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Progress in research methods of studying the neural crest JIANG Leheng, YIN Ningbei Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 469-.   Abstract （593）      PDF（pc） （993KB）（1710）       Knowledge map    Save The neural crest is a migratory， multipotent stem cell population during vertebrate embryogenesis， and lineage tracing is the focus of its research. Over the 150 years since its first discovery， understanding of the neural crest has gone through a transition from morphological observations to single-cell level. In this paper， important approaches applied to study the neural crest were reviewed including radioisotope labeling， chimeras， vital dye labeling， in vitro clonal analysis， conditional genetic recombination and single-cell sequencing. Related Articles | Metrics | Comments（0）

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Diagnosis and treatment of vascular anomalies in the era of precision medicine YANG Xiaonan, ZHANG Ye Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 599-.   Abstract （141）      PDF（pc） （1038KB）（1474）       Knowledge map    Save Vascular anomalies are classified into hemangiomas and vascular malformations， representing a group of diseases that include （but not limited to） more than 30 types of hemangiomas， over 60 types of vascular malformations， and more than 20 syndromes related to vascular anomalies. Deepening understanding and improving diagnosis and treatment have always been the focus and difficulty in clinical work. With the continuous advancement of medical science and technology， the diagnosis and treatment of vascular anomalies are rapidly entering a new medical era-the era of precision medicine. Precision medicine relies on in-depth research of molecular mechanisms， advanced diagnostic technologies， personalized treatment plans and multidisciplinary diagnosis and treatment mode， and its clinical expansion and promotion in clinical practice have brought revolutionary changes to the diagnosis and treatment of vascular anomalies. In this paper， the progress and future development direction of the diagnosis and treatment of vascular anomalies in the era of precision medicine were reviewed. Related Articles | Metrics | Comments（0）

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Research progress of intramuscular fatty infiltration LU Baixue, GAO Weicheng Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 481-.   Abstract （473）      PDF（pc） （970KB）（1182）       Knowledge map    Save Fat infiltration plays an important role in the pathological development of muscle related diseases， and is closely related to disease recurrence and poor prognosis. In recent years， the research on the potential mechanism of intramuscular fat infiltration has been highly popular at home and abroad， mainly focusing on the basic and clinical research related to skeletal muscle and myocardial fat infiltration. In this paper， the relevant literature on the pathogenesis of intramuscular fat infiltration in skeletal muscle and myocardium in recent years was reviewed， to provide assistance for the basic and clinical research of intramuscular fat infiltration related diseases. Related Articles | Metrics | Comments（0）

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Application of cerium oxide nanoparticles in wound healing ZHU Yulin, LIU Jing, DENG Guoying Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 574-.   Abstract （193）      PDF（pc） （948KB）（878）       Knowledge map    Save Wound healing is a complex physiological process， which can be divided into four main stages： Hemostasis， inflammation， proliferation and migration， and tissue remodeling. At the same time， granulation formation， inflammatory cell infiltration， necrotic tissue cleaning， scar remodeling and other reactions are involved. In some pathological cases， the natural healing process of the wound may be stalled， resulting in repeated attacks and even death from shock. In recent years， the search for high safety and high efficiency medical materials has attracted much attention from researchers. Among them， cerium oxide nanoparticles are a unique material which can promote wound healing and play an important role in all stages of wound healing. Nano-cerium oxide particles not only have antioxidant， antibacterial and anti-inflammatory functions， but also can be used as drug carriers in wound repair to ensure the benign absorption of the body， and can be used as tissue scaffolds to promote the development and maturity of new structures. Therefore， exploring the role of cerium oxide nanoparticles in wound healing may be a new strategy for wound repair. In this paper， the effects of cerium oxide nanoparticles on wound repair were reviewed to provide references for their further application and development in the future. Related Articles | Metrics | Comments（0）

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Research on positive psychological qualities， negative emotions， and quality of life in adult patients with port-wine stain WANG Wanyi, HU Jiahua, YU Wenxin, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 693-.   Abstract （110）      PDF（pc） （1036KB）（877）       Knowledge map    Save Objective To understand the current status of positive psychological qualities （hope trait， self-compassion）， anxiety， depression， and quality of life in adult patients with port-wine stain （PWS）， and to provide a basis for implementing psychological interventions from the perspective of positive psychology. Methods A convenient sampling method was used to select 119 adult patients with fresh red nevus who underwent pulsed dye laser treatment from March to June 2023 as the study subjects. The survey tools included a general information questionnaire， Herth Hope Index， Self-Compassion Scale， Depression Screening Scale， Anxiety Screening Scale， and Health Status Questionnaire. Correlation analysis between variables was conducted. Results The average score of hope trait in 119 PWS patients was 30.8±7.7， with 16.0% of patients having low levels of hope trait， and the self-compassion score was 82.4±10.9. 48.7% of patients were positive for depression， and 65.5% of patients were positive for anxiety. The average score of quality of life was 68.3±12.5. There was a significant negative correlation between positive psychological qualities （hope trait， self-compassion） and negative emotions （anxiety， depression）， and a significant positive correlation between positive psychological qualities （hope trait， self-compassion） and quality of life （P<0.05）. Conclusion The positive psychological qualities of adult PWS patients are at a moderate level， with experiencing negative emotions such as anxiety and depression， leading to decreased quality of life. Positive psychological qualities are key factors in improving negative emotions and enhancing quality of life in PWS patients， and personalized intervention strategies for positive psychological qualities can be explored in the future. Related Articles | Metrics | Comments（0）

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#br# Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 702-.   Abstract （148）      PDF（pc） （1165KB）（870）       Knowledge map    Save Distal arthrogryposis represents a group of congenital malformations with genetic factors， and distal arthrogryposis type 9 is attributed to mutations in the FBN2 gene. Differing from other subtypes where muscular tissues are affected，FBN2 gene mutation primarily impacts the embryonic development of connective tissues， giving rise to distinctive clinical phenotypes. To date， the specific pathogenic mechanisms of this condition remain elusive. In this paper， the recent research progress of distal arthrogryposis type 9 was reviewed， aiming to enhance our understanding of the disease. With the advancement and widespread use of sequencing technologies， the potential discovery of additional mutation loci and patient cohorts holds promise for elucidating genotype-phenotype correlations. Furthermore， there is a pressing need to promote the development of appropriate cellular and animal models to further elucidate its pathogenic mechanisms， offering novel avenues for disease diagnosis and therapeutic interventions. Related Articles | Metrics | Comments（0）

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Neuroprotective effect of Liraglutide（LRG）on spinal cord injury（SCI）in rats by inhibiting ferroptosis DING Shuai, ZHANG Guangquan, GAO Kun, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 422-.   Abstract （394）      PDF（pc） （2406KB）（817）       Knowledge map    Save Objective　To observe the neuroprotective effect of liraglutide（ LRG） on spinal cord injury（ SCI） rats， and to explore whether its mechanism is related to inhibiting ferroptosis. Methods　A total of 90 female Wistar rats were randomly divided into sham group（ n=30）， SCI group（ n=30） and LRG+SCI group（ n=30）. A rat model of SCI was established using the modified Allen’s method. For the SCI+LRG group， LRG （200 µg/kg） was administered immediately via subcutaneous injection（ s.c.） following SCI， and then subsequently given once a day for the next ten days. Animals in both the sham and SCI group were administrated with equal volumes of sterile PBS. The iron content and glutathione（ GSH） level in spinal cord were detected by the kit at 24， 48 and 72 h after operation. The expression levels of xCT and GPX4 protein were analyzed by Western blot. The BBB locomotion rating scale was used to investigate the hindlimb function 1， 3， 7， 14， 28 days after injury. HE staining and Nissl Staining were performed to evaluate the structural damage and surviving neurons around the injured area 28 days after operation， and the neuron apoptosis was detected by immunofluorescence staining. Results.　Compared with the sham operation group， the iron content in SCI group was significantly increased within 3 days after injury （P<0.05）， and GSH level was significantly decreased （P<0.05）. LRG treatment effectively decreased the iron contents in injured spinal cords（ P<0.05）， and increased GSH level （P<0.05）. In addition， LRG treatment significantly increased the expression levels of xCT and GPX4 in injured spinal cords（ P<0.01）. Compared with SCI group， the BBB score of LRG group was significantly higher at 7， 14 and 28 days after injury （P<0.05）. HE staining and Nissl staining showed that cavity of damaged regions of LRG group was lower than that of SCI group （P<0.05）， and the number of motoneurons in the spinal ventral horn of rat treated with LRG was higher than that of SCI group （P<0.05）. Immunofluorescence staining showed that the ratio of cleaved-caspase 3-positive neurons was remarkably increased after SCI（ P<0.05） and LRG significantly reduced the ratio of cleaved-caspase 3-positive neurons（ P<0.05）. Conclusion　LRG treatment after SCI may promote SCI repair， protect damaged neurons and restore motor function through inhibiting ferroptosis in the microenvironment at the lesion site. Related Articles | Metrics | Comments（0）

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Research progress of 3D adipose tissue model ZHU Congxiao, YIN Ningbei Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 562-.   Abstract （195）      PDF（pc） （975KB）（708）       Knowledge map    Save As the largest endocrine organ and the main energy storage system in the human body， adipose tissue plays a pivotal role in regulating energy homeostasis. Pathological conditions such as insulin resistance， chronic inflammation and mitochondrial dysfunction are closely related to adipose metabolic disorders. In vitro models are significant tools for studying the mechanism of associated disorders. At present， three-dimensional culture is a common model for in vitro adipose tissue research because it can imitate the process of adipose metabolism to a certain extent. In order to serve as a resource for future scientific investigations， an overview of three-dimensional adipose tissue models and their properties was provided in this paper. Related Articles | Metrics | Comments（0）

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The application of artificial intelligence（AI）in rhinoplasty PAN Xingyi, LI Zijun, ZHEN Yonghuan, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 659-.   Abstract （271）      PDF（pc） （1055KB）（532）       Knowledge map    Save With the advancement of medical technology and the improvement of patients' demand for personalized aesthetics， rhinoplasty has become one of the most challenging surgeries in plastic surgery. It requires not only precise anatomical knowledge but also a surgical plan that incorporates the patient's unique facial features and aesthetic expectations. In recent years， the application of artificial intelligence （AI） in the medical field has been booming， with its data analysis capabilities and automation offering new solutions for rhinoplasty. This review aimed to explore the specific applications of AI in rhinoplasty， including how AI can be used for preoperative planning， surgical navigation， and postoperative evaluation. By analyzing the key roles of AI in rhinoplasty， this paper highlighted the importance of AI in enhancing surgical precision， personalized design， and outcome predictability. Additionally， it discussed the potential value of AI in optimizing surgical plans， reducing complication risks， and improving patient satisfaction. Moreover， this paper addressed the limitations of AI in rhinoplasty， particularly its applicability in clinical decision-making and the challenge of insufficient personalization in aesthetic design， and prospected the future improvement direction of the AI technology and its further potential in rhinoplasty. Related Articles | Metrics | Comments（0）

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“Starship”in skin regeneration：Exploring the breakthroughs and potential of acellular dermal matrix applied in skin expansion LUO Xusong Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 503-.   Abstract （202）      PDF（pc） （950KB）（515）       Knowledge map    Save The simultaneous reconstruction of appearance and function following large-area skin defects remains an unresolved challenge in clinical practice. Although skin expansion technology has been widely employed in tissue repair and reconstruction， its development has stagnated， primarily due to low expansion efficiency， high complication rates， and poorly understood mechanisms. To address this issue， an innovative approach utilizing acellular dermal matrix was proposed to assist in skin expansion and achieved promising preliminary clinical results. Acellular dermal matrix provides a “biocompatible” interface， balances mechanical forces， and serves as an active scaffold to support various cell types. However， its specific mechanism of action during the skin expansion process warrants further investigation. By acting as an expansion companion， acellular dermal matrix synergistically enhances skin expansion and holds the potential to break through current expansion limitations， thereby unlocking the full potential of skin expansion technology. Related Articles | Metrics | Comments（0）

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Constructing a quality evaluation index system based on Donabedian theory for surgical care in plastic and reconstructive surgery specialties QIAN Fuwen, YANG Yuelai, ZHU Yonggan Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 447-.   Abstract （394）      PDF（pc） （968KB）（501）       Knowledge map    Save Objective　To establish the evaluation index system of nursing quality of plastic and reconstructive surgery specialties based on Donabedian theory. Methods　 Thirty five experts from Three-A hospitals in China in plastic and reconstructive surgery were consulted through email from April to June in 2023. The primary nursing quality evaluation index system of plastic and reconstructive surgery specialties was drawn up through literature research and qualitative interview methods. Two rounds of expert consultation were conducted by Delphi method to establish the nursing quality evaluation index system of plastic and reconstructive surgery specialties. Results　The composition of experts in the two rounds of consultation was consistent， and the Cr of the experts was 0.777 1. In this study， the coefficient of variation of the secondary and tertiary indexes was 0.107-0.129， and the coefficient of variation was below 0.15， indicating that the two round consultations were credible and the coordination of the experts was good. Eventually， experts were consistant with each other in regard to all the indexes， the evaluation indexes of nursing quality in plastic and reconstructive surgery including 3 primary indexes， 10 secondary indexes and 47 tertiary indexes were determined through two round consultations by email. Conclusion　 This study established a relatively scientific， rigorous and comprehensive evaluation index system for the quality of surgical care in plastic and reconstructive surgery， providing a theoretical basis for optimizing the quality of nursing care in plastic and reconstructive surgery and improving the satisfaction of patients and doctors. Related Articles | Metrics | Comments（0）

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Application and research progress of digital technology in breast augmentation with implants YUAN Guohao, ZENG Li, WANG Haibin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 653-.   Abstract （115）      PDF（pc） （1045KB）（409）       Knowledge map    Save Breast augmentation is the second most in-demand cosmetic surgery worldwide. With the rise of precision and minimally invasive concepts， digital technology has evolved， including 3D scanning imaging， digital endoscopy， and a variety of digital photographic examinations that are widely used in breast augmentation. These techniques help operators to accurately assess breast morphology before surgery， precisely control the process during surgery， and accurately and conveniently follow up after surgery， thus maximizing the benefits to patients. In this paper， the application and research progress of digital technology in breast implant augmentation were reviewed in order to provide reference and theoretical basis for clinical surgery and follow-up. Related Articles | Metrics | Comments（0）

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Generating insulin-producing cells from human adipose-derived stem cells：Comparison of three differentiation protocols YANG Jing, LIU Xingran, YIN Xiya, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 507-.   Abstract （196）      PDF（pc） （6161KB）（402）       Knowledge map    Save Objective The induced differentiation of adipose stem cells into insulin-secreting cells is a new strategy for the treatment of diabetes mellitus. The efficiency of the induced differentiation schemes reported so far varies greatly. This study aims to compare the differentiation efficiency of three induced differentiation schemes. Methods Fat samples from the same batch were collected to extract fat stem cells for passage culture， and the third-generation fat stem cells were self-aggregated into balls for induction and differentiation in different phases （one-step method， two-step method and three-step method）. The expression levels of key genes and proteins in the products of the three schemes at the corresponding stages were detected by PCR and immunofluorescence， and the function of insulin secreting cells was detected by glucose stimulation of insulin secretion experiment. Results Compared with other schemes， the gene expressions of the key transcription factors INS，NKX6.1 and PDX1 in the insulin secreting cells induced by the three-step method were significantly increased， and there were significant differences. Key protein C-peptide and NKX6.1/PDX1 were co-expressed in insulin-secreting cells. Functionally， the insulin secreting cells induced by the three-step method can significantly increase insulin secretion under high glucose stimulation. Conclusion Under the same differentiation conditions， the differentiation efficiency of adipose stem cells induced into insulin secreting cells by the three-step method is superior to that by the two-step method and the one-step method， which provides a basis for establishing an efficient and safe induction differentiation scheme of insulin secreting cells. Related Articles | Metrics | Comments（0）

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Effect of Yes-related protein on the survival rate of fat transplantation and its mechanism LIU Yuxin, SUN Jiaming, YU Li Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 672-.   Abstract （144）      PDF（pc） （8525KB）（325）       Knowledge map    Save Objective To investigate the effect of YAP on fat graft survival and its possible mechanism. Methods 3T3L1 cells were cultured in vitro and treated with YAP siRNA or YAP-overexpression plasmids carried by lentiviral vectors，resulting in the following groups： negative control siRNA （NC）， YAP-si1， YAP-si2， and YAP-si3； lentiviral vector（Vector） and YAP-overexpression （YAP）. Cell proliferation was assessed using EdU staining. Differentiation into adipocyteswas induced， and early and late stages of differentiation were analyzed by Oil Red O staining， with lipid droplet accumulationquantified using Image-Pro Plus 6.0 software. Triglyceride content was measured using a triglyceride assay kit， and PCR andWestern blot were used to assess the expression of genes and proteins related to adipocyte differentiation. For in vivo experiments， a subcutaneous fat transplantation model in nude mice was established. A total of 8 mice were randomly divided into NC siRNA group， YAP knockdown （si-YAP） group， adeno-associated virus （AAV） vector group， and YAP overexpression （AAV-YAP） groups， with 2 mice per group. Each mouse received 0.2 mL of fat injection at four different sites， totaling 0.8 mL. Subsequent injections of 0.2 mL of NC siRNA， YAP siRNA， AAV vector， or AAV vector-mediated YAP-overexpression plasmid were administered into the transplanted fat. Fat was collected at 1，2， and 4 weeks post transplantation， and fat weight and volume were measured to evaluate survival rates. Hematoxylin-eosin staining and immunofluorescence were used to examine fat structure， number of oil droplets， and viable adipocytes. Results In cell experiments， YAP knockdown did not significantly affect proliferation or apoptosis of 3T3-L1 cells compared to controls， but resulted in increased Oil Red O staining area （P<0.05）， higher triglyceride content （P<0.05）， and elevated expression of adipogenic genes and proteins （P<0.05）. Conversely， YAP overexpression led to increased proliferation of 3T3-L1 cells with unchanged apoptosis rates， decreased Oil Red O staining area （P<0.05）， lower triglyceride content （P<0.05）， and reduced expression of adipogenic genes and proteins （P<0.05） compared to the lentiviral vector group. In animal experiments， the si-YAP group exhibited increased fat weight and volume， more intact fat structure， reduced oil droplet number， and more viable adipocytes compared to the NC group. In contrast， the AAV-YAP group had decreased fat weight and volume， less intact fat structure， increased oil droplet number， and fewer viable adipocytes compared to the AAV vector group. Conclusion YAP significantly inhibits the survival rate of transplanted fat. Furthermore， YAP affects 3T3-L1 adipogenesis by modulating the PPARγ pathway. Related Articles | Metrics | Comments（0）

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Research progress of in vitro wear test and computational wear simulation of ankle joint prosthesis YANG Shu, ZHANG Yanwei, GAO Jintao, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 584-.   Abstract （137）      PDF（pc） （3042KB）（266）       Knowledge map    Save Aseptic loosening caused by wear and wear particles is the main cause for the failure of artificial ankle joints. The in vitro tests and computational simulation are important methods for pre-clinical evaluation of prosthetic wear performance. In this paper， the kinematic and dynamic curves used in wear studies of ankle prosthesis were compared. Afterwards， the results of the wear studies were summarized and analyzed. The results showed that： ① Due to the lack of ISO testing standard in the early stage， there are differences in the loading conditions of various studies， mainly reflected in axial load and anteroposterior displacement. Therefore， it is difficult to obtain the wear mechanism of ankle prostheses through the horizontal comparison. ② Foreign researchers have studied the effects of factors such as the implant design， materials， testing conditions， and lubricating media of artificial ankle joint prostheses on wear test results， but relevant literature has not been published in China. ③ The numerical simulation wear results of artificial ankle joint are similar to its in vitro test results， indicating that the validated simulation model can be used to predict the wear performance of ankle joint prostheses. Related Articles | Metrics | Comments（0）

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Analysis of sex and age-related differences in lower eyelids morphology：A three-dimensional image digital study based on the Chinese population CHI Yarong, SUN Yixin, JIN Lin, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 623-.   Abstract （97）      PDF（pc） （8367KB）（248）       Knowledge map    Save Objective To provide comprehensive anthropometric data on the lower eyelid region among different age and gender groups of Chinese individuals through three-dimensional imaging analysis. Methods Sixty-two healthy subjects aged 20-35 and 50-65 were recruited to acquire their three-dimensional facial images. Utilizing 27 landmarks， a total of 37 lower eyelid measurement indicators were established， comprising of 21 straight lines，5 curvatures，4 angles，2 areas， and 5 ratios. The age and gender characteristics of the lower eyelid were summarized by comparing the measurement results among different age groups and gender groups. Results Compared to females， longer palpebral fissure， lower tear troughs and lidcheek junction， smaller inner and outer canthal angles， as well as a larger area and proportion of the lower eyelid region were found in males. With aging， there is a gradual reduction in the height of the palpebral fissure and inner canthal angle，accompanied by sagging of the tear trough and lid-cheek junction， enlargement of the lower eyelid area， and swelling of the lower eyelid. Conclusion The proportion of the eyebrow-eye unit occupied by the lower eyelid region is greater in males than in females. In elderly individuals， there is a noticeable sagging of the tear trough and lid-cheek junction， accompanied by swelling of the lower palpebral region. These findings can serve as a valuable reference for cosmetic procedures and oculoplastic surgery. Related Articles | Metrics | Comments（0）

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Research progress of copper-based nanoparticles and copper-containing antibacterial implants FU Guangjie, HUANG Leiyun, BAI Zhenglin, et al Journal of Tissue Engineering and Reconstructive Surgery    2025, 21 (1): 93-.   Abstract （104）      PDF（pc） （1065KB）（213）       Knowledge map    Save  Due to the excessive and unreasonable use of antibiotics， the incidence of bacterial resistance and the improvement of drug resistance have gradually become a serious problem faced by orthopedic medical workers. Therefore， it is necessary to find an antibacterial agent with excellent antibacterial ability， excellent biocompatibility and not easy to produce drug resistance， which can replace antibiotics for orthopedic clinical. At present， scholars at home and abroad have proved that copper-based nanoparticles have small size， large specific surface area， excellent antimicrobial performance and are not easy to produce drug resistance. In the future， there is hope to replace antibiotics in clinical applications. In this paper， the main antibacterial mechanisms， biocompatibility， biological control of copper-based nanoparticles and the research progress of orthopedic copper-containing implants were reviewed. The existing problems and challenges of copper-based nanoparticles and copper-containing antibacterial implants were discussed， and the future of such antibacterial materials was prospected， so as to promote the clinical application of copper-based nanoparticles and orthopedic copper-containing antibacterial implants. Related Articles | Metrics | Comments（0）

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Preparation and application of collagen-based biomaterials in bone and cartilage regeneration and repair DUAN Jing, YANG Bing Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 707-.   Abstract （278）      PDF（pc） （1040KB）（197）       Knowledge map    Save Collagen-based biomaterials can be used as ideal biomaterials for bone and cartilage regeneration and repair due to their good biological activity and biocompatibility. However， due to the weak macroscopic mechanical properties of collagen， which cannot meet the mechanical requirements of natural cartilage and bone tissue， the mechanical properties are often improved by cross-linking modification. In addition， different material forms require different forming technologies. In this paper， the cross-linking methods and forming technologies of collagen-based biomaterials were reviewed， and the construction of collagen scaffolds and the selection of implanted cells for bone and cartilage regeneration and repair in recent years were summarized， aiming to provide clues and ideas for the development of collagen-based biomaterials preparation technology and the transformation of clinical applications. Related Articles | Metrics | Comments（0）

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Successful repair of skin tissue expansion devices implantation with partial exposure of dilated sac： Two cases repor·t WU Weimin, LAN Tianyao, ZHENG Huarong, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 460-.   Abstract （198）      PDF（pc） （9569KB）（190）       Knowledge map    Save From September 2023 to December 2023， two patients with burn scar formation were admitted. The skin and soft tissue expander was implanted in stage I， and part of the expander balloon was exposed after surgery. In one case， the exposed area was about 5 cm×5 cm and the volume was about 50 mL， accounting for 20% of the total water injection. The exposed area of the other case is about 3 cm×2 cm， and the volume is about 20 mL， accounting for 5% of the total water injection. The causes of the exposed expander balloon were analyzed， and dressing change was given. At the same time， water injection and pressure bandaging were used to save the exposed expander balloon. In the end， 270 mL and 360 mL water were successfully injected， accounting for about 67% and 90% of the rated capacity of the skin soft tissue expander. Postoperative scar repair results were good in 2 patients， no necrosis of expanded flap， no motor and sensory dysfunction， and the patients were satisfied. The reasons for the partial exposure of the expansion balloon after the implantation of the skin and soft tissue expander are as follows： 1. Scar expansion is limited and the surrounding conditions are not sufficient， and the wound is easy to split； 2. Too long electric coagulation time leads to local full-layer necrosis of the flap， which easily leads to the exposure of the expander. The experience in the treatment of such complications： prevention and treatment of infection， external bandaging and fixation to reduce the tension of local exposed balloon. In addition， negative pressure closure and drainage can promote wound healing. Related Articles | Metrics | Comments（0）

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Three-dimensional imaging study of nasal basal depression XU Yang, ZHANG Liyuan, DING Wei, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 632-.   Abstract （146）      PDF（pc） （1755KB）（174）       Knowledge map    Save Objective By comparing the Cone beam CT （CBCT） of bone class Ⅲ and normal occlusion， the difference of bony nasal base between them was compared to provide the basis for the diagnosis and treatment of nasal base depression. Methods From January 2020 to December 2023，40 patients （20 cases of bone class Ⅲ and 20 cases of normal occlusion） were selected， and the CBCT related data were measured and imported into Simplant pro 11.04 software for threedimensional fixed-point pointing， and the differences of nasal base between the two groups were compared. Results There were statistically significant differences in the absolute/relative protrusion of the upper alveolar seat point， the absolute/ relative protrusion of the anterior nasal point， the absolute/relative protrusion of the bilateral paranasal and infraorbital points， the absolute/relative protrusion of the bilateral paranasal points， and the absolute/relative protrusion of the bilateral canine socket between the patients with bone class Ⅲ and the patients with normal combination （P<0.05）. Conclusion CBCT has certain significance in the auxiliary diagnosis of nasal base depression， and after three-dimensional reconstruction measurement， the points A， AN， B3， mid-ParaN-D-IF and ParaN of bony Ⅲ patients are moved back compared with those of normal patients. Related Articles | Metrics | Comments（0）