Objective To study the sensitization of silk fibroin-based nerve guidance conduits (SF-NGCs) in vitro. Methods According to ISO 10993-10:1995 standard, maximization test was conducted in guinea pig. The skin sensitization reactions, including erythema and oedema, induced by SF-NGCs, normal saline and formalin solution were observed and scored respectively at 24, 48 and 72 h exposure of the infusion of the materials. The allergenic rates and mean response score were calculated. Results The allergenic rates a...
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