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Evaluation of facial injection filling materials for medical aesthetics ZHAO Chenyu, LI Chongchong, SUN Xue, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (5): 517-.   Abstract （527）      PDF（pc） （874KB）（4895）       Knowledge map    Save With economic development and technological progress, the demand for medical aesthetics has increased sig nificantly, and medical biomaterials are widely used. It is necessary to further improve the evaluation of their effectiveness and safety. At present, the evaluation of its physicochemical properties and biology is adopted in China. However, the clinical effec tiveness is a multi-faceted evaluation without unified criteria. Most of the evaluation mainly adopts objective indicators for quan titative analysis, while subjective feelings are secondary criteria. In this paper, the main facial fillers and the evaluation methods of their physicochemical properties were reviewed. Related Articles | Metrics | Comments（0）

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Research progress on the mechanism of skin aging caused by ultraviolet radiation CHEN Heng, WANG Jue, ZHOU Xu Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 382-.   Abstract （334）      PDF（pc） （992KB）（3001）       Knowledge map    Save Skin exposed to sunlight for a long period of time will have impaired function and even genetic material alteration， which is manifested by aging characteristics such as water loss， elasticity loss， wrinkle growth， melanin deposition and dryness. There are many ways to cause skin photoaging and the mechanism is complex， the ultraviolet light in sunlight has a particularly obvious effect on skin aging， the ultraviolet light that can act on the skin is divided into two kinds： UVA and UVB. They mainly act on the skin through five mechanisms that lead to photoaging： oxidative stress， damaging genetic material， changing the epidermal microbial community， destroying the function and structure of organelles， and reshaping the extracellular matrix （ECM）.In this paper， these five mechanisms were reviewed， and research directions and prospects in this field were proposed. Related Articles | Metrics | Comments（0）

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Research progress of three-dimensional functional skin model construction in vitro LI Yang, XI Taotao, ZHANG Bo, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 240-.   Abstract （210）      PDF（pc） （1034KB）（2623）       Knowledge map    Save Tissue engineering technology has been widely used in tissue and organ repair and has become an important method of regenerative medicine technique. The appearance of tissue engineering skin provides a new method for the treatment of large-area cutaneous defect in clinic. Because of the complicated skin-structure， it is an enormous challenge to building a functional three-dimensional skin tissue engineering model to simulate or replace the original skin. Based on this， from the aspects of cell types and sources， techniques， types， applications and prospects of skin tissue engineering models， the latest progress of in vitro 3D functional skin tissue model construction was reviewed in order to provide a theoretical basis for the construction of ideal skin tissue model. Related Articles | Metrics | Comments（0）

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New advances in the study of scaffold materials for cartilage tissue engineering YUE Guangren, WANG Ximei, LI Yu Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 408-413.   Abstract （447）      PDF（pc） （875KB）（2250）       Knowledge map    Save Lacking blood vessels and nerve nourishment, cartilage has limited ability to repair and regenerate. Combining scaffolds, cells and active factors, tissue engineering has been considered as an important new direction for repairing cartilage injury. Scaffold plays an important role in the cartilage regeneration process, not only providing a support site for cell adhesion, but also improving the local microenvironment and affecting cell proliferation and differentiation. Many materials have been used to make biodegradable scaffolds: natural materials, synthetic materials and composite materials. In this paper, the materials that have been relatively widely used in cartilage tissue engineering were reviewed so as to provide valuable reference for researchers in this field. Related Articles | Metrics | Comments（0）

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Overview of sensitive skin and treatment progress of aesthetic medicine LU Nan, WU Min, SONG Jiao, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 323-.   Abstract （405）      PDF（pc） （708KB）（2100）       Knowledge map    Save 敏感性皮肤 ；　机制 ；　诊断 ；　治疗 ；　光电治疗 Related Articles | Metrics | Comments（0）

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Analysis of mutation type and clinical significance of congenital melanocytic nevi ZHAO Yifei, ZOU Yun, CHEN Hui, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 258-.   Abstract （426）      PDF（pc） （843KB）（1928）       Knowledge map    Save Objective To explore the molecular characteristics of giant congenital melanocytic nevi (GCMN) and their clinical significance. Methods The samples of patients diagnosed with GCMN were subjected whole-exome sequencing and bio-information analysis to clarify the pathogenic genes and distribution patterns. Results In 50 samples (25 pairs of tissues and blood) from 25 patients, 21 patients had somatic mutations, including NRAS gene (19 cases) and BRAF gene (1 case). New mutations were detected in 2 patients’ lesions and blood, and the mutant genes were MET gene and IDH1 gene. In addition, no causative mutation was detected in 4 patients. There was no statistic difference between GCMN genotype and phenotype. Conclusion NRAS somatic mutation is the most common mutation in GCMN, and BRAF gene has also been detected. Potential new mutated IDH1 and MET genes were also found. Related Articles | Metrics | Comments（0）

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Transplantation of human induced pluripotent stem cell derived cardiac progenitor cells for acute myocardial infarction in rats LUO Runjiao, AI Xuefeng, LI Kaixiang, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 213-.   Abstract （191）      PDF（pc） （3951KB）（1774）       Knowledge map    Save Objective　To explore the effect of human induced pluripotent stem cell-derived cardiac progenitor cells trans plantation on acute myocardial infarction in rats. Methods　Immunofluorescence staining was used to identify the pluripotency of human induced pluripotent stem cells, and GiWi method was used to differentiate them into cardiac progenitor cells in vitro, and then they were further differentiated into cardiomyocytes. Flow cytometry and immunofluorescence staining were used to evaluate the differentiation efficiency and morphology of the obtained cardiac progenitor cells and cardiomyocytes. The rat model of acute myocardial infarction was established by ligation of the left anterior descending coronary artery. TTC staining and echo cardiography were used to evaluate the model. Cardiac progenitor cells were transplanted into the marginal area of myocardial  infarction, and cardiac function was detected by echocardiography at 1 week and 4 weeks after operation. HE and Masson stain ing were used to evaluate the size of infarct area and the degree of fibrosis. Immunofluorescence staining was used to evaluate the survival and differentiation of cardiac progenitor cells in vivo. Results　The stem markers OCT4, SOX2, Nanog and Tra-1-60 were highly expressed in human induced pluripotent stem cells. The in vitro differentiation efficiency of cardiac progenitor cells was as high as 77.8%, expressing Isl1, a specific marker of cardiac progenitor cells. It can further differentiate into cardiomyo cytes with an efficiency of 83.3%, and high expression of cTnT, α-actinin and other myocardial specific markers. The rat model of acute myocardial infarction was successfully established. TTC staining showed that the infarct area was white and the left ven tricular ejection fraction was decreased. At 4 weeks after transplantation, compared with the model group, the cardiac function of the cell group was improved, ventricular dilatation was weakened, and fibrosis was alleviated. The transplanted cells survived in vivo and differentiated into cardiomyocytes. Conclusion　Cardiac progenitor cells derived from human induced pluripotent stem cells have high differentiation efficiency in vitro, can survive and differentiate into cardiomyocytes after transplantation in vivo, inhibit ventricular remodeling and improve cardiac function. Related Articles | Metrics | Comments（0）

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Research progress of tissue engineering ligament and scaffold materials ZHONG Rui, GAO Jingyu, YAN Chengyuan, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 308-.   Abstract （312）      PDF（pc） （927KB）（1560）       Knowledge map    Save 　The reconstruction scheme of the existing artificial ligament products has been relatively mature in clinical ap plication. In order to prevent the occurrence of postoperative complications such as difficult tendon-bone healing, expansion of the bone tunnel, synovial inflammatory reaction, infection, and external fixation loosening after ligament reconstruction, tendon tissue construction using tissue engineering technology has become a possible development direction in the future. In this paper, the progress of the construction of tissue-engineered tendon and its scaffold materials was reviewed, the urgent problems to be solved and the future development direction were discussed. Related Articles | Metrics | Comments（0）

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The incidence and risk factors of breast cancer-related lymphedema ZHANG Yingying, LI Hua, GUAN Jiaqin, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 242-.   Abstract （576）      PDF（pc） （1127KB）（1371）       Knowledge map    Save Objective　To explore the incidence rate, severity and risk factors of breast cancer-related lymphedema (BCRL) among breast cancer survivors. Methods　Data collected from 128 patients underwent breast cancer operation during September 1 to December 31, 2019. All the patients were female, aging (49.0±6.8) years (29-81 years). The Norman questionnaire and arm circumference measurement were used to evaluate the BCRL status and treatment status of breast cancer patients from subjective and objective perspectives at 6, 12, 24 and 36 months after surgery separately. The influence of the correlation factors on BRCL occurrence was analyzed by Logistic analysis. Results　BRCL incidences were 9.4%, 25%, 23.4% and 23.4% at 6, 12, 24, 36 months according to arm circumference measurement, while 12.5%, 26.6%, 25.0% and 25.0% by Norman questionnaire. Among the 128 patients, 30 were diagnosed with BCRL after breast cancer surgery, among which the incidence of stage Ⅰ lymphedema, stage Ⅱ lymphedema and stage Ⅲ lymphedema were 15.6%, 6.3% and 1.6%, respectively. Age, body mass index (BMI)  radiotherapy, the number of positive lymph nodes and surgery method showed differences between the the BCRL group and control group. Both CDT or LVA showed improvement for the BCRL patients. Conclusion　BCRL is a common complication for breast cancer patients after surgery. It can be fairly diagnosed in the first year after surgery without the increasing incidence of BCRL over time throughout 3 years. BMI, radiotherapy were found to be independent risk factors in the development of BCRL in this study. Related Articles | Metrics | Comments（0）

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Research progress of 3D bioprinting technology in dermal regeneration XU Pengqin, HAN Chunmao Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 302-.   Abstract （359）      PDF（pc） （973KB）（1325）       Knowledge map    Save 　Soft tissue defects of skin are common in clinical practice. The restoration of dermal damage, to a large ex tent, contributes to the repairing effects and scar formation of skin soft tissue defects. Three-dimensional (3D) bioprinting is an emerging technology that can accurately distribute biomaterials and living cells. It creates intricate stereoscopic structures which facilitates regenerative repair of dermal defects. Due to limitations of printing method, bio-ink, and seed cells, 3D bioprinting technology for skin is still in the lab stage. With the development of 3D bioprinting, especially in novel bio-ink exploitation and technical optimization, high resolution 3D bioprinting will enable us to customize elaborate functionalized skin models and even cutaneous appendages, providing new strategies in dermal regenerative repairment. Related Articles | Metrics | Comments（0）

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Advances of facial skin typing methods  CHEN Zixuan, ZHANG Zheng, ZHANG Yixin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 378-.   Abstract （151）      PDF（pc） （954KB）（1300）       Knowledge map    Save Skin typing is a common method for describing skin characteristics. Traditional skin typing methods （such as the Fitzpatrick Skin Phototype and Baumann Skin Typing） have their own advantages and disadvantages. However， the above skin typing methods rely on subjective judgement， lacking quantitative analysis of skin objective parameters. In recent years， the measurement technology of objective parameters such as sebum secretion and transepidermal water loss has made great progress， making it possible to describe skin types with objective parameters. Additionally， image recognition technology based on facial photos can extract facial skin features and provide a basis for skin typing. This article reviewed subjective skin typing methods， skin objective parameter detection， and skin analysis technology based on image recognition， and discussed the development process of skin typing from qualitative-quantitative-visualization， in order to provide a theoretical basis for objective and precise skin typing in the future. Related Articles | Metrics | Comments（0）

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Research progress of traumatic optic neuropathy LI Xinyu, GUO Zhilin Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 315-.   Abstract （331）      PDF（pc） （791KB）（1286）       Knowledge map    Save 　Traumatic optic neuropathy (TON) often occurs after cerebral injury and is mainly in young people. Optic nerve injury can lead to vision loss in mild cases and loss of vision in severe cases, seriously affecting the physical and mental health and working life of patients. Currently, there are different opinions on the treatment of TON, both surgical and non-surgical, and there is no method that is satisfactory to doctors and patients. In this paper, the recent advances in the study of optic nerve injury were reviewed in order to provide new ideas for clinical treatment. Related Articles | Metrics | Comments（0）

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The pathogenesis and therapeutic strategies for congenital melanocytic nevi LI Dongdong, WANG Bin Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 254-.   Abstract （244）      PDF（pc） （1226KB）（1253）       Knowledge map    Save Congenital melanocytic nevus is a common skin developmental abnormality that can occur in any part of the body where melanocytes are present. Its occurrence is closely related to somatic cell mutations， regulated by multiple signaling pathways， and has diverse clinical manifestations. Surgical excision and dilator are still the main treatments for CMN， and laser therapy is a powerful mean to eliminate pigmentation and remove satellite lesions. Targeted therapy and immunotherapy are becoming a new direction for the treatment of congenital melanin giant nevi. Related Articles | Metrics | Comments（0）

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Skin characteristics and nursing after photoelectric injury DONG Jiying, HAN Shuqing, LU Nan, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (2): 265-.   Abstract （183）      PDF（pc） （986KB）（1169）       Knowledge map    Save Photoelectric therapy plays a role in treating diseases and skin beauty by starting the process of skin wound repair. This paper summarized the changes in the acute skin injury period after different types of photoelectric therapy， the process and characteristics of skin injury repair after surgery， and the principles of skin care after surgery， in order to reduce the occurrence of adverse reactions and accelerate skin repair after surgery， reduce downtime， and improve patient satisfaction. Related Articles | Metrics | Comments（0）

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Research progress of three dimensional bio-printing technology for formation of vascular network in bone tissue ZHAI Chuanxing, WANG Zhimeng, WANG Guodong, et al Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 298-.   Abstract （191）      PDF（pc） （913KB）（1139）       Knowledge map    Save Vascularization of bone grafts is one of the major challenges facing bone tissue engineering (BTE). The ultimate goal of the construction of vascularized BTE is to provide a bone environment rich in functional vascular networks to achieve efficient bone integration and accelerate the functional recovery after implantation. In this paper, the research progress of 3D bio-printing in the formation of vascular network in bone tissue was reviewed, the formation mechanism of vascular network and the characteristics of 3D bio-printing technology were elaborated, the current vascularization strategies in BTE were summarized, and its development prospects were prospected. Related Articles | Metrics | Comments（0）

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Progress in research methods of studying the neural crest JIANG Leheng, YIN Ningbei Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 469-.   Abstract （526）      PDF（pc） （993KB）（948）       Knowledge map    Save The neural crest is a migratory， multipotent stem cell population during vertebrate embryogenesis， and lineage tracing is the focus of its research. Over the 150 years since its first discovery， understanding of the neural crest has gone through a transition from morphological observations to single-cell level. In this paper， important approaches applied to study the neural crest were reviewed including radioisotope labeling， chimeras， vital dye labeling， in vitro clonal analysis， conditional genetic recombination and single-cell sequencing. Related Articles | Metrics | Comments（0）

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Sterilization methods for biomaterials in biomedical applications WU Ke, ZHANG Guo, ZHOU Muran, et al Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (3): 354-.   Abstract （94）      PDF（pc） （1846KB）（944）       Knowledge map    Save From the first generation of inert materials to the third generation of active materials， biomaterials have developed rapidly in recent years， showing great application prospects in biomedicine， but its effective sterilization has become increasingly difficult. Effective sterilization and disinfection of biomaterials are essential to achieve clinical transformation. This review summarized the classical and emerging sterilization methods for biomaterials and the impact of these sterilization technologies on the physicochemical properties of biomaterials. This review also discussed the sterilization effect， toxicity， and problems in the practical application of various methods， intending to provide a reference for the selection of sterilization methods in the research of biomaterials. Related Articles | Metrics | Comments（0）

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Research progress of NOTCH signaling pathway and endothelial-to-mesenchymal transition in infantile hemangioma SUN Xiaoting, MA Xiaorong Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (4): 414-.   Abstract （189）      PDF（pc） （854KB）（926）       Knowledge map    Save Infantile hemangioma (IH) is a benign tumor that occurs in infants and childhood. The pathogenesis of IH has not been fully elucidated. Although the course of the disease is self-limiting, partial patients may have sequelae that affect the aesthetics or normal function. NOTCH signaling is an evolutionarily conserved signaling pathway, that plays vital roles in many physiological and pathological processes, such as cell differentiation, embryonic vascular development, tissue itself-renewal, the occurrence of tumor and inflammation, and regulation of vascular function. Endothelial-to-mesenchymal transition (EndMT) is a mechanism in which endothelial cells (ECs) lose their unique properties and acquire mesenchymal and stem cell-like characteristics under the influence of multiple factors. EndMT can be involved in a variety of pathologies, including embryonic development, malignant tumor invasion, and fibrotic disease. Recent findings have shown that inhibition of the NOTCH signaling pathway might accelerate the regression of IH and interfere with disease progression caused by EndMT. In this paper, the progression of endothelial-to-mesenchymal transition and NOTCH signaling pathway in IH were reviewed Related Articles | Metrics | Comments（0）

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Soft tissue anatomy and safe spaces for injectable filler placement in forehead region GU Tianyi, TENG Li Journal of Tissue Engineering and Reconstructive Surgery    2023, 19 (3): 319-.   Abstract （153）      PDF（pc） （1185KB）（925）       Knowledge map    Save 　Due to the advantages like less trauma, quicker recovery and relatively uncomplicated operation, more and more beauty seekers prefer injectable fillers to improve the appearance of the forehead. Completely understanding the complex anato my of the forehead region is helpful to avoid severe complications such as vascular occlusion, and to improve patient satisfaction. In this paper, the relevant literature was reviewed to summarize the systematic anatomy knowledge on forehead region and the safe spaces for forehead augmentation, to provide sufficient theoretical support for clinical injection and filling of forehead region. Related Articles | Metrics | Comments（0）

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Research progress of intramuscular fatty infiltration LU Baixue, GAO Weicheng Journal of Tissue Engineering and Reconstructive Surgery    2024, 20 (4): 481-.   Abstract （387）      PDF（pc） （970KB）（870）       Knowledge map    Save Fat infiltration plays an important role in the pathological development of muscle related diseases， and is closely related to disease recurrence and poor prognosis. In recent years， the research on the potential mechanism of intramuscular fat infiltration has been highly popular at home and abroad， mainly focusing on the basic and clinical research related to skeletal muscle and myocardial fat infiltration. In this paper， the relevant literature on the pathogenesis of intramuscular fat infiltration in skeletal muscle and myocardium in recent years was reviewed， to provide assistance for the basic and clinical research of intramuscular fat infiltration related diseases. Related Articles | Metrics | Comments（0）