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    Research progress on the mechanism of skin aging caused by ultraviolet radiation
    CHEN Heng, WANG Jue, ZHOU Xu
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 382-.  
    Abstract224)      PDF(pc) (992KB)(2138)       Save
    Skin exposed to sunlight for a long period of time will have impaired function and even genetic material
    alteration, which is manifested by aging characteristics such as water loss, elasticity loss, wrinkle growth, melanin
    deposition and dryness. There are many ways to cause skin photoaging and the mechanism is complex, the ultraviolet light in
    sunlight has a particularly obvious effect on skin aging, the ultraviolet light that can act on the skin is divided into two kinds:
    UVA and UVB. They mainly act on the skin through five mechanisms that lead to photoaging: oxidative stress, damaging
    genetic material, changing the epidermal microbial community, destroying the function and structure of organelles, and
    reshaping the extracellular matrix (ECM).In this paper, these five mechanisms were reviewed, and research directions and
    prospects in this field were proposed.
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    Research progress of three-dimensional functional skin model construction in vitro
    LI Yang, XI Taotao, ZHANG Bo, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 240-.  
    Abstract157)      PDF(pc) (1034KB)(976)       Save
    Tissue engineering technology has been widely used in tissue and organ repair and has become an important
    method of regenerative medicine technique. The appearance of tissue engineering skin provides a new method for the
    treatment of large-area cutaneous defect in clinic. Because of the complicated skin-structure, it is an enormous challenge to
    building a functional three-dimensional skin tissue engineering model to simulate or replace the original skin. Based on this,
    from the aspects of cell types and sources, techniques, types, applications and prospects of skin tissue engineering models,
    the latest progress of in vitro 3D functional skin tissue model construction was reviewed in order to provide a theoretical basis
    for the construction of ideal skin tissue model.
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    Sterilization methods for biomaterials in biomedical applications
    WU Ke, ZHANG Guo, ZHOU Muran, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 354-.  
    Abstract59)      PDF(pc) (1846KB)(826)       Save
    From the first generation of inert materials to the third generation of active materials, biomaterials have
    developed rapidly in recent years, showing great application prospects in biomedicine, but its effective sterilization has
    become increasingly difficult. Effective sterilization and disinfection of biomaterials are essential to achieve clinical
    transformation. This review summarized the classical and emerging sterilization methods for biomaterials and the impact of
    these sterilization technologies on the physicochemical properties of biomaterials. This review also discussed the sterilization
    effect, toxicity, and problems in the practical application of various methods, intending to provide a reference for the
    selection of sterilization methods in the research of biomaterials.
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     Skin characteristics and nursing after photoelectric injury
    DONG Jiying, HAN Shuqing, LU Nan, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 265-.  
    Abstract131)      PDF(pc) (986KB)(770)       Save
    Photoelectric therapy plays a role in treating diseases and skin beauty by starting the process of skin wound repair. This paper summarized the changes in the acute skin injury period after different types of photoelectric therapy, the process and characteristics of skin injury repair after surgery, and the principles of skin care after surgery, in order to reduce the occurrence of adverse reactions and accelerate skin repair after surgery, reduce downtime, and improve patient satisfaction.
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    Advances of facial skin typing methods 

    CHEN Zixuan, ZHANG Zheng, ZHANG Yixin
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 378-.  
    Abstract89)      PDF(pc) (954KB)(658)       Save
    Skin typing is a common method for describing skin characteristics. Traditional skin typing methods (such as
    the Fitzpatrick Skin Phototype and Baumann Skin Typing) have their own advantages and disadvantages. However, the above
    skin typing methods rely on subjective judgement, lacking quantitative analysis of skin objective parameters. In recent years,
    the measurement technology of objective parameters such as sebum secretion and transepidermal water loss has made great
    progress, making it possible to describe skin types with objective parameters. Additionally, image recognition technology
    based on facial photos can extract facial skin features and provide a basis for skin typing. This article reviewed subjective skin
    typing methods, skin objective parameter detection, and skin analysis technology based on image recognition, and discussed
    the development process of skin typing from qualitative-quantitative-visualization, in order to provide a theoretical basis for
    objective and precise skin typing in the future.
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    The pathogenesis and therapeutic strategies for congenital melanocytic nevi
    LI Dongdong, WANG Bin
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 254-.  
    Abstract146)      PDF(pc) (1226KB)(625)       Save
    Congenital melanocytic nevus is a common skin developmental abnormality that can occur in any part of the
    body where melanocytes are present. Its occurrence is closely related to somatic cell mutations, regulated by multiple
    signaling pathways, and has diverse clinical manifestations. Surgical excision and dilator are still the main treatments for
    CMN, and laser therapy is a powerful mean to eliminate pigmentation and remove satellite lesions. Targeted therapy and
    immunotherapy are becoming a new direction for the treatment of congenital melanin giant nevi.
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    Advances in molecular mechanisms of pathological scar formation
    JIA Yuxin, XU Heng, ZHANG Yixin
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 248-.  
    Abstract64)      PDF(pc) (1007KB)(549)       Save
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    Clinical study of novel supramolecular salicylic acid technique in the treatment of acne rosacea
    HUANG Yan
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 216-.  
    Abstract168)      PDF(pc) (1822KB)(419)       Save
    Objective To explore the efficacy and safety of 30% supramolecular salicylic acid in the treatment of acne rosacea. Methods A total of 165 patients diagnosed with rosacea from 2019 to 2021 were selected and randomly divided into control group and observation group. Among them, 85 patients in the observation group received traditional treatment combined with supramolecular salicylic acid and skin repair moisturizer. The control group of 80 patients was treated with traditional regimen. The therapeutic effect and incidence of adverse reactions were statistically analyzed in the two groups. Results Before treatment, there were no statistical differences in facial spots, red areas and pores between the two groups (P>0.05), and after treatment, the above indexes were improved, and the observation group was better than the control group (P<0.05) . The total effective rate of the observation group was 97.65%, which was significantly higher than that of the control group (85%, P<0.05) . The incidence of adverse reactions in observation group was 17.65%, which was significantly lower than that in control group (35%, P<0.05). Conclusion Supramolecular salicylic acid combined with traditional drugs has significant effect and low incidence of adverse reactions in the treatment of rosacea, and can be used as an adjuvant therapy for rosacea.
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    Research on vascularization strategy of bone tissue engineering graft
    ZHANG Yifan, ZHANG Guo, WANG Zhenxing, et a(l
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 234-.  
    Abstract69)      PDF(pc) (1008KB)(390)       Save
    Bone tissue engineering is a promising method for repairing large-scale bone defects. Bone is a dynamic and
    highly vascularized tissue, and the formation of vascular tissue in an appropriate time is the key to ensure the survival, repair
    and remodeling of bone graft, as well as one of the main challenges of bone tissue engineering. In this paper, the research
    progress of vascularization of bone tissue engineering grafts from the perspective of the significance of vascularization and
    strategies based on seed cells, angiogenic factors, scaffold structure, immune regulation, and prevascularization was
    reviewed .
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    Low-level laser therapy for androgenetic alopecia ;A consensus among chinese experts

    Hair Medicine Branch of the Chinese Society of Aesthetic and Plastic Surgery, Chinese Non-government Medical Institutions Association Dermatology Branch Hair Medicine and Scalp Health Management Professional
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 157-.  
    Abstract177)      PDF(pc) (959KB)(302)       Save
    Low-level laser therapy for androgenetic alopecia has been used clinically for over ten years, with definite efficacy and high safety. A variety of low-level laser devices have been approved and marketed domestically, and are widely used in clinical settings, yet there are currently no unified usage standards. This consensus compiled and summarized relevant guidelines and clinical research from both domestic and international sources in recent years, providing a reference for the correct selection and use of low-level laser therapy for androgenetic alopecia in clinical practice.
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    Fluid mechanics finite element analysis of 3D printed porous biological scaffolds with different microstructures based on cell adhesion
    WU Qiyou, CUI Boyu, XIA Wei, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 293-.  
    Abstract91)      PDF(pc) (4864KB)(293)       Save
    Objective To study the influence of 3D-printed bone scaffolds with different pore morphologies on cell
    adhesion. Methods Utilizing MSLattice software, four porous structures with different pore morphologies, namely cubic,
    Hexagon, diamond, and gyroid, were designed. The principles of finite element analysis (FEM) and computational fluid
    dynamics (CFD) were employed using Siemens Star CCM+ software to simulate the fluid flow within the four scaffold
    structures, model the process of cell adhesion, measure the fluid flow velocity and pressure within the scaffold, as well as the
    fluid permeability and the thickness of the adhesion layer. Results Upon the passage of fluid through the four types of
    scaffolds, the pressure gradually diminished. However, due to the relatively regular structure of the scaffolds, the pressure
    exhibited a gradient distribution. The simulated pressure values before fluid flow through the four types of scaffolds were, in
    sequence: Gyroid>Cubic>Diamond>Hexagon. Flow velocity: Cubic>Gyroid>Diamond>Hexagon. The permeability of the four
    types of scaffolds: Diamond>Hexagon>Cubic>Gyroid. Adhesion layer thickness: Gyroid>Hexagon>Cubic>Diamond.
    Conclusion The fluid mechanics analysis results show that the gyroid scaffold has lower permeability and the highest
    adhesion layer thickness, which is more conducive to cell adhesion.
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    The establishment of granulomatous mastitis rat model

    MA Lina, WU Jingjing, CHEN Hongfeng
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 184-.  
    Abstract132)      PDF(pc) (4529KB)(252)       Save
    Objective To establish a rat model of granulomatous mastitis through the combination of gastrin-induced
    elevation of serum lactogen and rat milk injection, and to analyze and evaluate the value of each modeling factor and index on
    the model, and to explore an animal model that better fits the characteristics of the disease. Methods Sixteen adult female
    Wistar rats were divided into two groups:6 rats in the normal control group and 10 rats in the model group. The normal control
    group was not given any special treatment. Rats in the model group were injected subcutaneously with gastrin for 2 weeks, and
    the rats were injected locally with a suspension (milk plus adjuvant) on the 1st,7th and 14th days respectively. The changes
    in body weight and mammary mass size were measured once a week. Serum prolactin levels were detected by ELISA before, at
    the 2nd and 4th week of modeling. After the rats were executed, the histopathological changes of mammary glands were
    observed by HE staining. The serum levels of IL-1β and IL-6 were measured by high-throughput liquid-phase protein
    microarray assay before and after modeling. Results After modeling, the skin and breast lumps of the model rats showed
    similar clinical manifestations as those of patients with granulomatous mastitis. In terms of serum prolactin level, the PRL
    level of the model group was higher than that of the normal control group at week 2(P<0.001); The PRL level of the model group was still higher than that of the normal control group at week 4(P<0.01). In terms of pathomorphology, some of the masses were visible as acne-like material to the naked eye, and microscopically the lesion areas were seen as multifocal scattered distribution of epithelioid cells constituting granulomatous nodules with a variety of inflammatory cell infiltrates,
    mainly lymphocytes, and foamy histiocytes, plasma cells, multinucleated giant cells and macrophages. The levels of serum
    interleukin 1β(IL-1β) and interleukin 6(IL-6) after modeling were higher than before modeling (P<0.01). Conclusion  Gastrin-induced elevation of serum lactogen combined with rat milk injection can successfully establish granulomatous mastitis model after 4 weeks of modeling.
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    Recent advances of multiomics approaches for pathologic scars
    ZHENG Hongkun, SHAN Shengzhou, JI Xiangyang, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 362-.  
    Abstract87)      PDF(pc) (984KB)(196)       Save
    Pathologic scars, including keloids and hypertrophic scars, not only affect aesthetics but also compromise
    patients' daily lives and psychological well-being. Despite recent progress in understanding the pathogenesis of pathologic
    scars, effective treatments remain a challenge. In this paper, the research advancements of multi-omics approaches for
    pathologic scars were summarized, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and
    single-cell omics. By providing a comprehensive overview of these cutting-edge techniques, the review aimed to inspire novel
    therapeutic strategies for the management of pathologic scars.
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    Observation of the effects of individualized comprehensive treatment in periocular rejuvenation
    LI Zhengbin, PAN Long, YANG Ningning, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 326-.  
    Abstract101)      PDF(pc) (2397KB)(151)       Save
    Objective To observe the effects of individualized comprehensive treatment of periocular aging, and to
    explore a better plan for restoring the youthful state of the periocular area. Methods A retrospective analysis was conducted
    on beauty seekers from May 2018 to May 2023. A total of 522 beauty seekers who met the indications for periocular
    rejuvenation treatment were selected. According to their demands and actual conditions, individualized comprehensive
    treatment plans were formulated, including but not limited to surgery, botulinum toxin injection for wrinkle removal,
    autologous fat transplantation, and hyaluronic acid filling. The treatment effect was observed, and the satisfaction of the
    beauty seekers was evaluated 6 months after the operation. Results The total satisfaction rate of all followed-up cases (n=
    522)was 97.9%. Among them,495 were very satisfied,16 were basically satisfied, and 11 were dissatisfied. There were no
    serious complications after the operation, and the overall shape of the periocular area presented a full and youthful state.
    Conclusion The individualized application of the comprehensive diagnostic and treatment plan combining injection filling
    and surgical operation can effectively restore the youthful appearance of the periocular area, and is being recognized by more
    and more beauty seekers.
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     Evaluation of the efficacy of fluorescent light energy(FLE)in the treatment of chronic skin ulcers
    CHEN XiaoLi, LIANG Yujia, CHEN Shandan, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 331-.  
    Abstract71)      PDF(pc) (3893KB)(151)       Save
    Objective To investigate the clinical efficacy and safety of fluorescent light energy (FLE) combined with
    comprehensive nursing intervention in treating chronic skin ulcers (CSUs).Methods From October 2020 to March 2023,5patients with CSU were enrolled and treated with FLE combined with standardized comprehensive nursing intervention. Each
    patient was debrided before treatment. The FLE system consists of Lumiheal® medical wound gel dressing (Hunan Klox
    Pharmaceutical Co., Ltd.) and mitochondrial photon therapy device (Hunan Klox Pharmaceutical Co., Ltd.).During treatment, freshly prepared Lumiheal® medical wound gel dressing was applied to the local skin lesion with a thickness of
    about 2 mm, and then the mitochondrial photon therapy device (light power density≥40 mW/cm2 ) was adjusted to a distance
    of 5 cm from the wound surface, and luminated for 5 minutes. FLE treatment was applied twice a week for 6 consecutive times
    with comprehensive nursing intervention. The clinical efficacy, safety, and patient satisfaction of wound healing and tissue
    remodeling were evaluated after the treatment. Results The healing rate of 5 patients was 100%, the satisfaction rate of
    patients and their families was 100%, and no obvious adverse reactions were observed during treatment. Conclusion FLE
    therapy combined with comprehensive nursing intervention can shorten the healing time of ulcers, reduce economic loss,
    reduce overall medical expenses and improve patient satisfaction.
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    Advances in molecular genetics of dermatofibrosarcoma protuberans

    DENG Yuqi, LIANG Xiao, SUN Di, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 260-.  
    Abstract80)      PDF(pc) (995KB)(125)       Save
    Dermatofibrosarcoma protuberans (DFSP), one of the most common skin sarcomas, lacks specific clinical
    and radiological features and exhibits complex histopathology. It is characterized by slow and irregular infiltration of
    surrounding tissues, and surgical resection is the primary treatment modality. Currently, DFSP presents clinical challenges in
    terms of high misdiagnosis and recurrence rates, necessitating the development of specific diagnostic markers and effective
    therapeutic targets. This article aimed to provide a comprehensive review of the latest molecular genetics advancements in
    DFSP, with the goal of offering new insights for its diagnosis and treatment.
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    Enrichment of signaling pathways and dynamic expression of the FZD family during endogenous periosteum-guided bone regeneration
    CHEN Xiaoxue, YU Baofu, WANG Zi, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 285-.  
    Abstract75)      PDF(pc) (4004KB)(115)       Save
    Objective To investigate the signaling pathway enrichment and dynamic expression of FZD family during
    endogenous periosteum-guided bone regeneration. Methods A porcine closed rib periosteum-guided bone regeneration
    model was established, and periosteum and regenerated bone tissues were collected at seven time points for gene sequencing,
    differential gene screening and enrichment analysis of their related signaling pathways. The FZD molecular family, which is
    closely related to the process of bone regeneration, was selected for focused analysis, and the dynamic expression changes of
    each member of FZD and the expression correlation between them were detected and analyzed. Results A total of seven
    genes were persistently differentially expressed at different time points within 1 month after surgery in the experimental group
    compared with the control group. Differential gene enrichment showed that there was mainly an immune response in the early
    stage, and tissue development and remodeling were achieved later. The expression of each member of the FZD family
    fluctuated at different time points, and the expression peak of most members was 3 days after surgery, while the fold change
    of the experimental group was more obvious than that of the control group at 1 month after surgery, and FZD1 and FZD2 were
    the highest, and there was a high correlation between them. Conclusion The differential genes in the process of periosteum
    guided bone regeneration and the related signaling pathways screened in this study provide a theoretical basis for further
    molecular mechanism studies, while the dynamic expression changes of the FZD molecular family play an important role in
    the process, and the specific biological mechanisms involved in the process need to be verified by further studies.
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    Progress in research methods of studying the neural crest

    JIANG Leheng, YIN Ningbei
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 469-.  
    Abstract474)      PDF(pc) (993KB)(108)       Save
    The neural crest is a migratory, multipotent stem cell population during vertebrate embryogenesis, and lineage tracing is the focus of its research. Over the 150 years since its first discovery, understanding of the neural crest has gone through a transition from morphological observations to single-cell level. In this paper, important approaches applied to study the neural crest were reviewed including radioisotope labeling, chimeras, vital dye labeling, in vitro clonal analysis, conditional genetic recombination and single-cell sequencing.
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    Discussion on talent cultivation of plastic surgery in the new era
    ZHANG Hanrui, HUANG Xin, LI Qingfeng, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 388-.  
    Abstract165)      PDF(pc) (927KB)(96)       Save
    Plastic surgery is a specialized branch of surgery that has two main development directions: Reconstructive
    plastic surgery and aesthetic plastic surgery. In recent years, there has been a growing inclination among young doctors to
    prioritize aesthetic plastic surgery over reconstructive surgery, which has hindered the sustainable development of plastic
    surgery. Meanwhile, emerging technology has provided new opportunities for talent cultivation. The education model for young
    doctors should advance with time. Therefore, the recommendations such as strengthening medical history education, guiding
    correct understanding, and innovating teaching models, have been proposed to improve the quality and efficiency of talent
    cultivation. These efforts aim to cultivate highly qualified talents with strong professional skills and a sense of responsibility,
    who can adapt to the development needs of the discipline.
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    Etiology and treatment of intracranial hypertension secondary to craniosynostosis

    ZANG Tianying, TANG Xiaojun
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 368-.  
    Abstract64)      PDF(pc) (995KB)(93)       Save
    Craniosynostosis is a common craniofacial malformation, which incidence rate ranks second in congenital
    craniofacial skeletal malformations. In addition to appearance deformity and dysfunction, intracranial hypertension is also a
    common complication, which may cause serious clinical consequences such as vomiting, papilledema, brain hernia, death
    and so on. Therefore, early screening, risk assessment of intracranial hypertension, pathogenesis research and clinical
    treatment of children with craniosynostosis are very important. In this paper, the pathogenesis, clinical symptoms, diagnosis,
    treatment, risk assessment and prevention of intracranial hypertension secondary to craniosynostosis were reviewed.
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