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Research progress on the mechanism of skin aging caused by ultraviolet radiation CHEN Heng, WANG Jue, ZHOU Xu Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 382-.   Abstract （549）      PDF（pc） （992KB）（5581）       Knowledge map    Save Skin exposed to sunlight for a long period of time will have impaired function and even genetic material alteration， which is manifested by aging characteristics such as water loss， elasticity loss， wrinkle growth， melanin deposition and dryness. There are many ways to cause skin photoaging and the mechanism is complex， the ultraviolet light in sunlight has a particularly obvious effect on skin aging， the ultraviolet light that can act on the skin is divided into two kinds： UVA and UVB. They mainly act on the skin through five mechanisms that lead to photoaging： oxidative stress， damaging genetic material， changing the epidermal microbial community， destroying the function and structure of organelles， and reshaping the extracellular matrix （ECM）.In this paper， these five mechanisms were reviewed， and research directions and prospects in this field were proposed. Related Articles | Metrics | Comments（0）

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Research progress of three-dimensional functional skin model construction in vitro LI Yang, XI Taotao, ZHANG Bo, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 240-.   Abstract （414）      PDF（pc） （1034KB）（4336）       Knowledge map    Save Tissue engineering technology has been widely used in tissue and organ repair and has become an important method of regenerative medicine technique. The appearance of tissue engineering skin provides a new method for the treatment of large-area cutaneous defect in clinic. Because of the complicated skin-structure， it is an enormous challenge to building a functional three-dimensional skin tissue engineering model to simulate or replace the original skin. Based on this， from the aspects of cell types and sources， techniques， types， applications and prospects of skin tissue engineering models， the latest progress of in vitro 3D functional skin tissue model construction was reviewed in order to provide a theoretical basis for the construction of ideal skin tissue model. Related Articles | Metrics | Comments（0）

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Advances of facial skin typing methods  CHEN Zixuan, ZHANG Zheng, ZHANG Yixin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 378-.   Abstract （248）      PDF（pc） （954KB）（2409）       Knowledge map    Save Skin typing is a common method for describing skin characteristics. Traditional skin typing methods （such as the Fitzpatrick Skin Phototype and Baumann Skin Typing） have their own advantages and disadvantages. However， the above skin typing methods rely on subjective judgement， lacking quantitative analysis of skin objective parameters. In recent years， the measurement technology of objective parameters such as sebum secretion and transepidermal water loss has made great progress， making it possible to describe skin types with objective parameters. Additionally， image recognition technology based on facial photos can extract facial skin features and provide a basis for skin typing. This article reviewed subjective skin typing methods， skin objective parameter detection， and skin analysis technology based on image recognition， and discussed the development process of skin typing from qualitative-quantitative-visualization， in order to provide a theoretical basis for objective and precise skin typing in the future. Related Articles | Metrics | Comments（0）

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The pathogenesis and therapeutic strategies for congenital melanocytic nevi LI Dongdong, WANG Bin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 254-.   Abstract （464）      PDF（pc） （1226KB）（2261）       Knowledge map    Save Congenital melanocytic nevus is a common skin developmental abnormality that can occur in any part of the body where melanocytes are present. Its occurrence is closely related to somatic cell mutations， regulated by multiple signaling pathways， and has diverse clinical manifestations. Surgical excision and dilator are still the main treatments for CMN， and laser therapy is a powerful mean to eliminate pigmentation and remove satellite lesions. Targeted therapy and immunotherapy are becoming a new direction for the treatment of congenital melanin giant nevi. Related Articles | Metrics | Comments（0）

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Progress in research methods of studying the neural crest JIANG Leheng, YIN Ningbei Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 469-.   Abstract （634）      PDF（pc） （993KB）（2076）       Knowledge map    Save The neural crest is a migratory， multipotent stem cell population during vertebrate embryogenesis， and lineage tracing is the focus of its research. Over the 150 years since its first discovery， understanding of the neural crest has gone through a transition from morphological observations to single-cell level. In this paper， important approaches applied to study the neural crest were reviewed including radioisotope labeling， chimeras， vital dye labeling， in vitro clonal analysis， conditional genetic recombination and single-cell sequencing. Related Articles | Metrics | Comments（0）

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Diagnosis and treatment of vascular anomalies in the era of precision medicine YANG Xiaonan, ZHANG Ye Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 599-.   Abstract （191）      PDF（pc） （1038KB）（1517）       Knowledge map    Save Vascular anomalies are classified into hemangiomas and vascular malformations， representing a group of diseases that include （but not limited to） more than 30 types of hemangiomas， over 60 types of vascular malformations， and more than 20 syndromes related to vascular anomalies. Deepening understanding and improving diagnosis and treatment have always been the focus and difficulty in clinical work. With the continuous advancement of medical science and technology， the diagnosis and treatment of vascular anomalies are rapidly entering a new medical era-the era of precision medicine. Precision medicine relies on in-depth research of molecular mechanisms， advanced diagnostic technologies， personalized treatment plans and multidisciplinary diagnosis and treatment mode， and its clinical expansion and promotion in clinical practice have brought revolutionary changes to the diagnosis and treatment of vascular anomalies. In this paper， the progress and future development direction of the diagnosis and treatment of vascular anomalies in the era of precision medicine were reviewed. Related Articles | Metrics | Comments（0）

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Skin characteristics and nursing after photoelectric injury DONG Jiying, HAN Shuqing, LU Nan, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 265-.   Abstract （328）      PDF（pc） （986KB）（1397）       Knowledge map    Save Photoelectric therapy plays a role in treating diseases and skin beauty by starting the process of skin wound repair. This paper summarized the changes in the acute skin injury period after different types of photoelectric therapy， the process and characteristics of skin injury repair after surgery， and the principles of skin care after surgery， in order to reduce the occurrence of adverse reactions and accelerate skin repair after surgery， reduce downtime， and improve patient satisfaction. Related Articles | Metrics | Comments（0）

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Recent advances of multiomics approaches for pathologic scars ZHENG Hongkun, SHAN Shengzhou, JI Xiangyang, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 362-.   Abstract （191）      PDF（pc） （984KB）（1336）       Knowledge map    Save Pathologic scars， including keloids and hypertrophic scars， not only affect aesthetics but also compromise patients' daily lives and psychological well-being. Despite recent progress in understanding the pathogenesis of pathologic scars， effective treatments remain a challenge. In this paper， the research advancements of multi-omics approaches for pathologic scars were summarized， encompassing genomics， epigenomics， transcriptomics， proteomics， metabolomics， and single-cell omics. By providing a comprehensive overview of these cutting-edge techniques， the review aimed to inspire novel therapeutic strategies for the management of pathologic scars. Related Articles | Metrics | Comments（0）

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Research progress of 3D adipose tissue model ZHU Congxiao, YIN Ningbei Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 562-.   Abstract （266）      PDF（pc） （975KB）（1332）       Knowledge map    Save As the largest endocrine organ and the main energy storage system in the human body， adipose tissue plays a pivotal role in regulating energy homeostasis. Pathological conditions such as insulin resistance， chronic inflammation and mitochondrial dysfunction are closely related to adipose metabolic disorders. In vitro models are significant tools for studying the mechanism of associated disorders. At present， three-dimensional culture is a common model for in vitro adipose tissue research because it can imitate the process of adipose metabolism to a certain extent. In order to serve as a resource for future scientific investigations， an overview of three-dimensional adipose tissue models and their properties was provided in this paper. Related Articles | Metrics | Comments（0）

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Research progress of intramuscular fatty infiltration LU Baixue, GAO Weicheng Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 481-.   Abstract （565）      PDF（pc） （970KB）（1318）       Knowledge map    Save Fat infiltration plays an important role in the pathological development of muscle related diseases， and is closely related to disease recurrence and poor prognosis. In recent years， the research on the potential mechanism of intramuscular fat infiltration has been highly popular at home and abroad， mainly focusing on the basic and clinical research related to skeletal muscle and myocardial fat infiltration. In this paper， the relevant literature on the pathogenesis of intramuscular fat infiltration in skeletal muscle and myocardium in recent years was reviewed， to provide assistance for the basic and clinical research of intramuscular fat infiltration related diseases. Related Articles | Metrics | Comments（0）

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Low-level laser therapy for androgenetic alopecia ；A consensus among chinese experts Hair Medicine Branch of the Chinese Society of Aesthetic and Plastic Surgery, Chinese Non-government Medical Institutions Association Dermatology Branch Hair Medicine and Scalp Health Management Professional Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 157-.   Abstract （500）      PDF（pc） （959KB）（1163）       Knowledge map    Save Low-level laser therapy for androgenetic alopecia has been used clinically for over ten years， with definite efficacy and high safety. A variety of low-level laser devices have been approved and marketed domestically， and are widely used in clinical settings， yet there are currently no unified usage standards. This consensus compiled and summarized relevant guidelines and clinical research from both domestic and international sources in recent years， providing a reference for the correct selection and use of low-level laser therapy for androgenetic alopecia in clinical practice. Related Articles | Metrics | Comments（0）

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Advances in molecular genetics of dermatofibrosarcoma protuberans DENG Yuqi, LIANG Xiao, SUN Di, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 260-.   Abstract （224）      PDF（pc） （995KB）（1138）       Knowledge map    Save Dermatofibrosarcoma protuberans （DFSP）， one of the most common skin sarcomas， lacks specific clinical and radiological features and exhibits complex histopathology. It is characterized by slow and irregular infiltration of surrounding tissues， and surgical resection is the primary treatment modality. Currently， DFSP presents clinical challenges in terms of high misdiagnosis and recurrence rates， necessitating the development of specific diagnostic markers and effective therapeutic targets. This article aimed to provide a comprehensive review of the latest molecular genetics advancements in DFSP， with the goal of offering new insights for its diagnosis and treatment. Related Articles | Metrics | Comments（0）

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#br# Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 702-.   Abstract （209）      PDF（pc） （1165KB）（1120）       Knowledge map    Save Distal arthrogryposis represents a group of congenital malformations with genetic factors， and distal arthrogryposis type 9 is attributed to mutations in the FBN2 gene. Differing from other subtypes where muscular tissues are affected，FBN2 gene mutation primarily impacts the embryonic development of connective tissues， giving rise to distinctive clinical phenotypes. To date， the specific pathogenic mechanisms of this condition remain elusive. In this paper， the recent research progress of distal arthrogryposis type 9 was reviewed， aiming to enhance our understanding of the disease. With the advancement and widespread use of sequencing technologies， the potential discovery of additional mutation loci and patient cohorts holds promise for elucidating genotype-phenotype correlations. Furthermore， there is a pressing need to promote the development of appropriate cellular and animal models to further elucidate its pathogenic mechanisms， offering novel avenues for disease diagnosis and therapeutic interventions. Related Articles | Metrics | Comments（0）

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Sterilization methods for biomaterials in biomedical applications WU Ke, ZHANG Guo, ZHOU Muran, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 354-.   Abstract （152）      PDF（pc） （1846KB）（1069）       Knowledge map    Save From the first generation of inert materials to the third generation of active materials， biomaterials have developed rapidly in recent years， showing great application prospects in biomedicine， but its effective sterilization has become increasingly difficult. Effective sterilization and disinfection of biomaterials are essential to achieve clinical transformation. This review summarized the classical and emerging sterilization methods for biomaterials and the impact of these sterilization technologies on the physicochemical properties of biomaterials. This review also discussed the sterilization effect， toxicity， and problems in the practical application of various methods， intending to provide a reference for the selection of sterilization methods in the research of biomaterials. Related Articles | Metrics | Comments（0）

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Research on positive psychological qualities， negative emotions， and quality of life in adult patients with port-wine stain WANG Wanyi, HU Jiahua, YU Wenxin, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 693-.   Abstract （140）      PDF（pc） （1036KB）（1012）       Knowledge map    Save Objective To understand the current status of positive psychological qualities （hope trait， self-compassion）， anxiety， depression， and quality of life in adult patients with port-wine stain （PWS）， and to provide a basis for implementing psychological interventions from the perspective of positive psychology. Methods A convenient sampling method was used to select 119 adult patients with fresh red nevus who underwent pulsed dye laser treatment from March to June 2023 as the study subjects. The survey tools included a general information questionnaire， Herth Hope Index， Self-Compassion Scale， Depression Screening Scale， Anxiety Screening Scale， and Health Status Questionnaire. Correlation analysis between variables was conducted. Results The average score of hope trait in 119 PWS patients was 30.8±7.7， with 16.0% of patients having low levels of hope trait， and the self-compassion score was 82.4±10.9. 48.7% of patients were positive for depression， and 65.5% of patients were positive for anxiety. The average score of quality of life was 68.3±12.5. There was a significant negative correlation between positive psychological qualities （hope trait， self-compassion） and negative emotions （anxiety， depression）， and a significant positive correlation between positive psychological qualities （hope trait， self-compassion） and quality of life （P<0.05）. Conclusion The positive psychological qualities of adult PWS patients are at a moderate level， with experiencing negative emotions such as anxiety and depression， leading to decreased quality of life. Positive psychological qualities are key factors in improving negative emotions and enhancing quality of life in PWS patients， and personalized intervention strategies for positive psychological qualities can be explored in the future. Related Articles | Metrics | Comments（0）

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Advances in molecular mechanisms of pathological scar formation JIA Yuxin, XU Heng, ZHANG Yixin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 248-.   Abstract （175）      PDF（pc） （1007KB）（936）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Fluid mechanics finite element analysis of 3D printed porous biological scaffolds with different microstructures based on cell adhesion WU Qiyou, CUI Boyu, XIA Wei, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 293-.   Abstract （215）      PDF（pc） （4864KB）（934）       Knowledge map    Save Objective To study the influence of 3D-printed bone scaffolds with different pore morphologies on cell adhesion. Methods Utilizing MSLattice software， four porous structures with different pore morphologies， namely cubic， Hexagon， diamond， and gyroid， were designed. The principles of finite element analysis （FEM） and computational fluid dynamics （CFD） were employed using Siemens Star CCM+ software to simulate the fluid flow within the four scaffold structures， model the process of cell adhesion， measure the fluid flow velocity and pressure within the scaffold， as well as the fluid permeability and the thickness of the adhesion layer. Results Upon the passage of fluid through the four types of scaffolds， the pressure gradually diminished. However， due to the relatively regular structure of the scaffolds， the pressure exhibited a gradient distribution. The simulated pressure values before fluid flow through the four types of scaffolds were， in sequence： Gyroid>Cubic>Diamond>Hexagon. Flow velocity： Cubic>Gyroid>Diamond>Hexagon. The permeability of the four types of scaffolds： Diamond>Hexagon>Cubic>Gyroid. Adhesion layer thickness： Gyroid>Hexagon>Cubic>Diamond. Conclusion The fluid mechanics analysis results show that the gyroid scaffold has lower permeability and the highest adhesion layer thickness， which is more conducive to cell adhesion. Related Articles | Metrics | Comments（0）

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Application of cerium oxide nanoparticles in wound healing ZHU Yulin, LIU Jing, DENG Guoying Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (5): 574-.   Abstract （330）      PDF（pc） （948KB）（915）       Knowledge map    Save Wound healing is a complex physiological process， which can be divided into four main stages： Hemostasis， inflammation， proliferation and migration， and tissue remodeling. At the same time， granulation formation， inflammatory cell infiltration， necrotic tissue cleaning， scar remodeling and other reactions are involved. In some pathological cases， the natural healing process of the wound may be stalled， resulting in repeated attacks and even death from shock. In recent years， the search for high safety and high efficiency medical materials has attracted much attention from researchers. Among them， cerium oxide nanoparticles are a unique material which can promote wound healing and play an important role in all stages of wound healing. Nano-cerium oxide particles not only have antioxidant， antibacterial and anti-inflammatory functions， but also can be used as drug carriers in wound repair to ensure the benign absorption of the body， and can be used as tissue scaffolds to promote the development and maturity of new structures. Therefore， exploring the role of cerium oxide nanoparticles in wound healing may be a new strategy for wound repair. In this paper， the effects of cerium oxide nanoparticles on wound repair were reviewed to provide references for their further application and development in the future. Related Articles | Metrics | Comments（0）

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Preparation and application of collagen-based biomaterials in bone and cartilage regeneration and repair DUAN Jing, YANG Bing Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (6): 707-.   Abstract （372）      PDF（pc） （1040KB）（908）       Knowledge map    Save Collagen-based biomaterials can be used as ideal biomaterials for bone and cartilage regeneration and repair due to their good biological activity and biocompatibility. However， due to the weak macroscopic mechanical properties of collagen， which cannot meet the mechanical requirements of natural cartilage and bone tissue， the mechanical properties are often improved by cross-linking modification. In addition， different material forms require different forming technologies. In this paper， the cross-linking methods and forming technologies of collagen-based biomaterials were reviewed， and the construction of collagen scaffolds and the selection of implanted cells for bone and cartilage regeneration and repair in recent years were summarized， aiming to provide clues and ideas for the development of collagen-based biomaterials preparation technology and the transformation of clinical applications. Related Articles | Metrics | Comments（0）

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Clinical study of novel supramolecular salicylic acid technique in the treatment of acne rosacea HUANG Yan Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 216-.   Abstract （460）      PDF（pc） （1822KB）（882）       Knowledge map    Save Objective To explore the efficacy and safety of 30% supramolecular salicylic acid in the treatment of acne rosacea. Methods A total of 165 patients diagnosed with rosacea from 2019 to 2021 were selected and randomly divided into control group and observation group. Among them， 85 patients in the observation group received traditional treatment combined with supramolecular salicylic acid and skin repair moisturizer. The control group of 80 patients was treated with traditional regimen. The therapeutic effect and incidence of adverse reactions were statistically analyzed in the two groups. Results Before treatment， there were no statistical differences in facial spots， red areas and pores between the two groups （P>0.05）， and after treatment， the above indexes were improved， and the observation group was better than the control group （P<0.05） . The total effective rate of the observation group was 97.65%， which was significantly higher than that of the control group （85%， P<0.05） . The incidence of adverse reactions in observation group was 17.65%， which was significantly lower than that in control group （35%， P<0.05）. Conclusion Supramolecular salicylic acid combined with traditional drugs has significant effect and low incidence of adverse reactions in the treatment of rosacea， and can be used as an adjuvant therapy for rosacea. Related Articles | Metrics | Comments（0）