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    Evaluation of facial injection filling materials for medical aesthetics
    ZHAO Chenyu, LI Chongchong, SUN Xue, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 517-.  
    Abstract425)      PDF(pc) (874KB)(3300)       Save
    With economic development and technological progress, the demand for medical aesthetics has increased sig
    nificantly, and medical biomaterials are widely used. It is necessary to further improve the evaluation of their effectiveness and
    safety. At present, the evaluation of its physicochemical properties and biology is adopted in China. However, the clinical effec
    tiveness is a multi-faceted evaluation without unified criteria. Most of the evaluation mainly adopts objective indicators for quan
    titative analysis, while subjective feelings are secondary criteria. In this paper, the main facial fillers and the evaluation methods
    of their physicochemical properties were reviewed.
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    Research progress on the mechanism of skin aging caused by ultraviolet radiation
    CHEN Heng, WANG Jue, ZHOU Xu
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 382-.  
    Abstract224)      PDF(pc) (992KB)(2138)       Save
    Skin exposed to sunlight for a long period of time will have impaired function and even genetic material
    alteration, which is manifested by aging characteristics such as water loss, elasticity loss, wrinkle growth, melanin
    deposition and dryness. There are many ways to cause skin photoaging and the mechanism is complex, the ultraviolet light in
    sunlight has a particularly obvious effect on skin aging, the ultraviolet light that can act on the skin is divided into two kinds:
    UVA and UVB. They mainly act on the skin through five mechanisms that lead to photoaging: oxidative stress, damaging
    genetic material, changing the epidermal microbial community, destroying the function and structure of organelles, and
    reshaping the extracellular matrix (ECM).In this paper, these five mechanisms were reviewed, and research directions and
    prospects in this field were proposed.
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     Overview of sensitive skin and treatment progress of aesthetic medicine

    LU Nan, WU Min, SONG Jiao, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 323-.  
    Abstract303)      PDF(pc) (708KB)(1544)       Save
    敏感性皮肤 ; 机制 ; 诊断 ; 治疗 ; 光电治疗
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    Analysis of mutation type and clinical significance of congenital melanocytic nevi

    ZHAO Yifei, ZOU Yun, CHEN Hui, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 258-.  
    Abstract324)      PDF(pc) (843KB)(1391)       Save
    Objective To explore the molecular characteristics of giant congenital melanocytic nevi (GCMN) and their
    clinical significance. Methods The samples of patients diagnosed with GCMN were subjected whole-exome sequencing and
    bio-information analysis to clarify the pathogenic genes and distribution patterns. Results In 50 samples (25 pairs of tissues
    and blood) from 25 patients, 21 patients had somatic mutations, including NRAS gene (19 cases) and BRAF gene (1 case). New
    mutations were detected in 2 patients’
    lesions and blood, and the mutant genes were MET gene and IDH1 gene. In addition,
    no causative mutation was detected in 4 patients. There was no statistic difference between GCMN genotype and phenotype.
    Conclusion NRAS somatic mutation is the most common mutation in GCMN, and BRAF gene has also been detected. Potential
    new mutated IDH1 and MET genes were also found.
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     Research progress of tissue engineering ligament and scaffold materials

    ZHONG Rui, GAO Jingyu, YAN Chengyuan, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 308-.  
    Abstract236)      PDF(pc) (927KB)(1220)       Save
     The reconstruction scheme of the existing artificial ligament products has been relatively mature in clinical ap
    plication. In order to prevent the occurrence of postoperative complications such as difficult tendon-bone healing, expansion of
    the bone tunnel, synovial inflammatory reaction, infection, and external fixation loosening after ligament reconstruction, tendon
    tissue construction using tissue engineering technology has become a possible development direction in the future. In this paper,
    the progress of the construction of tissue-engineered tendon and its scaffold materials was reviewed, the urgent problems to be
    solved and the future development direction were discussed.
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     Formation and correction of facial dynamic depression
    YUAN Ye, LI Qiang, LI Senkai
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (2): 206-.  
    Abstract187)      PDF(pc) (840KB)(1165)       Save
     Facial dynamic depression occurs or aggravates during facial expression activities, mainly including dimples on
    the cheeks and depression deformities caused by scars between the mimetic and the dermis. In this paper, the formation mecha
    nism of different types of facial dynamic depression and the current methods for deformity correction were all reviewed.
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    New advances in the study of scaffold materials for cartilage tissue engineering
    YUE Guangren, WANG Ximei, LI Yu
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 408-413.  
    Abstract405)      PDF(pc) (875KB)(1149)       Save
    Lacking blood vessels and nerve nourishment, cartilage has limited ability to repair and regenerate. Combining scaffolds, cells and active factors, tissue engineering has been considered as an important new direction for repairing cartilage injury. Scaffold plays an important role in the cartilage regeneration process, not only providing a support site for cell adhesion, but also improving the local microenvironment and affecting cell proliferation and differentiation. Many materials have been used to make biodegradable scaffolds: natural materials, synthetic materials and composite materials. In this paper, the materials that have been relatively widely used in cartilage tissue engineering were reviewed so as to provide valuable reference for researchers in this field.
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    Research progress of signal pathways in soft palate development 

    ZHAO Jingjing, WU Di
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (1): 75-.  
    Abstract140)      PDF(pc) (1131KB)(1133)       Save
     Cleft palate can adversely affect speech, swallowing, breathing and hearing. The latest progress in the study of soft
    palate development shows that the development of soft palate may be regulated by different pathways related to the development
    of hard palate. It is necessary to study the signal pathways involved in the development of soft palate. The soft palate includes
    three cell types: epithelial cells, cranial nerve crest-derived mesenchymal cells and muscle-derived cells, which interact with
    each other. In this paper, the research progress of soft palate development signal pathway in recent years was reviewed, in order
    to improve our understanding of the regulation mechanism of soft palate development, and provide a basis for improving the
    treatment of cleft soft palate in the future.
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    Progress in prevention and treatment of skin flap necrosis induced by ischemic reperfusion
    SUN Jiayuan, HOU Rui, ZHANG Ruhong
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (2): 193-.  
    Abstract195)      PDF(pc) (905KB)(1076)       Save
     Flap ischemia-reperfusion injury often occurs after skin flap transplantation surgery, which is an important cause
    of partial or total necrosis of skin flap. Nowadays, the pathogenesis of flap ischemia-reperfusion injury is not completely clear.
    It is generally believed that FIRI is related to the outbreak of reactive oxygen species, the infiltration of neutrophils and the ob
    struction of revascularization. Nanozyme is a kind of nano-material with enzyme-like properties, which has the advantages of low
    cost, good stability, simple preparation and easy storage. It can directly regulate the redox balance in cells and overcome many
    limitations of natural enzyme in enzyme therapy. As an ideal antioxidant, nanozyme will play a vital role in the field of biomed
    icine. In this paper, the mechanism of flap ischemia-reperfusion injury and the research and clinical application of treatment
    methods in recent years were reviewed, and the application of nanozyme in ischemia-reperfusion injury diseases was introduced,
    aiming to provide theoretical basis and new thinking about the treatment of flap ischemia-reperfusion injury.
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    The incidence and risk factors of breast cancer-related lymphedema

    ZHANG Yingying, LI Hua, GUAN Jiaqin, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 242-.  
    Abstract466)      PDF(pc) (1127KB)(1061)       Save
    Objective To explore the incidence rate, severity and risk factors of breast cancer-related lymphedema (BCRL)
    among breast cancer survivors. Methods Data collected from 128 patients underwent breast cancer operation during September
    1 to December 31, 2019. All the patients were female, aging (49.0±6.8) years (29-81 years). The Norman questionnaire and arm
    circumference measurement were used to evaluate the BCRL status and treatment status of breast cancer patients from subjective
    and objective perspectives at 6, 12, 24 and 36 months after surgery separately. The influence of the correlation factors on BRCL
    occurrence was analyzed by Logistic analysis. Results BRCL incidences were 9.4%, 25%, 23.4% and 23.4% at 6, 12, 24, 36
    months according to arm circumference measurement, while 12.5%, 26.6%, 25.0% and 25.0% by Norman questionnaire. Among the 128 patients, 30 were diagnosed with BCRL after breast cancer surgery, among which the incidence of stage Ⅰ
    lymphedema, stage Ⅱ lymphedema and stage Ⅲ lymphedema were 15.6%, 6.3% and 1.6%, respectively. Age, body mass index (BMI)  radiotherapy, the number of positive lymph nodes and surgery method showed differences between the the BCRL group and control group. Both CDT or LVA showed improvement for the BCRL patients. Conclusion BCRL is a common complication for
    breast cancer patients after surgery. It can be fairly diagnosed in the first year after surgery without the increasing incidence of
    BCRL over time throughout 3 years. BMI, radiotherapy were found to be independent risk factors in the development of BCRL in
    this study.
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    Research progress of three dimensional bio-printing technology for formation of vascular network in bone tissue

    ZHAI Chuanxing, WANG Zhimeng, WANG Guodong, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 298-.  
    Abstract177)      PDF(pc) (913KB)(1035)       Save
    Vascularization of bone grafts is one of the major challenges facing bone tissue engineering (BTE). The ultimate
    goal of the construction of vascularized BTE is to provide a bone environment rich in functional vascular networks to achieve
    efficient bone integration and accelerate the functional recovery after implantation. In this paper, the research progress of 3D
    bio-printing in the formation of vascular network in bone tissue was reviewed, the formation mechanism of vascular network and
    the characteristics of 3D bio-printing technology were elaborated, the current vascularization strategies in BTE were summarized,
    and its development prospects were prospected.
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    Review on the feasibility of poly lactic acid as GBR barrier membrane
    LI Lulu, SUN Zhen, LI Na, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (2): 189-.  
    Abstract232)      PDF(pc) (837KB)(993)       Save
    Barrier membrane is the key to the success of guided bone regeneration (GBR). The ideal barrier membrane ma
    terial should have good biocompatibility, mechanical properties, biodegradability and osteogenic guidance. At present, the Bio
    Gide biofilm is more mature in clinical application, but it is expensive and the use cost is high. Polylactic acid is a kind of material,
    which is simple to make, has good biocompatibility, degradability and mechanical property, and is expected to be used as a GBR
    barrier membrane. In this paper, the properties of polylactic acid and its feasibility as GBR barrier membrane were reviewed.
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    Research progress of three-dimensional functional skin model construction in vitro
    LI Yang, XI Taotao, ZHANG Bo, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 240-.  
    Abstract157)      PDF(pc) (1034KB)(976)       Save
    Tissue engineering technology has been widely used in tissue and organ repair and has become an important
    method of regenerative medicine technique. The appearance of tissue engineering skin provides a new method for the
    treatment of large-area cutaneous defect in clinic. Because of the complicated skin-structure, it is an enormous challenge to
    building a functional three-dimensional skin tissue engineering model to simulate or replace the original skin. Based on this,
    from the aspects of cell types and sources, techniques, types, applications and prospects of skin tissue engineering models,
    the latest progress of in vitro 3D functional skin tissue model construction was reviewed in order to provide a theoretical basis
    for the construction of ideal skin tissue model.
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     Research progress of traumatic optic neuropathy

    LI Xinyu, GUO Zhilin
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 315-.  
    Abstract248)      PDF(pc) (791KB)(949)       Save
     Traumatic optic neuropathy (TON) often occurs after cerebral injury and is mainly in young people. Optic nerve
    injury can lead to vision loss in mild cases and loss of vision in severe cases, seriously affecting the physical and mental health
    and working life of patients. Currently, there are different opinions on the treatment of TON, both surgical and non-surgical, and
    there is no method that is satisfactory to doctors and patients. In this paper, the recent advances in the study of optic nerve injury
    were reviewed in order to provide new ideas for clinical treatment.
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    Analysis of the mechanism of fibroblast involvement in scarless healing of oral mucosa based on single cell transcriptome sequencing

    XUANYUAN Xinyang, XU Jiacheng, WANG Mengting, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (2): 115-.  
    Abstract462)      PDF(pc) (3654KB)(924)       Save
    Objective To explore the heterogeneity of human normal oral mucosa and skin fibroblasts and the mechanism of
    oral mucosal fibroblasts in promoting scarless wound healing. Methods Single-cell transcriptome sequencing data were obtained
    from the GEO database for 13 cases of oral mucosa and 8 cases of skin. The 64,633 cells were subjected to quality control, dimen sionality, clustering and cell annotation. Fibroblasts were extracted and annotated for subsets definition, differential gene enrichment
    and intercellular interactions analysis. Results Fibroblasts can be divided into 5 subsets: inflammatory, adipose, mesenchymal,
    contractile, and Wnt-inhibited. The proportion of inflammatory fibroblasts was significantly upregulated in the oral mucosa and
    was associated with immune cell recruitment. CXCL13, EEF1A1 and B2M genes were highly expressed in oral mucosa fibro
    blasts. Gene ontology (GO) functional analysis showed that scar healing-related pathways such as immune response and pro-in
    flammatory pathways were activated in oral fibroblasts. Cellular interaction analysis revealed that the interaction between fibro
    blast subsets was significantly changed, the information flow of oral mucosal COLLAGEN signaling pathway was upregulated, and
    the score of collagen degradation genes including MMP1 and MMP10 were also increased (P<0.05). Conclusion Fibroblasts
    in normal skin and oral mucosa differ significantly in their subpopulation and function. The stronger inflammatory characteristics
    and collagen metabolism of oral mucosal fibroblasts may drive the scarless wound healing.
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    Research progress of 3D bioprinting technology in dermal regeneration

    XU Pengqin, HAN Chunmao
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 302-.  
    Abstract306)      PDF(pc) (973KB)(912)       Save
     Soft tissue defects of skin are common in clinical practice. The restoration of dermal damage, to a large ex
    tent, contributes to the repairing effects and scar formation of skin soft tissue defects. Three-dimensional (3D) bioprinting is an
    emerging technology that can accurately distribute biomaterials and living cells. It creates intricate stereoscopic structures which
    facilitates regenerative repair of dermal defects. Due to limitations of printing method, bio-ink, and seed cells, 3D bioprinting
    technology for skin is still in the lab stage. With the development of 3D bioprinting, especially in novel bio-ink exploitation and
    technical optimization, high resolution 3D bioprinting will enable us to customize elaborate functionalized skin models and even
    cutaneous appendages, providing new strategies in dermal regenerative repairment.
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    Application of two-dimensional nanomaterial MXenes in tissue engineering
    ZHOU Hongling, WU Yeke, ZHAO Lixing
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (2): 178-.  
    Abstract289)      PDF(pc) (900KB)(867)       Save
    Owing to the advantages of high conductivity, hydrophilicity, high specific surface area, fascinating mechanical
    strength and photothermal conversion performance, transition metal carbides, nitrides or carbonitrides (MXenes), as a new kind
    of two-dimensional materials, have shown remarkable potential applications in the field of biomedicine, especially in tissue en
    gineering. In this paper, the research progress of biocompatibility of MXenes was briefly summarized, the application of MXenes
    in tissue engineering such as bone repair and skin regeneration was emphatically introduced, and finally the challenges and po
    tential research directions of MXenes in tissue engineering were prospected, aiming to provide some insights for the research and
    clinical application of MXenes in tissue engineering.
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    Sterilization methods for biomaterials in biomedical applications
    WU Ke, ZHANG Guo, ZHOU Muran, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 354-.  
    Abstract59)      PDF(pc) (1846KB)(826)       Save
    From the first generation of inert materials to the third generation of active materials, biomaterials have
    developed rapidly in recent years, showing great application prospects in biomedicine, but its effective sterilization has
    become increasingly difficult. Effective sterilization and disinfection of biomaterials are essential to achieve clinical
    transformation. This review summarized the classical and emerging sterilization methods for biomaterials and the impact of
    these sterilization technologies on the physicochemical properties of biomaterials. This review also discussed the sterilization
    effect, toxicity, and problems in the practical application of various methods, intending to provide a reference for the
    selection of sterilization methods in the research of biomaterials.
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    Research progress of flap blood flow monitoring methods 

    SONG Zhen, LIN Guangxian, FAN Fei
    Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (1): 83-.  
    Abstract189)      PDF(pc) (1138KB)(781)       Save
    Reconstruction of defects using flap is a common method in plastic and reconstructive surgery, and the survival
    of the flap is the key to the success of the operation. The design of the skin flap before and during the operation needs to consider
    the condition of the flap blood supply. Postoperative monitoring of the flap blood flow is helpful for early detection and treatment
    of flap blood flow problems, avoiding vascular crisis and flap necrosis happened. Therefore, flap blood flow monitoring is crucial
    to the survival of the flap. In this paper, the flap blood flow monitoring methods currently used in clinical and animal experiments,
    in order to provide a reference for the choice of flap blood flow monitoring methods in clinical and animal experiments
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     Skin characteristics and nursing after photoelectric injury
    DONG Jiying, HAN Shuqing, LU Nan, et al
    Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 265-.  
    Abstract131)      PDF(pc) (986KB)(770)       Save
    Photoelectric therapy plays a role in treating diseases and skin beauty by starting the process of skin wound repair. This paper summarized the changes in the acute skin injury period after different types of photoelectric therapy, the process and characteristics of skin injury repair after surgery, and the principles of skin care after surgery, in order to reduce the occurrence of adverse reactions and accelerate skin repair after surgery, reduce downtime, and improve patient satisfaction.
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