coated conductors (CCs) have attracted considerable concern because of their outstanding current carrying capacity in magnetic fields of high strengths. A huge electromagnetic force is generated in the superconducting coil when conducting large currents in strong magnetic field. Thus, management of stress and strain has become a key technical challenge for the stability and safety of superconducting coil during operation. To accurately predict the electro-magnetic and mechanical characteristics of superconducting coil in strong magnetic field, an electromechanical model on the basis of the H-formulation and arbitrary Lagrangian-Eulerian (ALE) method is proposed here with FE software. To verify the proposed model, the simulation outcomes of the coil during magnetization are compared with the experimental outcomes. The coupling effect of magnet at high field strengths is dependent on the position of the coil. To reduce the screening current effect, the overshoot method with plateau is found superior to the traditional overshoot method, and an increase in the stabilization time can decrease the maximum value of stress. Finally, the electromechanical behaviors of single winding coil and two-tapes co-winding coil are compared.

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