胆汁酸与肠道微生物相互作用及其在帕金森病中的作用

doi:10.16138/j.1673-6087.2025.04.16

摘要/Abstract

摘要：

胆汁酸是胆固醇代谢的重要产物之一，不仅具有乳化脂质的作用，而且可作为信号分子，对糖、脂质、能量代谢稳态和机体免疫功能发挥重要的调节作用。胆汁酸一方面受到宿主和肠道微生物的影响，另一方面又能重塑肠道环境稳态，并通过微生物-肠-脑轴（microbiome-gut-brain axis, MGBA）对中枢神经系统进行调控。因此，胆汁酸信号通路的稳态对神经系统生理功能的维持具有重要意义。本文将从胆汁酸与肠道微生物相互作用的角度出发，综述胆汁酸代谢异常与帕金森病（Parkinson disease, PD）的关系，及其在PD治疗中的潜在作用。

关键词: 胆汁酸, 肠道微生物, 帕金森病

Abstract:

Bile acids are amphipathic molecules derived from cholesterol, which facilitate the absorption of lipids, and also serve as signaling molecules in regulating metabolic homeostasis and immune response. Bile acid is modified by intestinal flora, and on the other hand, it alters the composition of gut microbiota and exerts potential effects on the microbiota-gut-brain axis(MGBA). Through this bidirectional communication system, bile acid signaling homeostasis plays a modulatory role for maintaining the physiological function of nervous system. In recent years, increasing evidence indicates that the bile acid associated with dysbiosis in gut microbiota may be an early sign of Parkinson disease (PD), which triggered the exploration of new pathological mechanisms and diagnostic biomarkers for PD. This article reviews the relationship between abnormal bile acid metabolism and PD as well as its potential role in PD treatment from the perspective of interaction between bile acids and intestinal microorganism.

Key words: Bile acids, Gut microbiota, Parkinson disease

中图分类号:

R742.5

刘书萌, 艾鹏辉, 肖勤, 杨晓东. 胆汁酸与肠道微生物相互作用及其在帕金森病中的作用[J]. 内科理论与实践, 2025, 20(04): 345-350.

LIU Shumeng, AI Penghui, XIAO Qin, YANG Xiaodong. Interaction between bile acids and gut microbiota and their role in Parkinson disease[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(04): 345-350.

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