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Evaluation of facial injection filling materials for medical aesthetics ZHAO Chenyu, LI Chongchong, SUN Xue, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 517-.   Abstract （637）      PDF（pc） （874KB）（7097）       Knowledge map    Save With economic development and technological progress, the demand for medical aesthetics has increased sig nificantly, and medical biomaterials are widely used. It is necessary to further improve the evaluation of their effectiveness and safety. At present, the evaluation of its physicochemical properties and biology is adopted in China. However, the clinical effec tiveness is a multi-faceted evaluation without unified criteria. Most of the evaluation mainly adopts objective indicators for quan titative analysis, while subjective feelings are secondary criteria. In this paper, the main facial fillers and the evaluation methods of their physicochemical properties were reviewed. Related Articles | Metrics | Comments（0）

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Research progress on the mechanism of skin aging caused by ultraviolet radiation CHEN Heng, WANG Jue, ZHOU Xu Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 382-.   Abstract （416）      PDF（pc） （992KB）（5151）       Knowledge map    Save Skin exposed to sunlight for a long period of time will have impaired function and even genetic material alteration， which is manifested by aging characteristics such as water loss， elasticity loss， wrinkle growth， melanin deposition and dryness. There are many ways to cause skin photoaging and the mechanism is complex， the ultraviolet light in sunlight has a particularly obvious effect on skin aging， the ultraviolet light that can act on the skin is divided into two kinds： UVA and UVB. They mainly act on the skin through five mechanisms that lead to photoaging： oxidative stress， damaging genetic material， changing the epidermal microbial community， destroying the function and structure of organelles， and reshaping the extracellular matrix （ECM）.In this paper， these five mechanisms were reviewed， and research directions and prospects in this field were proposed. Related Articles | Metrics | Comments（0）

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Research progress of three-dimensional functional skin model construction in vitro LI Yang, XI Taotao, ZHANG Bo, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 240-.   Abstract （297）      PDF（pc） （1034KB）（4100）       Knowledge map    Save Tissue engineering technology has been widely used in tissue and organ repair and has become an important method of regenerative medicine technique. The appearance of tissue engineering skin provides a new method for the treatment of large-area cutaneous defect in clinic. Because of the complicated skin-structure， it is an enormous challenge to building a functional three-dimensional skin tissue engineering model to simulate or replace the original skin. Based on this， from the aspects of cell types and sources， techniques， types， applications and prospects of skin tissue engineering models， the latest progress of in vitro 3D functional skin tissue model construction was reviewed in order to provide a theoretical basis for the construction of ideal skin tissue model. Related Articles | Metrics | Comments（0）

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New advances in the study of scaffold materials for cartilage tissue engineering YUE Guangren, WANG Ximei, LI Yu Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 408-413.   Abstract （521）      PDF（pc） （875KB）（2453）       Knowledge map    Save Lacking blood vessels and nerve nourishment, cartilage has limited ability to repair and regenerate. Combining scaffolds, cells and active factors, tissue engineering has been considered as an important new direction for repairing cartilage injury. Scaffold plays an important role in the cartilage regeneration process, not only providing a support site for cell adhesion, but also improving the local microenvironment and affecting cell proliferation and differentiation. Many materials have been used to make biodegradable scaffolds: natural materials, synthetic materials and composite materials. In this paper, the materials that have been relatively widely used in cartilage tissue engineering were reviewed so as to provide valuable reference for researchers in this field. Related Articles | Metrics | Comments（0）

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The pathogenesis and therapeutic strategies for congenital melanocytic nevi LI Dongdong, WANG Bin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 254-.   Abstract （351）      PDF（pc） （1226KB）（1970）       Knowledge map    Save Congenital melanocytic nevus is a common skin developmental abnormality that can occur in any part of the body where melanocytes are present. Its occurrence is closely related to somatic cell mutations， regulated by multiple signaling pathways， and has diverse clinical manifestations. Surgical excision and dilator are still the main treatments for CMN， and laser therapy is a powerful mean to eliminate pigmentation and remove satellite lesions. Targeted therapy and immunotherapy are becoming a new direction for the treatment of congenital melanin giant nevi. Related Articles | Metrics | Comments（0）

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Advances of facial skin typing methods  CHEN Zixuan, ZHANG Zheng, ZHANG Yixin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 378-.   Abstract （199）      PDF（pc） （954KB）（1836）       Knowledge map    Save Skin typing is a common method for describing skin characteristics. Traditional skin typing methods （such as the Fitzpatrick Skin Phototype and Baumann Skin Typing） have their own advantages and disadvantages. However， the above skin typing methods rely on subjective judgement， lacking quantitative analysis of skin objective parameters. In recent years， the measurement technology of objective parameters such as sebum secretion and transepidermal water loss has made great progress， making it possible to describe skin types with objective parameters. Additionally， image recognition technology based on facial photos can extract facial skin features and provide a basis for skin typing. This article reviewed subjective skin typing methods， skin objective parameter detection， and skin analysis technology based on image recognition， and discussed the development process of skin typing from qualitative-quantitative-visualization， in order to provide a theoretical basis for objective and precise skin typing in the future. Related Articles | Metrics | Comments（0）

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Progress in research methods of studying the neural crest JIANG Leheng, YIN Ningbei Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 469-.   Abstract （593）      PDF（pc） （993KB）（1708）       Knowledge map    Save The neural crest is a migratory， multipotent stem cell population during vertebrate embryogenesis， and lineage tracing is the focus of its research. Over the 150 years since its first discovery， understanding of the neural crest has gone through a transition from morphological observations to single-cell level. In this paper， important approaches applied to study the neural crest were reviewed including radioisotope labeling， chimeras， vital dye labeling， in vitro clonal analysis， conditional genetic recombination and single-cell sequencing. Related Articles | Metrics | Comments（0）

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Diagnosis and treatment of vascular anomalies in the era of precision medicine YANG Xiaonan, ZHANG Ye Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 599-.   Abstract （141）      PDF（pc） （1038KB）（1474）       Knowledge map    Save Vascular anomalies are classified into hemangiomas and vascular malformations， representing a group of diseases that include （but not limited to） more than 30 types of hemangiomas， over 60 types of vascular malformations， and more than 20 syndromes related to vascular anomalies. Deepening understanding and improving diagnosis and treatment have always been the focus and difficulty in clinical work. With the continuous advancement of medical science and technology， the diagnosis and treatment of vascular anomalies are rapidly entering a new medical era-the era of precision medicine. Precision medicine relies on in-depth research of molecular mechanisms， advanced diagnostic technologies， personalized treatment plans and multidisciplinary diagnosis and treatment mode， and its clinical expansion and promotion in clinical practice have brought revolutionary changes to the diagnosis and treatment of vascular anomalies. In this paper， the progress and future development direction of the diagnosis and treatment of vascular anomalies in the era of precision medicine were reviewed. Related Articles | Metrics | Comments（0）

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Advances on autophagy mechanism in cell survival and regeneration after autologous fat grafting JIA Xinyu, LI Facheng Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 420-.   Abstract （251）      PDF（pc） （821KB）（1318）       Knowledge map    Save Autologous fat grafting has been widely used in plastic surgery. However, the unstable volume retention rate has always been a significant problem, which is fundamentally due to the inadequate understanding of the mechanism of cell survival and regeneration after transplantation. Autophagy plays a vital role in metabolic adaptation, cell differentiation and apoptosis inhibition, and many advances have been made in autophagy after autologous fat grafting. This review focused on the autophagy ofadipocytes and adipose-derived stem cells and the relationship between autophagy and inflammation and vascular remodeling. It turned out that autophagy was closely related to cell survival and regeneration after autologous fat grafting, and moderately promoting autophagy may postoperatively improve the volume retention rate. Related Articles | Metrics | Comments（0）

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Skin characteristics and nursing after photoelectric injury DONG Jiying, HAN Shuqing, LU Nan, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 265-.   Abstract （258）      PDF（pc） （986KB）（1314）       Knowledge map    Save Photoelectric therapy plays a role in treating diseases and skin beauty by starting the process of skin wound repair. This paper summarized the changes in the acute skin injury period after different types of photoelectric therapy， the process and characteristics of skin injury repair after surgery， and the principles of skin care after surgery， in order to reduce the occurrence of adverse reactions and accelerate skin repair after surgery， reduce downtime， and improve patient satisfaction. Related Articles | Metrics | Comments（0）

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Recent advances of multiomics approaches for pathologic scars ZHENG Hongkun, SHAN Shengzhou, JI Xiangyang, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 362-.   Abstract （160）      PDF（pc） （984KB）（1207）       Knowledge map    Save Pathologic scars， including keloids and hypertrophic scars， not only affect aesthetics but also compromise patients' daily lives and psychological well-being. Despite recent progress in understanding the pathogenesis of pathologic scars， effective treatments remain a challenge. In this paper， the research advancements of multi-omics approaches for pathologic scars were summarized， encompassing genomics， epigenomics， transcriptomics， proteomics， metabolomics， and single-cell omics. By providing a comprehensive overview of these cutting-edge techniques， the review aimed to inspire novel therapeutic strategies for the management of pathologic scars. Related Articles | Metrics | Comments（0）

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Research progress of NOTCH signaling pathway and endothelial-to-mesenchymal transition in infantile hemangioma SUN Xiaoting, MA Xiaorong Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 414-.   Abstract （216）      PDF（pc） （854KB）（1182）       Knowledge map    Save Infantile hemangioma (IH) is a benign tumor that occurs in infants and childhood. The pathogenesis of IH has not been fully elucidated. Although the course of the disease is self-limiting, partial patients may have sequelae that affect the aesthetics or normal function. NOTCH signaling is an evolutionarily conserved signaling pathway, that plays vital roles in many physiological and pathological processes, such as cell differentiation, embryonic vascular development, tissue itself-renewal, the occurrence of tumor and inflammation, and regulation of vascular function. Endothelial-to-mesenchymal transition (EndMT) is a mechanism in which endothelial cells (ECs) lose their unique properties and acquire mesenchymal and stem cell-like characteristics under the influence of multiple factors. EndMT can be involved in a variety of pathologies, including embryonic development, malignant tumor invasion, and fibrotic disease. Recent findings have shown that inhibition of the NOTCH signaling pathway might accelerate the regression of IH and interfere with disease progression caused by EndMT. In this paper, the progression of endothelial-to-mesenchymal transition and NOTCH signaling pathway in IH were reviewed Related Articles | Metrics | Comments（0）

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Research progress of intramuscular fatty infiltration LU Baixue, GAO Weicheng Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 481-.   Abstract （473）      PDF（pc） （970KB）（1182）       Knowledge map    Save Fat infiltration plays an important role in the pathological development of muscle related diseases， and is closely related to disease recurrence and poor prognosis. In recent years， the research on the potential mechanism of intramuscular fat infiltration has been highly popular at home and abroad， mainly focusing on the basic and clinical research related to skeletal muscle and myocardial fat infiltration. In this paper， the relevant literature on the pathogenesis of intramuscular fat infiltration in skeletal muscle and myocardium in recent years was reviewed， to provide assistance for the basic and clinical research of intramuscular fat infiltration related diseases. Related Articles | Metrics | Comments（0）

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Research progress of the effect of radiotherapy on breast reconstruction with prosthesis and autologous tissue after breast cancer surgery REN Yanxin, YU Yan, XU Kexin, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 511-.   Abstract （386）      PDF（pc） （903KB）（1170）       Knowledge map    Save 　Breast integrity and beauty affect women’s physical and mental health. Immediate breast reconstruction after breast cancer mastectomy can significantly increase women’s self-confidence and improve women’s quality of life. As a conventional treatment for breast cancer, radiotherapy can reduce the local recurrence rate and disease-free survival rate of breast cancer. However, radiotherapy can increase the complication rate and failure rate of breast reconstruction immediately after breast cancer surgery. The two most commonly performed breast reconstruction procedures are breast reconstruction with autologous tissue and breast reconstruction with prosthesis. In this paper, the effects of radiotherapy on autologous tissue breast reconstruction and prosthesis breast reconstruction were reviewed. Related Articles | Metrics | Comments（0）

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Research progress on rehabilitation effect of respiratory training on breast cancer-related lymphedema LI Hui, YIN Yu, LI Chunxiao, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 430-.   Abstract （200）      PDF（pc） （839KB）（1111）       Knowledge map    Save 　Breast cancer-related lymphedema (BCRL) is one of the common postoperative complications of breast cancer. At present, there is no effective method to cure BCRL at home and abroad. Respiratory training, as a simple and easy training program, can improve the lymphedema of patients through a variety of mechanisms, improve the quality of life, and may provide a potential rehabilitation treatment for BCRL. Related Articles | Metrics | Comments（0）

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Advances in molecular genetics of dermatofibrosarcoma protuberans DENG Yuqi, LIANG Xiao, SUN Di, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 260-.   Abstract （184）      PDF（pc） （995KB）（1100）       Knowledge map    Save Dermatofibrosarcoma protuberans （DFSP）， one of the most common skin sarcomas， lacks specific clinical and radiological features and exhibits complex histopathology. It is characterized by slow and irregular infiltration of surrounding tissues， and surgical resection is the primary treatment modality. Currently， DFSP presents clinical challenges in terms of high misdiagnosis and recurrence rates， necessitating the development of specific diagnostic markers and effective therapeutic targets. This article aimed to provide a comprehensive review of the latest molecular genetics advancements in DFSP， with the goal of offering new insights for its diagnosis and treatment. Related Articles | Metrics | Comments（0）

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Sterilization methods for biomaterials in biomedical applications WU Ke, ZHANG Guo, ZHOU Muran, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 354-.   Abstract （129）      PDF（pc） （1846KB）（1007）       Knowledge map    Save From the first generation of inert materials to the third generation of active materials， biomaterials have developed rapidly in recent years， showing great application prospects in biomedicine， but its effective sterilization has become increasingly difficult. Effective sterilization and disinfection of biomaterials are essential to achieve clinical transformation. This review summarized the classical and emerging sterilization methods for biomaterials and the impact of these sterilization technologies on the physicochemical properties of biomaterials. This review also discussed the sterilization effect， toxicity， and problems in the practical application of various methods， intending to provide a reference for the selection of sterilization methods in the research of biomaterials. Related Articles | Metrics | Comments（0）

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Akkermansia muciniphila outer membrane protein 1100 promotes wound healing in diabetic rats LIN Weiyi, GE Chengwang, TANG Xiaowei, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 358-.   Abstract （200）      PDF（pc） （2047KB）（921）       Knowledge map    Save Objective　To investigate the effects of Akkermansia muciniphila outer membrane protein 1100 (Amuc_1100) on wound inflammation and collagen fiber synthesis in diabetic rats. Methods　Twenty male SD rats were induced into diabeticrats by intraperitoneal injection of streptozotocin. The defective wound model of full-thickness back skin was constructed and the rats were divided into two groups, control group and Amuc_1100 group. The Amuc_1100 group was injected locally with 300 μL Amuc_1100 solution with a concentration of 333 μg/mL, the control group was injected with the same amount of normal saline. Wounds were photographed and the wound healing rate were compared on day 0, 3, 7, 10 and 14, respectively. Five rats in each group were sacrificed and harvested on day 7 and 14. Hematoxylin-eosin (HE) staining was used to evaluate inflammatory cellinfiltration and histological morphology of the wound. Masson three-color staining was used to evaluate collagen fiber deposition. The mRNA expression levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), collagen fiber 1A1 (Col1A1) and collagen fiber 3A1 (Col3A1) were compared by real-time quantitative polymerase chain reaction (RT-PCR). Results　The wound healing rate in Amuc_1100 group was higher than that in control group on day 3, 7, 10 and 14 (P<0.05). HE staining showed that the Amuc_1100 group had less inflammatory cells and more collagen fiber deposition in wound tissue. Masson three-color staining showed that the collagen in the Amuc_1100 group was thicker, deeper dyed and more compact than control group. RT-PCR showed that the relative mRNA expressions of TNF-α and IL-6 were significantly decreased in Amuc_1100 group compared with the control group (P<0.05), and the relative mRNA expressions of IL-10, Col1A1 and Col3A1 were significantly increased compared with the control group (P<0.05). Conclusion　Amuc_1100 can improve the wound healing rate of diabetic rats, and the mechanism may be related to reducing local inflammatory response and increasing collagen fiber synthesis. Related Articles | Metrics | Comments（0）

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In-situ bioprinting and hair follicle reconstruction of full-layer skin injury LI Xingzhou, CHEN Xiaojun, SUN Mengzhe, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 336-.   Abstract （236）      PDF（pc） （1132KB）（920）       Knowledge map    Save Objective　Using in-situ bioprinting to repair full-thickness skin wound on the back of nude mice to achieve in-situ repairing and hair follicle reconstruction. Methods　Dorsal full-thickness skin defects (7 mm in diameter) was created and covered with CA/BC in nude mice. About 5×105 primary cells from neonatal C57 mice skin were used as seed cells and transplanted to the wound: 10 points of high-concentration cell plotting was printed in the CA/BC via in-situ bioprinting in ex perimental group while 1 mL injector was used manually in control group. After 4 weeks, wound repairing and hair growth were observed, and the structure of new hair follicles was examined by H&E staining. Results　The skin defect wound of the exper imental group recovered well with vigorous and uniform hair growth, while the hair of the control group was sparse, uneven or even no hair growth. HE staining showed that there was complete hair follicle structure in the new skin of the experimental group, while there was almost no hair follicle formation in the control group. Conclusion　The feasibility of in-situ bioprinting tech nology in skin defect repair and hair follicle reconstruction is preliminarily verified. Related Articles | Metrics | Comments（0）

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Application of anterograde and reverse dorsalis pedis skin flap for repairing defects in the lower leg and foot DU Xuanyu, CHEN Yong, WANG Qian, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 371-.   Abstract （177）      PDF（pc） （1269KB）（901）       Knowledge map    Save Objective　To explore the application of anterograde and reverse dorsalis pedis skin flap in the repair of the de fects in the lower leg and foot. Methods　From Jan. 2018 to Dec. 2021, 14 cases of dorsalis pedis flap were used to repair the defects in the lower leg and foot, including 9 cases of anterograde dorsalis pedis skin flap and 5 cases of reverse dorsalis pedis skin flap. The donor site was repaired with skin graft directly or covered with artificial dermis followed by skin graft 2-3 weeks later. Results　All flaps survived well with primary healing. Most of skin grafts survived and the residual wound healed with dressing change. In the follow-up period, the appearance of the flap was satisfactory. The appearance of donor sites repaired with artificial dermis and secondary skin graft were better than that repaired by skin graft only. Foot function recovered well. Conclusion　Dorsalis pedis flap is a reliable choice for repairing defects in the lower leg and foot. The application of artificial dermis before skin graft can obviously increase the survival rate and improve the long-term appearance of donor site. Related Articles | Metrics | Comments（0）