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Diagnosis and treatment of vascular anomalies in the era of precision medicine YANG Xiaonan, ZHANG Ye Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 599-.   Abstract （166）      PDF（pc） （1038KB）（1513）       Knowledge map    Save Vascular anomalies are classified into hemangiomas and vascular malformations， representing a group of diseases that include （but not limited to） more than 30 types of hemangiomas， over 60 types of vascular malformations， and more than 20 syndromes related to vascular anomalies. Deepening understanding and improving diagnosis and treatment have always been the focus and difficulty in clinical work. With the continuous advancement of medical science and technology， the diagnosis and treatment of vascular anomalies are rapidly entering a new medical era-the era of precision medicine. Precision medicine relies on in-depth research of molecular mechanisms， advanced diagnostic technologies， personalized treatment plans and multidisciplinary diagnosis and treatment mode， and its clinical expansion and promotion in clinical practice have brought revolutionary changes to the diagnosis and treatment of vascular anomalies. In this paper， the progress and future development direction of the diagnosis and treatment of vascular anomalies in the era of precision medicine were reviewed. Related Articles | Metrics | Comments（0）

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Research progress of 3D adipose tissue model ZHU Congxiao, YIN Ningbei Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 562-.   Abstract （244）      PDF（pc） （975KB）（1203）       Knowledge map    Save As the largest endocrine organ and the main energy storage system in the human body， adipose tissue plays a pivotal role in regulating energy homeostasis. Pathological conditions such as insulin resistance， chronic inflammation and mitochondrial dysfunction are closely related to adipose metabolic disorders. In vitro models are significant tools for studying the mechanism of associated disorders. At present， three-dimensional culture is a common model for in vitro adipose tissue research because it can imitate the process of adipose metabolism to a certain extent. In order to serve as a resource for future scientific investigations， an overview of three-dimensional adipose tissue models and their properties was provided in this paper. Related Articles | Metrics | Comments（0）

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#br# Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 702-.   Abstract （187）      PDF（pc） （1165KB）（1076）       Knowledge map    Save Distal arthrogryposis represents a group of congenital malformations with genetic factors， and distal arthrogryposis type 9 is attributed to mutations in the FBN2 gene. Differing from other subtypes where muscular tissues are affected，FBN2 gene mutation primarily impacts the embryonic development of connective tissues， giving rise to distinctive clinical phenotypes. To date， the specific pathogenic mechanisms of this condition remain elusive. In this paper， the recent research progress of distal arthrogryposis type 9 was reviewed， aiming to enhance our understanding of the disease. With the advancement and widespread use of sequencing technologies， the potential discovery of additional mutation loci and patient cohorts holds promise for elucidating genotype-phenotype correlations. Furthermore， there is a pressing need to promote the development of appropriate cellular and animal models to further elucidate its pathogenic mechanisms， offering novel avenues for disease diagnosis and therapeutic interventions. Related Articles | Metrics | Comments（0）

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Research on positive psychological qualities， negative emotions， and quality of life in adult patients with port-wine stain WANG Wanyi, HU Jiahua, YU Wenxin, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 693-.   Abstract （123）      PDF（pc） （1036KB）（976）       Knowledge map    Save Objective To understand the current status of positive psychological qualities （hope trait， self-compassion）， anxiety， depression， and quality of life in adult patients with port-wine stain （PWS）， and to provide a basis for implementing psychological interventions from the perspective of positive psychology. Methods A convenient sampling method was used to select 119 adult patients with fresh red nevus who underwent pulsed dye laser treatment from March to June 2023 as the study subjects. The survey tools included a general information questionnaire， Herth Hope Index， Self-Compassion Scale， Depression Screening Scale， Anxiety Screening Scale， and Health Status Questionnaire. Correlation analysis between variables was conducted. Results The average score of hope trait in 119 PWS patients was 30.8±7.7， with 16.0% of patients having low levels of hope trait， and the self-compassion score was 82.4±10.9. 48.7% of patients were positive for depression， and 65.5% of patients were positive for anxiety. The average score of quality of life was 68.3±12.5. There was a significant negative correlation between positive psychological qualities （hope trait， self-compassion） and negative emotions （anxiety， depression）， and a significant positive correlation between positive psychological qualities （hope trait， self-compassion） and quality of life （P<0.05）. Conclusion The positive psychological qualities of adult PWS patients are at a moderate level， with experiencing negative emotions such as anxiety and depression， leading to decreased quality of life. Positive psychological qualities are key factors in improving negative emotions and enhancing quality of life in PWS patients， and personalized intervention strategies for positive psychological qualities can be explored in the future. Related Articles | Metrics | Comments（0）

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Application of cerium oxide nanoparticles in wound healing ZHU Yulin, LIU Jing, DENG Guoying Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 574-.   Abstract （279）      PDF（pc） （948KB）（896）       Knowledge map    Save Wound healing is a complex physiological process， which can be divided into four main stages： Hemostasis， inflammation， proliferation and migration， and tissue remodeling. At the same time， granulation formation， inflammatory cell infiltration， necrotic tissue cleaning， scar remodeling and other reactions are involved. In some pathological cases， the natural healing process of the wound may be stalled， resulting in repeated attacks and even death from shock. In recent years， the search for high safety and high efficiency medical materials has attracted much attention from researchers. Among them， cerium oxide nanoparticles are a unique material which can promote wound healing and play an important role in all stages of wound healing. Nano-cerium oxide particles not only have antioxidant， antibacterial and anti-inflammatory functions， but also can be used as drug carriers in wound repair to ensure the benign absorption of the body， and can be used as tissue scaffolds to promote the development and maturity of new structures. Therefore， exploring the role of cerium oxide nanoparticles in wound healing may be a new strategy for wound repair. In this paper， the effects of cerium oxide nanoparticles on wound repair were reviewed to provide references for their further application and development in the future. Related Articles | Metrics | Comments（0）

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Preparation and application of collagen-based biomaterials in bone and cartilage regeneration and repair DUAN Jing, YANG Bing Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 707-.   Abstract （342）      PDF（pc） （1040KB）（798）       Knowledge map    Save Collagen-based biomaterials can be used as ideal biomaterials for bone and cartilage regeneration and repair due to their good biological activity and biocompatibility. However， due to the weak macroscopic mechanical properties of collagen， which cannot meet the mechanical requirements of natural cartilage and bone tissue， the mechanical properties are often improved by cross-linking modification. In addition， different material forms require different forming technologies. In this paper， the cross-linking methods and forming technologies of collagen-based biomaterials were reviewed， and the construction of collagen scaffolds and the selection of implanted cells for bone and cartilage regeneration and repair in recent years were summarized， aiming to provide clues and ideas for the development of collagen-based biomaterials preparation technology and the transformation of clinical applications. Related Articles | Metrics | Comments（0）

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“Starship”in skin regeneration：Exploring the breakthroughs and potential of acellular dermal matrix applied in skin expansion LUO Xusong Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 503-.   Abstract （229）      PDF（pc） （950KB）（702）       Knowledge map    Save The simultaneous reconstruction of appearance and function following large-area skin defects remains an unresolved challenge in clinical practice. Although skin expansion technology has been widely employed in tissue repair and reconstruction， its development has stagnated， primarily due to low expansion efficiency， high complication rates， and poorly understood mechanisms. To address this issue， an innovative approach utilizing acellular dermal matrix was proposed to assist in skin expansion and achieved promising preliminary clinical results. Acellular dermal matrix provides a “biocompatible” interface， balances mechanical forces， and serves as an active scaffold to support various cell types. However， its specific mechanism of action during the skin expansion process warrants further investigation. By acting as an expansion companion， acellular dermal matrix synergistically enhances skin expansion and holds the potential to break through current expansion limitations， thereby unlocking the full potential of skin expansion technology. Related Articles | Metrics | Comments（0）

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Research progress of copper-based nanoparticles and copper-containing antibacterial implants FU Guangjie, HUANG Leiyun, BAI Zhenglin, et al Journal of Tissue Engineering and Reconstructive Surgery    2025, 21 (1): 93-.   Abstract （153）      PDF（pc） （1065KB）（701）       Knowledge map    Save  Due to the excessive and unreasonable use of antibiotics， the incidence of bacterial resistance and the improvement of drug resistance have gradually become a serious problem faced by orthopedic medical workers. Therefore， it is necessary to find an antibacterial agent with excellent antibacterial ability， excellent biocompatibility and not easy to produce drug resistance， which can replace antibiotics for orthopedic clinical. At present， scholars at home and abroad have proved that copper-based nanoparticles have small size， large specific surface area， excellent antimicrobial performance and are not easy to produce drug resistance. In the future， there is hope to replace antibiotics in clinical applications. In this paper， the main antibacterial mechanisms， biocompatibility， biological control of copper-based nanoparticles and the research progress of orthopedic copper-containing implants were reviewed. The existing problems and challenges of copper-based nanoparticles and copper-containing antibacterial implants were discussed， and the future of such antibacterial materials was prospected， so as to promote the clinical application of copper-based nanoparticles and orthopedic copper-containing antibacterial implants. Related Articles | Metrics | Comments（0）

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The application of artificial intelligence（AI）in rhinoplasty PAN Xingyi, LI Zijun, ZHEN Yonghuan, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 659-.   Abstract （323）      PDF（pc） （1055KB）（649）       Knowledge map    Save With the advancement of medical technology and the improvement of patients' demand for personalized aesthetics， rhinoplasty has become one of the most challenging surgeries in plastic surgery. It requires not only precise anatomical knowledge but also a surgical plan that incorporates the patient's unique facial features and aesthetic expectations. In recent years， the application of artificial intelligence （AI） in the medical field has been booming， with its data analysis capabilities and automation offering new solutions for rhinoplasty. This review aimed to explore the specific applications of AI in rhinoplasty， including how AI can be used for preoperative planning， surgical navigation， and postoperative evaluation. By analyzing the key roles of AI in rhinoplasty， this paper highlighted the importance of AI in enhancing surgical precision， personalized design， and outcome predictability. Additionally， it discussed the potential value of AI in optimizing surgical plans， reducing complication risks， and improving patient satisfaction. Moreover， this paper addressed the limitations of AI in rhinoplasty， particularly its applicability in clinical decision-making and the challenge of insufficient personalization in aesthetic design， and prospected the future improvement direction of the AI technology and its further potential in rhinoplasty. Related Articles | Metrics | Comments（0）

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Application and research progress of digital technology in breast augmentation with implants YUAN Guohao, ZENG Li, WANG Haibin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 653-.   Abstract （125）      PDF（pc） （1045KB）（553）       Knowledge map    Save Breast augmentation is the second most in-demand cosmetic surgery worldwide. With the rise of precision and minimally invasive concepts， digital technology has evolved， including 3D scanning imaging， digital endoscopy， and a variety of digital photographic examinations that are widely used in breast augmentation. These techniques help operators to accurately assess breast morphology before surgery， precisely control the process during surgery， and accurately and conveniently follow up after surgery， thus maximizing the benefits to patients. In this paper， the application and research progress of digital technology in breast implant augmentation were reviewed in order to provide reference and theoretical basis for clinical surgery and follow-up. Related Articles | Metrics | Comments（0）

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Research progress of in vitro wear test and computational wear simulation of ankle joint prosthesis YANG Shu, ZHANG Yanwei, GAO Jintao, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 584-.   Abstract （173）      PDF（pc） （3042KB）（452）       Knowledge map    Save Aseptic loosening caused by wear and wear particles is the main cause for the failure of artificial ankle joints. The in vitro tests and computational simulation are important methods for pre-clinical evaluation of prosthetic wear performance. In this paper， the kinematic and dynamic curves used in wear studies of ankle prosthesis were compared. Afterwards， the results of the wear studies were summarized and analyzed. The results showed that： ① Due to the lack of ISO testing standard in the early stage， there are differences in the loading conditions of various studies， mainly reflected in axial load and anteroposterior displacement. Therefore， it is difficult to obtain the wear mechanism of ankle prostheses through the horizontal comparison. ② Foreign researchers have studied the effects of factors such as the implant design， materials， testing conditions， and lubricating media of artificial ankle joint prostheses on wear test results， but relevant literature has not been published in China. ③ The numerical simulation wear results of artificial ankle joint are similar to its in vitro test results， indicating that the validated simulation model can be used to predict the wear performance of ankle joint prostheses. Related Articles | Metrics | Comments（0）

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Effect of Yes-related protein on the survival rate of fat transplantation and its mechanism LIU Yuxin, SUN Jiaming, YU Li Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 672-.   Abstract （173）      PDF（pc） （8525KB）（421）       Knowledge map    Save Objective To investigate the effect of YAP on fat graft survival and its possible mechanism. Methods 3T3L1 cells were cultured in vitro and treated with YAP siRNA or YAP-overexpression plasmids carried by lentiviral vectors，resulting in the following groups： negative control siRNA （NC）， YAP-si1， YAP-si2， and YAP-si3； lentiviral vector（Vector） and YAP-overexpression （YAP）. Cell proliferation was assessed using EdU staining. Differentiation into adipocyteswas induced， and early and late stages of differentiation were analyzed by Oil Red O staining， with lipid droplet accumulationquantified using Image-Pro Plus 6.0 software. Triglyceride content was measured using a triglyceride assay kit， and PCR andWestern blot were used to assess the expression of genes and proteins related to adipocyte differentiation. For in vivo experiments， a subcutaneous fat transplantation model in nude mice was established. A total of 8 mice were randomly divided into NC siRNA group， YAP knockdown （si-YAP） group， adeno-associated virus （AAV） vector group， and YAP overexpression （AAV-YAP） groups， with 2 mice per group. Each mouse received 0.2 mL of fat injection at four different sites， totaling 0.8 mL. Subsequent injections of 0.2 mL of NC siRNA， YAP siRNA， AAV vector， or AAV vector-mediated YAP-overexpression plasmid were administered into the transplanted fat. Fat was collected at 1，2， and 4 weeks post transplantation， and fat weight and volume were measured to evaluate survival rates. Hematoxylin-eosin staining and immunofluorescence were used to examine fat structure， number of oil droplets， and viable adipocytes. Results In cell experiments， YAP knockdown did not significantly affect proliferation or apoptosis of 3T3-L1 cells compared to controls， but resulted in increased Oil Red O staining area （P<0.05）， higher triglyceride content （P<0.05）， and elevated expression of adipogenic genes and proteins （P<0.05）. Conversely， YAP overexpression led to increased proliferation of 3T3-L1 cells with unchanged apoptosis rates， decreased Oil Red O staining area （P<0.05）， lower triglyceride content （P<0.05）， and reduced expression of adipogenic genes and proteins （P<0.05） compared to the lentiviral vector group. In animal experiments， the si-YAP group exhibited increased fat weight and volume， more intact fat structure， reduced oil droplet number， and more viable adipocytes compared to the NC group. In contrast， the AAV-YAP group had decreased fat weight and volume， less intact fat structure， increased oil droplet number， and fewer viable adipocytes compared to the AAV vector group. Conclusion YAP significantly inhibits the survival rate of transplanted fat. Furthermore， YAP affects 3T3-L1 adipogenesis by modulating the PPARγ pathway. Related Articles | Metrics | Comments（0）

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Generating insulin-producing cells from human adipose-derived stem cells：Comparison of three differentiation protocols YANG Jing, LIU Xingran, YIN Xiya, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 507-.   Abstract （245）      PDF（pc） （6161KB）（419）       Knowledge map    Save Objective The induced differentiation of adipose stem cells into insulin-secreting cells is a new strategy for the treatment of diabetes mellitus. The efficiency of the induced differentiation schemes reported so far varies greatly. This study aims to compare the differentiation efficiency of three induced differentiation schemes. Methods Fat samples from the same batch were collected to extract fat stem cells for passage culture， and the third-generation fat stem cells were self-aggregated into balls for induction and differentiation in different phases （one-step method， two-step method and three-step method）. The expression levels of key genes and proteins in the products of the three schemes at the corresponding stages were detected by PCR and immunofluorescence， and the function of insulin secreting cells was detected by glucose stimulation of insulin secretion experiment. Results Compared with other schemes， the gene expressions of the key transcription factors INS，NKX6.1 and PDX1 in the insulin secreting cells induced by the three-step method were significantly increased， and there were significant differences. Key protein C-peptide and NKX6.1/PDX1 were co-expressed in insulin-secreting cells. Functionally， the insulin secreting cells induced by the three-step method can significantly increase insulin secretion under high glucose stimulation. Conclusion Under the same differentiation conditions， the differentiation efficiency of adipose stem cells induced into insulin secreting cells by the three-step method is superior to that by the two-step method and the one-step method， which provides a basis for establishing an efficient and safe induction differentiation scheme of insulin secreting cells. Related Articles | Metrics | Comments（0）

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Expression of TLR4/NF-κB signaling pathway in scar cancer tissues and effect of TAK-242 on scar cancer cells HUO Wenliang, TIAN Xiaorui, ZHANG Jinruo, et al Journal of Tissue Engineering and Reconstructive Surgery    2025, 21 (1): 14-.   Abstract （293）      PDF（pc） （7568KB）（326）       Knowledge map    Save Objective To analyze the expression of Toll like receptor 4（TLR4） and nuclear factor kappa B （NF-κB） in scar cancer tissues， and to investigate the effect of TLR4 inhibitor TAK-242 on scar cancer cells. Methods 20 cases of normal skin tissue， 20 cases of hypertrophic scar tissue， and 20 cases of scar cancer tissue were collected. Immunohistochemistry and reverse transcription polymerase chain reaction （RT-PCR） were used to detect the expression of TLR4 and NF-κB protein and mRNA. The relationship between the expression of TLR4， NF-κB and clinical pathological factors such as patient gender， age， and tumor differentiation degree was analyzed. Scar cancer cells were cultured in vitro and treated with TLR4 inhibitor TAK-242. Cell proliferation activity was detected by MTT assay， and the expression of TLR4， NF- κB， MMP9， and TGF-β1 proteins was detected by Western blot assay. Results Compared with the control group， the expression of TLR4， NF-κB protein and mRNA in scar tissue and scar cancer tissue was significantly increased（P< 0.05）； Compared with scar tissue， the expression of TLR4， NF-κB protein and mRNA in scar cancer tissue was significantly increased （P<0.05）. The expression of TLR4 and NF- κB in scar cancer tissue was related to the degree of tumor differentiation （P<0.05）. After intervention with TLR4 inhibitor TAK-242， the proliferation activity of scar cancer cells was  significantly reduced （P<0.05）， and the protein expression of TLR4， NF- κB， MMP9， and TGF-β1 was downregulated （P< 0.05）. Conclusion The TLR4/NF-κB signaling pathway is involved in the pathological process of scar tissue carcinogenesis， and the TLR4 inhibitor TAK-242 can inhibit scar cancer proliferation， which is expected to become a new target for scar tissue treatment. Related Articles | Metrics | Comments（0）

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Research progress on the age-related changes in facial skin in Chinese women LU Nan, HUANG Tao, SONG Jiao, et al Journal of Tissue Engineering and Reconstructive Surgery    2025, 21 (2): 205-.   Abstract （183）      PDF（pc） （1033KB）（273）       Knowledge map    Save Skin is the largest organ in the human body and serves as the boundary between the internal and external environments. The aging process of facial skin is influenced by various factors， such as exposure to sunlight， environmental pollution， and lifestyle habits. Over time， facial skin exhibits typical signs of aging， including wrinkles， sagging， roughness， pigmentation， uneven skin tone， dryness， and decreased elasticity. With the rapid development of the economy and people's pursuit of a high-quality life， the quest for face rejuvenation has gained increasing attention. In this paper， research progress of age-related changes in facial skin among Chinese women was reviewed to offer theoretical support for the development of skincare products and the treatment practices of dermatologists. Related Articles | Metrics | Comments（0）

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Analysis of sex and age-related differences in lower eyelids morphology：A three-dimensional image digital study based on the Chinese population CHI Yarong, SUN Yixin, JIN Lin, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 623-.   Abstract （115）      PDF（pc） （8367KB）（259）       Knowledge map    Save Objective To provide comprehensive anthropometric data on the lower eyelid region among different age and gender groups of Chinese individuals through three-dimensional imaging analysis. Methods Sixty-two healthy subjects aged 20-35 and 50-65 were recruited to acquire their three-dimensional facial images. Utilizing 27 landmarks， a total of 37 lower eyelid measurement indicators were established， comprising of 21 straight lines，5 curvatures，4 angles，2 areas， and 5 ratios. The age and gender characteristics of the lower eyelid were summarized by comparing the measurement results among different age groups and gender groups. Results Compared to females， longer palpebral fissure， lower tear troughs and lidcheek junction， smaller inner and outer canthal angles， as well as a larger area and proportion of the lower eyelid region were found in males. With aging， there is a gradual reduction in the height of the palpebral fissure and inner canthal angle，accompanied by sagging of the tear trough and lid-cheek junction， enlargement of the lower eyelid area， and swelling of the lower eyelid. Conclusion The proportion of the eyebrow-eye unit occupied by the lower eyelid region is greater in males than in females. In elderly individuals， there is a noticeable sagging of the tear trough and lid-cheek junction， accompanied by swelling of the lower palpebral region. These findings can serve as a valuable reference for cosmetic procedures and oculoplastic surgery. Related Articles | Metrics | Comments（0）

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Three-dimensional imaging study of nasal basal depression XU Yang, ZHANG Liyuan, DING Wei, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 632-.   Abstract （180）      PDF（pc） （1755KB）（237）       Knowledge map    Save Objective By comparing the Cone beam CT （CBCT） of bone class Ⅲ and normal occlusion， the difference of bony nasal base between them was compared to provide the basis for the diagnosis and treatment of nasal base depression. Methods From January 2020 to December 2023，40 patients （20 cases of bone class Ⅲ and 20 cases of normal occlusion） were selected， and the CBCT related data were measured and imported into Simplant pro 11.04 software for threedimensional fixed-point pointing， and the differences of nasal base between the two groups were compared. Results There were statistically significant differences in the absolute/relative protrusion of the upper alveolar seat point， the absolute/ relative protrusion of the anterior nasal point， the absolute/relative protrusion of the bilateral paranasal and infraorbital points， the absolute/relative protrusion of the bilateral paranasal points， and the absolute/relative protrusion of the bilateral canine socket between the patients with bone class Ⅲ and the patients with normal combination （P<0.05）. Conclusion CBCT has certain significance in the auxiliary diagnosis of nasal base depression， and after three-dimensional reconstruction measurement， the points A， AN， B3， mid-ParaN-D-IF and ParaN of bony Ⅲ patients are moved back compared with those of normal patients. Related Articles | Metrics | Comments（0）

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The perioperative nursing of breast reconstruction using profunda artery perforator（ PAP） flap ZHOU Xiaoping, DI Meihua, HE Minmin Journal of Tissue Engineering and Reconstructive Surgery    2025, 21 (2): 134-.   Abstract （89）      PDF（pc） （1040KB）（221）       Knowledge map    Save Objective　 To explore the perioperative nursing care for patients undergoing breast reconstruction with profunda artery perforator （PAP） flap. Methods　Sixteen patients who underwent breast reconstruction with PAP flap were provided with preoperative psychological care， dietary preparation， postoperative dietary care， and local wound care. Clinical nursing points were summarized. Results　The patients recovered well after surgery， were satisfied with the surgical outcomes， and were discharged smoothly. Conclusion　Close observation of the dynamic changes in the patient's condition， along with sufficient， standardized， and effective nursing are important guarantees for the success of the surgery. Related Articles | Metrics | Comments（0）

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Automated cephalometric analysis of craniomaxillofacial deformities based on artificial intelligence technologies XU Meng, LUO Zhaoyang, SONG Tao Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 605-.   Abstract （120）      PDF（pc） （5192KB）（180）       Knowledge map    Save Objective To develop a new automatic landmark detection framework for the diagnosis and treatment of patients with severe craniomaxillofacial （CMF） deformities， addressing the issues of limited data quantity and large morphological differences. Methods This study proposed a method based on a three-dimensional （3D） point cloud deformation model and deep learning networks. First， normal human data was deformed to simulate severe CMF patient data for data augmentation. Then， a coarse-to-fine strategy was adopted， where initial coarse localization of landmarks was performed using a 3D point cloud convolutional neural network （CNN） semantic segmentation model， followed by fine localization using different models based on whether the landmarks are located in bone defect areas. Results The experiments demonstrated that the proposed method outperformed existing technologies in the detection of both normal and defective landmarks. The average errors for normal landmarks and defective landmarks detected under CT scanning were 1.19 mm and 1.13 mm， respectively， and under CBCT scanning were 0.91 mm and 0.94 mm， respectively. Conclusion The new method can effectively improve the accuracy of landmark detection for severe CMF deformities， which is significant for clinical surgical design and patient treatment. Related Articles | Metrics | Comments（0）

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Research progress on modified hydroxyapatite-based bone repair materials HUANG Leiyun, BAI Zhenglin, FU Guangjie, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 568-.   Abstract （244）      PDF（pc） （1027KB）（180）       Knowledge map    Save As a kind of biomedical material， modified hydroxyapatite-based material has good mechanical properties， biocompatibility and osteoinductive ability. It has the advantages of similar composition with natural bone， not easy to cause immune rejection， good biological activity and compatibility， non-toxic， degradable， easy to prepare and process， and makes up for the shortcomings of natural bone material transplantation. In this paper， the biological modification， physicochemical modification and composite modification methods of the material were introduced， and the effects of different modification methods on the properties of the material were compared. In addition， the current problems and challenges of modified hydroxyapatite-based material were presented in the discussion section， and the future development of this kind of material was also prospected. Related Articles | Metrics | Comments（0）